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gamma chain deficiency

immunodeficiency disorder in which the body produces very few T cells and NK cells
Class type of: severe combined immunodeficiency, T+ B+ severe combined immunodeficiency, X-linked recessive disease Q1423538

Facts

9 properties
Instance of
rare disease, class of disease[5]
Subclass of
severe combined immunodeficiency, T+ B+ severe combined immunodeficiency, X-linked recessive disease
Age of onset
neonatal onset[10]
Genetic association
IL2RG[9]
Has phenotype
lymphopenia, recurrent fever, pneumonia, Skin rash, diarrhea, immunoglobulin A deficiency, selective IgG deficiency disease, Recurrent opportunistic infections, cough, sepsis, failure to thrive, chronic mucocutaneous candidiasis, jaundice, hepatomegaly, Increased circulating IgG concentration, lymphoproliferative disorders[12][13][14][15][16][17][18][19][20][21][22][23][24][25]
Health specialty
hematology[8]
NCI Thesaurus ID
C4682[7]
On focus list of Wikimedia project
WikiProject Medicine[11]
Prevalence
+0.00005[6]
🏷️ Also known as
en X-Linked Severe Combined Immunodeficiency en XSCID en X-SCID en gamma chain deficiency en Immunodeficiency 4 en Scidx en SCID-X1 en SCIDX1 en Scid, X-Linked en SEVERE COMBINED IMMUNODEFICIENCY, X-LINKED en SEVERE COMBINED IMMUNODEFICIENCY, X-LINKED; SCIDX1 en Severe Combined Immunodeficiency, X-Linked, T Cell-Negative, B Cell-Positive, Nk Cell-Negative en T-B+ SCID due to gamma chain deficiency en T-B+ severe combined immunodeficiency due to gamma chain deficiency en T-B+ severe combined immunodeficiency, X-linked en thymic epithelial hypoplasia en X-Linked Combined Immunodeficiency Diseases ar عوز المناعة المشترك الشديد المرتبط بالصبغي إكس de Severe Combined Immunodeficiency Disorder de SCID-X1
🔖 Identifiers · 20
Disease Ontology ID
DOID:0060013
DiseasesDB
33502
Exact match
purl.obolibrary.org, identifiers.org, www.orpha.net
Experimental Factor Ontology ID
0005555
Freebase ID
/m/0c7c71
GARD rare disease ID
5618
Genetics Home Reference Conditions ID
x-linked-severe-combined-immunodeficiency
ICD-10 ID
D80.0
ICD-10-CM
D81.2
ICD-9 ID
279.2
MeSH descriptor ID
D053632
MeSH tree code
C16.320.322.968, C16.614.815.500, C20.673.795.750.500, C16.320.798.750.500
Show all 20 identifiers +8
Medical Dictionary for Regulatory Activities ID
10060747
Microsoft Academic ID (discontinued)
2778862115, 2909551392
Mondo ID
MONDO_0010315
OMIM ID
300400
Orphanet ID
276
Raras disease ID
D00276
UMLS CUI
C2931540, C1279481, C4707334
WikiProjectMed ID
X-linked severe combined immunodeficiency

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🔗 Connections
Genetic association 1
IL2RG
Health specialty 1
hematology
Instance of 1
rare disease
On focus list of Wikimedia project 1
WikiProject Medicine
Subclass of 1
severe combined immunodeficiency
← Genetic association 1
IL2RG
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Summary

gamma chain deficiency is a rare disease[1]. It is a type of severe combined immunodeficiency[2], T+ B+ severe combined immunodeficiency[3], and X-linked recessive disease[4].

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [5] ↑ . wikidata.org.
  2. [2] ↑ . Disease Ontology. Retrieved . wikidata.org.
  3. [3] ↑ . Monarch Disease Ontology release 2018-06-29. Retrieved . wikidata.org.
  4. [4] ↑ . Disease Ontology. Retrieved . wikidata.org.
  5. [6] ↑ . Retrieved . wikidata.org.
  6. [7] ↑ . Disease Ontology. Retrieved . wikidata.org.
  7. [8] ↑ . wikidata.org.
  8. [9] ↑ . UniProt. Retrieved . search.clinicalgenome.org. Provenance: wikidata.org.
  9. [10] ↑ . Retrieved . wikidata.org.
  10. [11] ↑ . wikidata.org.
  11. [12] ↑ . Retrieved . wikidata.org.
  12. [13] ↑ . Retrieved . wikidata.org.
  13. [14] ↑ . Retrieved . wikidata.org.
  14. [15] ↑ . Retrieved . wikidata.org.
  15. [16] ↑ . Retrieved . wikidata.org.
  16. [17] ↑ . Retrieved . wikidata.org.
  17. [18] ↑ . Retrieved . wikidata.org.
  18. [19] ↑ . Retrieved . wikidata.org.
  19. [20] ↑ . Retrieved . wikidata.org.
  20. [21] ↑ . Retrieved . wikidata.org.
  21. [22] ↑ . Retrieved . wikidata.org.
  22. [23] ↑ . Retrieved . wikidata.org.
  23. [24] ↑ . Retrieved . wikidata.org.
  24. [25] ↑ . Retrieved . wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). gamma chain deficiency. Retrieved November 7, 2026, from https://4ort.xyz/entity/gamma-chain-deficiency
MLA “gamma chain deficiency.” 4ort.xyz Knowledge Graph, 4ort.xyz, 7 Nov. 2026, https://4ort.xyz/entity/gamma-chain-deficiency.
BibTeX @misc{4ortxyz_gamma-chain-deficiency_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{gamma chain deficiency}}, year = {2026}, url = {https://4ort.xyz/entity/gamma-chain-deficiency}, note = {Accessed: 2026-11-07}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): gamma chain deficiency — https://4ort.xyz/entity/gamma-chain-deficiency (retrieved 2026-11-07)

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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 17d ago · ACorrêa (WMB) · 2026-10-23 view diff on Wikidata ↗
    Prevalence → 0.00005
    Age of onset → neonatal onset
    Has phenotype → lymphopenia, recurrent fever, pneumonia +1
    Raras disease ID → D00276
    "Changed labels, descriptions, aliases and claims: QuickStatements 3.0 batch #61469: Raras.org data import"
  2. 18w ago · JhealdBatch bot · 2026-07-05 view diff on Wikidata ↗
    On focus list of Wikimedia project → WikiProject Medicine
    Health specialty → hematology
    Subclass of → severe combined immunodeficiency, T+ B+ severe combined immunodeficiency, X-linked recessive disease
    Genetic association → IL2RG
    + 1 other property edited (see Wikidata diff for full list)
    "Changed the item: QuickStatements 3.0 batch #39953: deprecate redundant disease superclasses (2)"
Live feed via Wikidata EventStreams. New edits appear within minutes of being made on Wikidata.