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lipoprotein lipase

mammalian protein found in Homo sapiens
Protein protein Q420014

Facts

9 properties
Instance of
protein
Part of
Lipoprotein lipase, PLAT/LH2 domain superfamily, Alpha/Beta hydrolase fold, Lipase, N-terminal domain, protein family, vitellogenins, PLAT/LH2 domain, protein family[2][3][4][5][6][7]
Biological process
positive regulation of inflammatory response, lipid metabolism, positive regulation of cholesterol storage, response to glucose, retinoid metabolic process, triglyceride catabolic process, lipid catabolic process, positive regulation of macrophage derived foam cell differentiation, positive regulation of sequestering of triglyceride, fatty acid biosynthetic process, very-low-density lipoprotein particle remodeling, response to cold, phospholipid metabolic process, cholesterol homeostasis, triglyceride metabolic process, triglyceride homeostasis, triglyceride biosynthetic process, low-density lipoprotein particle mediated signaling, chylomicron remodeling, regulation of lipoprotein lipase activity, response to bacterium, chylomicron remodeling, negative regulation of cellular response to insulin stimulus[33][34][35][36][37][38][39][40][41][42][43][44][45][46]
Cell component
membrane, extracellular matrix, chylomicron, plasma membrane, very-low-density lipoprotein particle, extracellular region, cell surface, anchored component of membrane, extracellular exosome, extracellular space, extracellular space[23][24][25][26][27][28][29][30][31][32]
EC enzyme number
3.1.1.32, 3.1.1.34[11][12]
Encoded by
LPL[47]
Found in taxon
Homo sapiens[48]
Has part(s)
PLAT/LH2 domain, Lipase/vitellogenin, Lipase, N-terminal[8][9][10]
Molecular function
triglyceride binding, apolipoprotein binding, heparin binding, lipoprotein lipase activity, triglyceride lipase activity, phospholipase activity, carboxylic ester hydrolase activity, protein binding, signaling receptor binding, hydrolase activity[13][14][15][16][17][18][19][20][21][22]
🏷️ Also known as
en lipoprotein lipase en LPL en uniprot:P06858 ar ليبوبروتين ليباز da Lipoproteinlipase es Lipoproteinlipasa fi Lipoproteiinilipaasi fr Lipoproteine lipase fr Lipoprotéine lipase id Lipase pankreatik it Lipoproteina lipasi ja リポタンパク質リパーゼ nl Lipoproteinelipase nl Lipoproteine Lipase nl Lipoproteïnelipase nl Lipoproteïne Lipase ro lipoprotein lipază ro LPL ru Липопротеинлипаза sv Lipoproteinlipas
🔖 Identifiers · 8
OpenAlex ID
C94879076
Ensembl protein ID
ENSP00000428237, ENSP00000428496, ENSP00000428557, ENSP00000431028, ENSP00000497642, ENSP00000497560
Exact match
purl.uniprot.org
Freebase ID
/m/04l_4w
Microsoft Academic ID (discontinued)
94879076
RefSeq protein ID
NP_000228
Store medisinske leksikon ID
lipoprotein-lipase, lipoproteinlipase
UniProt protein ID
P06858

Report an error or request removal Lineage (PROV-JSON)

🔗 Connections
Cell component 6
plasma membrane, extracellular matrix, chylomicron, extracellular exosome, extracellular space, extracellular space
Biological process 1
lipid metabolism
Found in taxon 1
Homo sapiens
Instance of 1
protein
Molecular function 1
protein binding
Part of 1
vitellogenins
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Summary

lipoprotein lipase is a protein[1].

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [2] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  2. [3] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  3. [4] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  4. [5] ↑ . wikidata.org.
  5. [6] ↑ . wikidata.org.
  6. [7] ↑ . wikidata.org.
  7. [8] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  8. [9] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  9. [10] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  10. [11] ↑ . UniProt. Retrieved . wikidata.org.
  11. [12] ↑ . UniProt. Retrieved . wikidata.org.
  12. [13] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [14] ↑ . Mechanism of triglyceride lowering in mice expressing human apolipoprotein A5. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [15] ↑ . Missense mutation (Gly----Glu188) of human lipoprotein lipase imparting functional deficiency. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [16] ↑ . Apolipoprotein C-II39-62 activates lipoprotein lipase by direct lipid-independent binding. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [17] ↑ . Apolipoprotein C-II39-62 activates lipoprotein lipase by direct lipid-independent binding. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [18] ↑ . Apolipoprotein C-II39-62 activates lipoprotein lipase by direct lipid-independent binding. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [19] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [20] ↑ . Chylomicronemia with low postheparin lipoprotein lipase levels in the setting of GPIHBP1 defects. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [21] ↑ . Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [22] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [23] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [24] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [25] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [26] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  26. [27] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  27. [28] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  28. [29] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  29. [30] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  30. [31] ↑ . Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  31. [32] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  32. [33] ↑ . MicroRNA-590 attenuates lipid accumulation and pro-inflammatory cytokine secretion by targeting lipoprotein lipase gene in human THP-1 macrophages. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  33. [34] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  34. [35] ↑ . VLDL-induced triglyceride accumulation in human macrophages is mediated by modulation of LPL lipolytic activity in the absence of change in LPL mass. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  35. [36] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  36. [37] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  37. [38] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  38. [39] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  39. [40] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  40. [41] ↑ . VLDL-induced triglyceride accumulation in human macrophages is mediated by modulation of LPL lipolytic activity in the absence of change in LPL mass. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  41. [42] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  42. [43] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  43. [44] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  44. [45] ↑ . Apolipoprotein C-II39-62 activates lipoprotein lipase by direct lipid-independent binding. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  45. [46] ↑ . MicroRNA-590 attenuates lipid accumulation and pro-inflammatory cytokine secretion by targeting lipoprotein lipase gene in human THP-1 macrophages. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  46. [47] ↑ . UniProt. Retrieved . wikidata.org.
  47. [48] ↑ . UniProt. Retrieved . wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). lipoprotein lipase. Retrieved November 5, 2026, from https://4ort.xyz/entity/lipoprotein-lipase
MLA “lipoprotein lipase.” 4ort.xyz Knowledge Graph, 4ort.xyz, 5 Nov. 2026, https://4ort.xyz/entity/lipoprotein-lipase.
BibTeX @misc{4ortxyz_lipoprotein-lipase_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{lipoprotein lipase}}, year = {2026}, url = {https://4ort.xyz/entity/lipoprotein-lipase}, note = {Accessed: 2026-11-05}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): lipoprotein lipase — https://4ort.xyz/entity/lipoprotein-lipase (retrieved 2026-11-05)

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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 21d ago · OKA bot bot · 2026-10-16 view diff on Wikidata ↗
    Wikipedia languages → ['ar', 'bs', 'ca', 'commons', 'da', 'de', 'en', 'es', 'fi', 'fr', 'gl', 'hr', 'i
    Store medisinske leksikon ID → lipoprotein-lipase, lipoproteinlipase
    Claims rich → —
    "/* wbeditentity-statements-single-property-update:1||2 */ Store medisinske leksikon ID, SML ID lipoprotein-lipase deprecated (now SML lipoproteinlipase), SML ID lipoproteinlipase from Store medisinske"
  2. 15w ago · Boghog · 2026-07-23 view diff on Wikidata ↗
    Instance of → —
    Part of → —
    Encoded by → LPL
    Biological process → positive regulation of inflammatory response, lipid metabolism, positive regulation of cholesterol storage +20
    + 9 other properties edited (see Wikidata diff for full list)
    "/* wbcreateclaim-create:1| */ EC enzyme number: 3.1.1.32, [[:toollabs:quickstatements/#/batch/261446|batch #261446]]"
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