Properties
Biological process
negative regulation of neuron apoptotic process, response to ionizing radiation, germ cell development, positive regulation of calcium ion transport into cytosol, glycosphingolipid metabolic process, B cell apoptotic process, response to salt stress, Sertoli cell proliferation, thymocyte apoptotic process, T cell homeostatic proliferation, post-embryonic development, regulation of mitochondrial membrane permeability involved in apoptotic process, negative regulation of protein binding, cellular response to DNA damage stimulus, regulation of mitochondrial membrane permeability involved in programmed necrotic cell death, odontogenesis of dentin-containing tooth, positive regulation of extrinsic apoptotic signaling pathway in absence of ligand, positive regulation of IRE1-mediated unfolded protein response, blood vessel remodeling, positive regulation of neuron apoptotic process, apoptotic process involved in blood vessel morphogenesis, activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c, spermatogenesis, apoptotic signaling pathway, cell population proliferation, mitochondrion morphogenesis, activation of cysteine-type endopeptidase activity involved in apoptotic process, negative regulation of cell population proliferation, cellular response to organic substance, B cell homeostatic proliferation, limb morphogenesis, release of matrix enzymes from mitochondria, extrinsic apoptotic signaling pathway, kidney development, activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway, negative regulation of apoptotic signaling pathway, myeloid cell homeostasis, regulation of neuron apoptotic process, regulation of cysteine-type endopeptidase activity involved in apoptotic process, endoplasmic reticulum calcium ion homeostasis, response to wounding, intrinsic apoptotic signaling pathway by p53 class mediator, hypothalamus development, viral process, protein homooligomerization, response to gamma radiation, negative regulation of fibroblast proliferation, positive regulation of intrinsic apoptotic signaling pathway, response to toxic substance, B cell negative selection, mitochondrial fusion, neuron apoptotic process, male gonad development, positive regulation of B cell apoptotic process, regulation of protein heterodimerization activity, positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway, cellular response to UV, sex differentiation, neuron migration, B cell homeostasis, positive regulation of release of sequestered calcium ion into cytosol, positive regulation of apoptotic process involved in mammary gland involution, nervous system development, spermatid differentiation, development of secondary sexual characteristics, positive regulation of developmental pigmentation, retina development in camera-type eye, response to axon injury, positive regulation of mitochondrial membrane permeability involved in apoptotic process, cerebral cortex development, ovarian follicle development, fertilization, ectopic germ cell programmed cell death, homeostasis of number of cells within a tissue, positive regulation of release of cytochrome c from mitochondria, B cell receptor apoptotic signaling pathway, negative regulation of endoplasmic reticulum calcium ion concentration, regulation of protein homodimerization activity, apoptotic process involved in embryonic digit morphogenesis, leukocyte homeostasis, positive regulation of apoptotic DNA fragmentation, mitochondrial fragmentation involved in apoptotic process, positive regulation of endoplasmic reticulum unfolded protein response, establishment or maintenance of transmembrane electrochemical gradient, homeostasis of number of cells, vagina development, post-embryonic camera-type eye morphogenesis, regulation of mammary gland epithelial cell proliferation, retinal cell programmed cell death, regulation of cell cycle, regulation of mitochondrial membrane potential, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, apoptotic mitochondrial changes, protein complex oligomerization, regulation of nitrogen utilization, negative regulation of peptidyl-serine phosphorylation, positive regulation of apoptotic process, positive regulation of protein oligomerization, extrinsic apoptotic signaling pathway via death domain receptors, release of cytochrome c from mitochondria, apoptotic process, protein insertion into mitochondrial membrane involved in apoptotic signaling pathway, intrinsic apoptotic signaling pathway, regulation of apoptotic process, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, intrinsic apoptotic signaling pathway in response to DNA damage, extrinsic apoptotic signaling pathway in absence of ligand, release of cytochrome c from mitochondria, transcription initiation from RNA polymerase II promoter, mitochondrial fusion, intrinsic apoptotic signaling pathway in response to DNA damage, Unfolded Protein Response, positive regulation of apoptotic process, positive regulation of release of cytochrome c from mitochondria, extrinsic apoptotic signaling pathway in absence of ligand, negative regulation of mitochondrial membrane potential
Cell component
cytosol, nuclear envelope, membrane, Bcl-2 family protein complex, mitochondrion, nucleus, mitochondrial permeability transition pore complex, mitochondrial membranes, BAX complex, endoplasmic reticulum, extracellular exosome, pore complex, integral component of membrane, intracellular anatomical structure, endoplasmic reticulum membrane, cytoplasm, mitochondrial outer membrane, mitochondrial outer membrane, membrane, extracellular exosome, cell periphery
Has part(s)
Apoptosis regulator, Bcl-2, BH3 motif, conserved site, Apoptosis regulator, Bcl-2, BH1 motif, conserved site, Apoptosis regulator, Bcl-2, BH2 motif, conserved site
Has parts
Apoptosis regulator, Bcl-2, BH3 motif, conserved site, Apoptosis regulator, Bcl-2, BH1 motif, conserved site, Apoptosis regulator, Bcl-2, BH2 motif, conserved site
Molecular function
protein homodimerization activity, channel activity, protein binding, BH3 domain binding, chaperone binding, protein heterodimerization activity, identical protein binding, lipid binding, Hsp70 protein binding, channel activity, protein homodimerization activity, protein heterodimerization activity
Part of
Blc2-like superfamily, Apoptosis regulator BAX, bcl-2 family, Apoptosis regulator, Bcl-2, BH3 motif, conserved site, protein family, Apoptosis regulator, Bcl-2, BH1 motif, conserved site, protein family, Apoptosis regulator, Bcl-2, BH2 motif, conserved site, protein family
External References (10)
Ensembl protein id
ENSP00000426328, ENSP00000263262, ENSP00000293288, ENSP00000346461, ENSP00000348871, ENSP00000389971, ENSP00000375744, ENSP00000426184, ENSP00000441413
Freebase id
/m/0fky8z
Mesh descriptor id
D051028
Mesh tree code
D12.644.360.075.718.400, D12.776.476.075.718.400
Microsoft academic id (discontinued)
2780362710, 2909544034
Openalex id
C2909544034, C2780362710
Pdb structure id
4BDU, 1F16, 2G5B, 2K7W, 2LR1, 3PK1, 3PL7, 4BD2, 4BD6, 4BD7, 4BD8, 4UF2, 4ZIE, 4ZIF, 4ZIG, 4ZIH, 4ZII, 4S0O
Refseq protein id
NP_001278357, NP_001278358, NP_001278359, NP_001278360, NP_004315, NP_620116, NP_620118, NP_620119, XP_016882566
Transporter classification database id
1.A.21.1.2
