Xanthine dehydrogenase

mammalian protein found in Homo sapiens

Protein protein Q1436420

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Xanthine dehydrogenase

Summary

Xanthine dehydrogenase is a protein^[1].

Key Facts

Xanthine dehydrogenase's instance of is recorded as protein^[2].
Xanthine dehydrogenase's physically interacts with is recorded as allopurinol^[3].
Xanthine dehydrogenase's physically interacts with is recorded as topiroxostat^[4].
Xanthine dehydrogenase is part of Aldehyde oxidase/xanthine dehydrogenase^[5].
Xanthine dehydrogenase is part of FAD-binding, type PCMH-like superfamily^[6].
Xanthine dehydrogenase is part of [2Fe-2S]-binding domain superfamily^[7].
Xanthine dehydrogenase is part of Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain superfamily^[8].
Xanthine dehydrogenase is part of CO dehydrogenase flavoprotein, C-terminal domain superfamily^[9].
Xanthine dehydrogenase is part of 2Fe-2S ferredoxin-like superfamily^[10].
Xanthine dehydrogenase is part of Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead superfamily^[11].
Xanthine dehydrogenase is part of 2Fe-2S ferredoxin-type iron-sulfur binding domain, protein family^[12].
Xanthine dehydrogenase is part of Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead, protein family^[13].
Xanthine dehydrogenase is part of Molybdopterin dehydrogenase, FAD-binding domain, protein family^[14].
Xanthine dehydrogenase is part of [2Fe-2S]-binding domain, protein family^[15].
Xanthine dehydrogenase is part of Xanthine dehydrogenase, small subunit, protein family^[16].
Xanthine dehydrogenase is part of CO dehydrogenase flavoprotein, C-terminal domain, protein family^[17].
Xanthine dehydrogenase is part of FAD-binding domain, PCMH-type, protein family^[18].
Xanthine dehydrogenase is part of Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain, protein family^[19].
Xanthine dehydrogenase is part of 2Fe-2S ferredoxin, iron-sulphur binding site, protein family^[20].
Xanthine dehydrogenase is part of Oxidoreductase, molybdopterin binding site, protein family^[21].
Xanthine dehydrogenase comprises Molybdopterin dehydrogenase, FAD-binding^[22].
Xanthine dehydrogenase comprises 2Fe-2S ferredoxin-type iron-sulfur binding domain^[23].
Xanthine dehydrogenase comprises Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead^[24].
Xanthine dehydrogenase comprises Oxidoreductase, molybdopterin binding site^[25].
Xanthine dehydrogenase comprises Xanthine dehydrogenase, small subunit^[26].

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Quick Facts

Instance of protein

Part of Aldehyde oxidase/xanthine dehydrogenase, FAD-binding, type PCMH-like superfamily, [2Fe-2S]-binding domain superfamily, Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain superfamily, CO dehydrogenase flavoprotein, C-terminal domain superfamily, 2Fe-2S ferredoxin-like superfamily, Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead superfamily, 2Fe-2S ferredoxin-type iron-sulfur binding domain, protein family, Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead, protein family, Molybdopterin dehydrogenase, FAD-binding domain, protein family, [2Fe-2S]-binding domain, protein family, Xanthine dehydrogenase, small subunit, protein family, CO dehydrogenase flavoprotein, C-terminal domain, protein family, FAD-binding domain, PCMH-type, protein family, Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain, protein family, 2Fe-2S ferredoxin, iron-sulphur binding site, protein family, Oxidoreductase, molybdopterin binding site, protein family

Properties

Biological process positive regulation of p38MAPK cascade, negative regulation of protein phosphorylation, negative regulation of protein kinase B signaling, purine nucleotide catabolic process, negative regulation of endothelial cell differentiation, negative regulation of gene expression, negative regulation of endothelial cell proliferation, positive regulation of reactive oxygen species metabolic process, negative regulation of vasculogenesis, negative regulation of vascular endothelial growth factor signaling pathway, lactation, regulation of epithelial cell differentiation, xanthine catabolic process, activation of cysteine-type endopeptidase activity involved in apoptotic process, electron transport chain, xanthine catabolic process

Cell component cytoplasm, cytosol, peroxisome, sarcoplasmic reticulum, extracellular region, extracellular space, extracellular space

Ec enzyme number 1.17.1.4, 1.17.3.2

Encoded by XDH

Exact match identifiers.org, purl.uniprot.org, www.ncbi.nlm.nih.gov

Found in taxon Homo sapiens

Has part(s) Molybdopterin dehydrogenase, FAD-binding, 2Fe-2S ferredoxin-type iron-sulfur binding domain, Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead, Oxidoreductase, molybdopterin binding site, Xanthine dehydrogenase, small subunit, Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding, FAD-binding domain, PCMH-type, CO dehydrogenase flavoprotein, C-terminal, [2Fe-2S]-binding, 2Fe-2S ferredoxin, iron-sulphur binding site

Molecular function iron ion binding, protein homodimerization activity, xanthine oxidase activity, flavin adenine dinucleotide binding, oxidoreductase activity, acting on CH-OH group of donors, iron-sulfur cluster binding, metal ion binding, catalytic activity, molybdopterin cofactor binding, electron transfer activity, xanthine dehydrogenase activity, oxidoreductase activity, 2 iron, 2 sulfur cluster binding, oxidoreductase activity, acting on the aldehyde or oxo group of donors, xanthine dehydrogenase activity, flavin adenine dinucleotide binding, FAD binding, xanthine oxidase activity

Physically interacts with allopurinol, topiroxostat

External References (8)

Ensembl protein id ENSP00000368727

Freebase id /m/03cmjk4

Mesh descriptor id D014968

Mesh tree code D08.811.682.047.892

Pdb structure id 2CKJ, 2E1Q

Refseq protein id NP_000370, XP_011531397, XP_011531398

Umls cui C0043316

Uniprot protein id P47989

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Xanthine dehydrogenase — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ Xanthine dehydrogenase — physically interacts with (P129): allopurinol. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[4] ↑ Xanthine dehydrogenase — physically interacts with (P129): topiroxostat. Open Targets Platform. Retrieved 2023-08-14. platform.opentargets.org. Provenance: wikidata.org.
[5] ↑ Xanthine dehydrogenase — part of (P361): Aldehyde oxidase/xanthine dehydrogenase. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Xanthine dehydrogenase — part of (P361): FAD-binding, type PCMH-like superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Xanthine dehydrogenase — part of (P361): [2Fe-2S]-binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ Xanthine dehydrogenase — part of (P361): Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ Xanthine dehydrogenase — part of (P361): CO dehydrogenase flavoprotein, C-terminal domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ Xanthine dehydrogenase — part of (P361): 2Fe-2S ferredoxin-like superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ Xanthine dehydrogenase — part of (P361): Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ Xanthine dehydrogenase — part of (P361): 2Fe-2S ferredoxin-type iron-sulfur binding domain, protein family. wikidata.org.
[13] ↑ Xanthine dehydrogenase — part of (P361): Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead, protein family. wikidata.org.
[14] ↑ Xanthine dehydrogenase — part of (P361): Molybdopterin dehydrogenase, FAD-binding domain, protein family. wikidata.org.
[15] ↑ Xanthine dehydrogenase — part of (P361): [2Fe-2S]-binding domain, protein family. wikidata.org.
[16] ↑ Xanthine dehydrogenase — part of (P361): Xanthine dehydrogenase, small subunit, protein family. wikidata.org.
[17] ↑ Xanthine dehydrogenase — part of (P361): CO dehydrogenase flavoprotein, C-terminal domain, protein family. wikidata.org.
[18] ↑ Xanthine dehydrogenase — part of (P361): FAD-binding domain, PCMH-type, protein family. wikidata.org.
[19] ↑ Xanthine dehydrogenase — part of (P361): Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain, protein family. wikidata.org.
[20] ↑ Xanthine dehydrogenase — part of (P361): 2Fe-2S ferredoxin, iron-sulphur binding site, protein family. wikidata.org.
[21] ↑ Xanthine dehydrogenase — part of (P361): Oxidoreductase, molybdopterin binding site, protein family. wikidata.org.
[22] ↑ Xanthine dehydrogenase — has part(s) (P527): Molybdopterin dehydrogenase, FAD-binding. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Xanthine dehydrogenase — has part(s) (P527): 2Fe-2S ferredoxin-type iron-sulfur binding domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Xanthine dehydrogenase — has part(s) (P527): Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Xanthine dehydrogenase — has part(s) (P527): Oxidoreductase, molybdopterin binding site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Xanthine dehydrogenase — has part(s) (P527): Xanthine dehydrogenase, small subunit. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Xanthine dehydrogenase is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

4ort.xyz Knowledge Graph. (2026). Xanthine dehydrogenase. Retrieved May 3, 2026, from https://4ort.xyz/entity/xanthine-dehydrogenase

MLA

“Xanthine dehydrogenase.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/xanthine-dehydrogenase.

BibTeX

@misc{4ortxyz_xanthine-dehydrogenase_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Xanthine dehydrogenase}}, year = {2026}, url = {https://4ort.xyz/entity/xanthine-dehydrogenase}, note = {Accessed: 2026-05-03}}

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According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Xanthine dehydrogenase — https://4ort.xyz/entity/xanthine-dehydrogenase (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/xanthine-dehydrogenase · Last refreshed: May 3, 2026

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

4d ago · Boghog · 2026-07-22 view diff on Wikidata ↗

Uniprot protein id → P47989

Umls cui → C0043316

Exact match → https://identifiers.org/uniprot:P47989, http://purl.uniprot.org/uniprot/P47989, https://www.ncbi.nlm.nih.gov/protein/P47989

Imported from → —

+ 18 other properties edited (see Wikidata diff for full list)

"/* wbcreateclaim-create:1| */ [[Property:P591]]: 1.17.1.4, #quickstatements; #temporary_batch_1784744182951"

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