dihydrofolate reductase

mammalian protein found in Homo sapiens
Protein protein Q417149
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dihydrofolate reductase

Summary

dihydrofolate reductase is a protein[1]. It ranks in the top 7% of protein entities by monthly Wikipedia readership (110 views/month).[2]

Key Facts

  • dihydrofolate reductase's image is recorded as PDB 8dfr EBI.jpg[3].
  • dihydrofolate reductase's instance of is recorded as protein[4].
  • dihydrofolate reductase's physically interacts with is recorded as methotrexate[5].
  • dihydrofolate reductase's physically interacts with is recorded as pemetrexed[6].
  • dihydrofolate reductase's physically interacts with is recorded as pralatrexate[7].
  • dihydrofolate reductase's physically interacts with is recorded as trimetrexate[8].
  • dihydrofolate reductase's physically interacts with is recorded as piritrexim[9].
  • dihydrofolate reductase's CAS Registry Number is recorded as 9002-03-3[10].
  • dihydrofolate reductase's UniProt protein ID is recorded as P00374[11].
  • dihydrofolate reductase's part of is recorded as Dihydrofolate reductase-like domain superfamily[12].
  • dihydrofolate reductase's part of is recorded as Dihydrofolate reductase domain, protein family[13].
  • dihydrofolate reductase's part of is recorded as Dihydrofolate reductase conserved site, protein family[14].
  • dihydrofolate reductase's has part is recorded as Dihydrofolate reductase domain[15].
  • dihydrofolate reductase's has part is recorded as Dihydrofolate reductase conserved site[16].
  • dihydrofolate reductase's EC enzyme number is recorded as 1.5.1.3[17].
  • dihydrofolate reductase's RefSeq protein ID is recorded as NP_000782[18].
  • dihydrofolate reductase's RefSeq protein ID is recorded as NP_001277283[19].
  • dihydrofolate reductase's RefSeq protein ID is recorded as NP_001277286[20].
  • dihydrofolate reductase's PDB structure ID is recorded as 1BOZ[21].
  • dihydrofolate reductase's PDB structure ID is recorded as 1DHF[22].
  • dihydrofolate reductase's PDB structure ID is recorded as 1DLR[23].
  • dihydrofolate reductase's PDB structure ID is recorded as 1DLS[24].
  • dihydrofolate reductase's PDB structure ID is recorded as 1DRF[25].
  • dihydrofolate reductase's PDB structure ID is recorded as 1HFP[26].
  • dihydrofolate reductase's PDB structure ID is recorded as 1HFQ[27].

Why It Matters

dihydrofolate reductase ranks in the top 7% of protein entities by monthly Wikipedia readership (110 views/month).[2] It has Wikipedia articles in 14 language editions, a strong signal of global cultural recognition.[28] It is known by 18 alternative names across languages and contexts.[29]

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [3] . wikidata.org.
  2. [4] . Q905695. Retrieved . wikidata.org.
  3. [5] . IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved . wikidata.org.
  4. [6] . IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved . wikidata.org.
  5. [7] . IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved . wikidata.org.
  6. [8] . IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved . wikidata.org.
  7. [9] . Open Targets Platform. Retrieved . platform.opentargets.org. Provenance: wikidata.org.
  8. [10] . wikidata.org.
  9. [11] . Q905695. Retrieved . wikidata.org.
  10. [12] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  11. [13] . wikidata.org.
  12. [14] . wikidata.org.
  13. [15] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  14. [16] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  15. [17] . wikidata.org.
  16. [18] . Q20641742. Retrieved . wikidata.org.
  17. [19] . Q20641742. Retrieved . wikidata.org.
  18. [20] . Q20641742. Retrieved . wikidata.org.
  19. [21] . Q905695. Retrieved . wikidata.org.
  20. [22] . Q905695. Retrieved . wikidata.org.
  21. [23] . Q905695. Retrieved . wikidata.org.
  22. [24] . Q905695. Retrieved . wikidata.org.
  23. [25] . Q905695. Retrieved . wikidata.org.
  24. [26] . Q905695. Retrieved . wikidata.org.
  25. [27] . Q905695. Retrieved . wikidata.org.

Class ancestry

  1. [1] . Wikidata. wikidata.org.

Aggregate / graph-position facts

  1. [2] . Wikimedia Foundation. dumps.wikimedia.org.
  2. [28] . Wikidata sitelinks. wikidata.org.
  3. [29] . Wikidata aliases. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). dihydrofolate reductase. Retrieved May 3, 2026, from https://4ort.xyz/entity/dihydrofolate-reductase
MLA “dihydrofolate reductase.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/dihydrofolate-reductase.
BibTeX @misc{4ortxyz_dihydrofolate-reductase_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{dihydrofolate reductase}}, year = {2026}, url = {https://4ort.xyz/entity/dihydrofolate-reductase}, note = {Accessed: 2026-05-03}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): dihydrofolate reductase — https://4ort.xyz/entity/dihydrofolate-reductase (retrieved 2026-05-03)

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