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pralatrexate

chemical compound
Class type of: unsaturated compound Q637059

Facts

14 properties
Instance of
group of stereoisomers
Subclass of
unsaturated compound
Has use
medication
Active ingredient in
Folotyn
Canonical SMILES
C#CCC(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
Chemical formula
C₂₃H₂₃N₇O₅
Isomeric SMILES
C#CCC(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O
LiverTox likelihood score
LiverTox toxicity likelihood category E*
Mass
+477.176067
Medical condition treated
mature T-cell and NK-cell lymphoma
Physically interacts with
dihydrofolate reductase
Stylized name
PRALAtrexate
Subject has role
protein synthesis inhibitor
World Health Organisation international non-proprietary name
pralatrexate
🏷️ Also known as
en Pralatrexato en Pralatrexatum en 10-Propargyl-10-deazaaminopterin en (2S)-2-({4-[1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl]benzoyl}amino)pentanedioic acid en (2S)-2-((4-((1RS)-1-((2,4-diaminopteridin-6-yl)methyl)but-3-ynyl)benzoyl)amino)pentanedioic acid en (2S)-2-((4-((1RS)-1-((2,4-Diaminopteridin-6-yl)methyl)but-3-ynyl)benzoyl)amino)pentanedioic acid en Folotyn® en HSDB 7786 en N-(4-(1-((2,4-Diamino-6-pteridinyl)methyl)-3-butynyl)benzoyl)-L-glutamic acid en PDX en pralatrexate en Pralatrexate ar فولوتن de Pralatrexat fa پرالاترکسات hu pralatrexát pl pralatreksat zh 普拉曲沙
🔖 Identifiers · 33
ATC code
L01BA05
CAS Registry Number
146464-95-1
ChEBI ID
71223
ChEMBL ID
CHEMBL1201746
ChemSpider ID
130578
DSSTOX compound identifier
DTXCID3028504
DSSTox substance ID
DTXSID3048578
DrugBank ID
DB06813
DrugCentral ID
4117
EC number
680-662-0
ECHA Substance Infocard ID
100.205.791
Freebase ID
/m/04kkx7n
Show all 33 identifiers +21
Guide to Pharmacology Ligand ID
6840
HSDB ID
7786
InChI
InChI=1S/C23H23N7O5/c1-2-3-14(10-15-11-26-20-18(27-15)19(24)29-23(25)30-20)12-4-6-13(7-5-12)21(33)28-16(22(34)35)8-9-17(31)32/h1,4-7,11,14,16H,3,8-10H2,(H,28,33)(H,31,32)(H,34,35)(H4,24,25,26,29,30)/t14?,16-/m0/s1
InChIKey
OGSBUKJUDHAQEA-WMCAAGNKSA-N
KEGG ID
D05589
LiverTox ID
Pralatrexate
MedlinePlus drug identifier
a610001
Microsoft Academic ID (discontinued)
2776209020
NDF-RT ID
N0000180303
NSC number
754230
PatientsLikeMe treatment ID
pralatrexate
Probes And Drugs ID
PD004103
PubChem CID
148121
Reaxys registry number
6624234
RxNorm CUI
662019
SPLASH
splash10-004i-1513900000-5596beb52832aa3566cc
SureChEMBL ID
15075302, 21633
UMLS CUI
C1721300
UNII
A8Q8I19Q20
UniChem compound ID
104472
WikiProjectMed ID
Pralatrexate

Report an error or request removal Lineage (PROV-JSON)

🔗 Connections
Has use 1
medication
Physically interacts with 1
dihydrofolate reductase
Subclass of 1
unsaturated compound
Subject has role 1
protein synthesis inhibitor
← Physically interacts with 1
dihydrofolate reductase
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Summary

pralatrexate is a group of stereoisomers[1]. pralatrexate is a type of unsaturated compound[2].

Key Facts

  • Physically interacts with: dihydrofolate reductase[3]
  • Canonical SMILES: C#CCC(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O[4]
  • Chemical formula: C₂₃H₂₃N₇O₅[5]
  • Has use: medication[6]
  • Isomeric SMILES: C#CCC(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC@@HC(=O)OC@@HC(=O)O">[7]
  • Mass: 477.176067 dalton[8]
  • Medical condition treated: mature T-cell and NK-cell lymphoma[9]
  • World Health Organisation international non-proprietary name: pralatrexate[10]
  • Subject has role: protein synthesis inhibitor[11]
  • Active ingredient in: Folotyn[12]
  • LiverTox likelihood score: LiverTox toxicity likelihood category E*[13]
  • Stylized name: PRALAtrexate[14]

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [3] ↑ . IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved . wikidata.org.
  2. [4] ↑ . PubChem. Retrieved . wikidata.org.
  3. [5] ↑ . PubChem. Retrieved . wikidata.org.
  4. [2] ↑ . wikidata.org.
  5. [6] ↑ . wikidata.org.
  6. [7] ↑ . PubChem. Retrieved . wikidata.org.
  7. [8] ↑ . PubChem. Retrieved . wikidata.org.
  8. [9] ↑ . Drug Indications Extracted from FAERS. Retrieved . wikidata.org.
  9. [10] ↑ . ChEBI. Retrieved . wikidata.org.
  10. [11] ↑ . NDF-RT. Retrieved . wikidata.org.
  11. [12] ↑ . RxNorm. Retrieved . wikidata.org.
  12. [13] ↑ . LiverTox. Retrieved . ncbi.nlm.nih.gov. Provenance: wikidata.org.
  13. [14] ↑ . ismp.org. Retrieved . ismp.org. Provenance: wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). pralatrexate. Retrieved November 4, 2026, from https://4ort.xyz/entity/pralatrexate
MLA “pralatrexate.” 4ort.xyz Knowledge Graph, 4ort.xyz, 4 Nov. 2026, https://4ort.xyz/entity/pralatrexate.
BibTeX @misc{4ortxyz_pralatrexate_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{pralatrexate}}, year = {2026}, url = {https://4ort.xyz/entity/pralatrexate}, note = {Accessed: 2026-11-04}}
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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 19w ago · Nabbegat · 2026-06-19 view diff on Wikidata ↗
    Instance of → group of stereoisomers
    Has use → medication
    LiverTox likelihood score → LiverTox toxicity likelihood category E*
    Medical condition treated → mature T-cell and NK-cell lymphoma
    + 8 other properties edited (see Wikidata diff for full list)
    "/* wbeditentity-update-languages-short:0||tr */ QuickStatements 3.0 [[:toollabs:qs-dev/batch/37300|batch #37300]]"
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