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trimetrexate

chemical compound
Class type of: trimethoxybenzene, aniline compounds, quinazoline Q126677485

Facts

12 properties
Instance of
type of chemical entity
Subclass of
trimethoxybenzene, aniline compounds, quinazoline[5][6][7]
Has use
medication[8]
Canonical SMILES
CC1=C(C=CC2=C1C(=NC(=N2)N)N)CNC3=CC(=C(C(=C3)OC)OC)OC[3]
Chemical formula
C₁₉H₂₃N₅O₃[4]
Conjugate acid
trimetrexate(1+)[15]
Defined daily dose
+85[16]
LiverTox likelihood score
LiverTox toxicity likelihood category E*[17]
Mass
+369.1800895959999[9]
Medical condition treated
pneumocystosis, pneumocystosis[10][11]
Physically interacts with
dihydrofolate reductase[2]
Subject has role
antifungal, antineoplastic antimetabolite, folic acid antagonists[12][13][14]
🏷️ Also known as
en trimetrexate ar تريمتريكست de Trimetrexat fa تری‌مترکسات it trimetrexato pl trimetreksat uk триметрексат
🔖 Identifiers · 30
ATC code
P01AX07
CAB ID
33662
CAS Registry Number
52128-35-5
ChEBI ID
9737
ChEMBL ID
CHEMBL119
ChemSpider ID
5381
DSSTOX compound identifier
DTXCID603714
DSSTox substance ID
DTXSID3023714
DrugBank ID
DB01157
DrugCentral ID
2757
Freebase ID
/m/0fgmbt
Guide to Pharmacology Ligand ID
7613
Show all 30 identifiers +18
HSDB ID
6545
Human Metabolome Database ID
HMDB0015288
InChI
InChI=1S/C19H23N5O3/c1-10-11(5-6-13-16(10)18(20)24-19(21)23-13)9-22-12-7-14(25-2)17(27-4)15(8-12)26-3/h5-8,22H,9H2,1-4H3,(H4,20,21,23,24)
InChIKey
NOYPYLRCIDNJJB-UHFFFAOYSA-N
KEGG ID
C11154
LiverTox ID
Trimetrexate
MeSH concept ID
M0025316
MeSH descriptor ID
D016597
MeSH tree code
D03.633.100.786.925
Microsoft Academic ID (discontinued)
2779307360
NDF-RT ID
N0000148354
NSC number
249008
PubChem CID
5583
RxNorm CUI
42333
SureChEMBL ID
3983
UMLS CUI
C0085176
UNII
UPN4ITI8T4
UniChem compound ID
504091

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🔗 Connections
← Drug or therapy used for treatment 3
pneumocystis pneumonia, pneumocystosis, pneumocystosis
Medical condition treated 2
pneumocystosis, pneumocystosis
Subject has role 2
antifungal, folic acid antagonists
Has use 1
medication
Physically interacts with 1
dihydrofolate reductase
← Physically interacts with 1
dihydrofolate reductase
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Summary

trimetrexate is a type of chemical entity[1].

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [2] ↑ . IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved . wikidata.org.
  2. [3] ↑ . PubChem. Retrieved . wikidata.org.
  3. [4] ↑ . wikidata.org.
  4. [5] ↑ . wikidata.org.
  5. [6] ↑ . wikidata.org.
  6. [7] ↑ . wikidata.org.
  7. [8] ↑ . wikidata.org.
  8. [9] ↑ . wikidata.org.
  9. [10] ↑ . NDF-RT. Retrieved . wikidata.org.
  10. [11] ↑ . Inxight: Drugs Database. Retrieved . drugs.ncats.io. Provenance: wikidata.org.
  11. [12] ↑ . Medical Subject Headings. Retrieved . wikidata.org.
  12. [13] ↑ . Medical Subject Headings. Retrieved . wikidata.org.
  13. [14] ↑ . Medical Subject Headings. Retrieved . wikidata.org.
  14. [15] ↑ . wikidata.org.
  15. [16] ↑ . whocc.no. whocc.no. Provenance: wikidata.org.
  16. [17] ↑ . LiverTox. Retrieved . ncbi.nlm.nih.gov. Provenance: wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). trimetrexate. Retrieved November 3, 2026, from https://4ort.xyz/entity/trimetrexate
MLA “trimetrexate.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 Nov. 2026, https://4ort.xyz/entity/trimetrexate.
BibTeX @misc{4ortxyz_trimetrexate_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{trimetrexate}}, year = {2026}, url = {https://4ort.xyz/entity/trimetrexate}, note = {Accessed: 2026-11-03}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): trimetrexate — https://4ort.xyz/entity/trimetrexate (retrieved 2026-11-03)

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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 29d ago · KrBot bot · 2026-10-08 view diff on Wikidata ↗
    Conjugate acid → trimetrexate(1+)
    Has use → medication
    Instance of → type of chemical entity
    Physically interacts with → dihydrofolate reductase
    + 10 other properties edited (see Wikidata diff for full list)
    "/* wbsetclaimvalue:1| */ Subclass of: aniline compounds, разрешение перенаправления / resolving redirect aniline → aniline compounds ([[:toollabs:editgroups/b/KrBotResolvingRedirect/Q108910534_Q7"
Live feed via Wikidata EventStreams. New edits appear within minutes of being made on Wikidata.