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APP

protein-coding gene in the species Homo sapiens
Class type of: protein-coding gene Q14865870

Facts

13 properties
Instance of
gene
Subclass of
protein-coding gene
Chromosome
human chromosome 21[14]
Cytogenetic location
21q21.3[17]
Encodes
Amyloid beta precursor protein[12]
Expressed in
prefrontal cortex, Brodmann area 9, renal medulla, internal globus pallidus, stromal cell of endometrium, tendon of biceps brachii, primary visual cortex, C1 segment, islet of Langerhans, Epithelium of choroid plexus[18][19][20][21][22][23][24][25][26][27]
Found in taxon
Homo sapiens[13]
Genetic association
Alzheimer's disease[15]
Genomic end
26171128, 27543446[6][7]
Genomic start
25880550, 27252861[4][5]
HomoloGene ID
56379[3]
Ortholog
App, App, apl-1, appb, appa[8][9][10][11]
Strand orientation
reverse strand[16]
🏷️ Also known as
en preA4 en AAA en ABETA en ABPP en AD1 en alpha-sAPP en amyloid beta precursor protein en APP en APPI en CTFgamma en CVAP en PN2 en PN-II cs Amyloidový prekurzorový protein fi Amyloidiprekursoriproteiini it Proteina precorritrice della beta-amiloide ja アミロイド前駆体タンパク質 ru Предшественник бета-амилоида zh 前類澱粉蛋白質 zh-hant 澱粉樣前體蛋白

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Summary

APP is a gene[1]. APP is a type of protein-coding gene[2].

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [2] ↑ . Ensembl Release 87. wikidata.org.
  2. [3] ↑ . NCBI Gene. Retrieved . wikidata.org.
  3. [4] ↑ . ensembl Release 106. wikidata.org.
  4. [5] ↑ . ensembl Release 106. wikidata.org.
  5. [6] ↑ . ensembl Release 106. wikidata.org.
  6. [7] ↑ . ensembl Release 106. wikidata.org.
  7. [8] ↑ . HomoloGene build68. omabrowser.org. Provenance: wikidata.org.
  8. [9] ↑ . HomoloGene build68. wikidata.org.
  9. [10] ↑ . HomoloGene build68. wikidata.org.
  10. [11] ↑ . Orthologous MAtrix. omabrowser.org. Provenance: wikidata.org.
  11. [12] ↑ . UniProt. Retrieved . wikidata.org.
  12. [13] ↑ . ensembl Release 106. wikidata.org.
  13. [14] ↑ . ensembl Release 106. wikidata.org.
  14. [15] ↑ . Open Targets Platform. Retrieved . platform.opentargets.org. Provenance: wikidata.org.
  15. [16] ↑ . ensembl Release 106. wikidata.org.
  16. [17] ↑ . NCBI Gene. Retrieved . wikidata.org.
  17. [18] ↑ . Bgee. Retrieved . bgee.org. Provenance: wikidata.org.
  18. [19] ↑ . Bgee. Retrieved . bgee.org. Provenance: wikidata.org.
  19. [20] ↑ . Bgee. Retrieved . bgee.org. Provenance: wikidata.org.
  20. [21] ↑ . Bgee. Retrieved . bgee.org. Provenance: wikidata.org.
  21. [22] ↑ . Bgee. Retrieved . bgee.org. Provenance: wikidata.org.
  22. [23] ↑ . Bgee. Retrieved . bgee.org. Provenance: wikidata.org.
  23. [24] ↑ . Bgee. Retrieved . bgee.org. Provenance: wikidata.org.
  24. [25] ↑ . Bgee. Retrieved . bgee.org. Provenance: wikidata.org.
  25. [26] ↑ . Bgee. Retrieved . bgee.org. Provenance: wikidata.org.
  26. [27] ↑ . Bgee. Retrieved . bgee.org. Provenance: wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). APP. Retrieved October 29, 2026, from https://4ort.xyz/entity/app-q14865870
MLA “APP.” 4ort.xyz Knowledge Graph, 4ort.xyz, 29 Oct. 2026, https://4ort.xyz/entity/app-q14865870.
BibTeX @misc{4ortxyz_app-q14865870_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{APP}}, year = {2026}, url = {https://4ort.xyz/entity/app-q14865870}, note = {Accessed: 2026-10-29}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): APP — https://4ort.xyz/entity/app-q14865870 (retrieved 2026-10-29)

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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 25w ago · Mathieu Kappler · 2026-05-20 view diff on Wikidata ↗
    HGNC gene symbol → APP
    Genetic association → Alzheimer's disease
    RefSeq RNA ID → NM_201414, NM_000484, NM_001136016 +8
    Exact match → http://identifiers.org/ncbigene/351
    + 23 other properties edited (see Wikidata diff for full list)
    "Changed [gsw] labels, descriptions or aliases: QuickStatements 3.0 batch #32527: human gene name and description in Alemannic"
Live feed via Wikidata EventStreams. New edits appear within minutes of being made on Wikidata.