Zinc finger CCCH type containing 12A

mammalian protein found in Mus musculus

Protein protein Q21496527

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Summary

Zinc finger CCCH type containing 12A is a protein^[1].

Key Facts

Zinc finger CCCH type containing 12A's instance of is recorded as protein^[2].
Zinc finger CCCH type containing 12A's UniProt protein ID is recorded as Q5D1E7^[3].
Zinc finger CCCH type containing 12A's part of is recorded as membrane protein^[4].
Zinc finger CCCH type containing 12A's part of is recorded as Ribonuclease Zc3h12a-like, NYN domain, protein family^[5].
Zinc finger CCCH type containing 12A's has part is recorded as Ribonuclease Zc3h12a-like, NYN domain^[6].
Zinc finger CCCH type containing 12A's RefSeq protein ID is recorded as NP_694799^[7].
Zinc finger CCCH type containing 12A's PDB structure ID is recorded as 5H9V^[8].
Zinc finger CCCH type containing 12A's PDB structure ID is recorded as 5H9W^[9].
Zinc finger CCCH type containing 12A's PDB structure ID is recorded as 2N5L^[10].
Zinc finger CCCH type containing 12A's PDB structure ID is recorded as 2N5J^[11].
Zinc finger CCCH type containing 12A's PDB structure ID is recorded as 2N5K^[12].
Zinc finger CCCH type containing 12A's molecular function is recorded as ribosome binding^[13].
Zinc finger CCCH type containing 12A's molecular function is recorded as RNA stem-loop binding^[14].
Zinc finger CCCH type containing 12A's molecular function is recorded as exoribonuclease activity^[15].
Zinc finger CCCH type containing 12A's molecular function is recorded as metal ion binding^[16].
Zinc finger CCCH type containing 12A's molecular function is recorded as endoribonuclease activity^[17].
Zinc finger CCCH type containing 12A's molecular function is recorded as mRNA 3'-UTR binding^[18].
Zinc finger CCCH type containing 12A's molecular function is recorded as protein binding^[19].
Zinc finger CCCH type containing 12A's molecular function is recorded as mRNA 3'-UTR AU-rich region binding^[20].
Zinc finger CCCH type containing 12A's molecular function is recorded as endonuclease activity^[21].
Zinc finger CCCH type containing 12A's molecular function is recorded as hydrolase activity^[22].
Zinc finger CCCH type containing 12A's molecular function is recorded as miRNA binding^[23].
Zinc finger CCCH type containing 12A's molecular function is recorded as chromatin binding^[24].
Zinc finger CCCH type containing 12A's molecular function is recorded as DNA binding^[25].
Zinc finger CCCH type containing 12A's molecular function is recorded as mRNA binding^[26].

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Quick Facts

Instance of protein

Part of membrane protein, Ribonuclease Zc3h12a-like, NYN domain, protein family

Properties

Biological process negative regulation of cardiac muscle contraction, negative regulation of protein phosphorylation, cell differentiation, cellular response to glucose starvation, positive regulation of execution phase of apoptosis, positive regulation of autophagy, negative regulation of interleukin-6 production, positive regulation of lipid storage, negative regulation of muscle cell apoptotic process, negative regulation of gene expression, multicellular organism development, cellular response to ionomycin, positive regulation of gene expression, positive regulation of reactive oxygen species metabolic process, negative regulation of nitric oxide biosynthetic process, RNA phosphodiester bond hydrolysis, cellular response to sodium arsenite, angiogenesis, cellular response to interleukin-1, nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay, cellular response to oxidative stress, negative regulation of tumor necrosis factor production, cellular response to lipopolysaccharide, negative regulation of NF-kappaB transcription factor activity, positive regulation of fat cell differentiation, negative regulation of cytokine production involved in inflammatory response, apoptotic process, positive regulation of endothelial cell migration, positive regulation of p38MAPK cascade, cellular response to tumor necrosis factor, positive regulation of protein import into nucleus, positive regulation of angiogenesis, positive regulation of defense response to virus by host, 3'-UTR-mediated mRNA destabilization, positive regulation of cell death, negative regulation by host of viral genome replication, regulation of gene expression, positive regulation of miRNA catabolic process, immune system process, RNA phosphodiester bond hydrolysis, endonucleolytic, RNA phosphodiester bond hydrolysis, exonucleolytic, nervous system development, positive regulation of transcription by RNA polymerase II, positive regulation of mRNA catabolic process, protein deubiquitination, inflammatory response, cellular response to virus, cellular response to chemokine, negative regulation of production of miRNAs involved in gene silencing by miRNA, protein complex oligomerization, cellular response to DNA damage stimulus, negative regulation of I-kappaB kinase/NF-kappaB signaling, positive regulation of protein deubiquitination, immune response-activating signal transduction, negative regulation of NIK/NF-kappaB signaling, T cell receptor signaling pathway, negative regulation of T-helper 17 cell differentiation

Cell component cytoplasm, rough endoplasmic reticulum, nucleoplasm, extrinsic component of endoplasmic reticulum membrane, nucleus, cytoskeleton, P-body, membrane, endoplasmic reticulum, rough endoplasmic reticulum membrane, cytoplasmic ribonucleoprotein granule, protein-containing complex

Encoded by Zc3h12a

Found in taxon house mouse

Has part(s) Ribonuclease Zc3h12a-like, NYN domain

Imported from wholeness_audit_2026-05-02

Molecular function ribosome binding, RNA stem-loop binding, exoribonuclease activity, metal ion binding, endoribonuclease activity, mRNA 3'-UTR binding, protein binding, mRNA 3'-UTR AU-rich region binding, endonuclease activity, hydrolase activity, miRNA binding, chromatin binding, DNA binding, mRNA binding, ribonuclease activity, RNA binding, thiol-dependent deubiquitinase, nuclease activity

External References (4)

Ensembl protein id ENSMUSP00000037172

Pdb structure id 5H9V, 5H9W, 2N5L, 2N5J, 2N5K

Refseq protein id NP_694799

Uniprot protein id Q5D1E7

🏷️ Also known as

en bifunctional endoribonuclease and deubiquitinase ZC3H12A en endoribonuclease ZC3H12A en MCP-1 treatment-induced protein en MCP-induced protein 1 en monocyte chemotactic protein-induced protein 1 en regnase-1 en ribonuclease ZC3H12A en Zc3h12a en zinc finger CCCH domain-containing protein 12A en Zinc finger CCCH type containing 12A

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Zinc finger CCCH type containing 12A — instance of (P31): protein. UniProt. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Zinc finger CCCH type containing 12A — UniProt protein ID (P352): Q5D1E7. UniProt. Retrieved 2022-05-25. wikidata.org.
[4] ↑ Zinc finger CCCH type containing 12A — part of (P361): membrane protein. wikidata.org.
[5] ↑ Zinc finger CCCH type containing 12A — part of (P361): Ribonuclease Zc3h12a-like, NYN domain, protein family. wikidata.org.
[6] ↑ Zinc finger CCCH type containing 12A — has part(s) (P527): Ribonuclease Zc3h12a-like, NYN domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Zinc finger CCCH type containing 12A — RefSeq protein ID (P637): NP_694799. Q20641742. Retrieved 2022-03-20. wikidata.org.
[8] ↑ Zinc finger CCCH type containing 12A — PDB structure ID (P638): 5H9V. UniProt. Retrieved 2016-08-09. wikidata.org.
[9] ↑ Zinc finger CCCH type containing 12A — PDB structure ID (P638): 5H9W. UniProt. Retrieved 2016-08-09. wikidata.org.
[10] ↑ Zinc finger CCCH type containing 12A — PDB structure ID (P638): 2N5L. UniProt. Retrieved 2016-08-09. wikidata.org.
[11] ↑ Zinc finger CCCH type containing 12A — PDB structure ID (P638): 2N5J. UniProt. Retrieved 2016-08-09. wikidata.org.
[12] ↑ Zinc finger CCCH type containing 12A — PDB structure ID (P638): 2N5K. UniProt. Retrieved 2016-08-09. wikidata.org.
[13] ↑ Zinc finger CCCH type containing 12A — molecular function (P680): ribosome binding. Regnase-1 and Roquin regulate inflammatory mRNAs. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ Zinc finger CCCH type containing 12A — molecular function (P680): RNA stem-loop binding. Regnase-1 and Roquin regulate inflammatory mRNAs. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ Zinc finger CCCH type containing 12A — molecular function (P680): exoribonuclease activity. Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ Zinc finger CCCH type containing 12A — molecular function (P680): metal ion binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ Zinc finger CCCH type containing 12A — molecular function (P680): endoribonuclease activity. Regnase-1 and Roquin regulate inflammatory mRNAs. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ Zinc finger CCCH type containing 12A — molecular function (P680): mRNA 3'-UTR binding. Regnase-1 and Roquin regulate inflammatory mRNAs. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ Zinc finger CCCH type containing 12A — molecular function (P680): protein binding. Regnase-1 and Roquin regulate inflammatory mRNAs. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Zinc finger CCCH type containing 12A — molecular function (P680): mRNA 3'-UTR AU-rich region binding. Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Zinc finger CCCH type containing 12A — molecular function (P680): endonuclease activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Zinc finger CCCH type containing 12A — molecular function (P680): hydrolase activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Zinc finger CCCH type containing 12A — molecular function (P680): miRNA binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Zinc finger CCCH type containing 12A — molecular function (P680): chromatin binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Zinc finger CCCH type containing 12A — molecular function (P680): DNA binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Zinc finger CCCH type containing 12A — molecular function (P680): mRNA binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Zinc finger CCCH type containing 12A is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

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MLA

“Zinc finger CCCH type containing 12A.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/zinc-finger-ccch-type-containing-12a-q21496527.

BibTeX

@misc{4ortxyz_zinc-finger-ccch-type-containing-12a-q21496527_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Zinc finger CCCH type containing 12A}}, year = {2026}, url = {https://4ort.xyz/entity/zinc-finger-ccch-type-containing-12a-q21496527}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Zinc finger CCCH type containing 12A — https://4ort.xyz/entity/zinc-finger-ccch-type-containing-12a-q21496527 (retrieved 2026-05-03)

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