Proteasome 26S subunit, non-ATPase 14

mammalian protein found in Homo sapiens

Protein protein Q21108543

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Proteasome 26S subunit, non-ATPase 14

Summary

Proteasome 26S subunit, non-ATPase 14 is a protein^[1].

Key Facts

Proteasome 26S subunit, non-ATPase 14's instance of is recorded as protein^[2].
Proteasome 26S subunit, non-ATPase 14's physically interacts with is recorded as carfilzomib^[3].
Proteasome 26S subunit, non-ATPase 14's physically interacts with is recorded as ixazomib^[4].
Proteasome 26S subunit, non-ATPase 14's physically interacts with is recorded as Oprozomib^[5].
Proteasome 26S subunit, non-ATPase 14's UniProt protein ID is recorded as O00487^[6].
Proteasome 26S subunit, non-ATPase 14's part of is recorded as 26S Proteasome non-ATPase regulatory subunit 14^[7].
Proteasome 26S subunit, non-ATPase 14's part of is recorded as MPN domain, protein family^[8].
Proteasome 26S subunit, non-ATPase 14's part of is recorded as Rpn11/EIF3F, C-terminal domain, protein family^[9].
Proteasome 26S subunit, non-ATPase 14's part of is recorded as JAB1/MPN/MOV34 metalloenzyme domain family^[10].
Proteasome 26S subunit, non-ATPase 14's has part is recorded as JAB1/MPN/MOV34 metalloenzyme domain^[11].
Proteasome 26S subunit, non-ATPase 14's has part is recorded as Rpn11/EIF3F, C-terminal^[12].
Proteasome 26S subunit, non-ATPase 14's has part is recorded as MPN domain^[13].
Proteasome 26S subunit, non-ATPase 14's RefSeq protein ID is recorded as NP_005796^[14].
Proteasome 26S subunit, non-ATPase 14's molecular function is recorded as metal ion binding^[15].
Proteasome 26S subunit, non-ATPase 14's molecular function is recorded as endopeptidase activator activity^[16].
Proteasome 26S subunit, non-ATPase 14's molecular function is recorded as proteasome binding^[17].
Proteasome 26S subunit, non-ATPase 14's molecular function is recorded as peptidase activity^[18].
Proteasome 26S subunit, non-ATPase 14's molecular function is recorded as protein binding^[19].
Proteasome 26S subunit, non-ATPase 14's molecular function is recorded as hydrolase activity^[20].
Proteasome 26S subunit, non-ATPase 14's molecular function is recorded as metallopeptidase activity^[21].
Proteasome 26S subunit, non-ATPase 14's molecular function is recorded as thiol-dependent deubiquitinase^[22].
Proteasome 26S subunit, non-ATPase 14's molecular function is recorded as Lys63-specific deubiquitinase activity^[23].
Proteasome 26S subunit, non-ATPase 14's molecular function is recorded as thiol-dependent deubiquitinase^[24].
Proteasome 26S subunit, non-ATPase 14's molecular function is recorded as metallopeptidase activity^[25].
Proteasome 26S subunit, non-ATPase 14's molecular function is recorded as proteasome binding^[26].

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Quick Facts

Instance of protein

Part of 26S Proteasome non-ATPase regulatory subunit 14, MPN domain, protein family, Rpn11/EIF3F, C-terminal domain, protein family, JAB1/MPN/MOV34 metalloenzyme domain family

Properties

Biological process regulation of proteasomal protein catabolic process, regulation of cellular amino acid metabolic process, antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent, ubiquitin-dependent protein catabolic process, regulation of mRNA stability, positive regulation of canonical Wnt signaling pathway, protein polyubiquitination, stimulatory C-type lectin receptor signaling pathway, tumor necrosis factor-mediated signaling pathway, MAPK cascade, proteolysis, cellular response to DNA damage stimulus, Fc-epsilon receptor signaling pathway, protein K63-linked deubiquitination, NIK/NF-kappaB signaling, double-strand break repair via homologous recombination, anaphase-promoting complex-dependent catabolic process, response to ethanol, double-strand break repair via nonhomologous end joining, T cell receptor signaling pathway, negative regulation of canonical Wnt signaling pathway, DNA repair, positive regulation of endopeptidase activity, Wnt signaling pathway, planar cell polarity pathway, proteasome-mediated ubiquitin-dependent protein catabolic process, negative regulation of G2/M transition of mitotic cell cycle, protein deubiquitination, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, neutrophil degranulation, transmembrane transport, regulation of transcription from RNA polymerase II promoter in response to hypoxia, post-translational protein modification, regulation of hematopoietic stem cell differentiation, protein deubiquitination, proteasome-mediated ubiquitin-dependent protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, interleukin-1-mediated signaling pathway, regulation of mitotic cell cycle phase transition

Cell component cytosol, proteasome accessory complex, nucleoplasm, cytosolic proteasome complex, proteasome regulatory particle, lid subcomplex, proteasome complex, extracellular exosome, nucleus, extracellular region, secretory granule lumen, ficolin-1-rich granule lumen, nucleus, proteasome regulatory particle, lid subcomplex

Encoded by PSMD14

Found in taxon Homo sapiens

Has part(s) JAB1/MPN/MOV34 metalloenzyme domain, Rpn11/EIF3F, C-terminal, MPN domain

Imported from wholeness_audit_2026-05-02

Molecular function metal ion binding, endopeptidase activator activity, proteasome binding, peptidase activity, protein binding, hydrolase activity, metallopeptidase activity, thiol-dependent deubiquitinase, Lys63-specific deubiquitinase activity, thiol-dependent deubiquitinase, metallopeptidase activity, proteasome binding

Physically interacts with carfilzomib, ixazomib, Oprozomib

External References (3)

Ensembl protein id ENSP00000386541, ENSP00000399311

Refseq protein id NP_005796

Uniprot protein id O00487

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Proteasome 26S subunit, non-ATPase 14 — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ Proteasome 26S subunit, non-ATPase 14 — physically interacts with (P129): carfilzomib. Open Targets Platform. Retrieved 2023-08-14. platform.opentargets.org. Provenance: wikidata.org.
[4] ↑ Proteasome 26S subunit, non-ATPase 14 — physically interacts with (P129): ixazomib. Open Targets Platform. Retrieved 2023-08-14. platform.opentargets.org. Provenance: wikidata.org.
[5] ↑ Proteasome 26S subunit, non-ATPase 14 — physically interacts with (P129): Oprozomib. Open Targets Platform. Retrieved 2023-08-14. platform.opentargets.org. Provenance: wikidata.org.
[6] ↑ Proteasome 26S subunit, non-ATPase 14 — UniProt protein ID (P352): O00487. Q905695. Retrieved 2019-11-13. wikidata.org.
[7] ↑ Proteasome 26S subunit, non-ATPase 14 — part of (P361): 26S Proteasome non-ATPase regulatory subunit 14. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ Proteasome 26S subunit, non-ATPase 14 — part of (P361): MPN domain, protein family. wikidata.org.
[9] ↑ Proteasome 26S subunit, non-ATPase 14 — part of (P361): Rpn11/EIF3F, C-terminal domain, protein family. wikidata.org.
[10] ↑ Proteasome 26S subunit, non-ATPase 14 — part of (P361): JAB1/MPN/MOV34 metalloenzyme domain family. wikidata.org.
[11] ↑ Proteasome 26S subunit, non-ATPase 14 — has part(s) (P527): JAB1/MPN/MOV34 metalloenzyme domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ Proteasome 26S subunit, non-ATPase 14 — has part(s) (P527): Rpn11/EIF3F, C-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ Proteasome 26S subunit, non-ATPase 14 — has part(s) (P527): MPN domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ Proteasome 26S subunit, non-ATPase 14 — RefSeq protein ID (P637): NP_005796. Q20641742. Retrieved 2020-05-30. wikidata.org.
[15] ↑ Proteasome 26S subunit, non-ATPase 14 — molecular function (P680): metal ion binding. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ Proteasome 26S subunit, non-ATPase 14 — molecular function (P680): endopeptidase activator activity. Relative structural and functional roles of multiple deubiquitylating proteins associated with mammalian 26S proteasome. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ Proteasome 26S subunit, non-ATPase 14 — molecular function (P680): proteasome binding. Relative structural and functional roles of multiple deubiquitylating proteins associated with mammalian 26S proteasome. Retrieved 2017-09-26. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ Proteasome 26S subunit, non-ATPase 14 — molecular function (P680): peptidase activity. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ Proteasome 26S subunit, non-ATPase 14 — molecular function (P680): protein binding. A proteome-scale map of the human interactome network. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Proteasome 26S subunit, non-ATPase 14 — molecular function (P680): hydrolase activity. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Proteasome 26S subunit, non-ATPase 14 — molecular function (P680): metallopeptidase activity. K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1. Retrieved 2017-09-26. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Proteasome 26S subunit, non-ATPase 14 — molecular function (P680): thiol-dependent deubiquitinase. K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Proteasome 26S subunit, non-ATPase 14 — molecular function (P680): Lys63-specific deubiquitinase activity. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Proteasome 26S subunit, non-ATPase 14 — molecular function (P680): thiol-dependent deubiquitinase. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Proteasome 26S subunit, non-ATPase 14 — molecular function (P680): metallopeptidase activity. K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Proteasome 26S subunit, non-ATPase 14 — molecular function (P680): proteasome binding. Relative structural and functional roles of multiple deubiquitylating proteins associated with mammalian 26S proteasome. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Proteasome 26S subunit, non-ATPase 14 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

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MLA

“Proteasome 26S subunit, non-ATPase 14.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/proteasome-26s-subunit-non-atpase-14.

BibTeX

@misc{4ortxyz_proteasome-26s-subunit-non-atpase-14_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Proteasome 26S subunit, non-ATPase 14}}, year = {2026}, url = {https://4ort.xyz/entity/proteasome-26s-subunit-non-atpase-14}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Proteasome 26S subunit, non-ATPase 14 — https://4ort.xyz/entity/proteasome-26s-subunit-non-atpase-14 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/proteasome-26s-subunit-non-atpase-14 · Last refreshed: May 3, 2026