Properties
Biological process
germ cell development, positive regulation of protein phosphorylation, response to amino acid, positive regulation of lipid biosynthetic process, positive regulation of actin filament polymerization, positive regulation of skeletal muscle hypertrophy, positive regulation of granulosa cell proliferation, regulation of carbohydrate utilization, post-embryonic development, positive regulation of dendritic spine development, positive regulation of translation, positive regulation of eating behavior, protein phosphorylation, mRNA stabilization, cell projection organization, regulation of glycogen biosynthetic process, positive regulation of cell growth involved in cardiac muscle cell development, positive regulation of neuron maturation, positive regulation of glial cell proliferation, cellular response to hypoxia, negative regulation of cell size, response to cocaine, positive regulation of protein kinase B signaling, cardiac muscle contraction, maternal process involved in female pregnancy, ruffle organization, regulation of GTPase activity, cardiac muscle cell development, positive regulation of transcription of nucleolar large rRNA by RNA polymerase I, regulation of membrane permeability, response to insulin, regulation of myelination, regulation of fatty acid beta-oxidation, regulation of osteoclast differentiation, positive regulation of cholangiocyte proliferation, regulation of protein kinase B signaling, spinal cord development, positive regulation of peptidyl-tyrosine phosphorylation, social behavior, protein autophosphorylation, negative regulation of cholangiocyte apoptotic process, regulation of brown fat cell differentiation, regulation of protein kinase activity, negative regulation of protein phosphorylation, positive regulation of oligodendrocyte differentiation, regulation of carbohydrate metabolic process, regulation of actin cytoskeleton organization, voluntary musculoskeletal movement, phosphorylation, multicellular organism growth, negative regulation of muscle atrophy, wound healing, positive regulation of neurogenesis, response to morphine, positive regulation of sensory perception of pain, protein catabolic process, 'de novo' pyrimidine nucleobase biosynthetic process, cellular response to nutrient levels, energy reserve metabolic process, peptidyl-threonine phosphorylation, positive regulation of transcription by RNA polymerase III, positive regulation of smooth muscle cell proliferation, visual learning, positive regulation of myotube differentiation, positive regulation of cell death, positive regulation of endothelial cell proliferation, negative regulation of iodide transmembrane transport, cardiac muscle tissue development, positive regulation of nitric oxide biosynthetic process, regulation of response to food, heart morphogenesis, positive regulation of neuron death, cardiac cell development, negative regulation of protein ubiquitination, brain development, positive regulation of gene expression, long-term memory, heart valve morphogenesis, peptidyl-serine phosphorylation, positive regulation of neuron projection development, regulation of cellular response to heat, positive regulation of lamellipodium assembly, positive regulation of stress fiber assembly, signal transduction, regulation of protein phosphorylation, negative regulation of macroautophagy, anoikis, TOR signaling, DNA repair, regulation of cell size, negative regulation of autophagy, positive regulation of epithelial to mesenchymal transition, regulation of macroautophagy, cellular response to amino acid starvation, positive regulation of keratinocyte migration, cellular response to amino acid stimulus, cellular response to leucine, positive regulation of wound healing, spreading of epidermal cells, cellular response to leucine starvation, cellular response to starvation, TORC1 signaling, growth, regulation of cell growth, response to nutrient, activation of protein kinase B activity, T-helper 1 cell lineage commitment, response to nutrient, negative regulation of autophagy, response to activity, negative regulation of macroautophagy, positive regulation of phosphoprotein phosphatase activity, TORC1 signaling, negative regulation of calcineurin-NFAT signaling cascade, regulation of translation at synapse, modulating synaptic transmission, positive regulation of cytoplasmic translational initiation, response to nutrient levels
Cell component
cytoplasm, cytosol, phosphatidylinositol 3-kinase complex, membrane, mitochondrion, TORC1 complex, organelle membrane, protein-containing complex, mitochondrial outer membrane, endoplasmic reticulum, TORC2 complex, Golgi apparatus, intracellular membrane-bounded organelle, nucleoplasm, soma, PML body, endoplasmic reticulum membrane, Golgi membrane, lysosomal membrane, dendrite, endomembrane system, nucleus, lysosome, lysosomal membrane, membrane, TORC1 complex, TORC2 complex, glutamatergic synapse, postsynaptic cytosol
Has part(s)
Domain of unknown function DUF3385, target of rapamycin protein, Phosphatidylinositol 3/4-kinase, conserved site, Phosphatidylinositol 3-/4-kinase, catalytic domain, FATC domain, PIK-related kinase, FKBP12-rapamycin binding domain, PIK-related kinase, FAT
Has parts
Domain of unknown function DUF3385, target of rapamycin protein, Phosphatidylinositol 3/4-kinase, conserved site, Phosphatidylinositol 3-/4-kinase, catalytic domain, FATC domain, PIK-related kinase, FKBP12-rapamycin binding domain, PIK-related kinase, FAT
Molecular function
protein domain specific binding, TFIIIC-class transcription factor complex binding, kinase activity, ATP binding, protein serine/threonine kinase activity, transferase activity, ribosome binding, protein binding, protein kinase binding, nucleotide binding, phosphoprotein binding, protein kinase activity, protein-containing complex binding, identical protein binding, protein serine/threonine kinase activity, translation regulator activity
Part of
Protein kinase-like domain superfamily, serine/threonine-protein kinase TOR, Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily, Armadillo-like helical, Armadillo-type fold, FKBP12-rapamycin binding domain superfamily, Tetratricopeptide-like helical domain superfamily, Phosphatidylinositol 3-/4-kinase, catalytic domain, protein family, PIK-related kinase, FAT family, FKBP12-rapamycin binding domain, protein family, PIK-related kinase family, FATC domain, protein family, Domain of unknown function DUF3385, target of rapamycin protein family, Phosphatidylinositol 3/4-kinase, conserved site, protein family
Physically interacts with
dactolisib, everolimus, ridaforolimus, temsirolimus, perhexiline, ridaforolimus, apitolisib, azd-8055, indoximod, sapanisertib, omipalisib, vistusertib
External References (7)
Ensembl protein id
ENSP00000354558, ENSP00000366034, ENSP00000398745
Freebase id
/m/0860kt
Microsoft academic id (discontinued)
2777949483, 2910776440
Openalex id
C2777949483, C86554907, C2909523446
Pdb structure id
4JT6, 1AUE, 1FAP, 1NSG, 2FAP, 2GAQ, 2NPU, 2RSE, 3FAP, 4DRH, 4DRI, 4DRJ, 4FAP, 4JSN, 4JSP, 4JSV, 4JSX, 4JT5, 5FLC
Refseq protein id
NP_004949, XP_005263495, XP_011539468, XP_016856389, XP_016856390, XP_016856391, XP_024301955
Uniprot protein id
P42345