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severe combined immunodeficiency

combined T cell and B cell immunodeficiency that is caused by a defect in several genes encoding for B and T lymphocytes resulting in individuals with non-functional immune systems
Class type of: combined immunodeficiency Q1334408

Facts

7 properties
Instance of
class of disease
Subclass of
combined immunodeficiency
Age of onset
infantile onset, neonatal onset[19][20]
Genetic association
CD4, ADA, AK2, CD3D, CD3E, CD247, CORO1A, IKBKB, IL2RG, IL7R, JAK3, LCK, LIG4, CIITA, PRKDC, PSMB10, PTPRC, RAC2, RAG1, RAG2, RFX5, RFXANK, RFXAP, RMRP, CD70, FOXN1, XRCC4, BCL11B, CARD11, DCLRE1C, LAT, CHD7, NHEJ1, INO80, CARMIL2[5][6][7][8][9][10][11][12][13][14][15][16][17][18]
Health specialty
immunology[4]
NCI Thesaurus ID
C3472[3]
On focus list of Wikimedia project
WikiProject Medicine[21]
🏷️ Also known as
en Severe combined immunodeficiency disease (disorder) en combined T and B cell inborn immunodeficiency en SCID en severe combined immunodeficiency en Severe combined immunodeficiency ar عوز المناعة المشترك الشديد cs těžké kombinované imunodeficience cs těžká kombinovaná imunodeficience el βαριά συνδυασμένη ανοσοανεπάρκεια es Inmunodeficiencia Combinada Severa es IDCG es Inmunodeficiencia combinada grave es Niño burbuja fa آگاماگلوبولینمی fa نقص ایمنی مرکب شدید fr alymphocytose fr déficit immunitaire combiné sévère he כשל חיסוני משולב חמור id Alimfoplasia timik id Alimfositosis
🔖 Identifiers · 26
OpenAlex ID
C2779468541
Disease Ontology ID
DOID:627
DiseasesDB
11978
EMedicine ID
888072
Encyclopedia of China (Third Edition) ID (2026)
2QTkua
Encyclopedia of China (Third Edition) old ID (2021)
52951
Encyclopædia Britannica Online ID
science/severe-combined-immunodeficiency
Exact match
purl.obolibrary.org, identifiers.org
Freebase ID
/m/01hw0d
GARD rare disease ID
7628
Human Phenotype Ontology ID
HP:0004430
ICD-10 ID
D81.0, D81.2, D81.1
Show all 26 identifiers +14
ICD-11 ID (Foundation)
963193284
ICD-11 ID (MMS)
4A01.10
ICD-9 ID
279.2
J9U entity ID
987007554195205171
JSTOR topic ID (archived)
severe-combined-immunodeficiency
MeSH descriptor ID
D016511
MeSH tree code
C16.614.815, C18.452.284.800, C20.673.795.750, C16.320.798.750
Microsoft Academic ID (discontinued)
2779468541, 2910298221
Orphanet ID
183660
PatientsLikeMe condition ID
scid
Raras disease ID
D183660
UMLS CUI
C0085110
WikiProjectMed ID
Severe combined immunodeficiency
WikiSkripta article ID
4362

Report an error or request removal Lineage (PROV-JSON)

🔗 Connections
Subtypes 4
adenosine deaminase deficiency, Omenn syndrome, gamma chain deficiency, Bare lymphocyte syndrome
Health specialty 1
immunology
On focus list of Wikimedia project 1
WikiProject Medicine
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Summary

severe combined immunodeficiency is a class of disease[1]. It is a type of combined immunodeficiency[2].

Related Entities

immunology

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [2] ↑ . Disease Ontology. Retrieved . wikidata.org.
  2. [3] ↑ . Disease Ontology. Retrieved . wikidata.org.
  3. [4] ↑ . wikidata.org.
  4. [5] ↑ . Retrieved . wikidata.org.
  5. [6] ↑ . Retrieved . wikidata.org.
  6. [7] ↑ . Retrieved . wikidata.org.
  7. [8] ↑ . Retrieved . wikidata.org.
  8. [9] ↑ . Retrieved . wikidata.org.
  9. [10] ↑ . Retrieved . wikidata.org.
  10. [11] ↑ . Retrieved . wikidata.org.
  11. [12] ↑ . Retrieved . wikidata.org.
  12. [13] ↑ . Retrieved . wikidata.org.
  13. [14] ↑ . Retrieved . wikidata.org.
  14. [15] ↑ . Retrieved . wikidata.org.
  15. [16] ↑ . Retrieved . wikidata.org.
  16. [17] ↑ . Retrieved . wikidata.org.
  17. [18] ↑ . Retrieved . wikidata.org.
  18. [19] ↑ . Retrieved . wikidata.org.
  19. [20] ↑ . Retrieved . wikidata.org.
  20. [21] ↑ . wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). severe combined immunodeficiency. Retrieved November 6, 2026, from https://4ort.xyz/entity/severe-combined-immunodeficiency
MLA “severe combined immunodeficiency.” 4ort.xyz Knowledge Graph, 4ort.xyz, 6 Nov. 2026, https://4ort.xyz/entity/severe-combined-immunodeficiency.
BibTeX @misc{4ortxyz_severe-combined-immunodeficiency_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{severe combined immunodeficiency}}, year = {2026}, url = {https://4ort.xyz/entity/severe-combined-immunodeficiency}, note = {Accessed: 2026-11-06}}
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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 16d ago · ACorrêa (WMB) · 2026-10-23 view diff on Wikidata ↗
    Encyclopedia of China (Third Edition) ID (2026) → 2QTkua
    Genetic association → CD4, ADA, AK2 +32
    Age of onset → infantile onset, neonatal onset
    Raras disease ID → D183660
    "Changed the item: QuickStatements 3.0 batch #61469: Raras.org data import"
  2. 23w ago · Twofivesixbot bot · 2026-05-27 view diff on Wikidata ↗
    Health specialty → immunology
    Instance of → class of disease
    Subclass of → combined immunodeficiency
    On focus list of Wikimedia project → WikiProject Medicine
    "Changed claim qualifiers: J9U entity ID: 987007554195205171, mv to monolingual text names on J9U statements"
Live feed via Wikidata EventStreams. New edits appear within minutes of being made on Wikidata.