Amyloid beta precursor protein
mammalian protein found in Homo sapiens
Facts
10 properties- Instance of
- protein
- Part of
- Amyloidogenic glycoprotein, amyloid-beta peptide superfamily, amyloid-beta precursor protein, Amyloidogenic glycoprotein, heparin-binding domain superfamily, E2 domain superfamily, Amyloidogenic glycoprotein, copper-binding domain superfamily, Pancreatic trypsin inhibitor Kunitz domain superfamily, PH-like domain superfamily, Beta amyloid, Pancreatic trypsin inhibitor Kunitz domain, protein family, Beta-amyloid precursor protein C-terminal domain, protein family, Amyloidogenic glycoprotein, heparin-binding domain, protein family, Amyloidogenic glycoprotein, copper-binding domain, protein family, Amyloidogenic glycoprotein, extracellular domain, protein family, Amyloidogenic glycoprotein, E2 domain, protein family, Proteinase inhibitor I2, Kunitz, conserved site, protein family, Amyloidogenic glycoprotein, intracellular domain, conserved site, protein family, Amyloidogenic glycoprotein, copper-binding domain conserved site, protein family[3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]
- Biological process
- cellular response to nerve growth factor stimulus, amyloid fibril formation, negative regulation of neuron differentiation, neuromuscular process controlling balance, protein phosphorylation, regulation of epidermal growth factor-activated receptor activity, cellular copper ion homeostasis, neuron projection development, cellular response to cAMP, suckling behavior, apoptotic process, locomotory behavior, adult locomotory behavior, positive regulation of mitotic cell cycle, axo-dendritic transport, response to oxidative stress, mRNA polyadenylation, collateral sprouting in absence of injury, ionotropic glutamate receptor signaling pathway, Notch signaling pathway, negative regulation of peptidase activity, smooth endoplasmic reticulum calcium ion homeostasis, synaptic assembly at neuromuscular junction, neuron remodeling, dendrite development, extracellular matrix organization, cholesterol metabolic process, mating behavior, cellular response to norepinephrine stimulus, nervous system development, cell adhesion, response to lead ion, regulation of gene expression, positive regulation of G2/M transition of mitotic cell cycle, axon midline choice point recognition, visual learning, endocytosis, axonogenesis, regulation of multicellular organism growth, platelet degranulation, positive regulation of peptidase activity, forebrain development, regulation of protein binding, regulation of translation, regulation of synapse structure or activity, cellular process or phenomenon, positive regulation of transcription by RNA polymerase II, negative regulation of endopeptidase activity, response to yeast, antibacterial humoral response, antifungal humoral response, innate immune response, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, neuron apoptotic process, positive regulation of protein phosphorylation, astrocyte activation involved in immune response, G protein-coupled receptor signaling pathway, learning or memory, learning, negative regulation of cell population proliferation, response to radiation, regulation of gene expression, positive regulation of gene expression, negative regulation of gene expression, positive regulation of peptidyl-threonine phosphorylation, microglia development, regulation of Wnt signaling pathway, positive regulation of protein binding, tumor necrosis factor production, positive regulation of peptidyl-serine phosphorylation, positive regulation of phosphorylation, post-translational protein modification, innate immune response, positive regulation of transcription by RNA polymerase II, positive regulation of JNK cascade, astrocyte activation, regulation of long-term neuronal synaptic plasticity, regulation of peptidyl-tyrosine phosphorylation, synapse organization, cognition, positive regulation of DNA-binding transcription factor activity, positive regulation of NF-kappaB transcription factor activity, positive regulation of astrocyte activation, positive regulation of ERK1 and ERK2 cascade, cellular response to copper ion, cellular response to manganese ion, modulation of excitatory postsynaptic potential, regulation of spontaneous synaptic transmission, negative regulation of long-term synaptic potentiation, positive regulation of long-term synaptic potentiation, positive regulation of NIK/NF-kappaB signaling, positive regulation of amyloid-beta formation, positive regulation of microglial cell activation, cellular response to amyloid-beta, negative regulation of low-density lipoprotein receptor activity, regulation of presynapse assembly, positive regulation of amyloid fibril formation, neuron projection maintenance, positive regulation of signaling receptor activity, regulation of NMDA receptor activity, positive regulation of T cell migration, response to interleukin-1, positive regulation of glycolytic process
- Cell component
- cytoplasm, endosome, cytosol, trans-Golgi network membrane, membrane, cell-cell junction, synapse, extracellular region, ciliary rootlet, spindle midzone, neuron projection, rough endoplasmic reticulum, dendritic spine, endosome lumen, dendritic shaft, cell surface, terminal bouton, membrane raft, extracellular exosome, integral component of membrane, Golgi apparatus, growth cone, neuromuscular junction, receptor complex, plasma membrane, apical part of cell, astrocyte projection, growth cone lamellipodium, axon, nuclear envelope lumen, clathrin-coated pit, platelet alpha granule lumen, integral component of plasma membrane, main axon, smooth endoplasmic reticulum, COPII-coated ER to Golgi transport vesicle, growth cone filopodium, cytoplasmic vesicle, extracellular space, Golgi lumen, perinuclear region of cytoplasm, extracellular space, endosome, early endosome, endoplasmic reticulum lumen, Golgi-associated vesicle, plasma membrane, cell projection, perikaryon, membrane raft, presynaptic active zone, recycling endosome, extracellular exosome, extracellular region, nucleus, synaptic vesicle
- Encoded by
- APP
- Found in taxon
- Homo sapiens
- Has part(s)
- Amyloidogenic glycoprotein, E2 domain, Amyloidogenic glycoprotein, heparin-binding, Proteinase inhibitor I2, Kunitz, conserved site, Amyloidogenic glycoprotein, extracellular domain conserved site, Pancreatic trypsin inhibitor Kunitz domain, Amyloidogenic glycoprotein, intracellular domain, conserved site, Amyloidogenic glycoprotein, extracellular, Beta-amyloid precursor protein C-terminal, Amyloidogenic glycoprotein, copper-binding, Amyloidogenic glycoprotein, amyloid-beta peptide[20][21][22][23]
- Has parts
- Amyloidogenic glycoprotein, E2 domain, Amyloidogenic glycoprotein, heparin-binding, Proteinase inhibitor I2, Kunitz, conserved site, Amyloidogenic glycoprotein, extracellular domain conserved site, Pancreatic trypsin inhibitor Kunitz domain, Amyloidogenic glycoprotein, intracellular domain, conserved site, Amyloidogenic glycoprotein, extracellular, Beta-amyloid precursor protein C-terminal, Amyloidogenic glycoprotein, copper-binding, Amyloidogenic glycoprotein, amyloid-beta peptide
- Molecular function
- heparin binding, signaling receptor binding, acetylcholine receptor binding, metal ion binding, enzyme binding, peptidase activator activity, peptidase inhibitor activity, protein binding, DNA binding, growth factor receptor binding, PTB domain binding, serine-type endopeptidase inhibitor activity, identical protein binding, transition metal ion binding, signaling receptor activator activity
- Physically interacts with
- aducanumab[2]
🏷️ Also known as
en CVAP
en testicular tissue protein Li 2
en protease nexin-II
en preA4
en PN-II
en peptidase nexin-II
en ABPP
en alzheimer disease amyloid protein
en amyloid beta (A4) precursor protein
en amyloid beta A4 protein
en amyloid-beta A4 protein
en amyloid-beta precursor protein
en Amyloid beta precursor protein
en amyloid precursor protein
en APP
en APPI
en beta-amyloid peptide
en beta-amyloid peptide(1-40)
en beta-amyloid peptide(1-42)
en beta-amyloid precursor protein
🔖 Identifiers · 9
- OpenAlex ID
- C31705614
- Ensembl protein ID
- ENSP00000284981, ENSP00000345463, ENSP00000346129, ENSP00000350578, ENSP00000351796, ENSP00000387483, ENSP00000352760, ENSP00000396923, ENSP00000398879, ENSP00000406539
- Exact match
- purl.uniprot.org
- Freebase ID
- /m/025s20g
- Microsoft Academic ID (discontinued)
- 31705614, 2908769674
- PDB structure ID
- 1AAP, 1AMB, 1AMC, 1AML, 1BA4, 1BA6, 1BJB, 1BJC, 1BRC, 1CA0, 1HZ3, 1IYT, 1MWP, 1OWT, 1QCM, 1QWP, 1QXC, 1QYT, 1TAW, 1TKN, 1X11, 1Z0Q, 1ZJD, 2BEG, 2BP4, 2FJZ, 2FK1, 2FK2, 2FK3, 2FKL, 2FMA, 2G47, 2IPU, 2LFM, 2LLM, 2LMN, 2LMO, 2LMP, 2LMQ, 2LOH, 2LP1, 2OTK, 2R0W, 2WK3, 2Y29, 2Y2A, 2Y3J, 2Y3K, 2Y3L, 3AYU, 3DXC, 3DXD, 3DXE, 3GCI, 3IFL, 3IFN, 3IFO, 3IFP, 3JTI, 3KTM, 3L33, 3L81, 3MOQ, 3NYL, 3SV1, 3U0T, 3UMH, 3UMI, 3UMK, 4HIX, 1ZE7, 1ZE9, 2LNQ, 2LZ3, 2LZ4, 2M4J, 2M9R, 2M9S, 2MGT, 2MJ1, 2MPZ, 2MVX, 2MXU, 3BAE, 3BKJ, 3JQ5, 3JQL, 3MXC, 3NYJ, 3OVJ, 3OW9, 4JFN, 4M1C, 4MDR, 4NGE, 4OJF, 4ONF, 4ONG, 4PQD, 4PWQ, 4MVI, 4MVK, 4MVL, 4XXD, 5CSZ, 5AMB, 5AEF, 5AM8, 5BUO, 5HOY, 5HOW, 5HOX, 5KK3, 5C67, 2NAO
- RefSeq protein ID
- NP_000475, NP_001129488, NP_001129601, NP_001129602, NP_001129603, NP_001191230, NP_001191231, NP_001191232, NP_958816, NP_958817, XP_024307843
- Transporter Classification Database ID
- 1.C.50.1.2
- UniProt protein ID
- P05067
🔗 Connections
Cell component 24
nucleus,
cytoplasm,
plasma membrane,
plasma membrane,
Golgi apparatus,
synapse,
axon,
cytosol
+16 more
Biological process 14
← Physically interacts with 2
Found in taxon 1
Instance of 1
Molecular function 1
Part of 1
Physically interacts with 1
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Summary
Amyloid beta precursor protein is a protein[1].