Nicastrin

mammalian protein found in Homo sapiens
Protein protein Q7024546
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Nicastrin

Summary

Nicastrin is a protein[1]. Nicastrin draws 15 Wikipedia views per month (protein category, ranking #154 of 987).[2]

Key Facts

  • Nicastrin's instance of is recorded as protein[3].
  • Nicastrin's physically interacts with is recorded as avagacestat[4].
  • Nicastrin's physically interacts with is recorded as begacestat[5].
  • Nicastrin's physically interacts with is recorded as nirogacestat[6].
  • Nicastrin is part of Nicastrin[7].
  • Nicastrin's molecular function is recorded as peptidase activity[8].
  • Nicastrin's molecular function is recorded as protein binding[9].
  • Nicastrin's molecular function is recorded as endopeptidase activity[10].
  • Nicastrin's cell component is recorded as Golgi apparatus[11].
  • Nicastrin's cell component is recorded as membrane[12].
  • Nicastrin's cell component is recorded as focal adhesion[13].
  • Nicastrin's cell component is recorded as melanosome[14].
  • Nicastrin's cell component is recorded as plasma membrane[15].
  • Nicastrin's cell component is recorded as integral component of plasma membrane[16].
  • Nicastrin's cell component is recorded as lysosomal membrane[17].
  • Nicastrin's cell component is recorded as endoplasmic reticulum[18].
  • Nicastrin's cell component is recorded as extracellular exosome[19].
  • Nicastrin's cell component is recorded as integral component of membrane[20].
  • Nicastrin's cell component is recorded as azurophil granule membrane[21].
  • Nicastrin's cell component is recorded as gamma-secretase complex[22].
  • Nicastrin's cell component is recorded as cytoplasmic vesicle membrane[23].
  • Nicastrin's cell component is recorded as cytoplasmic vesicle[24].
  • Nicastrin's cell component is recorded as cytoplasm[25].
  • Nicastrin's cell component is recorded as mitochondrion[26].
  • Nicastrin's cell component is recorded as lysosome[27].

Why It Matters

Nicastrin draws 15 Wikipedia views per month (protein category, ranking #154 of 987).[2] Nicastrin is known by 4 alternative names across languages and contexts.[28]

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [3] . Q905695. Retrieved . wikidata.org.
  2. [4] . Open Targets Platform. Retrieved . platform.opentargets.org. Provenance: wikidata.org.
  3. [5] . Open Targets Platform. Retrieved . platform.opentargets.org. Provenance: wikidata.org.
  4. [6] . Open Targets Platform. Retrieved . platform.opentargets.org. Provenance: wikidata.org.
  5. [7] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  6. [8] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  7. [9] . Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  8. [10] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  9. [11] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  10. [12] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  11. [13] . Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  12. [14] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [15] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [16] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [17] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [18] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [19] . Large-scale proteomics and phosphoproteomics of urinary exosomes. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [20] . Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [21] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [22] . Three-dimensional structure of human γ-secretase. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [23] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [24] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [25] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [26] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [27] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

  1. [1] . Wikidata. wikidata.org.

Aggregate / graph-position facts

  1. [2] . Wikimedia Foundation. dumps.wikimedia.org.
  2. [28] . Wikidata aliases. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). Nicastrin. Retrieved May 3, 2026, from https://4ort.xyz/entity/nicastrin
MLA “Nicastrin.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/nicastrin.
BibTeX @misc{4ortxyz_nicastrin_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Nicastrin}}, year = {2026}, url = {https://4ort.xyz/entity/nicastrin}, note = {Accessed: 2026-05-03}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Nicastrin — https://4ort.xyz/entity/nicastrin (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/nicastrin · Last refreshed:

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 6d ago · MatSuBot bot · 2026-05-18 view diff on Wikidata ↗
    Cell component Golgi apparatus, membrane, focal adhesion +30
    Instance of
    Physically interacts with avagacestat, begacestat, nirogacestat
    Molecular function peptidase activity, protein binding, endopeptidase activity
    + 7 other properties edited (see Wikidata diff for full list)
    "/* wbeditentity-update-languages-short:0||tt, uk */ import labels from sitelinks"
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