Quick Facts
Part of
Tyrosine-protein kinase ABL1/transforming protein Abl, Protein kinase-like domain superfamily, SH3-like domain superfamily, SH2 domain superfamily, F-actin binding domain, protein family, Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family, SH2 domain, protein family, Tyrosine-protein kinase ABL, SH2 domain, protein family, SH3 domain, protein family, Protein kinase domain, protein family, Protein kinase, ATP binding site, protein family, Tyrosine-protein kinase, catalytic domain, protein family, Tyrosine-protein kinase, active site, protein family
Properties
Biological process
positive regulation of protein phosphorylation, B-1 B cell homeostasis, regulation of axon extension, neuromuscular process controlling balance, positive regulation of muscle cell differentiation, cellular response to DNA damage stimulus, protein phosphorylation, regulation of cell adhesion, regulation of microtubule polymerization, DNA damage induced protein phosphorylation, intrinsic apoptotic signaling pathway in response to DNA damage, positive regulation of ERK1 and ERK2 cascade, substrate adhesion-dependent cell spreading, platelet-derived growth factor receptor-beta signaling pathway, positive regulation of actin filament binding, B cell receptor signaling pathway, apoptotic process, negative regulation of endothelial cell apoptotic process, cerebellum morphogenesis, regulation of actin cytoskeleton reorganization, regulation of transcription, DNA-templated, epidermal growth factor receptor signaling pathway, Fc-gamma receptor signaling pathway involved in phagocytosis, establishment of protein localization, thymus development, negative regulation of phospholipase C activity, positive regulation of mitotic cell cycle, actin filament branching, spleen development, response to oxidative stress, phagocytosis, positive regulation of peptidyl-tyrosine phosphorylation, regulation of response to DNA damage stimulus, mitochondrial depolarization, positive regulation of Wnt signaling pathway, planar cell polarity pathway, platelet-derived growth factor receptor signaling pathway, regulation of endocytosis, activation of protein kinase C activity, regulation of actin cytoskeleton organization, phosphorylation, signal transduction in response to DNA damage, positive regulation of oxidoreductase activity, positive regulation of release of sequestered calcium ion into cytosol, negative regulation of I-kappaB kinase/NF-kappaB signaling, regulation of cell motility, positive regulation of microtubule binding, cell adhesion, regulation of autophagy, peptidyl-tyrosine autophosphorylation, alpha-beta T cell differentiation, regulation of cellular senescence, negative regulation of protein serine/threonine kinase activity, actin cytoskeleton organization, negative regulation of cellular senescence, positive regulation of osteoblast proliferation, mitotic cell cycle, activated T cell proliferation, endocytosis, negative regulation of cell-cell adhesion, B cell proliferation involved in immune response, cellular response to dopamine, positive regulation of cytosolic calcium ion concentration, positive regulation of neuron death, regulation of cell cycle, negative regulation of BMP signaling pathway, autophagy, B cell proliferation, negative regulation of ubiquitin-protein transferase activity, microspike assembly, positive regulation of apoptotic process, regulation of extracellular matrix organization, positive regulation of I-kappaB kinase/NF-kappaB signaling, negative regulation of ERK1 and ERK2 cascade, transitional one stage B cell differentiation, DNA mismatch repair, Bergmann glial cell differentiation, peptidyl-tyrosine phosphorylation, collateral sprouting, cellular response to lipopolysaccharide, negative regulation of mitotic cell cycle, cellular response to hydrogen peroxide, DNA repair, innate immune response, neural tube closure, post-embryonic development, neuron differentiation, cellular response to oxidative stress, regulation of cell population proliferation, protein autophosphorylation, neuroepithelial cell differentiation, protein phosphorylation, integrin-mediated signaling pathway, positive regulation of endothelial cell migration, cell differentiation, regulation of Cdc42 protein signal transduction, peptidyl-tyrosine autophosphorylation, neuropilin signaling pathway, endothelial cell migration, regulation of T cell differentiation, positive regulation of transcription by RNA polymerase II, T cell receptor signaling pathway, positive regulation of stress fiber assembly, positive regulation of focal adhesion assembly, DNA conformation change, positive regulation of cell migration involved in sprouting angiogenesis, positive regulation of substrate adhesion-dependent cell spreading, negative regulation of long-term synaptic potentiation, regulation of hematopoietic stem cell differentiation, regulation of modification of synaptic structure, positive regulation of blood vessel branching, positive regulation of actin cytoskeleton reorganization
Cell component
cytoplasm, cytosol, nuclear membrane, membrane, extrinsic component of cytoplasmic side of plasma membrane, mitochondrion, actin cytoskeleton, perinuclear region of cytoplasm, cytoskeleton, nucleus, nucleolus, nucleoplasm, cell leading edge, nuclear body, nucleus, cytoplasm, dendrite, protein-containing complex, soma, postsynapse
Ec enzyme number
2.7.10.2
Has part(s)
tyrosine-protein kinase, active site, SH3 domain, protein kinase, ATP binding site, protein kinase domain, tyrosine-protein kinase, catalytic domain, SH2 domain, serine-threonine/tyrosine-protein kinase, catalytic domain, F-actin binding, Tyrosine-protein kinase ABL, SH2 domain
Has parts
tyrosine-protein kinase, active site, SH3 domain, protein kinase, ATP binding site, protein kinase domain, tyrosine-protein kinase, catalytic domain, SH2 domain, serine-threonine/tyrosine-protein kinase, catalytic domain, F-actin binding, Tyrosine-protein kinase ABL, SH2 domain
Molecular function
actin monomer binding, protein domain specific binding, SH3 domain binding, kinase activity, protein C-terminus binding, signaling receptor binding, ATP binding, protein kinase activity, nicotinate-nucleotide adenylyltransferase activity, non-membrane spanning protein tyrosine kinase activity, metal ion binding, proline-rich region binding, magnesium ion binding, transferase activity, actin filament binding, protein binding, syntaxin binding, protein kinase C binding, DNA binding, nucleotide binding, manganese ion binding, mitogen-activated protein kinase binding, protein tyrosine kinase activity, four-way junction DNA binding, bubble DNA binding, phosphotyrosine residue binding, transcription coactivator activity, protein kinase activity, non-membrane spanning protein tyrosine kinase activity, kinase activity, neuropilin binding, SH2 domain binding, ephrin receptor binding, supercoiled DNA binding, sequence-specific double-stranded DNA binding
Part of
Tyrosine-protein kinase ABL1/transforming protein Abl, Protein kinase-like domain superfamily, SH3-like domain superfamily, SH2 domain superfamily, F-actin binding domain, protein family, Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family, SH2 domain, protein family, Tyrosine-protein kinase ABL, SH2 domain, protein family, SH3 domain, protein family, Protein kinase domain, protein family, Protein kinase, ATP binding site, protein family, Tyrosine-protein kinase, catalytic domain, protein family, Tyrosine-protein kinase, active site, protein family
Physically interacts with
bafetinib, bosutinib, dasatinib, imatinib, nilotinib, ponatinib, saracatinib, imatinib, ponatinib, saracatinib, rebastinib, umbralisib, imatinib mesylate
External References (10)
Encyclopædia britannica online id
topic/BCR-abl
Ensembl protein id
ENSP00000323315, ENSP00000361423, ENSP00000376971
Freebase id
/m/07b808
Mesh descriptor id
D016313
Mesh tree code
G05.360.340.024.340.375.500.791.100
Microsoft academic id (discontinued)
125418893, 2910835860
Openalex id
C125418893
Pdb structure id
1AB2, 1AWO, 1BBZ, 1JU5, 1OPL, 1ZZP, 2ABL, 2E2B, 2FO0, 2G1T, 2G2F, 2G2H, 2G2I, 2GQG, 2HIW, 2HYY, 2HZ0, 2HZ4, 2HZI, 2V7A, 3CS9, 3EG0, 3EG1, 3EG2, 3EG3, 3EGU, 3K2M, 3QRI, 3QRJ, 3QRK, 3T04, 3UE4, 3UYO, 3PYY, 4J9B, 4J9C, 4J9D, 4J9E, 4J9F, 4J9G, 4J9H, 4J9I, 4JJB, 4JJC, 4JJD, 4TWP, 4WA9, 4XEY, 4YC8, 5DC9, 5DC4, 5DC0, 2O88, 5HU9
Refseq protein id
NP_005148, NP_009297
Uniprot protein id
P00519