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RPE65

protein-coding gene in the species Homo sapiens
Class type of: protein-coding gene Q18031223
RPE65
Pleiotrope · Public Domain · Wikimedia

Facts

13 properties
Instance of
gene
Subclass of
protein-coding gene
Chromosome
human chromosome 1[14]
Cytogenetic location
1p31.3[18]
Encodes
Retinoid isomerohydrolase RPE65[12]
Expressed in
retinal pigment epithelium, testicle, optic nerve, Epithelium of choroid plexus, hypothalamus, substantia nigra, lower lobe of lung, C1 segment, seminal vesicula, ventricular zone[19][20][21][22][23][24][25][26][27][28]
Found in taxon
Homo sapiens[13]
Genetic association
Leber congenital amaurosis 2, fundus dystrophy[15][16]
Genomic end
68915642, 68449954[6][7]
Genomic start
68428822, 68894505[4][5]
HomoloGene ID
20108[3]
Ortholog
Rpe65, Rpe65, rpe65a, rpe65c, rpe65b[8][9][10][11]
Strand orientation
reverse strand[17]
🏷️ Also known as
en BCO3 en LCA2 en mRPE65 en p63 en rd12 en retinal pigment epithelium specific protein 65 en retinal pigment epithelium-specific protein 65kDa en retinoid isomerohydrolase RPE65 en RP20 en RPE65 en RPE65, retinoid isomerohydrolase en sRPE65
🔖 Identifiers · 12
OpenAlex ID
C2780724529
Ensembl gene ID
ENSG00000116745
Ensembl transcript ID
ENST00000262340
Entrez Gene ID
6121
Exact match
identifiers.org
Freebase ID
/m/03gx0bf
HGNC ID
10294
HGNC gene symbol
RPE65
Microsoft Academic ID (discontinued)
2780724529
OMIM ID
180069
RefSeq RNA ID
NM_000329
UMLS CUI
C1419622

Report an error or request removal Lineage (PROV-JSON)

🔗 Connections
Expressed in 6
testicle, hypothalamus, optic nerve, seminal vesicula, substantia nigra, retinal pigment epithelium
Chromosome 1
human chromosome 1
Found in taxon 1
Homo sapiens
Instance of 1
gene
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Summary

RPE65 is a gene[1]. RPE65 is a type of protein-coding gene[2].

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [2] ↑ . Ensembl Release 87. wikidata.org.
  2. [3] ↑ . NCBI Gene. Retrieved . wikidata.org.
  3. [4] ↑ . ensembl Release 106. wikidata.org.
  4. [5] ↑ . ensembl Release 106. wikidata.org.
  5. [6] ↑ . ensembl Release 106. wikidata.org.
  6. [7] ↑ . ensembl Release 106. wikidata.org.
  7. [8] ↑ . HomoloGene build68. omabrowser.org. Provenance: wikidata.org.
  8. [9] ↑ . HomoloGene build68. omabrowser.org. Provenance: wikidata.org.
  9. [10] ↑ . HomoloGene build68. wikidata.org.
  10. [11] ↑ . HomoloGene build68. wikidata.org.
  11. [12] ↑ . UniProt. Retrieved . wikidata.org.
  12. [13] ↑ . ensembl Release 106. wikidata.org.
  13. [14] ↑ . ensembl Release 106. wikidata.org.
  14. [15] ↑ . UniProt. Retrieved . wikidata.org.
  15. [16] ↑ . ClinGen. Retrieved . search.clinicalgenome.org. Provenance: wikidata.org.
  16. [17] ↑ . ensembl Release 106. wikidata.org.
  17. [18] ↑ . NCBI Gene. Retrieved . wikidata.org.
  18. [19] ↑ . Bgee. Retrieved . bgee.org. Provenance: wikidata.org.
  19. [20] ↑ . Bgee. Retrieved . bgee.org. Provenance: wikidata.org.
  20. [21] ↑ . Bgee. Retrieved . bgee.org. Provenance: wikidata.org.
  21. [22] ↑ . Bgee. Retrieved . bgee.org. Provenance: wikidata.org.
  22. [23] ↑ . Bgee. Retrieved . bgee.org. Provenance: wikidata.org.
  23. [24] ↑ . Bgee. Retrieved . bgee.org. Provenance: wikidata.org.
  24. [25] ↑ . Bgee. Retrieved . bgee.org. Provenance: wikidata.org.
  25. [26] ↑ . Bgee. Retrieved . bgee.org. Provenance: wikidata.org.
  26. [27] ↑ . Bgee. Retrieved . bgee.org. Provenance: wikidata.org.
  27. [28] ↑ . Bgee. Retrieved . bgee.org. Provenance: wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). RPE65. Retrieved November 8, 2026, from https://4ort.xyz/entity/rpe65
MLA “RPE65.” 4ort.xyz Knowledge Graph, 4ort.xyz, 8 Nov. 2026, https://4ort.xyz/entity/rpe65.
BibTeX @misc{4ortxyz_rpe65_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{RPE65}}, year = {2026}, url = {https://4ort.xyz/entity/rpe65}, note = {Accessed: 2026-11-08}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): RPE65 — https://4ort.xyz/entity/rpe65 (retrieved 2026-11-08)

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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 25w ago · Mathieu Kappler · 2026-05-20 view diff on Wikidata ↗
    Genetic association → Leber congenital amaurosis 2, fundus dystrophy
    Chromosome → human chromosome 1
    Strand orientation → reverse strand
    Instance of → gene
    + 5 other properties edited (see Wikidata diff for full list)
    "Changed [gsw] labels, descriptions or aliases: QuickStatements 3.0 batch #32527: human gene name and description in Alemannic"
Live feed via Wikidata EventStreams. New edits appear within minutes of being made on Wikidata.