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carfilzomib

chemical compound
Class type of: chemical compound Q15366934

Facts

12 properties
Instance of
type of chemical entity
Subclass of
chemical compound
Has use
medication
Active ingredient in
Kyprolis
Canonical SMILES
CC(C)CC(C(=O)C1(CO1)C)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(C)C)NC(=O)C(CCC3=CC=CC=C3)NC(=O)CN4CCOCC4
Chemical formula
C₄₀H₅₇N₅O₇
Isomeric SMILES
CC(C)C[C@@H](C(=O)[C@]1(CO1)C)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC3=CC=CC=C3)NC(=O)CN4CCOCC4
LiverTox likelihood score
LiverTox toxicity likelihood category D
Mass
+719.425799
Physically interacts with
Proteasome 20S subunit beta 5, Proteasome 20S subunit alpha 8, Proteasome 20S subunit beta 10, Proteasome 20S subunit alpha 5, Proteasome 20S subunit alpha 3, Proteasome 20S subunit beta 5, Proteasome subunit beta 11, Proteasome 20S subunit alpha 7, Proteasome 26S subunit, non-ATPase 1, Proteasome 20S subunit beta 6, Proteasome 26S subunit, non-ATPase 14, Proteasome 20S subunit alpha 2, Proteasome 20S subunit beta 8, Proteasome 20S subunit alpha 6, Proteasome subunit beta 1, Proteasome 20S subunit beta 2
Pregnancy category
US pregnancy category D
World Health Organisation international non-proprietary name
carfilzomib
🏷️ Also known as
en carfilzomib en Carfilzomib en Kyprolis® en PR-171 ar كارفيلزوميب fa کارفیلزومیب he קרפילזומיב hu karfilzomib ja カルフィルゾミブ uk Карфілзоміб zh 卡非佐米
🔖 Identifiers · 33
OpenAlex ID
C2780108899
ATC code
L01XX45
CAS Registry Number
868540-17-4
ChEBI ID
65347
ChEMBL ID
CHEMBL451887
ChemSpider ID
9731489
DSSTOX compound identifier
DTXCID0028616
DSSTox substance ID
DTXSID4048690
DrugBank ID
DB08889
DrugCentral ID
4483
EC number
692-054-2
ECHA Substance Infocard ID
100.219.957
Show all 33 identifiers +21
Freebase ID
/m/0dd8z8c
Guide to Pharmacology Ligand ID
7420
InChI
InChI=1S/C40H57N5O7/c1-27(2)22-32(36(47)40(5)26-52-40)42-39(50)34(24-30-14-10-7-11-15-30)44-38(49)33(23-28(3)4)43-37(48)31(17-16-29-12-8-6-9-13-29)41-35(46)25-45-18-20-51-21-19-45/h6-15,27-28,31-34H,16-26H2,1-5H3,(H,41,46)(H,42,50)(H,43,48)(H,44,49)/t31-,32-,33-,34-,40+/m0/s1
InChIKey
BLMPQMFVWMYDKT-NZTKNTHTSA-N
KEGG ID
D08880
LiverTox ID
Carfilzomib
MeSH concept ID
M0516378
MedlinePlus drug identifier
a612031
Microsoft Academic ID (discontinued)
2780108899
NDF-RT ID
N0000185509
NSC number
758252
PatientsLikeMe treatment ID
carfilzomib
Probes And Drugs ID
PD004089
PubChem CID
11556711
Reaxys registry number
12488950
RxNorm CUI
1302966
SureChEMBL ID
85165
UMLS CUI
C2001856
UNII
72X6E3J5AR
UniChem compound ID
283760
WikiProjectMed ID
Carfilzomib

Report an error or request removal Lineage (PROV-JSON)

🔗 Connections
Has use 1
medication
Subclass of 1
chemical compound
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Summary

carfilzomib is a type of chemical entity[1].

Key Facts

  • Physically interacts with: Proteasome 20S subunit beta 5[2], Proteasome 20S subunit alpha 8[3], Proteasome 20S subunit beta 10[4], Proteasome 20S subunit alpha 5[5], Proteasome 20S subunit alpha 3[6], Proteasome subunit beta 11[7], Proteasome 20S subunit alpha 7[8], Proteasome 26S subunit, non-ATPase 1[9], Proteasome 20S subunit beta 6[10], Proteasome 26S subunit, non-ATPase 14[11], Proteasome 20S subunit alpha 2[12], Proteasome 20S subunit beta 8[13], Proteasome 20S subunit alpha 6[14], Proteasome subunit beta 1[15]
  • Canonical SMILES: CC(C)CC(C(=O)C1(CO1)C)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(C)C)NC(=O)C(CCC3=CC=CC=C3)NC(=O)CN4CCOCC4[16]
  • Chemical formula: C₄₀H₅₇N₅O₇[17]
  • Subclass of: chemical compound[18]
  • Has use: medication[19]
  • Isomeric SMILES: CC(C)CC@@HNC(=O)C@HNC(=O)C@HNC(=O)C@HNC(=O)CN4CCOCC4C@@HNC(=O)C@HNC(=O)C@HNC(=O)C@HNC(=O)CN4CCOCC4">[20]
  • Mass: 719.425799 dalton[21]
  • World Health Organisation international non-proprietary name: carfilzomib[22]
  • Pregnancy category: US pregnancy category D[23]
  • Active ingredient in: Kyprolis[24]
  • LiverTox likelihood score: LiverTox toxicity likelihood category D[25]

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [2] ↑ . IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved . wikidata.org.
  2. [3] ↑ . Open Targets Platform. Retrieved . platform.opentargets.org. Provenance: wikidata.org.
  3. [4] ↑ . Open Targets Platform. Retrieved . platform.opentargets.org. Provenance: wikidata.org.
  4. [5] ↑ . Open Targets Platform. Retrieved . platform.opentargets.org. Provenance: wikidata.org.
  5. [6] ↑ . Open Targets Platform. Retrieved . platform.opentargets.org. Provenance: wikidata.org.
  6. [7] ↑ . Open Targets Platform. Retrieved . platform.opentargets.org. Provenance: wikidata.org.
  7. [8] ↑ . Open Targets Platform. Retrieved . platform.opentargets.org. Provenance: wikidata.org.
  8. [9] ↑ . Open Targets Platform. Retrieved . platform.opentargets.org. Provenance: wikidata.org.
  9. [10] ↑ . Open Targets Platform. Retrieved . platform.opentargets.org. Provenance: wikidata.org.
  10. [11] ↑ . Open Targets Platform. Retrieved . platform.opentargets.org. Provenance: wikidata.org.
  11. [12] ↑ . Open Targets Platform. Retrieved . platform.opentargets.org. Provenance: wikidata.org.
  12. [13] ↑ . Open Targets Platform. Retrieved . platform.opentargets.org. Provenance: wikidata.org.
  13. [14] ↑ . Open Targets Platform. Retrieved . platform.opentargets.org. Provenance: wikidata.org.
  14. [15] ↑ . Open Targets Platform. Retrieved . platform.opentargets.org. Provenance: wikidata.org.
  15. [16] ↑ . PubChem. Retrieved . wikidata.org.
  16. [17] ↑ . PubChem. Retrieved . wikidata.org.
  17. [18] ↑ . wikidata.org.
  18. [19] ↑ . wikidata.org.
  19. [20] ↑ . PubChem. Retrieved . wikidata.org.
  20. [21] ↑ . PubChem. Retrieved . wikidata.org.
  21. [22] ↑ . ChEBI. Retrieved . wikidata.org.
  22. [23] ↑ . wikidata.org.
  23. [24] ↑ . RxNorm. Retrieved . wikidata.org.
  24. [25] ↑ . LiverTox. Retrieved . ncbi.nlm.nih.gov. Provenance: wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). carfilzomib. Retrieved November 6, 2026, from https://4ort.xyz/entity/carfilzomib
MLA “carfilzomib.” 4ort.xyz Knowledge Graph, 4ort.xyz, 6 Nov. 2026, https://4ort.xyz/entity/carfilzomib.
BibTeX @misc{4ortxyz_carfilzomib_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{carfilzomib}}, year = {2026}, url = {https://4ort.xyz/entity/carfilzomib}, note = {Accessed: 2026-11-06}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): carfilzomib — https://4ort.xyz/entity/carfilzomib (retrieved 2026-11-06)

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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 20w ago · Nabbegat · 2026-06-19 view diff on Wikidata ↗
    Instance of → type of chemical entity
    Has use → medication
    LiverTox likelihood score → LiverTox toxicity likelihood category D
    Subclass of → —
    + 7 other properties edited (see Wikidata diff for full list)
    "/* wbeditentity-update-languages-short:0||tr */ QuickStatements 3.0 [[:toollabs:qs-dev/batch/37300|batch #37300]]"
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