Tyrosine kinase non receptor 2

mammalian protein found in Homo sapiens

Protein protein Q21115284

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Tyrosine kinase non receptor 2

Summary

Tyrosine kinase non receptor 2 is a protein^[1].

Key Facts

Tyrosine kinase non receptor 2's instance of is recorded as protein^[2].
Tyrosine kinase non receptor 2's physically interacts with is recorded as bosutinib^[3].
Tyrosine kinase non receptor 2 is part of SH3-like domain superfamily^[4].
Tyrosine kinase non receptor 2 is part of Cdc42 binding domain-like superfamily^[5].
Tyrosine kinase non receptor 2 is part of Protein kinase-like domain superfamily^[6].
Tyrosine kinase non receptor 2 is part of Activated CDC42 kinase 1^[7].
Tyrosine kinase non receptor 2 is part of Mig-6 domain, protein family^[8].
Tyrosine kinase non receptor 2 is part of Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family^[9].
Tyrosine kinase non receptor 2 is part of Cdc42 binding domain-like, protein family^[10].
Tyrosine kinase non receptor 2 is part of SH3 domain, protein family^[11].
Tyrosine kinase non receptor 2 is part of Protein kinase domain, protein family^[12].
Tyrosine kinase non receptor 2 is part of Protein kinase, ATP binding site, protein family^[13].
Tyrosine kinase non receptor 2 is part of Tyrosine-protein kinase, catalytic domain, protein family^[14].
Tyrosine kinase non receptor 2 is part of Tyrosine-protein kinase, active site, protein family^[15].
Tyrosine kinase non receptor 2 comprises tyrosine-protein kinase, active site^[16].
Tyrosine kinase non receptor 2 comprises Cdc42 binding domain-like^[17].
Tyrosine kinase non receptor 2 comprises SH3 domain^[18].
Tyrosine kinase non receptor 2 comprises protein kinase, ATP binding site^[19].
Tyrosine kinase non receptor 2 comprises protein kinase domain^[20].
Tyrosine kinase non receptor 2 comprises tyrosine-protein kinase, catalytic domain^[21].
Tyrosine kinase non receptor 2 comprises Mig-6 domain^[22].
Tyrosine kinase non receptor 2 comprises serine-threonine/tyrosine-protein kinase, catalytic domain^[23].
Tyrosine kinase non receptor 2's molecular function is recorded as transferase activity^[24].
Tyrosine kinase non receptor 2's molecular function is recorded as nucleotide binding^[25].
Tyrosine kinase non receptor 2's molecular function is recorded as protein kinase activity^[26].

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Quick Facts

Instance of protein

Part of SH3-like domain superfamily, Cdc42 binding domain-like superfamily, Protein kinase-like domain superfamily, Activated CDC42 kinase 1, Mig-6 domain, protein family, Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family, Cdc42 binding domain-like, protein family, SH3 domain, protein family, Protein kinase domain, protein family, Protein kinase, ATP binding site, protein family, Tyrosine-protein kinase, catalytic domain, protein family, Tyrosine-protein kinase, active site, protein family

Properties

Biological process cell differentiation, endocytosis, phosphorylation, transmembrane receptor protein tyrosine kinase signaling pathway, small GTPase mediated signal transduction, protein phosphorylation, cell surface receptor signaling pathway, regulation of cell population proliferation, positive regulation of peptidyl-tyrosine phosphorylation, peptidyl-tyrosine autophosphorylation, regulation of clathrin-dependent endocytosis, innate immune response, cell migration, negative regulation of GTPase activity, signal transduction

Cell component endosome, membrane, extrinsic component of cytoplasmic side of plasma membrane, adherens junction, plasma membrane, cell junction, Grb2-EGFR complex, clathrin-coated pit, cytoplasmic vesicle membrane, cytoplasmic vesicle, nucleus, clathrin-coated vesicle, cytoplasm, perinuclear region of cytoplasm, membrane, cytoophidium

Ec enzyme number 2.7.10.2, 2.7.11.1

Encoded by TNK2

Found in taxon Homo sapiens

Has part(s) tyrosine-protein kinase, active site, Cdc42 binding domain-like, SH3 domain, protein kinase, ATP binding site, protein kinase domain, tyrosine-protein kinase, catalytic domain, Mig-6 domain, serine-threonine/tyrosine-protein kinase, catalytic domain

Molecular function transferase activity, nucleotide binding, protein kinase activity, epidermal growth factor receptor binding, GTPase inhibitor activity, metal ion binding, kinase activity, protein serine/threonine kinase activity, protein binding, identical protein binding, WW domain binding, protein tyrosine kinase activity, ATP binding, ubiquitin protein ligase binding, non-membrane spanning protein tyrosine kinase activity, protein serine/threonine/tyrosine kinase activity

Physically interacts with bosutinib

External References (4)

Ensembl protein id ENSP00000329425, ENSP00000371341, ENSP00000395588, ENSP00000392546

Pdb structure id 1CF4, 1U46, 1U4D, 1U54, 3EQP, 3EQR, 4EWH, 4HZR, 4HZS, 4ID7

Refseq protein id NP_001010938, NP_001294975, NP_005772, XP_005269325, XP_005269327, XP_005269331, XP_005269332, XP_011510619, XP_011510620, XP_011510622, XP_011510623, XP_016860997, XP_016860998, XP_016860999, XP_024309059, XP_024309060, XP_024309061, XP_024309062, XP_024309063

Uniprot protein id Q07912

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Tyrosine kinase non receptor 2 — instance of (P31): protein. Q905695. Retrieved 2018-12-05. wikidata.org.
[3] ↑ Tyrosine kinase non receptor 2 — physically interacts with (P129): bosutinib. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[4] ↑ Tyrosine kinase non receptor 2 — part of (P361): SH3-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Tyrosine kinase non receptor 2 — part of (P361): Cdc42 binding domain-like superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Tyrosine kinase non receptor 2 — part of (P361): Protein kinase-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Tyrosine kinase non receptor 2 — part of (P361): Activated CDC42 kinase 1. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ Tyrosine kinase non receptor 2 — part of (P361): Mig-6 domain, protein family. wikidata.org.
[9] ↑ Tyrosine kinase non receptor 2 — part of (P361): Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family. wikidata.org.
[10] ↑ Tyrosine kinase non receptor 2 — part of (P361): Cdc42 binding domain-like, protein family. wikidata.org.
[11] ↑ Tyrosine kinase non receptor 2 — part of (P361): SH3 domain, protein family. wikidata.org.
[12] ↑ Tyrosine kinase non receptor 2 — part of (P361): Protein kinase domain, protein family. wikidata.org.
[13] ↑ Tyrosine kinase non receptor 2 — part of (P361): Protein kinase, ATP binding site, protein family. wikidata.org.
[14] ↑ Tyrosine kinase non receptor 2 — part of (P361): Tyrosine-protein kinase, catalytic domain, protein family. wikidata.org.
[15] ↑ Tyrosine kinase non receptor 2 — part of (P361): Tyrosine-protein kinase, active site, protein family. wikidata.org.
[16] ↑ Tyrosine kinase non receptor 2 — has part(s) (P527): tyrosine-protein kinase, active site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ Tyrosine kinase non receptor 2 — has part(s) (P527): Cdc42 binding domain-like. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ Tyrosine kinase non receptor 2 — has part(s) (P527): SH3 domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ Tyrosine kinase non receptor 2 — has part(s) (P527): protein kinase, ATP binding site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Tyrosine kinase non receptor 2 — has part(s) (P527): protein kinase domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Tyrosine kinase non receptor 2 — has part(s) (P527): tyrosine-protein kinase, catalytic domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Tyrosine kinase non receptor 2 — has part(s) (P527): Mig-6 domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Tyrosine kinase non receptor 2 — has part(s) (P527): serine-threonine/tyrosine-protein kinase, catalytic domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Tyrosine kinase non receptor 2 — molecular function (P680): transferase activity. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Tyrosine kinase non receptor 2 — molecular function (P680): nucleotide binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Tyrosine kinase non receptor 2 — molecular function (P680): protein kinase activity. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Tyrosine kinase non receptor 2 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Tyrosine kinase non receptor 2. Retrieved May 3, 2026, from https://4ort.xyz/entity/tyrosine-kinase-non-receptor-2

MLA

“Tyrosine kinase non receptor 2.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/tyrosine-kinase-non-receptor-2.

BibTeX

@misc{4ortxyz_tyrosine-kinase-non-receptor-2_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Tyrosine kinase non receptor 2}}, year = {2026}, url = {https://4ort.xyz/entity/tyrosine-kinase-non-receptor-2}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Tyrosine kinase non receptor 2 — https://4ort.xyz/entity/tyrosine-kinase-non-receptor-2 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/tyrosine-kinase-non-receptor-2 · Last refreshed: May 3, 2026

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

4w ago · Boghog · 2026-07-24 view diff on Wikidata ↗

Imported from → —

Encoded by → TNK2

Wikidata description → mammalian protein found in Homo sapiens

Molecular function → transferase activity, nucleotide binding, protein kinase activity +13

+ 12 other properties edited (see Wikidata diff for full list)

"/* wbcreateclaim-create:1| */ [[Property:P591]]: 2.7.10.2, [[:toollabs:quickstatements/#/batch/261491|batch #261491]]"

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