tumor protein p53

mammalian protein found in Homo sapiens

Protein protein Q283350

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tumor protein p53

Summary

tumor protein p53 is a protein^[1]. It ranks in the top 0.91% of protein entities by monthly Wikipedia readership (1,374 views/month, #9 of 987).^[2]

Key Facts

tumor protein p53's instance of is recorded as protein^[3].
tumor protein p53 is part of p53-like transcription factor, DNA-binding^[4].
tumor protein p53 is part of p53-like tetramerisation domain superfamily^[5].
tumor protein p53 is part of p53/RUNT-type transcription factor, DNA-binding domain superfamily^[6].
tumor protein p53 is part of p53 tumour suppressor family^[7].
tumor protein p53 is part of pore-forming toxin^[8].
tumor protein p53 is part of p53 transactivation domain, protein family^[9].
tumor protein p53 is part of p53, tetramerisation domain, protein family^[10].
tumor protein p53 is part of p53, DNA-binding domain, protein family^[11].
tumor protein p53's Commons category is recorded as Tumor suppressor protein p53^[12].
tumor protein p53 comprises p53, DNA-binding domain^[13].
tumor protein p53 comprises p53, tetramerisation domain^[14].
tumor protein p53 comprises p53 transactivation domain^[15].

Why It Matters

tumor protein p53 ranks in the top 0.91% of protein entities by monthly Wikipedia readership (1,374 views/month, #9 of 987).^[2] It has Wikipedia articles in 25 language editions, a strong signal of global cultural recognition.^[16] It is known by 29 alternative names across languages and contexts.^[17]

⭐ Popularity Graph

9/100 established

🌐 Wiki Languages

37 / 423 langs top 5%

📈 Wikipedia Views · last 225h

1.2K/mo 2.6K/yr

🔗 Readers Also Explored · clickstream

tumor suppressor gene

Quick Facts

Instance of protein

Part of p53-like transcription factor, DNA-binding, p53-like tetramerisation domain superfamily, Q24771071, p53 tumour suppressor family, pore-forming toxin, p53 transactivation domain, protein family, Q83134107, p53, DNA-binding domain, protein family

Properties

Biological process positive regulation of histone deacetylation, Q14818020, rhythmic process, Q14818090, negative regulation of telomerase activity, Q15311211, cellular response to DNA damage stimulus, Q14818093, positive regulation of neuron apoptotic process, regulation of mitochondrial membrane permeability, positive regulation of reactive oxygen species metabolic process, cellular response to ionizing radiation, positive regulation of thymocyte apoptotic process, Q14818072, cell cycle, Ras protein signal transduction, cell population proliferation, Q14818081, negative regulation of cell population proliferation, Q2714458, Q14818061, regulation of transcription, DNA-templated, response to antibiotic, Q14763010, ER overload response, positive regulation of transcription, DNA-templated, negative regulation of cell growth, intrinsic apoptotic signaling pathway by p53 class mediator, positive regulation of peptidyl-tyrosine phosphorylation, viral process, response to gamma radiation, negative regulation of fibroblast proliferation, positive regulation of intrinsic apoptotic signaling pathway, cell differentiation, determination of adult lifespan, Q21109197, cellular response to UV, DNA damage response, signal transduction by p53 class mediator, negative regulation of apoptotic process, protein tetramerization, oxidative stress-induced premature senescence, Q14818087, circadian behavior, negative regulation of transcription, DNA-templated, protein localization, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, positive regulation of execution phase of apoptosis, multicellular organism development, positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway, positive regulation of gene expression, mitotic G1 DNA damage checkpoint signaling, positive regulation of protein oligomerization, positive regulation of apoptotic process, Q15313094, response to X-ray, positive regulation of transcription by RNA polymerase II, base-excision repair, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, regulation of cell cycle G2/M phase transition, proteasome-mediated ubiquitin-dependent protein catabolic process, Q21111563, Q14599311, Q14864650, positive regulation of protein export from nucleus, programmed cell death, regulation of apoptotic process, protein deubiquitination, Q14863700, negative regulation of transcription by RNA polymerase II, negative regulation of transcription by RNA polymerase II, regulation of transcription, DNA-templated, autophagy, cellular response to DNA damage stimulus, Q14818020, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, Q14914541, positive regulation of gene expression, cytokine-mediated signaling pathway, cellular response to UV, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, negative regulation of apoptotic process, negative regulation of transcription, DNA-templated, positive regulation of RNA polymerase II transcription preinitiation complex assembly, RNA polymerase II preinitiation complex assembly, protein homotetramerization, Q22295045, cellular response to gamma radiation, signal transduction by p53 class mediator, cellular response to actinomycin D, positive regulation of pri-miRNA transcription by RNA polymerase II, positive regulation of production of miRNAs involved in gene silencing by miRNA, positive regulation of intrinsic apoptotic signaling pathway, negative regulation of transcription by RNA polymerase II, in utero embryonic development, somitogenesis, release of cytochrome c from mitochondria, hematopoietic progenitor cell differentiation, T cell proliferation involved in immune response, Q14818007, Q14818009, response to ischemia, Q14818014, regulation of transcription by RNA polymerase II, protein import into nucleus, cellular response to DNA damage stimulus, Q14818020, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, Q14599315, transforming growth factor beta receptor signaling pathway, gastrulation, Q14818026, central nervous system development, development of the heart, circadian rhythm, negative regulation of DNA replication, negative regulation of cell population proliferation, determination of adult lifespan, rRNA transcription, response to UV, response to salt stress, embryo development ending in birth or egg hatching, response to X-ray, response to gamma radiation, negative regulation of gene expression, positive regulation of cardiac muscle cell apoptotic process, cerebellum development, DNA damage response, signal transduction by p53 class mediator, negative regulation of transforming growth factor beta receptor signaling pathway, positive regulation of histone deacetylation, mitotic G1 DNA damage checkpoint signaling, T cell differentiation in thymus, regulation of tissue remodeling, cellular response to UV, multicellular organism growth, positive regulation of mitochondrial membrane permeability, Q21119870, regulation of cell population proliferation, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, positive regulation of apoptotic process, negative regulation of apoptotic process, Q15313094, mitochondrial DNA repair, Q21107586, regulation of neuron apoptotic process, positive regulation of neuron apoptotic process, negative regulation of proteolysis, negative regulation of transcription, DNA-templated, positive regulation of transcription, DNA-templated, Q14863419, positive regulation of transcription by RNA polymerase II, negative regulation of fibroblast proliferation, circadian behavior, bone marrow development, Q14860195, positive regulation of peptidyl-tyrosine phosphorylation, protein stabilization, chromosome organization, protein homotetramerization, Q14818077, regulation of cell cycle, Q14863990, interferon-gamma-mediated signaling pathway, cardiac septum morphogenesis, positive regulation of transcription from RNA polymerase II promoter in response to hypoxia, positive regulation of programmed necrotic cell death, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, regulation of thymocyte apoptotic process, positive regulation of thymocyte apoptotic process, necroptosis, cellular response to ionizing radiation, cellular response to gamma radiation, Q21109192, intrinsic apoptotic signaling pathway by p53 class mediator, negative regulation of mitophagy, regulation of mitochondrial membrane permeability involved in apoptotic process, Q21109193, negative regulation of production of miRNAs involved in gene silencing by miRNA, negative regulation of glucose catabolic process to lactate via pyruvate, intrinsic apoptotic signaling pathway in response to hypoxia, Q21109197, regulation of fibroblast apoptotic process, negative regulation of reactive oxygen species metabolic process, regulation of cellular senescence

Cell component cytoplasm, Q39572, nucleus, nuclear body, transcription factor TFIID complex, nuclear matrix, Q2289104, nucleolus, Q79927, nucleoplasm, mitochondrial matrix, Q14817968, cytosol, intracellular anatomical structure, nucleus, transcription regulator complex, cytoplasm, protein-containing complex, Q2289104, cytosol, site of double-strand break

Encoded by Q14818098

Exact match purl.uniprot.org

Found in taxon Homo sapiens

Has effect DNA repair

Has part(s) Q24766732, p53, tetramerisation domain, p53 transactivation domain

Length +393

Mass +43653

Molecular function protein N-terminus binding, DNA-binding transcription factor activity, protein self-association, Q14902296, DNA-binding transcription factor activity, RNA polymerase II-specific, Q14863060, ATP binding, transcription factor binding, metal ion binding, protein phosphatase 2A binding, Q14599289, Q14633865, chromatin binding, protease binding, Q14817978, protein binding, Q14817989, copper ion binding, protein kinase binding, chaperone binding, DNA-binding transcription activator activity, RNA polymerase II-specific, receptor tyrosine kinase binding, Q14817974, identical protein binding, protein heterodimerization activity, Q14633869, RNA polymerase II transcription regulatory region sequence-specific DNA binding, DNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, Q14902296, TFIID-class transcription factor complex binding, Q14817974, DNA-binding transcription factor activity, mRNA 3'-UTR binding, identical protein binding, Q14865603, disordered domain specific binding, promoter-specific chromatin binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, chromatin binding, Q14633869, histone deacetylase regulator activity, protein homodimerization activity, MDM2/MDM4 family protein binding

P14541 1XfRBH

External References (13)

Encyclopedia of china (third edition) id 51630

Ensembl protein id ENSP00000484409, ENSP00000269305, ENSP00000391127, ENSP00000391478, ENSP00000398846, ENSP00000478219, ENSP00000478499, ENSP00000480868, ENSP00000481179, ENSP00000481638, ENSP00000482222, ENSP00000482258, ENSP00000482537, ENSP00000352610, ENSP00000410739, ENSP00000423862, ENSP00000424104, ENSP00000425104, ENSP00000426252, ENSP00000458393, ENSP00000473895, ENSP00000477531, ENSP00000481401, ENSP00000482903, ENSP00000484375, ENSP00000488924

Freebase id /m/0662g

Hgnc id 11998

Mesh descriptor id D016159

Mesh tree code D12.776.157.687.650, D12.776.260.820, D12.776.624.776.775, D12.776.660.720.650, D12.776.744.845

Microsoft academic id (discontinued) 2910259412

Openalex id C3017404179, C3020813896

Pdb structure id 4QO1, 1A1U, 1AIE, 1C26, 1DT7, 1GZH, 1H26, 1HS5, 1KZY, 1MA3, 1OLG, 1OLH, 1PES, 1PET, 1SAE, 1SAF, 1SAK, 1SAL, 1TSR, 1TUP, 1UOL, 1XQH, 1YC5, 1YCQ, 1YCR, 1YCS, 2AC0, 2ADY, 2AHI, 2ATA, 2B3G, 2BIM, 2BIN, 2BIO, 2BIP, 2BIQ, 2FEJ, 2FOJ, 2FOO, 2GS0, 2H1L, 2H2D, 2H2F, 2H4F, 2H4H, 2H4J, 2H59, 2J0Z, 2J10, 2J11, 2J1W, 2J1X, 2J1Y, 2J1Z, 2J20, 2J21, 2K8F, 2L14, 2LY4, 2MEJ, 2MWO, 2MWP, 2MZD, 2OCJ, 2PCX, 2RUK, 2VUK, 2WGX, 2X0U, 2X0V, 2X0W, 2XWR, 2YBG, 2YDR, 2Z5S, 2Z5T, 3D05, 3D06, 3D07, 3D08, 3D09, 3D0A, 3DAB, 3DAC, 3IGK, 3IGL, 3KMD, 3KZ8, 3LW1, 3OQ5, 3PDH, 3Q01, 3Q05, 3Q06, 3SAK, 3TG5, 3TS8, 3ZME, 4AGL, 4AGM, 4AGN, 4AGO, 4AGP, 4AGQ, 4BUZ, 4BV2, 4HFZ, 4HJE, 4IBQ, 4IBS, 4IBT, 4IBU, 4IBV, 4IBW, 4IBY, 4IBZ, 4IJT, 4KVP, 4LO9, 4LOE, 4LOF, 4MZI, 4MZR, 4X34, 4ZZJ, 5AOL, 5ABA, 5AOK, 2MWY, 5A7B, 5AOJ, 5AOI, 5ECG, 5AB9, 4FZ3, 4RP6, 4XR8, 5AOM, 4RP7, 5HOU, 5HP0, 5HPD, 5LGY, 5G4M, 5G4O, 5G4N, 5BUA

Refseq protein id NP_000537, NP_001119584, NP_001119585, NP_001119586, NP_001119587, NP_001119588, NP_001119589, NP_001119590, NP_001263624, NP_001263625, NP_001263626, NP_001263627, NP_001263628, NP_001263689, NP_001263690

Transporter classification database id 1.C.110.1.1

Umls cui C0146283, C0080055

Uniprot protein id P04637

🌐 Available in 25 languages

enP53 arبي53 csP53 daP53 deP53 esP53 faپی۵۳ fiP53 frP53 heP53 huP53 idP53 itP53 jaP53遺伝子 koP53 nlP53 (eiwit) plP53 ptP53 roP53 ruP53 thP53 trP53 ukP53 viP53 zhP53

🏷️ Also known as

en tumor protein 53 en Tumor suppressor p53 en Tumor Suppressor Protein p53 en tumor supressor p53 en antigen NY-CO-13 en cellular tumor antigen p53 en mutant tumor protein 53 en p53 en p53 tumor suppressor en phosphoprotein p53 en TP53 en transformation-related protein 53 ar P53 ar البروتين 53 ar بي 53 de Wächter des Genoms es Gen p53 es Gen TP53 es TP53 fa پی53

🔗 Connections

Cell component 17

mitochondrion, nucleus, nucleus, cytoplasm, cytoplasm, endoplasmic reticulum, nucleolus, cytosol +9 more

Biological process 11

apoptotic process, cell cycle, circadian rhythm, autophagy, cell differentiation, gastrulation, programmed cell death, cell population proliferation +3 more

Found in taxon 1

Homo sapiens

Has effect 1

DNA repair

Instance of 1

protein

Molecular function 1

protein binding

Part of 1

pore-forming toxin

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). tumor protein p53. Retrieved May 3, 2026, from https://4ort.xyz/entity/tumor-protein-p53

MLA “tumor protein p53.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/tumor-protein-p53.

BibTeX

@misc{4ortxyz_tumor-protein-p53_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{tumor protein p53}}, year = {2026}, url = {https://4ort.xyz/entity/tumor-protein-p53}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): tumor protein p53 — https://4ort.xyz/entity/tumor-protein-p53 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/tumor-protein-p53 · Last refreshed: May 3, 2026

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

15d ago · Nyuhn · 2026-07-10 view diff on Wikidata ↗

Length → {'unit': 'Q8066', 'amount': '+393'}

Has parts → —

Has part(s) → p53, DNA-binding domain, p53, tetramerisation domain, p53 transactivation domain

Mass → {'unit': 'Q483261', 'amount': '+43653'}

+ 12 other properties edited (see Wikidata diff for full list)

"/* wbeditentity-update:0| */ QuickStatements 3.0 [[:toollabs:qs-dev/batch/40849|batch #40849]]: ZGBK ID"

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tumor protein p53

tumor protein p53

Summary

Key Facts

Why It Matters

References

Direct Wikidata claims

Class ancestry

Aggregate / graph-position facts

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