Adenosine deaminase
mammalian protein found in Homo sapiens
Facts
10 properties- Instance of
- protein
- Part of
- adenosine deaminase, Metal-dependent hydrolase, Adenosine/AMP deaminase domain, protein family, Adenosine/AMP deaminase active site, protein family[3][4][5][6]
- Biological process
- positive regulation of T cell differentiation, histamine secretion, negative regulation of circadian sleep/wake cycle, non-REM sleep, purine nucleotide salvage, positive regulation of T cell differentiation in thymus, positive regulation of calcium-mediated signaling, xanthine biosynthetic process, response to hypoxia, lung development, placenta development, deoxyadenosine catabolic process, positive regulation of T cell receptor signaling pathway, adenosine metabolic process, purine-containing compound salvage, dATP catabolic process, ageing, negative regulation of thymocyte apoptotic process, negative regulation of apoptotic process, in utero embryonic development, negative regulation of mature B cell apoptotic process, nucleotide metabolic process, response to vitamin E, positive regulation of heart rate, negative regulation of adenosine receptor signaling pathway, response to morphine, regulation of cell-cell adhesion mediated by integrin, T cell activation, cell adhesion, positive regulation of T cell activation, positive regulation of B cell proliferation, trophectodermal cell differentiation, regulation of circadian sleep/wake cycle, sleep, hypoxanthine biosynthetic process, purine ribonucleoside monophosphate biosynthetic process, germinal center B cell differentiation, liver development, lung alveolus development, Peyer's patch development, negative regulation of mucus secretion, inosine biosynthetic process, positive regulation of smooth muscle contraction, negative regulation of inflammatory response, negative regulation of leukocyte migration, positive regulation of germinal center formation, positive regulation of alpha-beta T cell differentiation, embryonic digestive tract development, negative regulation of penile erection, regulation of T cell differentiation, response to hydrogen peroxide, adenosine catabolic process, hypoxanthine salvage, adenosine catabolic process, T cell activation, inosine biosynthetic process, negative regulation of adenosine receptor signaling pathway[30][31][32][33][34][35][36][37][38][39][40][41][42][43]
- Cell component
- membrane, cytoplasmic vesicle lumen, cell surface, cell junction, soma, dendrite cytoplasm, cytoplasmic vesicle, external side of plasma membrane, extracellular space, cytoplasm, lysosome, cytosol, plasma membrane, external side of plasma membrane[17][18][19][20][21][22][23][24][25][26][27][28][29]
- EC enzyme number
- 3.5.4.4[9]
- Encoded by
- ADA
- Found in taxon
- Homo sapiens
- Molecular function
- deaminase activity, zinc ion binding, metal ion binding, hydrolase activity, purine nucleoside binding, protein binding, adenosine deaminase activity, adenosine deaminase activity[10][11][12][13][14][15][16]
- Physically interacts with
- pentostatin, coformycin[1][2]
🏷️ Also known as
en ADA
en adenosine aminohydrolase
en adenosine deaminase
en Adenosine deaminase
de Adenosin-Deaminase
de Adenosindeaminase
de Adenosindesaminase
de Adenosin-Desaminase
es Adenosin desaminasa
es Adenosín desaminasa
fa ادنوزین دامیناز
fa آدنوزین دآمیناز
fi Adenosiinideaminaasi
fr Adénosine désaminase
it adenosina deaminasi
ja ADA欠損症
ja アデノシンデアミナーゼ
pt Adenosina deaminase
pt Adenosina desaminase
ro Adenozin deaminază
🔖 Identifiers · 11
- OpenAlex ID
- C34628245, C2909627636
- Ensembl protein ID
- ENSP00000361965, ENSP00000440946, ENSP00000441818, ENSP00000446464
- Exact match
- purl.uniprot.org
- Freebase ID
- /m/04ndg6
- Microsoft Academic ID (discontinued)
- 34628245, 2909476619
- NDL Authority ID
- 00575923
- PDB structure ID
- 3IAR
- RefSeq protein ID
- NP_000013, NP_001308979, NP_001308980
- ScienceDirect topic ID
- agricultural-and-biological-sciences/adenosine-deaminase
- UniProt protein ID
- P00813
- WordNet 3.1 Synset ID
- 14731522-n
📚 Sources · 1
- ndl_authorities data obtained from Web NDL Authorities (National Diet Library)
⛏️ Lake Facts
· open-dataset statements via 4ort-mint
From open datasets, joined by identifier and shown only for properties Wikidata does not state on this entity — except where the dataset is the registry authority for the fact (ClinicalTrials.gov on trial registration data): there its value is shown instead, with Wikidata's noted beside it. Every row carries its dataset edition and licence.
Library of Congress Authorities IDP244
sh85000847
2026-10-01
ndl_authorities (pdl-1.0)
as of 2026-10-01
where from?
- Source
- ndl_authorities
- Edition
- 20261001 · as of 2026-10-01 · newer edition 20261103 landed
- Licence
- pdl-1.0
- Credit
- data obtained from Web NDL Authorities (National Diet Library)
- Bronze
- manifest sha256
6e048898660f1188… - Transform
- 4ort-mint · lake · version not recorded
data obtained from Web NDL Authorities (National Diet Library)
🔗 Connections
Cell component 6
Biological process 3
Found in taxon 1
Instance of 1
Molecular function 1
Physically interacts with 1
← FactGrid item ID 1
← Physically interacts with 1
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