ruxolitinib
chemical compound
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Summary
ruxolitinib is a type of chemical entity[1]. ruxolitinib is a type of 3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1-pyrazolyl]propanenitrile[2].
Key Facts
- Physically interacts with: Janus kinase 1[3], Janus kinase 2[4], Janus kinase 3[5], tyrosine kinase 2[6]
- Manufacturer: Novartis[7]
- Canonical SMILES: C1CCC(C1)C(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3[8]
- Chemical formula: C₁₇H₁₈N₆[9]
- Has use: medication[10], chemical probe[11]
- Significant drug interaction: idelalisib[12]
- Isomeric SMILES: C1CCC(C1)C@@HN2C=C(C=N2)C3=C4C=CNC4=NC=N3C@@HN2C=C(C=N2)C3=C4C=CNC4=NC=N3">[13]
- Mass: 306.159 dalton[14]
- Medical condition treated: thrombogavitis[15], leukemia[16], hematopoietic system disease[17], thrombocytopenia[18], myelodysplastic syndrome[19], polycythemia vera[20], graft-versus-host disease[21], polycythemia[22], acute myeloid leukemia[23], myelofibrosis[24], essential thrombocytosis[25]
- World Health Organisation international non-proprietary name: ruxolitinib[26]
- Subject has role: protein kinase inhibitors[27]
- Stereoisomer of: (3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile[28]
- Pregnancy category: Australian pregnancy category C[29], US pregnancy category C[30]
- Legal status (medicine): boxed warning[31]
- Active ingredient in: Jakafi[32]
- LiverTox likelihood score: LiverTox toxicity likelihood category C[33]