SRC proto-oncogene, non-receptor tyrosine kinase

mammalian protein found in Homo sapiens

Protein protein Q21109354

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Summary

SRC proto-oncogene, non-receptor tyrosine kinase is a protein^[1].

Key Facts

Physically interacts with: bosutinib^[2], dasatinib^[3], saracatinib^[4], SU6656^[5], saracatinib^[6], PD166285^[7]
Part of: SH3-like domain superfamily^[8], Protein kinase-like domain superfamily^[9], SH2 domain superfamily^[10], Src family kinases (SFKs) [cytosol]^[11], Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family^[12], SH2 domain, protein family^[13], SH3 domain, protein family^[14], Protein kinase domain, protein family^[15], Protein kinase, ATP binding site, protein family^[16], Tyrosine-protein kinase, catalytic domain, protein family^[17], Tyrosine-protein kinase, active site, protein family^[18]
Has part(s): tyrosine-protein kinase, active site^[19], protein kinase domain^[20], protein kinase, ATP binding site^[21], SH2 domain^[22]

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Rous sarcoma virus

non-receptor tyrosine kinase

Harold E. Varmus

SH2 domain

sarcoma

Quick Facts

Instance of protein

Part of SH3-like domain superfamily, Protein kinase-like domain superfamily, SH2 domain superfamily, Src family kinases (SFKs) [cytosol], Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family, SH2 domain, protein family, SH3 domain, protein family, Protein kinase domain, protein family, Protein kinase, ATP binding site, protein family, Tyrosine-protein kinase, catalytic domain, protein family, Tyrosine-protein kinase, active site, protein family

Properties

Biological process response to mineralocorticoid, negative regulation of telomere maintenance via telomerase, response to interleukin-1, positive regulation of MAP kinase activity, positive regulation of canonical Wnt signaling pathway, negative regulation of telomerase activity, cellular response to progesterone stimulus, regulation of intracellular estrogen receptor signaling pathway, stress fiber assembly, positive regulation of protein serine/threonine kinase activity, platelet activation, positive regulation of smooth muscle cell migration, protein phosphorylation, regulation of vascular permeability, vascular endothelial growth factor receptor signaling pathway, positive regulation of ERK1 and ERK2 cascade, regulation of podosome assembly, cell cycle, substrate adhesion-dependent cell spreading, osteoclast development, cell population proliferation, transforming growth factor beta receptor signaling pathway, cellular response to hypoxia, cellular response to transforming growth factor beta stimulus, negative regulation of protein homooligomerization, positive regulation of protein kinase B signaling, positive regulation of lamellipodium morphogenesis, epidermal growth factor receptor signaling pathway, branching involved in mammary gland duct morphogenesis, Fc-gamma receptor signaling pathway involved in phagocytosis, negative regulation of intrinsic apoptotic signaling pathway, negative regulation of extrinsic apoptotic signaling pathway, response to mechanical stimulus, response to virus, positive regulation of epithelial cell migration, signal complex assembly, stimulatory C-type lectin receptor signaling pathway, positive regulation of platelet-derived growth factor receptor signaling pathway, oogenesis, positive regulation of transcription, DNA-templated, regulation of epithelial cell migration, response to nutrient levels, positive regulation of DNA biosynthetic process, cellular response to insulin stimulus, protein autophosphorylation, viral process, negative regulation of focal adhesion assembly, response to acidic pH, response to fatty acid, regulation of cell projection assembly, phosphorylation, immune system process, negative regulation of mitochondrial depolarization, positive regulation of integrin activation, negative regulation of apoptotic process, cellular response to platelet-derived growth factor stimulus, positive regulation of podosome assembly, positive regulation of glucose metabolic process, transcytosis, cellular response to fluid shear stress, response to electrical stimulus, positive regulation of protein transport, uterus development, protein destabilization, regulation of cell-cell adhesion, peptidyl-tyrosine autophosphorylation, integrin-mediated signaling pathway, positive regulation of insulin receptor signaling pathway, progesterone receptor signaling pathway, negative regulation of transcription, DNA-templated, adherens junction organization, negative regulation of anoikis, response to hydrogen peroxide, leukocyte migration, activation of protein kinase B activity, negative regulation of cysteine-type endopeptidase activity involved in apoptotic process, intracellular signal transduction, regulation of early endosome to late endosome transport, ephrin receptor signaling pathway, T cell costimulation, positive regulation of intracellular signal transduction, regulation of caveolin-mediated endocytosis, regulation of cell cycle, positive regulation of phosphatidylinositol 3-kinase activity, cellular response to reactive oxygen species, cellular response to peptide hormone stimulus, positive regulation of gene expression, cellular response to fatty acid, regulation of cell population proliferation, angiotensin-activated signaling pathway involved in heart process, peptidyl-serine phosphorylation, positive regulation of protein autophosphorylation, positive regulation of cyclin-dependent protein serine/threonine kinase activity, positive regulation of apoptotic process, forebrain development, regulation of protein binding, cellular response to lipopolysaccharide, regulation of bone resorption, cell migration, signal transduction, positive regulation of cell adhesion, cell adhesion, positive regulation of protein processing, innate immune response, positive regulation of peptidyl-tyrosine phosphorylation, neurotrophin TRK receptor signaling pathway, positive regulation of small GTPase mediated signal transduction, bone resorption, central nervous system development, positive regulation of protein localization to nucleus, platelet-derived growth factor receptor signaling pathway, ERBB2 signaling pathway, intracellular estrogen receptor signaling pathway, axon guidance, macroautophagy, peptidyl-tyrosine phosphorylation, entry of bacterium into host cell, cell-cell adhesion, primary ovarian follicle growth, positive regulation of ovarian follicle development, transmembrane receptor protein tyrosine kinase signaling pathway, positive regulation of phosphatidylinositol 3-kinase signaling, peptidyl-tyrosine phosphorylation, cell differentiation, bone resorption, phosphatidylinositol phosphate biosynthetic process, positive regulation of protein kinase B signaling, regulation of postsynaptic neurotransmitter receptor activity, positive regulation of non-membrane spanning protein tyrosine kinase activity, negative regulation of extrinsic apoptotic signaling pathway, negative regulation of intrinsic apoptotic signaling pathway, G protein-coupled receptor signaling pathway, cellular response to hydrogen peroxide, positive regulation of platelet-derived growth factor receptor-beta signaling pathway, odontogenesis

Cell component cytoplasm, cytosol, membrane, extrinsic component of cytoplasmic side of plasma membrane, ruffle membrane, mitochondrion, perinuclear region of cytoplasm, caveola, neuron projection, cytoskeleton, nucleus, lysosome, extracellular exosome, late endosome, plasma membrane, actin filament, postsynaptic density, mitochondrial inner membrane, podosome, nucleoplasm, extracellular exosome, glutamatergic synapse, postsynaptic specialization, intracellular component

Ec enzyme number 2.7.10.2

Encoded by SRC

Found in taxon Homo sapiens

Has part(s) tyrosine-protein kinase, active site, protein kinase domain, protein kinase, ATP binding site, SH2 domain, tyrosine-protein kinase, catalytic domain, SH3 domain, serine-threonine/tyrosine-protein kinase, catalytic domain

Has parts tyrosine-protein kinase, active site, protein kinase domain, protein kinase, ATP binding site, SH2 domain, tyrosine-protein kinase, catalytic domain, SH3 domain, serine-threonine/tyrosine-protein kinase, catalytic domain

Molecular function transmembrane transporter binding, protein domain specific binding, protein-containing complex binding, SH2 domain binding, kinase activity, signaling receptor binding, estrogen receptor binding, ATP binding, protein kinase activity, insulin receptor binding, non-membrane spanning protein tyrosine kinase activity, kinase binding, heme binding, enzyme binding, transferase activity, ephrin receptor binding, scaffold protein binding, integrin binding, protein binding, protein kinase binding, cell adhesion molecule binding, protein kinase C binding, hormone receptor binding, nucleotide binding, growth factor receptor binding, phosphoprotein binding, protein tyrosine kinase activity, protein C-terminus binding, ubiquitin protein ligase binding, cadherin binding, connexin binding, protein tyrosine kinase activity, non-membrane spanning protein tyrosine kinase activity, signaling receptor binding, cadherin binding, phosphatidylinositol-4,5-bisphosphate 3-kinase activity, growth factor receptor binding, integrin binding

Physically interacts with bosutinib, dasatinib, saracatinib, SU6656, saracatinib, PD166285

Identifiers (13)

Image (Wikimedia Commons) PBB Protein SRC image.jpg ↗

Ensembl protein id ENSP00000350941, ENSP00000362659, ENSP00000362668, ENSP00000362680

Exact match identifiers.org, purl.uniprot.org, www.ncbi.nlm.nih.gov

Freebase id /m/03cxgjp

Mesh descriptor id D016392

Mesh tree code D08.811.913.696.620.682.725.800.630, D12.776.476.568.800.630, D12.776.624.664.700.202

Microsoft academic id (discontinued) 2.9B (108.6M–2.9B, n=3)

Openalex id C108636557

Pdb structure id 1A07, 1A08, 1A09, 1A1A, 1A1B, 1A1C, 1A1E, 1FMK, 1HCS, 1HCT, 1KSW, 1O41, 1O42, 1O43, 1O44, 1O45, 1O46, 1O47, 1O48, 1O49, 1O4A, 1O4B, 1O4C, 1O4D, 1O4E, 1O4F, 1O4G, 1O4H, 1O4I, 1O4J, 1O4K, 1O4L, 1O4M, 1O4N, 1O4O, 1O4P, 1O4Q, 1O4R, 1SHD, 1Y57, 1YI6, 1YOJ, 1YOL, 1YOM, 2BDF, 2H8H, 3VRO, 3ZMP, 3ZMQ, 4F59, 4F5A, 4F5B, 4HXJ, 4K11, 4MXO, 4MXX, 4MXY, 4MXZ

Refseq protein id NP_005408, NP_938033, XP_011527315, XP_016883513, XP_016883514, XP_016883515, XP_016883516

Transporter classification database id 8.A.23.1.12

Umls cui C0080059

Uniprot protein id P12931

🌐 Available in 6 languages

enProto-oncogene tyrosine-protein kinase Src arبروتين تيروزين كيناز طليعة الجين الورمي اللحمي csSrc deTyrosinkinase Src faC-Src trSrc

🏷️ Also known as

en tyrosine-protein kinase SRC-1 en v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog en p60-Src en pp60c-src en proto-oncogene c-Src en protooncogene SRC, Rous sarcoma en proto-oncogene tyrosine-protein kinase Src en SRC en SRC proto-oncogene, non-receptor tyrosine kinase en tyrosine kinase pp60c-src ar بروتين تيروزين كيناز طليعة الجين الورمي اللحمي de Tyrosinkinase Src fa C-Src zh SRC激酶

🔗 Connections

Biological process 14

cell cycle, cell differentiation, oogenesis, innate immune response, phosphorylation, signal transduction, cell population proliferation, cell adhesion +6 more

Cell component 13

mitochondrion, nucleus, cytoplasm, plasma membrane, lysosome, cytoskeleton, cytosol, actin filament +5 more

Physically interacts with 3

dasatinib, bosutinib, SU6656

← Physically interacts with 3

dasatinib, bosutinib, SU6656

Has part(s) 2

SH2 domain, SH3 domain

Has these parts 2

SH2 domain, SH3 domain

Encoded by 1

SRC

Found in taxon 1

Homo sapiens

Instance of 1

protein

Molecular function 1

protein binding

← Encodes 1

SRC

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ SRC proto-oncogene, non-receptor tyrosine kinase — physically interacts with (P129): bosutinib. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[3] ↑ SRC proto-oncogene, non-receptor tyrosine kinase — physically interacts with (P129): dasatinib. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[4] ↑ SRC proto-oncogene, non-receptor tyrosine kinase — physically interacts with (P129): saracatinib. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[5] ↑ SRC proto-oncogene, non-receptor tyrosine kinase — physically interacts with (P129): SU6656. IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved 2016-08-17. wikidata.org.
[6] ↑ SRC proto-oncogene, non-receptor tyrosine kinase — physically interacts with (P129): saracatinib. Open Targets Platform. Retrieved 2023-08-14. platform.opentargets.org. Provenance: wikidata.org.
[7] ↑ SRC proto-oncogene, non-receptor tyrosine kinase — physically interacts with (P129): PD166285. Open Targets Platform. Retrieved 2023-08-14. platform.opentargets.org. Provenance: wikidata.org.
[8] ↑ SRC proto-oncogene, non-receptor tyrosine kinase — part of (P361): SH3-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ SRC proto-oncogene, non-receptor tyrosine kinase — part of (P361): Protein kinase-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ SRC proto-oncogene, non-receptor tyrosine kinase — part of (P361): SH2 domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ SRC proto-oncogene, non-receptor tyrosine kinase — part of (P361): Src family kinases (SFKs) [cytosol]. wikidata.org.
[12] ↑ SRC proto-oncogene, non-receptor tyrosine kinase — part of (P361): Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family. wikidata.org.
[13] ↑ SRC proto-oncogene, non-receptor tyrosine kinase — part of (P361): SH2 domain, protein family. wikidata.org.
[14] ↑ SRC proto-oncogene, non-receptor tyrosine kinase — part of (P361): SH3 domain, protein family. wikidata.org.
[15] ↑ SRC proto-oncogene, non-receptor tyrosine kinase — part of (P361): Protein kinase domain, protein family. wikidata.org.
[16] ↑ SRC proto-oncogene, non-receptor tyrosine kinase — part of (P361): Protein kinase, ATP binding site, protein family. wikidata.org.
[17] ↑ SRC proto-oncogene, non-receptor tyrosine kinase — part of (P361): Tyrosine-protein kinase, catalytic domain, protein family. wikidata.org.
[18] ↑ SRC proto-oncogene, non-receptor tyrosine kinase — part of (P361): Tyrosine-protein kinase, active site, protein family. wikidata.org.
[19] ↑ SRC proto-oncogene, non-receptor tyrosine kinase — has part(s) (P527): tyrosine-protein kinase, active site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ SRC proto-oncogene, non-receptor tyrosine kinase — has part(s) (P527): protein kinase domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ SRC proto-oncogene, non-receptor tyrosine kinase — has part(s) (P527): protein kinase, ATP binding site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ SRC proto-oncogene, non-receptor tyrosine kinase — has part(s) (P527): SH2 domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ SRC proto-oncogene, non-receptor tyrosine kinase is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

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MLA

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BibTeX

@misc{4ortxyz_src-proto-oncogene-non-receptor-tyrosine-kinase_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{SRC proto-oncogene, non-receptor tyrosine kinase}}, year = {2026}, url = {https://4ort.xyz/entity/src-proto-oncogene-non-receptor-tyrosine-kinase}, note = {Accessed: 2026-11-01}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): SRC proto-oncogene, non-receptor tyrosine kinase — https://4ort.xyz/entity/src-proto-oncogene-non-receptor-tyrosine-kinase (retrieved 2026-11-01)

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