Janus kinase 2

mammalian protein found in Homo sapiens

Protein protein Q3162114

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Key Facts

Physically interacts with: baricitinib^[1], momelotinib^[2], pacritinib^[3], ruxolitinib^[4], upadacitinib^[5], azd-1480^[6], bms-911543^[7], gandotinib^[8], peficitinib^[9], zotiraciclib^[10]
Part of: Protein kinase-like domain superfamily^[11], tyrosine-protein kinase, non-receptor Jak2^[12], SH2 domain superfamily^[13], FERM superfamily, second domain^[14], Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family^[15], SH2 domain, protein family^[16], Band 4.1 domain, protein family^[17], Janus kinase 2, pseudokinase domain, protein family^[18], Janus kinase 2, catalytic domain, protein family^[19], JAK2, FERM domain C-lobe, protein family^[20], Tyrosine-protein kinase JAK2, SH2 domain, protein family^[21], FERM domain, protein family^[22], Protein kinase domain, protein family^[23], Protein kinase, ATP binding site, protein family^[24]
Has part(s): tyrosine-protein kinase, active site^[25], protein kinase, ATP binding site^[26], protein kinase domain^[27], tyrosine-protein kinase, catalytic domain^[28], SH2 domain^[29], serine-threonine/tyrosine-protein kinase, catalytic domain^[30], Band 4.1 domain^[31], FERM domain^[32], Janus kinase 2, catalytic domain^[33], Janus kinase 2, pseudokinase domain^[34], Tyrosine-protein kinase JAK2, SH2 domain^[35], JAK2, FERM domain C-lobe^[36]
EC enzyme number: 2.7.10.2^[37]

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Quick Facts

Instance of protein

Part of Protein kinase-like domain superfamily, tyrosine-protein kinase, non-receptor Jak2, SH2 domain superfamily, FERM superfamily, second domain, Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family, SH2 domain, protein family, Band 4.1 domain, protein family, Janus kinase 2, pseudokinase domain, protein family, Janus kinase 2, catalytic domain, protein family, JAK2, FERM domain C-lobe, protein family, Tyrosine-protein kinase JAK2, SH2 domain, protein family, FERM domain, protein family, Protein kinase domain, protein family, Protein kinase, ATP binding site, protein family, Tyrosine-protein kinase, catalytic domain, protein family, Tyrosine-protein kinase, active site, protein family

Properties

Biological process negative regulation of neuron apoptotic process, intrinsic apoptotic signaling pathway in response to oxidative stress, adaptive immune response, interferon-gamma-mediated signaling pathway, negative regulation of DNA binding, tumor necrosis factor-mediated signaling pathway, protein phosphorylation, positive regulation of phosphoprotein phosphatase activity, growth hormone receptor signaling pathway, positive regulation of interleukin-1 beta production, positive regulation of DNA binding, mesoderm development, activation of cysteine-type endopeptidase activity involved in apoptotic process, negative regulation of cell population proliferation, apoptotic process, regulation of apoptotic process, positive regulation of cell activation, mammary gland epithelium development, extrinsic apoptotic signaling pathway, axon regeneration, activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway, response to antibiotic, positive regulation of nitric-oxide synthase biosynthetic process, response to oxidative stress, response to tumor necrosis factor, response to interleukin-12, positive regulation of cell differentiation, positive regulation of tumor necrosis factor production, positive regulation of peptidyl-tyrosine phosphorylation, erythrocyte differentiation, protein autophosphorylation, platelet-derived growth factor receptor signaling pathway, positive regulation of cell-substrate adhesion, positive regulation of growth hormone receptor signaling pathway, G protein-coupled receptor signaling pathway, cell differentiation, growth hormone receptor signaling pathway via JAK-STAT, positive regulation of inflammatory response, phosphorylation, immune system process, positive regulation of DNA-binding transcription factor activity, negative regulation of cardiac muscle cell apoptotic process, actin filament polymerization, response to lipopolysaccharide, regulation of inflammatory response, peptidyl-tyrosine autophosphorylation, enzyme linked receptor protein signaling pathway, positive regulation of insulin secretion, receptor signaling pathway via JAK-STAT, intracellular signal transduction, negative regulation of cell-cell adhesion, mineralocorticoid receptor signaling pathway, negative regulation of heart contraction, positive regulation of cell migration, positive regulation of cytosolic calcium ion concentration, positive regulation of nitric oxide biosynthetic process, blood coagulation, response to hydroperoxide, MAPK cascade, regulation of interferon-gamma-mediated signaling pathway, regulation of cell population proliferation, positive regulation of cell population proliferation, hormone-mediated signaling pathway, positive regulation of apoptotic process, positive regulation of phosphatidylinositol 3-kinase signaling, peptidyl-tyrosine phosphorylation, cell migration, signal transduction, positive regulation of epithelial cell apoptotic process, positive regulation of growth factor dependent skeletal muscle satellite cell proliferation, innate immune response, negative regulation of cell death, positive regulation of vascular associated smooth muscle cell proliferation, positive regulation of tyrosine phosphorylation of STAT protein, activation of Janus kinase activity, tyrosine phosphorylation of STAT protein, interleukin-12-mediated signaling pathway, cytokine-mediated signaling pathway, interleukin-23-mediated signaling pathway, interleukin-6-mediated signaling pathway, interleukin-27-mediated signaling pathway, interleukin-35-mediated signaling pathway, chromatin organization, regulation of receptor signaling pathway via JAK-STAT, positive regulation of phosphatidylinositol 3-kinase signaling, cytokine-mediated signaling pathway, innate immune response, regulation of nitric oxide biosynthetic process, positive regulation of Ras protein signal transduction, modulation of chemical synaptic transmission, postsynapse to nucleus signaling pathway, positive regulation of cold-induced thermogenesis, microglial cell activation, receptor signaling pathway via JAK-STAT, positive regulation of MHC class II biosynthetic process

Cell component cytoplasm, cytosol, membrane, extrinsic component of cytoplasmic side of plasma membrane, caveola, cytoskeleton, nucleus, nuclear matrix, endosome lumen, membrane raft, endomembrane system, nucleoplasm, plasma membrane, focal adhesion, postsynapse, glutamatergic synapse

Ec enzyme number 2.7.10.2

Encoded by JAK2

Found in taxon Homo sapiens

Has part(s) tyrosine-protein kinase, active site, protein kinase, ATP binding site, protein kinase domain, tyrosine-protein kinase, catalytic domain, SH2 domain, serine-threonine/tyrosine-protein kinase, catalytic domain, Band 4.1 domain, FERM domain, Janus kinase 2, catalytic domain, Janus kinase 2, pseudokinase domain, Tyrosine-protein kinase JAK2, SH2 domain, JAK2, FERM domain C-lobe

Molecular function SH2 domain binding, kinase activity, signaling receptor binding, ATP binding, growth hormone receptor binding, interleukin-12 receptor binding, metal ion binding, heme binding, histone kinase activity (H3-Y41 specific), transferase activity, histone binding, protein binding, protein tyrosine kinase activity, protein kinase binding, nucleotide binding, non-membrane spanning protein tyrosine kinase activity, identical protein binding, protein kinase activity, protein C-terminus binding, type 1 angiotensin receptor binding, acetylcholine receptor binding, phosphatidylinositol 3-kinase binding, insulin receptor substrate binding, peptide hormone receptor binding, histone kinase activity (H3-Y41 specific)

Physically interacts with baricitinib, momelotinib, pacritinib, ruxolitinib, momelotinib, upadacitinib, azd-1480, bms-911543, gandotinib, peficitinib, zotiraciclib

Identifiers (8)

Ensembl protein id ENSP00000371067, ENSP00000489812, ENSP00000490624

Exact match identifiers.org, purl.uniprot.org, www.ncbi.nlm.nih.gov

Mesh descriptor id D053614

Mesh tree code D08.811.913.696.620.682.725.124.200, D12.776.476.568.124.200, D12.776.624.664.700.117

Pdb structure id 5AEP, 2B7A, 2W1I, 2XA4, 3E62, 3E63, 3E64, 3FUP, 3IO7, 3IOK, 3JY9, 3KCK, 3KRR, 3LPB, 3Q32, 3RVG, 3TJC, 3TJD, 3UGC, 3ZMM, 4AQC, 4BBE, 4BBF, 4C61, 4C62, 4D0W, 4D0X, 4D1S, 4E4M, 4E6D, 4E6Q, 4F08, 4F09, 4FVP, 4FVQ, 4FVR, 4GFM, 4GMY, 4HGE, 4IVA, 4JI9, 4JIA, 4P7E, 4ZIM, 4YTC, 4YTF, 4YTH, 4YTI, 5CF4, 5CF5, 5CF6, 5CF8, 5I4N, 4Z32, 5L3A

Refseq protein id NP_001309123, NP_001309124, NP_001309125, NP_001309127, NP_001309128, NP_001309133, NP_004963

Umls cui C0169661

Uniprot protein id O60674

🏷️ Also known as

en JAK-2 en JAK2 en Janus kinase 2 en Janus kinase 2 (a protein tyrosine kinase) en tyrosine-protein kinase JAK2

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[1] ↑ Janus kinase 2 — physically interacts with (P129): baricitinib. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[2] ↑ Janus kinase 2 — physically interacts with (P129): momelotinib. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[3] ↑ Janus kinase 2 — physically interacts with (P129): pacritinib. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[4] ↑ Janus kinase 2 — physically interacts with (P129): ruxolitinib. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[5] ↑ Janus kinase 2 — physically interacts with (P129): upadacitinib. Open Targets Platform. Retrieved 2023-08-14. platform.opentargets.org. Provenance: wikidata.org.
[6] ↑ Janus kinase 2 — physically interacts with (P129): azd-1480. Open Targets Platform. Retrieved 2023-08-14. platform.opentargets.org. Provenance: wikidata.org.
[7] ↑ Janus kinase 2 — physically interacts with (P129): bms-911543. Open Targets Platform. Retrieved 2023-08-14. platform.opentargets.org. Provenance: wikidata.org.
[8] ↑ Janus kinase 2 — physically interacts with (P129): gandotinib. Open Targets Platform. Retrieved 2023-08-14. platform.opentargets.org. Provenance: wikidata.org.
[9] ↑ Janus kinase 2 — physically interacts with (P129): peficitinib. Open Targets Platform. Retrieved 2023-08-14. platform.opentargets.org. Provenance: wikidata.org.
[10] ↑ Janus kinase 2 — physically interacts with (P129): zotiraciclib. Open Targets Platform. Retrieved 2023-08-14. platform.opentargets.org. Provenance: wikidata.org.
[11] ↑ Janus kinase 2 — part of (P361): Protein kinase-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ Janus kinase 2 — part of (P361): tyrosine-protein kinase, non-receptor Jak2. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ Janus kinase 2 — part of (P361): SH2 domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ Janus kinase 2 — part of (P361): FERM superfamily, second domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ Janus kinase 2 — part of (P361): Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family. wikidata.org.
[16] ↑ Janus kinase 2 — part of (P361): SH2 domain, protein family. wikidata.org.
[17] ↑ Janus kinase 2 — part of (P361): Band 4.1 domain, protein family. wikidata.org.
[18] ↑ Janus kinase 2 — part of (P361): Janus kinase 2, pseudokinase domain, protein family. wikidata.org.
[19] ↑ Janus kinase 2 — part of (P361): Janus kinase 2, catalytic domain, protein family. wikidata.org.
[20] ↑ Janus kinase 2 — part of (P361): JAK2, FERM domain C-lobe, protein family. wikidata.org.
[21] ↑ Janus kinase 2 — part of (P361): Tyrosine-protein kinase JAK2, SH2 domain, protein family. wikidata.org.
[22] ↑ Janus kinase 2 — part of (P361): FERM domain, protein family. wikidata.org.
[23] ↑ Janus kinase 2 — part of (P361): Protein kinase domain, protein family. wikidata.org.
[24] ↑ Janus kinase 2 — part of (P361): Protein kinase, ATP binding site, protein family. wikidata.org.
[25] ↑ Janus kinase 2 — has part(s) (P527): tyrosine-protein kinase, active site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Janus kinase 2 — has part(s) (P527): protein kinase, ATP binding site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[27] ↑ Janus kinase 2 — has part(s) (P527): protein kinase domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[28] ↑ Janus kinase 2 — has part(s) (P527): tyrosine-protein kinase, catalytic domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[29] ↑ Janus kinase 2 — has part(s) (P527): SH2 domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[30] ↑ Janus kinase 2 — has part(s) (P527): serine-threonine/tyrosine-protein kinase, catalytic domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[31] ↑ Janus kinase 2 — has part(s) (P527): Band 4.1 domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[32] ↑ Janus kinase 2 — has part(s) (P527): FERM domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[33] ↑ Janus kinase 2 — has part(s) (P527): Janus kinase 2, catalytic domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[34] ↑ Janus kinase 2 — has part(s) (P527): Janus kinase 2, pseudokinase domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[35] ↑ Janus kinase 2 — has part(s) (P527): Tyrosine-protein kinase JAK2, SH2 domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[36] ↑ Janus kinase 2 — has part(s) (P527): JAK2, FERM domain C-lobe. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[37] ↑ Janus kinase 2 — EC enzyme number (P591): 2.7.10.2. UniProt. Retrieved 2026-07-23. wikidata.org.

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APA

4ort.xyz Knowledge Graph. (2026). Janus kinase 2. Retrieved October 30, 2026, from https://4ort.xyz/entity/janus-kinase-2

MLA “Janus kinase 2.” 4ort.xyz Knowledge Graph, 4ort.xyz, 30 Oct. 2026, https://4ort.xyz/entity/janus-kinase-2.

BibTeX

@misc{4ortxyz_janus-kinase-2_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Janus kinase 2}}, year = {2026}, url = {https://4ort.xyz/entity/janus-kinase-2}, note = {Accessed: 2026-10-30}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Janus kinase 2 — https://4ort.xyz/entity/janus-kinase-2 (retrieved 2026-10-30)

Canonical URL: https://4ort.xyz/entity/janus-kinase-2 · Last refreshed: October 30, 2026

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

14w ago · Boghog · 2026-07-23 view diff on Wikidata ↗

Uniprot protein id → O60674

Umls cui → C0169661

Exact match → https://identifiers.org/uniprot:O60674, http://purl.uniprot.org/uniprot/O60674, https://www.ncbi.nlm.nih.gov/protein/O60674

Imported from → —

+ 16 other properties edited (see Wikidata diff for full list)

"/* wbcreateclaim-create:1| */ Ec enzyme number: 2.7.10.2, [[:toollabs:quickstatements/#/batch/261446|batch #261446]]"

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