What is the Karplus equation?

The Karplus equation describes the relationship between the vicinal coupling constants (³J) in NMR spectroscopy and the dihedral angles in molecules. It is expressed as \( J(\phi) = A \cos^2 \phi + B \cos \phi + C \), where \( \phi \) is the torsion angle. This equation is critical for determining the three-dimensional structures of organic and biological molecules.

Where did Martin Karplus teach?

Karplus held professorships at Harvard University, the University of Strasbourg (France), and Columbia University. He also conducted research at the California Institute of Technology and was affiliated with the International Academy of Quantum Molecular Science.

How did Karplus's work impact computational chemistry?

His development of multiscale modeling techniques allowed scientists to simulate large biomolecular systems with unprecedented accuracy. By integrating quantum and classical mechanics, his methods enabled the study of protein dynamics, drug interactions, and enzymatic reactions, advancing fields like structural biology and drug design.

What is CHARMM, and how is it used?

CHARMM (Chemistry at Harvard Macromolecular Mechanics) is a molecular dynamics simulation software suite co-created by Karplus. It is used to model the behavior of biological macromolecules, such as proteins and nucleic acids, under physiological conditions. Researchers worldwide rely on CHARMM for studying molecular interactions, folding pathways, and thermodynamic properties.

Martin Karplus

Q: What awards did Martin Karplus receive?

He received numerous honors, including: - Nobel Prize in Chemistry (2013) - Guggenheim Fellowship - Commander of the Legion of Honour (France) - Austrian Decoration for Science and Art - Linus Pauling Award (1987) - Irving Langmuir Award in Chemical Physics - Honorary doctorates from the University of Vienna and other institutions.

Austrian-born American theoretical chemist (1930–2024)

Person Human Q903471

Facts

21 properties

Instance of: human
Sex or gender: male^[41]
Date of birth: March 15, 1930, 1930^[10]
Date of death: December 28, 2024
Place of birth: Vienna
Place of death: Cambridge
Country of citizenship: Austria, United States^[11]^[12]
Occupation: theoretical chemist, university teacher, biophysicist, chemist, scientist
Employer: Harvard University, Columbia University, University of Strasbourg^[15]^[16]^[17]
Field of work: NMR spectroscopy, theoretical chemistry^[13]^[14]
Educated at: Harvard University, California Institute of Technology, Harvard College, Newton North High School^[18]^[19]^[20]^[21]
Award received: Nobel Prize in Chemistry, Guggenheim Fellowship, ACS Award in Theoretical Chemistry, Commander of the Legion of Honour, honorary doctor of the University of Vienna, Irving Langmuir Award in Chemical Physics, honorary citizen of Vienna, Foreign Member of the Royal Society, Austrian Decoration for Science and Art, Linus Pauling Award, ACS Award for Computers in Chemical and Pharmaceutical Research, Clarivate Citation Laureates^[23]^[24]^[25]^[26]^[27]^[28]^[29]^[30]^[31]^[32]^[33]^[34]
Sibling: Robert Karplus
Doctoral advisor: Linus Pauling^[22]
Doctoral student: Arieh Warshel, Paul Brumer, Klaus Schulten, J. Andrew McCammon, Bernie Shizgal, Bruce Tidor, Collin Melveton Stultz^[42]^[43]^[44]^[45]^[46]^[47]^[48]
Languages spoken, written or signed: English^[51]
Family name: Karplus^[49]
Given name: Martin^[50]
Interested in: theoretical chemistry
Maintained by WikiProject: WikiProject Mathematics
Member of: Royal Society of London, National Academy of Sciences, International Academy of Quantum Molecular Science, American Academy of Arts and Sciences, Austrian Academy of Sciences, Royal Netherlands Academy of Arts and Sciences^[35]^[36]^[37]^[38]^[39]^[40]

🏷️ Also known as

en Martin Karplus en M. Karplus en M Karplus en Karplus en Karplus M en Karplus M. ar مارتين كاربلوس cs M. Karplus el Μάρτιν Κάρπλους fa مارتین کارپلاس he מרטין קרפלוס hi मार्टिन कारप्लस ja マーティン・カープラス ko 마틴 카플러스 ro Karplus ro M. Karplus ru Карплус, Мартин ru Мартин Карплус uk Мартін Карплус zh 马丁·卡普拉斯

🔖 Identifiers · 75

ISNI: 0000000110224970
VIAF cluster ID: 22222638
Library of Congress Authorities ID: n86129197
GND ID: 13236736X
Image (Wikimedia Commons): Martin Karplus Nobel Prize 22 2013.jpg ↗
Academic Tree ID: 52510
Article ID in the Lithuanian Universal Encyclopedia Online: martin-karplus
Austria-Forum person ID: Karplus,_Martin, Karplus%2C_Martin
Awards & Winners artist ID: 0c397v
BIBSYS ID: 90340694
Bibliothèque nationale de France ID: 12381732d
Brockhaus Enzyklopädie online ID: karplus-martin

Show all 75 identifiers +63

CNRS Talent page: martin-karplus
CONOR.SI ID: 125802851
Canadiana Name Authority ID: ncf12125799
CiNii Research ID: 1140563741527437312
Cyprus University of Technology ID: 38139
DBA ID: karplus-martin
DBLP author ID: 63/958
DDB person (GND) ID: 13236736X
De Agostini ID: Karplus,Martin
Dimensions author ID: 1.1B (1.1B–12.4B, n=3)
Encyclopædia Britannica Online ID: biography/Martin-Karplus
FAST ID: 1958456
FactGrid item ID: Lena Olin
Fellow of the Royal Society ID: 11725
Freebase ID: /m/0c397v
Geni profile ID: 6000000018231475302
Gran Enciclopèdia Catalana ID: martin-karplus
Gran Enciclopèdia Catalana ID (former scheme): 21167893
Great Russian Encyclopedia Online ID (2017): 3455345
Great Russian Encyclopedia portal ID: karplus-martin-8d8c5a
Guggenheim fellows ID: martin-karplus
Hrvatska enciklopedija ID: 69567
IdRef ID: 032871864
J9U entity ID: 987007451821405171
JRC Names ID: 1739195
Jewish Encyclopedia ID (Russian): 15813
KBR person ID: 13948142
Libris-URI: rp357v890jqlb9w
MR Author ID: 98655
Mathematics Genealogy Project ID: 144879
Munzinger person ID: 00000029722
NACSIS-CAT author ID: DA02819822
NE.se ID: martin-karplus
NL CR AUT ID: ntk20221145564
NNDB people ID: 219/000165721
NSK (VIAF) ID: 000023176
NSK ID: 981005681723409366
NUKAT ID: n01092101
National Academy of Sciences member ID: 53964
National Library of Poland MMS ID: 9810615161105606
National Virtual Library of India ID: 417316
Nationale Thesaurus voor Auteursnamen ID: 072375507
Nobel Laureate API ID: 889
Online PWN Encyclopedia ID: 5289557
Open Library ID: OL2037186A
PhDTree person ID: karplus-martin
Prabook ID: 1305798
RERO ID (legacy): A003443100
SELIBR ID: 232179
SHARE Catalogue author ID: 1101
SNAC ARK ID: w6qz2d6d
SNK ID: 155186
Savoirs ENS ID: 820
ScholarGPS scholar ID: 92242619525641
Scopus author ID: 15132101700
Slovak National Library (VIAF) ID: vtls010426688
Treccani ID: martin-karplus
Vienna History Wiki ID: 36893
Who's Who UK ID: U266363
Who's Who in France biography ID: 75009
WorldCat Entities ID: E39PBJwX6dRwjj3pBxHCmGDDv3
Yale LUX ID: person/02b07206-df3a-4955-95f9-cff61bbdff06
ZbMATH author ID: karplus.martin

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🔗 Connections

Award received 9

Nobel Prize in Chemistry, Guggenheim Fellowship, Austrian Decoration for Science and Art, Commander of the Legion of Honour, Linus Pauling Award, Clarivate Citation Laureates, Irving Langmuir Award in Chemical Physics, honorary citizen of Vienna +1 more

Member of 6

Royal Society of London, National Academy of Sciences, American Academy of Arts and Sciences, Austrian Academy of Sciences, Royal Netherlands Academy of Arts and Sciences, International Academy of Quantum Molecular Science

Occupation 4

scientist, chemist, university teacher, biophysicist

Educated at 3

Harvard University, California Institute of Technology, Harvard College

Employer 3

Harvard University, Columbia University, University of Strasbourg

Country of citizenship 2

United States, Austria

Field of work 2

theoretical chemistry, NMR spectroscopy

Doctoral advisor 1

Linus Pauling

Doctoral advisors 1

Linus Pauling

Doctoral student 1

Arieh Warshel

Doctoral students 1

Arieh Warshel

FactGrid item ID 1

Lena Olin

Given name 1

Martin

Instance of 1

human

Interested in 1

theoretical chemistry

Languages spoken, written or signed 1

English

Maintained by WikiProject 1

WikiProject Mathematics

Named after 1

Karplus equation

Place of birth 1

Vienna

Place of death 1

Cambridge

Sex or gender 1

male

Sibling 1

Robert Karplus

Siblings 1

Robert Karplus

← Developer 1

CHARMM

← Winner 1

Irving Langmuir Award in Chemical Physics

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Summary

Martin Karplus was born on March 15, 1930^[1], in Vienna^[2]. He died on December 28, 2024^[3], in Cambridge^[4]. He worked as a theoretical chemist^[5], university teacher^[6], biophysicist^[7], chemist^[8], and scientist^[9].

Body

Works and Contributions

Things named for Martin Karplus include Karplus equation^[52].

Why It Matters

Entities named for him include Karplus equation^[52].

His notable doctoral advisees include Arieh Warshel^[53], a biochemist^[54], b. 1940^[55], of Israel^[56], awarded the Nobel Prize in Chemistry^[57], specialised in biochemistry^[58].

FAQs

Where was Martin Karplus born?

Martin Karplus was born in Vienna^[2].

Where did Martin Karplus die?

Martin Karplus passed away in Cambridge^[4].

What did Martin Karplus do for work?

Martin Karplus worked as a theoretical chemist^[5], university teacher^[6], biophysicist^[7], chemist^[8], and scientist^[9].

Where did Martin Karplus go to school?

Martin Karplus was educated at Harvard University^[18], California Institute of Technology^[19], Harvard College^[20], and Newton North High School^[21].

What awards did Martin Karplus receive?

Honors received include Nobel Prize in Chemistry^[23], Guggenheim Fellowship^[24], ACS Award in Theoretical Chemistry^[25], and Commander of the Legion of Honour^[26].

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Martin Karplus — place of birth (P19): Vienna. Integrated Authority File. Retrieved 2014-12-17. wikidata.org.
[4] ↑ Martin Karplus — place of death (P20): Cambridge. magnifuneralhome.com. magnifuneralhome.com. Provenance: wikidata.org.
[41] ↑ Martin Karplus — sex or gender (P21): male. Virtual International Authority File. Retrieved 2018-11-04. wikidata.org.
[11] ↑ Martin Karplus — country of citizenship (P27): Austria. wikidata.org.
[12] ↑ Martin Karplus — country of citizenship (P27): United States. wikidata.org.
[18] ↑ Martin Karplus — educated at (P69): Harvard University. wikidata.org.
[19] ↑ Martin Karplus — educated at (P69): California Institute of Technology. wikidata.org.
[20] ↑ Martin Karplus — educated at (P69): Harvard College. wikidata.org.
[21] ↑ Martin Karplus — educated at (P69): Newton North High School. Retrieved 2021-03-04. wikidata.org.
[13] ↑ Martin Karplus — field of work (P101): NMR spectroscopy. wikidata.org.
[14] ↑ Martin Karplus — field of work (P101): theoretical chemistry. Czech National Authority Database. Retrieved 2022-11-07. wikidata.org.
[5] ↑ Martin Karplus — occupation (P106): theoretical chemist. wikidata.org.
[6] ↑ Martin Karplus — occupation (P106): university teacher. Integrated Authority File. Retrieved 2026-04-20. wikidata.org.
[7] ↑ Martin Karplus — occupation (P106): biophysicist. Retrieved 2019-06-20. wikidata.org.
[8] ↑ Martin Karplus — occupation (P106): chemist. Czech National Authority Database. Retrieved 2022-12-20. wikidata.org.
[9] ↑ Martin Karplus — occupation (P106): scientist. Czech National Authority Database. Retrieved 2022-12-20. wikidata.org.
[15] ↑ Martin Karplus — employer (P108): Harvard University. wikidata.org.
[16] ↑ Martin Karplus — employer (P108): Columbia University. wikidata.org.
[17] ↑ Martin Karplus — employer (P108): University of Strasbourg. lemonde.fr. lemonde.fr. Provenance: wikidata.org.
[23] ↑ Martin Karplus — award received (P166): Nobel Prize in Chemistry. nobelprize.org. Retrieved 2020-05-05. nobelprize.org. Provenance: wikidata.org.
[24] ↑ Martin Karplus — award received (P166): Guggenheim Fellowship. Guggenheim Fellows database. wikidata.org.
[25] ↑ Martin Karplus — award received (P166): ACS Award in Theoretical Chemistry. phys-acs.org. phys-acs.org. Provenance: wikidata.org.
[26] ↑ Martin Karplus — award received (P166): Commander of the Legion of Honour. wikidata.org.
[27] ↑ Martin Karplus — award received (P166): honorary doctor of the University of Vienna. geschichte.univie.ac.at. geschichte.univie.ac.at. Provenance: wikidata.org.
[28] ↑ Martin Karplus — award received (P166): Irving Langmuir Award in Chemical Physics. Irving Langmuir Award in Chemical Physics. Retrieved 2018-10-06. aps.org. Provenance: wikidata.org.
[29] ↑ Martin Karplus — award received (P166): honorary citizen of Vienna. wikidata.org.
[30] ↑ Martin Karplus — award received (P166): Foreign Member of the Royal Society. Complete List of Royal Society Fellows 1660-2007. wikidata.org.
[31] ↑ Martin Karplus — award received (P166): Austrian Decoration for Science and Art. wikidata.org.
[32] ↑ Martin Karplus — award received (P166): Linus Pauling Award. acspss.org. acspss.org. Provenance: wikidata.org.
[33] ↑ Martin Karplus — award received (P166): ACS Award for Computers in Chemical and Pharmaceutical Research. acs.org. acs.org. Provenance: wikidata.org.
[34] ↑ Martin Karplus — award received (P166): Clarivate Citation Laureates. clarivate.com. Retrieved 2023-09-23. clarivate.com. Provenance: wikidata.org.
[22] ↑ Martin Karplus — doctoral advisor (P184): Linus Pauling. wikidata.org.
[42] ↑ Martin Karplus — doctoral student (P185): Arieh Warshel. wikidata.org.
[43] ↑ Martin Karplus — doctoral student (P185): Paul Brumer. wikidata.org.
[44] ↑ Martin Karplus — doctoral student (P185): Klaus Schulten. wikidata.org.
[45] ↑ Martin Karplus — doctoral student (P185): J. Andrew McCammon. wikidata.org.
[46] ↑ Martin Karplus — doctoral student (P185): Bernie Shizgal. Mathematics Genealogy Project. wikidata.org.
[47] ↑ Martin Karplus — doctoral student (P185): Bruce Tidor. Mathematics Genealogy Project. wikidata.org.
[48] ↑ Martin Karplus — doctoral student (P185): Collin Melveton Stultz. Mathematics Genealogy Project. wikidata.org.
[35] ↑ Martin Karplus — member of (P463): Royal Society of London. wikidata.org.
[36] ↑ Martin Karplus — member of (P463): National Academy of Sciences. wikidata.org.
[37] ↑ Martin Karplus — member of (P463): International Academy of Quantum Molecular Science. wikidata.org.
[38] ↑ Martin Karplus — member of (P463): American Academy of Arts and Sciences. wikidata.org.
[39] ↑ Martin Karplus — member of (P463): Austrian Academy of Sciences. wikidata.org.
[40] ↑ Martin Karplus — member of (P463): Royal Netherlands Academy of Arts and Sciences. wikidata.org.
[1] ↑ Martin Karplus — date of birth (P569): March 15, 1930. SNAC. Retrieved 2017-10-09. wikidata.org.
[10] ↑ Martin Karplus — date of birth (P569): 1930. Czech National Authority Database. Retrieved 2022-03-31. wikidata.org.
[3] ↑ Martin Karplus — date of death (P570): December 28, 2024. magnifuneralhome.com. Retrieved 2025-01-04. magnifuneralhome.com. Provenance: wikidata.org.
[49] ↑ Martin Karplus — family name (P734): Karplus. wikidata.org.
[50] ↑ Martin Karplus — given name (P735): Martin. wikidata.org.
[51] ↑ Martin Karplus — languages spoken, written or signed (P1412): English. BnF authorities. Retrieved 2015-10-10. wikidata.org.

Inverse relationships (entities pointing at this one)

Inline context (facts about related entities)

[54] ↑ Arieh Warshel — P106: biochemist. Wikidata. wikidata.org. → on this site
[55] ↑ Arieh Warshel — P569: b. 1940. Wikidata. wikidata.org. → on this site
[56] ↑ Arieh Warshel — P27: Israel. Wikidata. wikidata.org. → on this site
[57] ↑ Arieh Warshel — P166: Nobel Prize in Chemistry. Wikidata. wikidata.org. → on this site
[58] ↑ Arieh Warshel — P101: biochemistry. Wikidata. wikidata.org. → on this site

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4ort.xyz Knowledge Graph. (2026). Martin Karplus. Retrieved November 6, 2026, from https://4ort.xyz/entity/martin-karplus

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