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pentostatin

chemical compound
Class type of: alkaloid Q425470

Facts

16 properties
Instance of
type of chemical entity
Subclass of
alkaloid
Has use
medication
Canonical SMILES
C1C(C(OC1N2C=NC3=C2NC=NCC3O)CO)O
Chemical formula
C₁₁H₁₆N₄O₄
Found in taxon
Streptomyces antibioticus
Isomeric SMILES
C1[C@@H]([C@H](O[C@H]1N2C=NC3=C2NC=NC[C@H]3O)CO)O
Legal status (medicine)
boxed warning
Mass
+268.117
Medical condition treated
hairy cell leukemia, chronic lymphocytic leukemia
Physically interacts with
Adenosine deaminase
Pregnancy category
US pregnancy category D
Significant drug interaction
fludarabine, (RS)-cyclophosphamide, fludarabine, (RS)-cyclophosphamide, (RS)-cyclophosphamide
Stereoisomer of
(8S)-3-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-7,8-dihydro-4H-imidazo[4,5-d][1,3]diazepin-8-ol
Subject has role
enzyme inhibitor, DNA polymerase inhibitors, antineoplastic, adenosine deaminase inhibitors, developmental toxicant
World Health Organisation international non-proprietary name
pentostatin
🏷️ Also known as
en Pentostatinum en 2'-deoxycoformycin en Co-vidarabine en deoxycoformycin en Nipent® en pentostatin en Pentostatin en Pentostatina en Pentostatine ar بنتوستاتين fa پنتوستاتین ja ペントスタチン pl pentostatyna zh 喷司他丁 zh-hant 噴司他丁
🔖 Identifiers · 42
OpenAlex ID
C2775952470, C2910277799
ATC code
L01XX08
CA PROP 65 ID
pentostatin
CAS Registry Number
53910-25-1
CCDC Number
1139904
CSD Refcode
DFIMZP01
ChEBI ID
27834
ChEMBL ID
CHEMBL1580
ChemSpider ID
388759
DSSTOX compound identifier
DTXCID403436
DSSTox substance ID
DTXSID2023436
DeCS ID
24830
Show all 42 identifiers +30
DrugBank ID
DB00552
DrugCentral ID
2098
EC number
637-271-5
ECHA Substance Infocard ID
100.164.991
Freebase ID
/m/08n5_y
Guide to Pharmacology Ligand ID
4805
HSDB ID
6547
Human Metabolome Database ID
HMDB0014692
InChI
InChI=1S/C11H16N4O4/c16-3-8-6(17)1-9(19-8)15-5-14-10-7(18)2-12-4-13-11(10)15/h4-9,16-18H,1-3H2,(H,12,13)/t6-,7+,8+,9+/m0/s1
InChIKey
FPVKHBSQESCIEP-JQCXWYLXSA-N
KEGG ID
C02267
MeSH concept ID
M0023987
MeSH descriptor ID
D015649
MeSH tree code
D03.383.742.680.350.200.700, D13.570.230.677, D13.570.685.350.200.700
MedlinePlus drug identifier
a692004
Microsoft Academic ID (discontinued)
2775952470
NDF-RT ID
N0000148177
NSC number
218321, 247520
Natural Product Atlas ID
NPA032760
PDB ligand ID
DCF
PDB structure ID
1A4L, 2PGR
PatientsLikeMe treatment ID
pentostatin
Probes And Drugs ID
PD009968
PubChem CID
439693
RxNorm CUI
8011
SureChEMBL ID
2817
UMLS CUI
C0030896
UNII
395575MZO7
UniChem compound ID
499252
WikiProjectMed ID
Pentostatin

Report an error or request removal Lineage (PROV-JSON)

🔗 Connections
Significant drug interaction 3
(RS)-cyclophosphamide, (RS)-cyclophosphamide, (RS)-cyclophosphamide
Subject has role 3
enzyme inhibitor, antineoplastic, DNA polymerase inhibitors
← Significant drug interaction 3
(RS)-cyclophosphamide, (RS)-cyclophosphamide, (RS)-cyclophosphamide
Medical condition treated 2
chronic lymphocytic leukemia, hairy cell leukemia
← Drug or therapy used for treatment 2
chronic lymphocytic leukemia, hairy cell leukemia
Has use 1
medication
Legal status (medicine) 1
boxed warning
Physically interacts with 1
Adenosine deaminase
Subclass of 1
alkaloid
← Physically interacts with 1
Adenosine deaminase
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Summary

pentostatin is a type of chemical entity[1]. pentostatin is a type of alkaloid[2].

Key Facts

  • Physically interacts with: Adenosine deaminase[3]
  • Canonical SMILES: C1C(C(OC1N2C=NC3=C2NC=NCC3O)CO)O[4]
  • Chemical formula: C₁₁H₁₆N₄O₄[5]
  • Has use: medication[6]
  • Found in taxon: Streptomyces antibioticus[7]
  • Significant drug interaction: fludarabine[8], (RS)-cyclophosphamide[9]
  • Isomeric SMILES: C1C@@HOC@@HO">[10]
  • Mass: 268.117 dalton[11]
  • Medical condition treated: hairy cell leukemia[12], chronic lymphocytic leukemia[13]
  • World Health Organisation international non-proprietary name: pentostatin[14]
  • Subject has role: enzyme inhibitor[15], DNA polymerase inhibitors[16], antineoplastic[17], adenosine deaminase inhibitors[18], developmental toxicant[19]
  • Stereoisomer of: (8S)-3-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-7,8-dihydro-4H-imidazo[4,5-d][1,3]diazepin-8-ol[20]
  • Pregnancy category: US pregnancy category D[21]
  • Legal status (medicine): boxed warning[22]

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [3] ↑ . IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved . wikidata.org.
  2. [4] ↑ . PubChem. Retrieved . wikidata.org.
  3. [5] ↑ . PubChem. Retrieved . wikidata.org.
  4. [2] ↑ . wikidata.org.
  5. [6] ↑ . wikidata.org.
  6. [7] ↑ . Improved production of pentostatin and identification of fermentation cometabolites. wikidata.org.
  7. [8] ↑ . A reference set of clinically relevant adverse drug-drug interactions. wikidata.org.
  8. [9] ↑ . A reference set of clinically relevant adverse drug-drug interactions. wikidata.org.
  9. [10] ↑ . PubChem. Retrieved . wikidata.org.
  10. [11] ↑ . PubChem. Retrieved . wikidata.org.
  11. [12] ↑ . NDF-RT. Retrieved . wikidata.org.
  12. [13] ↑ . Drug Indications Extracted from FAERS. Retrieved . wikidata.org.
  13. [14] ↑ . ChEMBL. Retrieved . wikidata.org.
  14. [15] ↑ . NDF-RT. Retrieved . wikidata.org.
  15. [16] ↑ . NDF-RT. Retrieved . wikidata.org.
  16. [17] ↑ . Medical Subject Headings. Retrieved . wikidata.org.
  17. [18] ↑ . Medical Subject Headings. Retrieved . wikidata.org.
  18. [19] ↑ . California Proposition 65 list of chemicals. Retrieved . oehha.ca.gov. Provenance: wikidata.org.
  19. [20] ↑ . wikidata.org.
  20. [21] ↑ . wikidata.org.
  21. [22] ↑ . nctr-crs.fda.gov. nctr-crs.fda.gov. Provenance: wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). pentostatin. Retrieved November 10, 2026, from https://4ort.xyz/entity/pentostatin
MLA “pentostatin.” 4ort.xyz Knowledge Graph, 4ort.xyz, 10 Nov. 2026, https://4ort.xyz/entity/pentostatin.
BibTeX @misc{4ortxyz_pentostatin_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{pentostatin}}, year = {2026}, url = {https://4ort.xyz/entity/pentostatin}, note = {Accessed: 2026-11-10}}
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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 20w ago · Nabbegat · 2026-06-19 view diff on Wikidata ↗
    Legal status (medicine) → boxed warning
    Stereoisomer of → (8S)-3-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-7
    Instance of → type of chemical entity
    Has use → medication
    + 8 other properties edited (see Wikidata diff for full list)
    "Changed [tr] labels, descriptions or aliases: QuickStatements 3.0 batch #37300"
Live feed via Wikidata EventStreams. New edits appear within minutes of being made on Wikidata.