BCL2 apoptosis regulator
mammalian protein found in Homo sapiens
Facts
11 properties- Instance of
- protein
- Part of
- Blc2-like superfamily, Apoptosis regulator, Bcl-2, Apoptosis regulator, Bcl-2 protein, BH4 family, Apoptosis regulator, Bcl-2, BH3 motif, conserved site, protein family, Apoptosis regulator, Bcl-2, BH1 motif, conserved site, protein family, Apoptosis regulator, Bcl-2, BH2 motif, conserved site, protein family, Apoptosis regulator, Bcl-2, BH4 motif, conserved site, protein family[5][6][7][8][9][10][11]
- Biological process
- negative regulation of neuron apoptotic process, intrinsic apoptotic signaling pathway in response to oxidative stress, ureteric bud development, renal system process, organ growth, T cell differentiation in thymus, lymphocyte homeostasis, response to steroid hormone, positive regulation of catalytic activity, ear development, glomerulus development, post-embryonic development, cellular response to DNA damage stimulus, T cell homeostasis, negative regulation of ossification, negative regulation of G1/S transition of mitotic cell cycle, positive regulation of smooth muscle cell migration, regulation of protein localization, T cell differentiation, B cell lineage commitment, response to ischemia, regulation of mitochondrial membrane permeability, humoral immune response, defense response to virus, mesenchymal cell development, positive regulation of multicellular organism growth, animal organ morphogenesis, developmental pigmentation, hair follicle morphogenesis, B cell differentiation, cell population proliferation, metanephros development, melanocyte differentiation, negative regulation of autophagy, positive regulation of neuron maturation, negative regulation of myeloid cell apoptotic process, cellular response to hypoxia, pigment granule organization, negative regulation of cell population proliferation, B cell receptor signaling pathway, cellular response to organic substance, regulation of apoptotic process, response to cytokine, cellular response to glucose starvation, regulation of protein stability, ossification, positive regulation of melanocyte differentiation, axon regeneration, kidney development, actin filament organization, thymus development, negative regulation of intrinsic apoptotic signaling pathway, negative regulation of apoptotic signaling pathway, response to nicotine, spleen development, endoplasmic reticulum calcium ion homeostasis, positive regulation of skeletal muscle fiber development, response to oxidative stress, lymphoid progenitor cell differentiation, positive regulation of peptidyl-serine phosphorylation, CD8-positive, alpha-beta T cell lineage commitment, reactive oxygen species metabolic process, negative regulation of retinal cell programmed cell death, branching involved in ureteric bud morphogenesis, gland morphogenesis, positive regulation of cell growth, positive regulation of B cell proliferation, negative regulation of cell growth, response to gamma radiation, positive regulation of intrinsic apoptotic signaling pathway, response to toxic substance, digestive tract morphogenesis, neuron apoptotic process, male gonad development, regulation of protein heterodimerization activity, regulation of glycoprotein biosynthetic process, regulation of viral genome replication, female pregnancy, negative regulation of mitochondrial depolarization, protein dephosphorylation, protein polyubiquitination, cellular calcium ion homeostasis, B cell homeostasis, behavioral fear response, oocyte development, regulation of cell-matrix adhesion, response to iron ion, negative regulation of cell migration, regulation of autophagy, positive regulation of developmental pigmentation, developmental growth, regulation of transmembrane transporter activity, ovarian follicle development, regulation of gene expression, negative regulation of calcium ion transport into cytosol, negative regulation of osteoblast proliferation, homeostasis of number of cells within a tissue, pigmentation, response to radiation, regulation of catalytic activity, peptidyl-threonine phosphorylation, regulation of protein homodimerization activity, negative regulation of anoikis, response to hydrogen peroxide, T cell lineage commitment, cochlear nucleus development, leukocyte homeostasis, regulation of programmed cell death, regulation of calcium ion transport, axonogenesis, negative regulation of cellular pH reduction, response to glucocorticoid, regulation of cell cycle, regulation of mitochondrial membrane potential, melanin metabolic process, focal adhesion assembly, positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway, B cell proliferation, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, immune system development, apoptotic mitochondrial changes, peptidyl-serine phosphorylation, regulation of nitrogen utilization, cell morphogenesis, positive regulation of cell population proliferation, negative regulation of reactive oxygen species metabolic process, response to UV-B, regulation of developmental pigmentation, negative regulation of extrinsic apoptotic signaling pathway in absence of ligand, extrinsic apoptotic signaling pathway via death domain receptors, release of cytochrome c from mitochondria, negative regulation of mitotic cell cycle, extrinsic apoptotic signaling pathway in absence of ligand, apoptotic process, transmembrane transport, intrinsic apoptotic signaling pathway in response to DNA damage, growth, cell-cell adhesion, cytokine-mediated signaling pathway, negative regulation of apoptotic process, hemopoiesis, intrinsic apoptotic signaling pathway in response to DNA damage, regulation of growth, negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, negative regulation of apoptotic process, extrinsic apoptotic signaling pathway in absence of ligand, negative regulation of intrinsic apoptotic signaling pathway, positive regulation of cell population proliferation
- Cell component
- cytoplasm, cytosol, nuclear membrane, membrane, mitochondrion, nucleus, mitochondrial membranes, myelin sheath, mitochondrial outer membrane, endoplasmic reticulum, pore complex, integral component of membrane, intracellular anatomical structure, endoplasmic reticulum membrane, nucleoplasm, protein-containing complex, mitochondrial outer membrane
- Different from
- bcl-2 family
- Encoded by
- BCL2
- Found in taxon
- Homo sapiens
- Has part(s)
- Apoptosis regulator, Bcl-2 protein, BH4, Apoptosis regulator, Bcl-2, BH3 motif, conserved site, Apoptosis regulator, Bcl-2, BH4 motif, conserved site, Apoptosis regulator, Bcl-2, BH2 motif, conserved site, Apoptosis regulator, Bcl-2, BH1 motif, conserved site[12][13][14][15][16]
- Has parts
- Apoptosis regulator, Bcl-2 protein, BH4, Apoptosis regulator, Bcl-2, BH3 motif, conserved site, Apoptosis regulator, Bcl-2, BH4 motif, conserved site, Apoptosis regulator, Bcl-2, BH2 motif, conserved site, Apoptosis regulator, Bcl-2, BH1 motif, conserved site
- Molecular function
- protein phosphatase binding, transcription factor binding, protein phosphatase 2A binding, channel inhibitor activity, protein homodimerization activity, channel activity, protease binding, protein binding, sequence-specific DNA binding, BH3 domain binding, identical protein binding, protein heterodimerization activity, ubiquitin protein ligase binding, protein homodimerization activity, protein heterodimerization activity
- Physically interacts with
- navitoclax, navitoclax, venetoclax[2][3][4]
🏷️ Also known as
en protein phosphatase 1, regulatory subunit 50
en apoptosis regulator Bcl-2
en B-cell CLL/lymphoma 2
en Bcl-2
en BCL2
en BCL2 apoptosis regulator
en PPP1R50
ar عائلة بي سي إل 2
es Bcl 2
fr Bcl2
pt BCL2
zh Bcl2蛋白
🔖 Identifiers · 11
- Encyclopædia Britannica Online ID
- topic/BCL-2-protein, topic/BCL-2-gene
- Ensembl protein ID
- ENSP00000329623, ENSP00000381185, ENSP00000466417
- Exact match
- purl.uniprot.org
- Freebase ID
- /m/021m67f
- HGNC ID
- 990
- Microsoft Academic ID (discontinued)
- 2909467883, 2910218159
- PDB structure ID
- 1G5M, 1GJH, 1YSW, 2O21, 2O22, 2O2F, 2W3L, 2XA0, 4AQ3, 4IEH, 4LVT, 4LXD, 4MAN, 5AGW, 5AGX, 5FCG
- RefSeq protein ID
- NP_000624, NP_000648, XP_011524437, XP_016881406
- Transporter Classification Database ID
- 1.A.21.1.10
- UniProt protein ID
- P10415
- WikiProjectMed ID
- Bcl-2
🔗 Connections
Cell component 9
Biological process 6
Different from 1
Found in taxon 1
Instance of 1
Molecular function 1
Physically interacts with 1
← Different from 1
← FactGrid item ID 1
← Physically interacts with 1
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Summary
BCL2 apoptosis regulator is a protein[1].