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temsirolimus

chemical compound
Class type of: LSM-4295 Q7699074

Facts

14 properties
Instance of
type of chemical entity
Subclass of
LSM-4295
Has use
medication
Active ingredient in
Torisel
Canonical SMILES
CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)OC(=O)C(C)(CO)CO)C)C)O)OC)C)C)C)OC
Chemical formula
C₅₆H₈₇NO₁₆
Has part(s)
carbon
Isomeric SMILES
C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)OC(=O)C(C)(CO)CO)C)/C)O)OC)C)C)/C)OC
Mass
+1029.602486
Medical condition treated
kidney cancer, renal cell carcinoma, mantle cell lymphoma
Physically interacts with
mechanistic target of rapamycin kinase
Pregnancy category
Australian pregnancy category D, US pregnancy category D
Significant drug interaction
idelalisib, fluconazole, fluconazole, fluconazole, fluconazole, fluconazole
Subject has role
protein kinase inhibitors
🏷️ Also known as
en Torisel® en temsirolimus en Temsirolimus en 42-[3-Hydroxy-2-(hydroxymethyl)-2-methylpropanoate]rapamycin en CCI 779 en CCI-779 ar تمسيروليمس ar تيمزيروليموس es temsirólimus es temsirolimus fa تمسیرولیموس he טמסירולימוס ja テムシロリムス pl temsyrolimus ru темсиролимус zh 坦罗莫司 zh 馱瑞塞爾 zh-hant 坦羅莫司
🔖 Identifiers · 32
OpenAlex ID
C2776820818
ATC code
L01XE09
CAS Registry Number
162635-04-3
ChEBI ID
79699
ChEMBL ID
CHEMBL1201182
ChemSpider ID
21468899
DSSTOX compound identifier
DTXCID0020945
DSSTox substance ID
DTXSID2040945
DrugBank ID
DB06287
DrugCentral ID
4161
EC number
686-177-0
ECHA Substance Infocard ID
100.211.882
Show all 32 identifiers +20
Freebase ID
/m/02w7vrw
Guide to Pharmacology Ligand ID
5892
HSDB ID
7931
Human Metabolome Database ID
HMDB0015632
InChI
InChI=1S/C56H87NO16/c1-33-17-13-12-14-18-34(2)45(68-9)29-41-22-20-39(7)56(67,73-41)51(63)52(64)57-24-16-15-19-42(57)53(65)71-46(30-43(60)35(3)26-38(6)49(62)50(70-11)48(61)37(5)25-33)36(4)27-40-21-23-44(47(28-40)69-10)72-54(66)55(8,31-58)32-59/h12-14,17-18,26,33,35-37,39-42,44-47,49-50,58-59,62,67H,15-16,19-25,27-32H2,1-11H3/b14-12+,17-13+,34-18+,38-26+/t33-,35-,36-,37-,39-,40+,41+,42+,44-,45+,46+,47-,49-,50+,56-/m1/s1
InChIKey
CBPNZQVSJQDFBE-FUXHJELOSA-N
KEGG ID
C15182, D06068
MedlinePlus drug identifier
a607071
Microsoft Academic ID (discontinued)
2776820818
NDF-RT ID
N0000176108
PDB ligand ID
A4I
PatientsLikeMe treatment ID
temsirolimus
Probes And Drugs ID
PD003551
PubChem CID
6918289
RxNorm CUI
657797
SureChEMBL ID
18792
UMLS CUI
C1707080
UNII
624KN6GM2T
UniChem compound ID
414792
WikiProjectMed ID
Temsirolimus

Report an error or request removal Lineage (PROV-JSON)

🔗 Connections
Significant drug interaction 6
fluconazole, fluconazole, fluconazole, fluconazole, fluconazole, idelalisib
← Significant drug interaction 6
fluconazole, fluconazole, fluconazole, fluconazole, fluconazole, idelalisib
Medical condition treated 3
kidney cancer, renal cell carcinoma, mantle cell lymphoma
← Drug or therapy used for treatment 3
kidney cancer, renal cell carcinoma, mantle cell lymphoma
Has part(s) 1
carbon
Has use 1
medication
Physically interacts with 1
mechanistic target of rapamycin kinase
Subject has role 1
protein kinase inhibitors
← Physically interacts with 1
mechanistic target of rapamycin kinase
Press Enter · cited answer in seconds

Summary

temsirolimus is a type of chemical entity[1].

Key Facts

  • Physically interacts with: mechanistic target of rapamycin kinase[2]
  • Canonical SMILES: CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)OC(=O)C(C)(CO)CO)C)C)O)OC)C)C)C)OC[3]
  • Chemical formula: C₅₆H₈₇NO₁₆[4]
  • Subclass of: LSM-4295[5]
  • Has use: medication[6]
  • Has part(s): carbon[7]
  • Significant drug interaction: idelalisib[8], fluconazole[9]
  • Isomeric SMILES: C[C@@H]1CC[C@H]2CC@@HOCC@HC@HC[C@@H]4CC[C@H]([">[10]
  • Mass: 1029.602486 dalton[11]
  • Medical condition treated: kidney cancer[12], renal cell carcinoma[13], mantle cell lymphoma[14]
  • Subject has role: protein kinase inhibitors[15]
  • Pregnancy category: Australian pregnancy category D[16], US pregnancy category D[17]
  • Active ingredient in: Torisel[18]

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [2] ↑ . IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved . wikidata.org.
  2. [3] ↑ . PubChem. Retrieved . wikidata.org.
  3. [4] ↑ . PubChem. Retrieved . wikidata.org.
  4. [5] ↑ . wikidata.org.
  5. [6] ↑ . wikidata.org.
  6. [7] ↑ . wikidata.org.
  7. [8] ↑ . A reference set of clinically relevant adverse drug-drug interactions. wikidata.org.
  8. [9] ↑ . A reference set of clinically relevant adverse drug-drug interactions. wikidata.org.
  9. [10] ↑ . PubChem. Retrieved . wikidata.org.
  10. [11] ↑ . PubChem. Retrieved . wikidata.org.
  11. [12] ↑ . Drug Indications Extracted from FAERS. Retrieved . wikidata.org.
  12. [13] ↑ . Drug Indications Extracted from FAERS. Retrieved . wikidata.org.
  13. [14] ↑ . Drug Indications Extracted from FAERS. Retrieved . wikidata.org.
  14. [15] ↑ . NDF-RT. Retrieved . wikidata.org.
  15. [16] ↑ . wikidata.org.
  16. [17] ↑ . wikidata.org.
  17. [18] ↑ . ema.europa.eu. Retrieved . ema.europa.eu. Provenance: wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). temsirolimus. Retrieved November 11, 2026, from https://4ort.xyz/entity/temsirolimus
MLA “temsirolimus.” 4ort.xyz Knowledge Graph, 4ort.xyz, 11 Nov. 2026, https://4ort.xyz/entity/temsirolimus.
BibTeX @misc{4ortxyz_temsirolimus_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{temsirolimus}}, year = {2026}, url = {https://4ort.xyz/entity/temsirolimus}, note = {Accessed: 2026-11-11}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): temsirolimus — https://4ort.xyz/entity/temsirolimus (retrieved 2026-11-11)

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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 20w ago · FlocciNivis · 2026-06-25 view diff on Wikidata ↗
    PDB ligand ID → A4I
    "Created claim: PDB ligand ID: A4I, batch #259826"
  2. 20w ago · Nabbegat · 2026-06-19 view diff on Wikidata ↗
    Instance of → type of chemical entity
    Has use → medication
    Medical condition treated → kidney cancer, renal cell carcinoma, mantle cell lymphoma
    Significant drug interaction → idelalisib, fluconazole
    + 7 other properties edited (see Wikidata diff for full list)
    "Changed [tr] labels, descriptions or aliases: QuickStatements 3.0 batch #37300"
Live feed via Wikidata EventStreams. New edits appear within minutes of being made on Wikidata.