gamma-secretase complex

protein complex that has aspartic-type endopeptidase activity, and contains a catalytic subunit, presenilin (PS), that is a prototypical member of the GxGD-type aspartyl peptidases. The complex also contains additional subunits, including nicastrin
Thing cellular_component Q15328541
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gamma-secretase complex

Summary

gamma-secretase complex is a cellular component[1]. It draws 34 Wikipedia views per month (cellular_component category, ranking #108 of 301).[2]

Key Facts

  • gamma-secretase complex's instance of is recorded as cellular component[3].
  • gamma-secretase complex's instance of is recorded as group or class of transmembrane transport proteins[4].
  • gamma-secretase complex's instance of is recorded as family of protein complexes[5].
  • gamma-secretase complex's subclass of is recorded as plasma membrane protein complex[6].
  • gamma-secretase complex's subclass of is recorded as group translocator[7].
  • gamma-secretase complex's subclass of is recorded as aspartate protease[8].
  • gamma-secretase complex's subclass of is recorded as catalytic complex[9].
  • gamma-secretase complex's Commons category is recorded as Gamma secretase[10].
  • gamma-secretase complex's Freebase ID is recorded as /m/026b7cn[11].
  • gamma-secretase complex's molecular function is recorded as aspartic endopeptidase activity, intramembrane cleaving[12].
  • gamma-secretase complex's Gene Ontology ID is recorded as GO:0070765[13].
  • gamma-secretase complex's has part is recorded as Peptidase A22A, presenilin 1[14].
  • gamma-secretase complex's has part is recorded as Nicastrin[15].
  • gamma-secretase complex's has part is recorded as Gamma-secretase subunit Aph-1[16].
  • gamma-secretase complex's has part is recorded as Gamma-secretase aspartyl protease complex, presenilin enhancer-2 subunit[17].
  • gamma-secretase complex's exact match is recorded as http://purl.obolibrary.org/obo/GO_0070765[18].
  • gamma-secretase complex's exact match is recorded as http://tcdb.org/search/result.php?tc=4.G.1[19].
  • gamma-secretase complex's Microsoft Academic ID is recorded as 2778171954[20].
  • gamma-secretase complex's Transporter Classification Database ID is recorded as 4.G.1[21].
  • gamma-secretase complex's OpenAlex ID is recorded as C2778171954[22].

Why It Matters

gamma-secretase complex draws 34 Wikipedia views per month (cellular_component category, ranking #108 of 301).[2] It has Wikipedia articles in 5 language editions, a strong signal of global cultural recognition.[23] It is known by 11 alternative names across languages and contexts.[24]

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [3] . Gene Ontology release 2019-10-07. Retrieved . wikidata.org.
  2. [4] . wikidata.org.
  3. [5] . γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2. wikidata.org.
  4. [6] . Gene Ontology release 2019-10-07. Retrieved . wikidata.org.
  5. [7] . wikidata.org.
  6. [8] . wikidata.org.
  7. [9] . Gene Ontology release 2022-07-01. Retrieved . wikidata.org.
  8. [10] . wikidata.org.
  9. [11] . wikidata.org.
  10. [12] . InterPro release 2019-Nov-12. wikidata.org.
  11. [13] . Gene Ontology release 2019-10-07. Retrieved . wikidata.org.
  12. [14] . γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2. wikidata.org.
  13. [15] . γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2. wikidata.org.
  14. [16] . γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2. wikidata.org.
  15. [17] . γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2. wikidata.org.
  16. [18] . Gene Ontology release 2019-10-07. Retrieved . wikidata.org.
  17. [19] . wikidata.org.
  18. [20] . wikidata.org.
  19. [21] . wikidata.org.
  20. [22] . OpenAlex. Retrieved . docs.openalex.org. Provenance: wikidata.org.

Class ancestry

  1. [1] . Wikidata. wikidata.org.

Aggregate / graph-position facts

  1. [2] . Wikimedia Foundation. dumps.wikimedia.org.
  2. [23] . Wikidata sitelinks. wikidata.org.
  3. [24] . Wikidata aliases. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). gamma-secretase complex. Retrieved May 3, 2026, from https://4ort.xyz/entity/gamma-secretase-complex
MLA “gamma-secretase complex.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/gamma-secretase-complex.
BibTeX @misc{4ortxyz_gamma-secretase-complex_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{gamma-secretase complex}}, year = {2026}, url = {https://4ort.xyz/entity/gamma-secretase-complex}, note = {Accessed: 2026-05-03}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): gamma-secretase complex — https://4ort.xyz/entity/gamma-secretase-complex (retrieved 2026-05-03)

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