Janus kinase 2

mammalian protein found in Homo sapiens

Protein protein Q3162114

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Janus kinase 2

Summary

Janus kinase 2 is a protein^[1].

Key Facts

Janus kinase 2's instance of is recorded as protein^[2].
Janus kinase 2's physically interacts with is recorded as baricitinib^[3].
Janus kinase 2's physically interacts with is recorded as momelotinib^[4].
Janus kinase 2's physically interacts with is recorded as pacritinib^[5].
Janus kinase 2's physically interacts with is recorded as ruxolitinib^[6].
Janus kinase 2's physically interacts with is recorded as momelotinib^[7].
Janus kinase 2's physically interacts with is recorded as upadacitinib^[8].
Janus kinase 2's physically interacts with is recorded as azd-1480^[9].
Janus kinase 2's physically interacts with is recorded as bms-911543^[10].
Janus kinase 2's physically interacts with is recorded as gandotinib^[11].
Janus kinase 2's physically interacts with is recorded as peficitinib^[12].
Janus kinase 2's physically interacts with is recorded as zotiraciclib^[13].
Janus kinase 2's UniProt protein ID is recorded as O60674^[14].
Janus kinase 2's part of is recorded as Protein kinase-like domain superfamily^[15].
Janus kinase 2's part of is recorded as tyrosine-protein kinase, non-receptor Jak2^[16].
Janus kinase 2's part of is recorded as SH2 domain superfamily^[17].
Janus kinase 2's part of is recorded as FERM superfamily, second domain^[18].
Janus kinase 2's part of is recorded as Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family^[19].
Janus kinase 2's part of is recorded as SH2 domain, protein family^[20].
Janus kinase 2's part of is recorded as Band 4.1 domain, protein family^[21].
Janus kinase 2's part of is recorded as Janus kinase 2, pseudokinase domain, protein family^[22].
Janus kinase 2's part of is recorded as Janus kinase 2, catalytic domain, protein family^[23].
Janus kinase 2's part of is recorded as JAK2, FERM domain C-lobe, protein family^[24].
Janus kinase 2's part of is recorded as Tyrosine-protein kinase JAK2, SH2 domain, protein family^[25].
Janus kinase 2's part of is recorded as FERM domain, protein family^[26].

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Quick Facts

Instance of protein

Part of Protein kinase-like domain superfamily, tyrosine-protein kinase, non-receptor Jak2, SH2 domain superfamily, FERM superfamily, second domain, Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family, SH2 domain, protein family, Band 4.1 domain, protein family, Janus kinase 2, pseudokinase domain, protein family, Janus kinase 2, catalytic domain, protein family, JAK2, FERM domain C-lobe, protein family, Tyrosine-protein kinase JAK2, SH2 domain, protein family, FERM domain, protein family, Protein kinase domain, protein family, Protein kinase, ATP binding site, protein family, Tyrosine-protein kinase, catalytic domain, protein family, Tyrosine-protein kinase, active site, protein family

Properties

Biological process negative regulation of neuron apoptotic process, intrinsic apoptotic signaling pathway in response to oxidative stress, adaptive immune response, interferon-gamma-mediated signaling pathway, negative regulation of DNA binding, tumor necrosis factor-mediated signaling pathway, protein phosphorylation, positive regulation of phosphoprotein phosphatase activity, growth hormone receptor signaling pathway, positive regulation of interleukin-1 beta production, positive regulation of DNA binding, mesoderm development, activation of cysteine-type endopeptidase activity involved in apoptotic process, negative regulation of cell population proliferation, apoptotic process, regulation of apoptotic process, positive regulation of cell activation, mammary gland epithelium development, extrinsic apoptotic signaling pathway, axon regeneration, activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway, response to antibiotic, positive regulation of nitric-oxide synthase biosynthetic process, response to oxidative stress, response to tumor necrosis factor, response to interleukin-12, positive regulation of cell differentiation, positive regulation of tumor necrosis factor production, positive regulation of peptidyl-tyrosine phosphorylation, erythrocyte differentiation, protein autophosphorylation, platelet-derived growth factor receptor signaling pathway, positive regulation of cell-substrate adhesion, positive regulation of growth hormone receptor signaling pathway, G protein-coupled receptor signaling pathway, cell differentiation, growth hormone receptor signaling pathway via JAK-STAT, positive regulation of inflammatory response, phosphorylation, immune system process, positive regulation of DNA-binding transcription factor activity, negative regulation of cardiac muscle cell apoptotic process, actin filament polymerization, response to lipopolysaccharide, regulation of inflammatory response, peptidyl-tyrosine autophosphorylation, enzyme linked receptor protein signaling pathway, positive regulation of insulin secretion, receptor signaling pathway via JAK-STAT, intracellular signal transduction, negative regulation of cell-cell adhesion, mineralocorticoid receptor signaling pathway, negative regulation of heart contraction, positive regulation of cell migration, positive regulation of cytosolic calcium ion concentration, positive regulation of nitric oxide biosynthetic process, blood coagulation, response to hydroperoxide, MAPK cascade, regulation of interferon-gamma-mediated signaling pathway, regulation of cell population proliferation, positive regulation of cell population proliferation, hormone-mediated signaling pathway, positive regulation of apoptotic process, positive regulation of phosphatidylinositol 3-kinase signaling, peptidyl-tyrosine phosphorylation, cell migration, signal transduction, positive regulation of epithelial cell apoptotic process, positive regulation of growth factor dependent skeletal muscle satellite cell proliferation, innate immune response, negative regulation of cell death, positive regulation of vascular associated smooth muscle cell proliferation, positive regulation of tyrosine phosphorylation of STAT protein, activation of Janus kinase activity, tyrosine phosphorylation of STAT protein, interleukin-12-mediated signaling pathway, cytokine-mediated signaling pathway, interleukin-23-mediated signaling pathway, interleukin-6-mediated signaling pathway, interleukin-27-mediated signaling pathway, interleukin-35-mediated signaling pathway, chromatin organization, regulation of receptor signaling pathway via JAK-STAT, positive regulation of phosphatidylinositol 3-kinase signaling, cytokine-mediated signaling pathway, innate immune response, regulation of nitric oxide biosynthetic process, positive regulation of Ras protein signal transduction, modulation of chemical synaptic transmission, postsynapse to nucleus signaling pathway, positive regulation of cold-induced thermogenesis, microglial cell activation, receptor signaling pathway via JAK-STAT, positive regulation of MHC class II biosynthetic process

Cell component cytoplasm, cytosol, membrane, extrinsic component of cytoplasmic side of plasma membrane, caveola, cytoskeleton, nucleus, nuclear matrix, endosome lumen, membrane raft, endomembrane system, nucleoplasm, plasma membrane, focal adhesion, postsynapse, glutamatergic synapse

Encoded by JAK2

Exact match identifiers.org, purl.uniprot.org, www.ncbi.nlm.nih.gov

Found in taxon Homo sapiens

Has part(s) tyrosine-protein kinase, active site, protein kinase, ATP binding site, protein kinase domain, tyrosine-protein kinase, catalytic domain, SH2 domain, serine-threonine/tyrosine-protein kinase, catalytic domain, Band 4.1 domain, FERM domain, Janus kinase 2, catalytic domain, Janus kinase 2, pseudokinase domain, Tyrosine-protein kinase JAK2, SH2 domain, JAK2, FERM domain C-lobe

Imported from wholeness_audit_2026-05-02

Molecular function SH2 domain binding, kinase activity, signaling receptor binding, ATP binding, growth hormone receptor binding, interleukin-12 receptor binding, metal ion binding, heme binding, histone kinase activity (H3-Y41 specific), transferase activity, histone binding, protein binding, protein tyrosine kinase activity, protein kinase binding, nucleotide binding, non-membrane spanning protein tyrosine kinase activity, identical protein binding, protein kinase activity, protein C-terminus binding, type 1 angiotensin receptor binding, acetylcholine receptor binding, phosphatidylinositol 3-kinase binding, insulin receptor substrate binding, peptide hormone receptor binding, histone kinase activity (H3-Y41 specific)

Physically interacts with baricitinib, momelotinib, pacritinib, ruxolitinib, momelotinib, upadacitinib, azd-1480, bms-911543, gandotinib, peficitinib, zotiraciclib

External References (7)

Ensembl protein id ENSP00000371067, ENSP00000489812, ENSP00000490624

Mesh descriptor id D053614

Mesh tree code D08.811.913.696.620.682.725.124.200, D12.776.476.568.124.200, D12.776.624.664.700.117

Pdb structure id 5AEP, 2B7A, 2W1I, 2XA4, 3E62, 3E63, 3E64, 3FUP, 3IO7, 3IOK, 3JY9, 3KCK, 3KRR, 3LPB, 3Q32, 3RVG, 3TJC, 3TJD, 3UGC, 3ZMM, 4AQC, 4BBE, 4BBF, 4C61, 4C62, 4D0W, 4D0X, 4D1S, 4E4M, 4E6D, 4E6Q, 4F08, 4F09, 4FVP, 4FVQ, 4FVR, 4GFM, 4GMY, 4HGE, 4IVA, 4JI9, 4JIA, 4P7E, 4ZIM, 4YTC, 4YTF, 4YTH, 4YTI, 5CF4, 5CF5, 5CF6, 5CF8, 5I4N, 4Z32, 5L3A

Refseq protein id NP_001309123, NP_001309124, NP_001309125, NP_001309127, NP_001309128, NP_001309133, NP_004963

Umls cui C0169661

Uniprot protein id O60674

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Janus kinase 2 — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ Janus kinase 2 — physically interacts with (P129): baricitinib. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[4] ↑ Janus kinase 2 — physically interacts with (P129): momelotinib. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[5] ↑ Janus kinase 2 — physically interacts with (P129): pacritinib. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[6] ↑ Janus kinase 2 — physically interacts with (P129): ruxolitinib. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[7] ↑ Janus kinase 2 — physically interacts with (P129): momelotinib. Open Targets Platform. Retrieved 2023-08-14. platform.opentargets.org. Provenance: wikidata.org.
[8] ↑ Janus kinase 2 — physically interacts with (P129): upadacitinib. Open Targets Platform. Retrieved 2023-08-14. platform.opentargets.org. Provenance: wikidata.org.
[9] ↑ Janus kinase 2 — physically interacts with (P129): azd-1480. Open Targets Platform. Retrieved 2023-08-14. platform.opentargets.org. Provenance: wikidata.org.
[10] ↑ Janus kinase 2 — physically interacts with (P129): bms-911543. Open Targets Platform. Retrieved 2023-08-14. platform.opentargets.org. Provenance: wikidata.org.
[11] ↑ Janus kinase 2 — physically interacts with (P129): gandotinib. Open Targets Platform. Retrieved 2023-08-14. platform.opentargets.org. Provenance: wikidata.org.
[12] ↑ Janus kinase 2 — physically interacts with (P129): peficitinib. Open Targets Platform. Retrieved 2023-08-14. platform.opentargets.org. Provenance: wikidata.org.
[13] ↑ Janus kinase 2 — physically interacts with (P129): zotiraciclib. Open Targets Platform. Retrieved 2023-08-14. platform.opentargets.org. Provenance: wikidata.org.
[14] ↑ Janus kinase 2 — UniProt protein ID (P352): O60674. Q905695. Retrieved 2019-11-13. wikidata.org.
[15] ↑ Janus kinase 2 — part of (P361): Protein kinase-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ Janus kinase 2 — part of (P361): tyrosine-protein kinase, non-receptor Jak2. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ Janus kinase 2 — part of (P361): SH2 domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ Janus kinase 2 — part of (P361): FERM superfamily, second domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ Janus kinase 2 — part of (P361): Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family. wikidata.org.
[20] ↑ Janus kinase 2 — part of (P361): SH2 domain, protein family. wikidata.org.
[21] ↑ Janus kinase 2 — part of (P361): Band 4.1 domain, protein family. wikidata.org.
[22] ↑ Janus kinase 2 — part of (P361): Janus kinase 2, pseudokinase domain, protein family. wikidata.org.
[23] ↑ Janus kinase 2 — part of (P361): Janus kinase 2, catalytic domain, protein family. wikidata.org.
[24] ↑ Janus kinase 2 — part of (P361): JAK2, FERM domain C-lobe, protein family. wikidata.org.
[25] ↑ Janus kinase 2 — part of (P361): Tyrosine-protein kinase JAK2, SH2 domain, protein family. wikidata.org.
[26] ↑ Janus kinase 2 — part of (P361): FERM domain, protein family. wikidata.org.

Class ancestry

[1] ↑ Janus kinase 2 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). Janus kinase 2. Retrieved May 3, 2026, from https://4ort.xyz/entity/janus-kinase-2

MLA “Janus kinase 2.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/janus-kinase-2.

BibTeX

@misc{4ortxyz_janus-kinase-2_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Janus kinase 2}}, year = {2026}, url = {https://4ort.xyz/entity/janus-kinase-2}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Janus kinase 2 — https://4ort.xyz/entity/janus-kinase-2 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/janus-kinase-2 · Last refreshed: May 3, 2026