Janus kinase 3
mammalian protein found in Homo sapiens
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Summary
Janus kinase 3 is a protein[1].
Key Facts
- Physically interacts with: momelotinib[2], pacritinib[3], ruxolitinib[4], tofacitinib[5], upadacitinib[6], decernotinib[7], peficitinib[8]
- Part of: Protein kinase-like domain superfamily[9], tyrosine-protein kinase, non-receptor Jak3[10], SH2 domain superfamily[11], Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family[12], SH2 domain, protein family[13], Band 4.1 domain, protein family[14], FERM domain, protein family[15], Protein kinase domain, protein family[16], Protein kinase, ATP binding site, protein family[17], Tyrosine-protein kinase, catalytic domain, protein family[18], Tyrosine-protein kinase, active site, protein family[19]
- Has part(s): tyrosine-protein kinase, active site[20], protein kinase, ATP binding site[21], protein kinase domain[22], tyrosine-protein kinase, catalytic domain[23], SH2 domain[24], serine-threonine/tyrosine-protein kinase, catalytic domain[25], Band 4.1 domain[26], FERM domain[27]
- EC enzyme number: 2.7.10.2[28]
- Molecular function: transferase activity[29], nucleotide binding[30], protein kinase activity[31], non-membrane spanning protein tyrosine kinase activity[32], kinase activity[33], protein binding[34], protein tyrosine kinase activity[35], protein phosphatase binding[36], signaling receptor binding[37], ATP binding[38]
- Cell component: cytoplasm[39], membrane[40], extrinsic component of cytoplasmic side of plasma membrane[41], cytoskeleton[42], endomembrane system[43], cytosol[44], endosome[45], plasma membrane[46]
- Biological process: negative regulation of FasL production[47], negative regulation of interleukin-10 production[48], growth hormone receptor signaling pathway via JAK-STAT[49], response to interleukin-15[50], intracellular signal transduction[51], adaptive immune response[52], response to interleukin-4[53], phosphorylation[54]