T-box transcription factor 5

mammalian protein found in Homo sapiens

Protein protein Q21114550

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T-box transcription factor 5

Summary

T-box transcription factor 5 is a protein^[1].

Key Facts

T-box transcription factor 5's instance of is recorded as protein^[2].
T-box transcription factor 5's UniProt protein ID is recorded as Friedrich Wilhelm Held^[3].
T-box transcription factor 5's part of is recorded as p53-like transcription factor, DNA-binding^[4].
T-box transcription factor 5's part of is recorded as Transcription factor, T-box^[5].
T-box transcription factor 5's part of is recorded as T-box superfamily^[6].
T-box transcription factor 5's part of is recorded as Transcription factor, T-box, conserved site, protein family^[7].
T-box transcription factor 5's has part is recorded as Transcription factor, T-box, conserved site^[8].
T-box transcription factor 5's RefSeq protein ID is recorded as NP_000183^[9].
T-box transcription factor 5's RefSeq protein ID is recorded as NP_542448^[10].
T-box transcription factor 5's RefSeq protein ID is recorded as NP_852259^[11].
T-box transcription factor 5's RefSeq protein ID is recorded as XP_016875401^[12].
T-box transcription factor 5's PDB structure ID is recorded as 2X6U^[13].
T-box transcription factor 5's PDB structure ID is recorded as 2X6V^[14].
T-box transcription factor 5's PDB structure ID is recorded as 4S0H^[15].
T-box transcription factor 5's PDB structure ID is recorded as 5BQD^[16].
T-box transcription factor 5's molecular function is recorded as sequence-specific DNA binding^[17].
T-box transcription factor 5's molecular function is recorded as RNA polymerase II transcription regulatory region sequence-specific DNA binding^[18].
T-box transcription factor 5's molecular function is recorded as DNA-binding transcription activator activity, RNA polymerase II-specific^[19].
T-box transcription factor 5's molecular function is recorded as transcription factor binding^[20].
T-box transcription factor 5's molecular function is recorded as protein binding^[21].
T-box transcription factor 5's molecular function is recorded as DNA-binding transcription factor activity^[22].
T-box transcription factor 5's molecular function is recorded as DNA binding^[23].
T-box transcription factor 5's molecular function is recorded as RNA polymerase II cis-regulatory region sequence-specific DNA binding^[24].
T-box transcription factor 5's molecular function is recorded as DNA-binding transcription factor activity, RNA polymerase II-specific^[25].
T-box transcription factor 5's cell component is recorded as nucleoplasm^[26].

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Quick Facts

Instance of protein

Part of p53-like transcription factor, DNA-binding, Transcription factor, T-box, T-box superfamily, Transcription factor, T-box, conserved site, protein family

Properties

Biological process pattern specification process, forelimb morphogenesis, ventricular cardiac muscle tissue development, regulation of transcription, DNA-templated, bundle of His development, lung development, endocardial cushion development, cardiac muscle cell differentiation, cell-cell signaling, transcription, DNA-templated, morphogenesis of an epithelium, atrial septum morphogenesis, multicellular organism development, negative regulation of cell migration, positive regulation of cardiac muscle cell proliferation, atrioventricular valve morphogenesis, cell migration involved in coronary vasculogenesis, embryonic limb morphogenesis, pericardium development, positive regulation of cardioblast differentiation, positive regulation of secondary heart field cardioblast proliferation, transcription initiation from RNA polymerase II promoter, negative regulation of cardiac muscle cell proliferation, atrial septum development, embryonic forelimb morphogenesis, negative regulation of epithelial to mesenchymal transition, negative regulation of cell population proliferation, cardiac left ventricle formation, ventricular septum development, development of the heart, positive regulation of transcription, DNA-templated, positive regulation of transcription by RNA polymerase II

Cell component nucleoplasm, nucleus, protein-containing complex, protein-DNA complex, cytoplasm

Encoded by TBX5

Found in taxon Homo sapiens

Has part(s) Transcription factor, T-box, conserved site

Imported from wholeness_audit_2026-05-02

Molecular function sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, transcription factor binding, protein binding, DNA-binding transcription factor activity, DNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific

External References (4)

Ensembl protein id ENSP00000309913, ENSP00000337723, ENSP00000384152, ENSP00000433292

Pdb structure id 2X6U, 2X6V, 4S0H, 5BQD

Refseq protein id NP_000183, NP_542448, NP_852259, XP_016875401

Uniprot protein id Friedrich Wilhelm Held

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ T-box transcription factor 5 — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ T-box transcription factor 5 — UniProt protein ID (P352): Friedrich Wilhelm Held. Q905695. Retrieved 2019-11-13. wikidata.org.
[4] ↑ T-box transcription factor 5 — part of (P361): p53-like transcription factor, DNA-binding. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ T-box transcription factor 5 — part of (P361): Transcription factor, T-box. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ T-box transcription factor 5 — part of (P361): T-box superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ T-box transcription factor 5 — part of (P361): Transcription factor, T-box, conserved site, protein family. wikidata.org.
[8] ↑ T-box transcription factor 5 — has part(s) (P527): Transcription factor, T-box, conserved site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ T-box transcription factor 5 — RefSeq protein ID (P637): NP_000183. Q20641742. Retrieved 2020-05-30. wikidata.org.
[10] ↑ T-box transcription factor 5 — RefSeq protein ID (P637): NP_542448. Q20641742. Retrieved 2020-05-30. wikidata.org.
[11] ↑ T-box transcription factor 5 — RefSeq protein ID (P637): NP_852259. Q20641742. Retrieved 2020-05-30. wikidata.org.
[12] ↑ T-box transcription factor 5 — RefSeq protein ID (P637): XP_016875401. Q20641742. Retrieved 2020-05-30. wikidata.org.
[13] ↑ T-box transcription factor 5 — PDB structure ID (P638): 2X6U. Q905695. Retrieved 2016-08-09. wikidata.org.
[14] ↑ T-box transcription factor 5 — PDB structure ID (P638): 2X6V. Q905695. Retrieved 2016-08-09. wikidata.org.
[15] ↑ T-box transcription factor 5 — PDB structure ID (P638): 4S0H. Q905695. Retrieved 2016-08-09. wikidata.org.
[16] ↑ T-box transcription factor 5 — PDB structure ID (P638): 5BQD. Q905695. Retrieved 2016-08-09. wikidata.org.
[17] ↑ T-box transcription factor 5 — molecular function (P680): sequence-specific DNA binding. Functional analysis of TBX5 missense mutations associated with Holt-Oram syndrome. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ T-box transcription factor 5 — molecular function (P680): RNA polymerase II transcription regulatory region sequence-specific DNA binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ T-box transcription factor 5 — molecular function (P680): DNA-binding transcription activator activity, RNA polymerase II-specific. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ T-box transcription factor 5 — molecular function (P680): transcription factor binding. Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ T-box transcription factor 5 — molecular function (P680): protein binding. A WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt-Oram syndrome. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ T-box transcription factor 5 — molecular function (P680): DNA-binding transcription factor activity. Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ T-box transcription factor 5 — molecular function (P680): DNA binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ T-box transcription factor 5 — molecular function (P680): RNA polymerase II cis-regulatory region sequence-specific DNA binding. Intermolecular Interactions of Cardiac Transcription Factors NKX2.5 and TBX5. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ T-box transcription factor 5 — molecular function (P680): DNA-binding transcription factor activity, RNA polymerase II-specific. A census of human transcription factors: function, expression and evolution. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ T-box transcription factor 5 — cell component (P681): nucleoplasm. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ T-box transcription factor 5 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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BibTeX

@misc{4ortxyz_t-box-transcription-factor-5_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{T-box transcription factor 5}}, year = {2026}, url = {https://4ort.xyz/entity/t-box-transcription-factor-5}, note = {Accessed: 2026-05-03}}

LLM prompt

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