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dihydrofolate reductase

mammalian protein found in Homo sapiens
Protein protein Q417149

Facts

11 properties
Instance of
protein
Part of
Dihydrofolate reductase-like domain superfamily, Dihydrofolate reductase domain, protein family, Dihydrofolate reductase conserved site, protein family[7][8][9]
Biological process
response to methotrexate, dihydrofolate metabolic process, one-carbon metabolic process, axon regeneration, regulation of transcription involved in G1/S transition of mitotic cell cycle, tetrahydrofolate metabolic process, tetrahydrofolate biosynthetic process, positive regulation of nitric-oxide synthase activity, folic acid metabolic process, tetrahydrobiopterin biosynthetic process, regulation of removal of superoxide radicals, negative regulation of translation, dihydrofolate metabolic process, tetrahydrofolate biosynthetic process, folic acid metabolic process
Cell component
cytosol, cytoplasm, mitochondrion, cellular component, mitochondrion
EC enzyme number
1.5.1.3[12]
Encoded by
DHFR
Found in taxon
Homo sapiens
Has part(s)
Dihydrofolate reductase domain, Dihydrofolate reductase conserved site[10][11]
Has parts
Dihydrofolate reductase domain, Dihydrofolate reductase conserved site
Molecular function
methotrexate binding, folic acid binding, dihydrofolate reductase activity, NADPH binding, RNA binding, oxidoreductase activity, mRNA binding, folate reductase activity, translation repressor activity, mRNA regulatory element binding, sequence-specific mRNA binding, dihydrofolate reductase activity, NADP binding
Physically interacts with
methotrexate, pemetrexed, pralatrexate, trimetrexate, piritrexim[2][3][4][5][6]
🏷️ Also known as
en DHFR en dihydrofolate reductase en uniprot:P00374 ar اختزال ثنائي هيدروالفولات de Dihydrofolsäure-Reduktase de DHFR de Dihydrofolatreduktase de Dihydrofolat-Reduktase de Dihydrofolsäurereduktase es Dihidrofolato reductasa fa آنزیم احیاء دی هیدروفولات fa آنزیم احیا دی هیدروفولات fa انزیم احیاء دی هیدروفولات fa انزیم احیا دی هیدروفولات fr Dihydrofolatereductase fr DHFR fr Dihydrofolate réductase he DHFR he דיהידרופולאט רדוקטאז it Diidrofolato reduttasi
🔖 Identifiers · 11
OpenAlex ID
C2781320022
Image (Wikimedia Commons)
PDB 8dfr EBI.jpg ↗
CAS Registry Number
9002-03-3
Ensembl protein ID
ENSP00000396308, ENSP00000421334, ENSP00000426474, ENSP00000422732
Exact match
purl.uniprot.org
Freebase ID
/m/0pys4
Microsoft Academic ID (discontinued)
2781320022, 2909764806
PDB structure ID
1BOZ, 1DHF, 1DLR, 1DLS, 1DRF, 1HFP, 1HFQ, 1HFR, 1KMS, 1KMV, 1MVS, 1MVT, 1OHJ, 1OHK, 1PD8, 1PD9, 1PDB, 1S3U, 1S3V, 1S3W, 1U71, 1U72, 1YHO, 2C2S, 2C2T, 2DHF, 2W3A, 2W3B, 2W3M, 3EIG, 3F8Y, 3F8Z, 3F91, 3FS6, 3GHC, 3GHV, 3GHW, 3GI2, 3GYF, 3L3R, 3N0H, 3NTZ, 3NU0, 3NXO, 3NXR, 3NXT, 3NXV, 3NXX, 3NXY, 3NZD, 3OAF, 3S3V, 3S7A, 4DDR, 4G95, 4KAK, 4KBN, 4KD7, 4KEB, 4KFJ, 4M6J, 4M6K, 4M6L, 4QHV, 4QJC
Quora topic ID
Dhfr
RefSeq protein ID
NP_000782, NP_001277283, NP_001277286
UniProt protein ID
P00374

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🔗 Connections
Cell component 4
mitochondrion, mitochondrion, cytoplasm, cytosol
Physically interacts with 4
methotrexate, pemetrexed, pralatrexate, trimetrexate
← Physically interacts with 3
pemetrexed, pralatrexate, trimetrexate
Found in taxon 1
Homo sapiens
Instance of 1
protein
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Summary

dihydrofolate reductase is a protein[1].

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [2] ↑ . IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved . wikidata.org.
  2. [3] ↑ . IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved . wikidata.org.
  3. [4] ↑ . IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved . wikidata.org.
  4. [5] ↑ . IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved . wikidata.org.
  5. [6] ↑ . Open Targets Platform. Retrieved . platform.opentargets.org. Provenance: wikidata.org.
  6. [7] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  7. [8] ↑ . wikidata.org.
  8. [9] ↑ . wikidata.org.
  9. [10] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  10. [11] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  11. [12] ↑ . wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

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APA 4ort.xyz Knowledge Graph. (2026). dihydrofolate reductase. Retrieved November 2, 2026, from https://4ort.xyz/entity/dihydrofolate-reductase
MLA “dihydrofolate reductase.” 4ort.xyz Knowledge Graph, 4ort.xyz, 2 Nov. 2026, https://4ort.xyz/entity/dihydrofolate-reductase.
BibTeX @misc{4ortxyz_dihydrofolate-reductase_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{dihydrofolate reductase}}, year = {2026}, url = {https://4ort.xyz/entity/dihydrofolate-reductase}, note = {Accessed: 2026-11-02}}
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