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Presenilin 1

mammalian protein found in Homo sapiens
Protein protein Q4377404
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Presenilin 1

Summary

Presenilin 1 is a protein[1].

Key Facts

  • Presenilin 1's instance of is recorded as protein[2].
  • Presenilin 1's physically interacts with is recorded as semagacestat[3].
  • Presenilin 1's UniProt protein ID is recorded as P49768[4].
  • Presenilin 1's part of is recorded as Peptidase A22A, presenilin 1[5].
  • Presenilin 1's part of is recorded as Presenilin ER Ca2+ Leak Channel[6].
  • Presenilin 1's RefSeq protein ID is recorded as NP_000012[7].
  • Presenilin 1's RefSeq protein ID is recorded as NP_015557[8].
  • Presenilin 1's RefSeq protein ID is recorded as XP_005267921[9].
  • Presenilin 1's RefSeq protein ID is recorded as XP_005267923[10].
  • Presenilin 1's RefSeq protein ID is recorded as XP_011535274[11].
  • Presenilin 1's RefSeq protein ID is recorded as XP_011535275[12].
  • Presenilin 1's RefSeq protein ID is recorded as XP_011535276[13].
  • Presenilin 1's PDB structure ID is recorded as 2KR6[14].
  • Presenilin 1's PDB structure ID is recorded as 5A63[15].
  • Presenilin 1's PDB structure ID is recorded as 4UIS[16].
  • Presenilin 1's PDB structure ID is recorded as 5FN3[17].
  • Presenilin 1's PDB structure ID is recorded as 5FN4[18].
  • Presenilin 1's PDB structure ID is recorded as 5FN5[19].
  • Presenilin 1's PDB structure ID is recorded as 5FN2[20].
  • Presenilin 1's molecular function is recorded as PDZ domain binding[21].
  • Presenilin 1's molecular function is recorded as cadherin binding[22].
  • Presenilin 1's molecular function is recorded as peptidase activity[23].
  • Presenilin 1's molecular function is recorded as beta-catenin binding[24].
  • Presenilin 1's molecular function is recorded as protein binding[25].
  • Presenilin 1's molecular function is recorded as calcium channel activity[26].

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [2] ↑ . Q905695. Retrieved . wikidata.org.
  2. [3] ↑ . IUPHAR/BPS Guide to PHARMACOLOGY. Retrieved . wikidata.org.
  3. [4] ↑ . Q905695. Retrieved . wikidata.org.
  4. [5] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  5. [6] ↑ . Retrieved . wikidata.org.
  6. [7] ↑ . Q20641742. Retrieved . wikidata.org.
  7. [8] ↑ . Q20641742. Retrieved . wikidata.org.
  8. [9] ↑ . Q20641742. Retrieved . wikidata.org.
  9. [10] ↑ . Q20641742. Retrieved . wikidata.org.
  10. [11] ↑ . Q20641742. Retrieved . wikidata.org.
  11. [12] ↑ . Q20641742. Retrieved . wikidata.org.
  12. [13] ↑ . Q20641742. Retrieved . wikidata.org.
  13. [14] ↑ . Q905695. Retrieved . wikidata.org.
  14. [15] ↑ . Q905695. Retrieved . wikidata.org.
  15. [16] ↑ . Q905695. Retrieved . wikidata.org.
  16. [17] ↑ . Q905695. Retrieved . wikidata.org.
  17. [18] ↑ . Q905695. Retrieved . wikidata.org.
  18. [19] ↑ . Q905695. Retrieved . wikidata.org.
  19. [20] ↑ . Q905695. Retrieved . wikidata.org.
  20. [21] ↑ . Identification of a novel PSD-95/Dlg/ZO-1 (PDZ)-like protein interacting with the C terminus of presenilin-1. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [22] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [23] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [24] ↑ . The Presenilin 1 Protein Is a Component of a High Molecular Weight Intracellular Complex That Contains β-Catenin. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [25] ↑ . Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [26] ↑ . Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations. Retrieved . ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). Presenilin 1. Retrieved May 3, 2026, from https://4ort.xyz/entity/presenilin-1
MLA “Presenilin 1.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/presenilin-1.
BibTeX @misc{4ortxyz_presenilin-1_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Presenilin 1}}, year = {2026}, url = {https://4ort.xyz/entity/presenilin-1}, note = {Accessed: 2026-05-03}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Presenilin 1 — https://4ort.xyz/entity/presenilin-1 (retrieved 2026-05-03)

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