Quick Facts
Part of
Tyrosine protein kinase, EGF/ERB/XmrK receptor, Protein kinase-like domain superfamily, Growth factor receptor cysteine-rich domain superfamily, Receptor L-domain superfamily, Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family, Growth factor receptor domain 4, protein family, Receptor L-domain, protein family, Furin-like cysteine-rich domain, protein family, Protein kinase domain, protein family, Protein kinase, ATP binding site, protein family, Tyrosine-protein kinase, catalytic domain, protein family, Tyrosine-protein kinase, active site, protein family, Furin-like repeat, protein family
Properties
Biological process
positive regulation of protein phosphorylation, peripheral nervous system development, regulation of transcription, DNA-templated, negative regulation of immature T cell proliferation in thymus, positive regulation of MAP kinase activity, phosphorylation, transmembrane receptor protein tyrosine kinase signaling pathway, positive regulation of epithelial cell proliferation, cellular response to growth factor stimulus, wound healing, oligodendrocyte differentiation, regulation of angiogenesis, positive regulation of translation, transcription, DNA-templated, nervous system development, MAPK cascade, protein phosphorylation, development of the heart, cell surface receptor signaling pathway, positive regulation of GTPase activity, positive regulation of cell growth, regulation of microtubule-based process, neuromuscular junction development, regulation of ERK1 and ERK2 cascade, myelination, protein autophosphorylation, phosphatidylinositol 3-kinase signaling, positive regulation of transcription by RNA polymerase I, cell population proliferation, positive regulation of transcription by RNA polymerase III, motor neuron axon guidance, enzyme linked receptor protein signaling pathway, signal transduction, positive regulation of cell adhesion, positive regulation of protein targeting to membrane, ERBB2 signaling pathway, phosphatidylinositol phosphate biosynthetic process, positive regulation of gene expression, peptidyl-tyrosine phosphorylation, regulation of cell motility, cellular response to epidermal growth factor stimulus, regulation of transcription by RNA polymerase II, negative regulation of ERBB signaling pathway, positive regulation of protein kinase B signaling, negative regulation of signal transduction, cell differentiation, negative regulation of apoptotic process, positive regulation of ERK1 and ERK2 cascade, intracellular signal transduction, transmembrane receptor protein tyrosine kinase signaling pathway, positive regulation of cell population proliferation, neuron differentiation, positive regulation of MAPK cascade
Cell component
integral component of membrane, membrane, myelin sheath, receptor complex, plasma membrane, basolateral plasma membrane, apical plasma membrane, perinuclear region of cytoplasm, endosome membrane, cytoplasmic vesicle, nucleus, cytoplasm, cytosol, cytoplasm, integral component of plasma membrane, basal plasma membrane, receptor complex
Ec enzyme number
2.7.10.1
Has part(s)
tyrosine-protein kinase, active site, protein kinase, ATP binding site, protein kinase domain, tyrosine-protein kinase, catalytic domain, Growth factor receptor domain 4, Receptor L-domain, serine-threonine/tyrosine-protein kinase, catalytic domain, Furin-like repeat, Furin-like cysteine-rich domain
Has parts
tyrosine-protein kinase, active site, protein kinase, ATP binding site, protein kinase domain, tyrosine-protein kinase, catalytic domain, Growth factor receptor domain 4, Receptor L-domain, serine-threonine/tyrosine-protein kinase, catalytic domain, Furin-like repeat, Furin-like cysteine-rich domain
Molecular function
ErbB-3 class receptor binding, transferase activity, nucleotide binding, protein kinase activity, protein dimerization activity, growth factor binding, RNA polymerase I core binding, kinase activity, protein C-terminus binding, protein binding, identical protein binding, protein heterodimerization activity, transmembrane receptor protein tyrosine kinase activity, protein tyrosine kinase activity, protein phosphatase binding, ATP binding, transmembrane signaling receptor activity, phosphatidylinositol-4,5-bisphosphate 3-kinase activity, receptor tyrosine kinase, transmembrane signaling receptor activity, transmembrane receptor protein tyrosine kinase activity
Part of
Tyrosine protein kinase, EGF/ERB/XmrK receptor, Protein kinase-like domain superfamily, Growth factor receptor cysteine-rich domain superfamily, Receptor L-domain superfamily, Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family, Growth factor receptor domain 4, protein family, Receptor L-domain, protein family, Furin-like cysteine-rich domain, protein family, Protein kinase domain, protein family, Protein kinase, ATP binding site, protein family, Tyrosine-protein kinase, catalytic domain, protein family, Tyrosine-protein kinase, active site, protein family, Furin-like repeat, protein family
Physically interacts with
afatinib, canertinib, dacomitinib, lapatinib, mubritinib, neratinib, Margetuximab, dacomitinib, pertuzumab, tucatinib, bms-599626, bms-690514, cp-724714, cudc-101, poziotinib, sapitinib, varlitinib, tesevatinib
External References (11)
Ensembl protein id
ENSP00000269571, ENSP00000385185, ENSP00000446466, ENSP00000462438, ENSP00000404047, ENSP00000462024, ENSP00000462808, ENSP00000463002, ENSP00000463427, ENSP00000463714, ENSP00000463719, ENSP00000464252, ENSP00000464420
Freebase id
/m/08k67q
Mesh descriptor id
D018719
Mesh tree code
D08.811.913.696.620.682.725.400.009.400, D12.776.543.750.630.009.400, D12.776.543.750.750.400.074.400, D12.776.624.664.700.642, D23.050.301.500.600.700, D23.050.705.552.600.550, D23.101.140.642, D12.776.476.568.400.009.400
Microsoft academic id (discontinued)
2776872082
Openalex id
C2908728163
Pdb structure id
1MFG, 1MFL, 1MW4, 1N8Z, 1QR1, 1S78, 2A91, 2JWA, 2KS1, 2L4K, 3BE1, 3H3B, 3N85, 3PP0, 3RCD, 3MZW, 3WLW, 3WSQ, 4GFU, 4HRL, 4HRM, 4HRN, 2N2A
Refseq protein id
NP_001005862, NP_001276865, NP_001276866, NP_001276867, NP_004439, XP_024306409, XP_024306410, XP_024306411, NP_001369711, NP_001369712, NP_001369713, NP_001369714, NP_001369715, NP_001369716, NP_001369717, NP_001369718, NP_001369719, NP_001369720, NP_001369721, NP_001369722, NP_001369723, NP_001369724, NP_001369725, NP_001369726, NP_001369727, NP_001369728, NP_001369729, NP_001369730, NP_001369731, NP_001369732, NP_001369733, NP_001369734, NP_001369735
Umls cui
C0069515
Uniprot protein id
P04626
Wellcome collection concept id
qur8tv43