X-ray repair cross complementing 6

mammalian protein found in Homo sapiens

Protein protein Q21116645

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X-ray repair cross complementing 6

Summary

X-ray repair cross complementing 6 is a protein^[1]. It is known by 26 alternative names across languages and contexts.^[2]

Key Facts

X-ray repair cross complementing 6's instance of is recorded as protein^[3].
X-ray repair cross complementing 6 is part of von Willebrand factor A-like domain superfamily^[4].
X-ray repair cross complementing 6 is part of SAP domain superfamily^[5].
X-ray repair cross complementing 6 is part of Ku70^[6].
X-ray repair cross complementing 6 is part of Ku70, bridge and pillars domain superfamily^[7].
X-ray repair cross complementing 6 is part of SPOC-like, C-terminal domain superfamily^[8].
X-ray repair cross complementing 6 is part of Ku70/Ku80, N-terminal alpha/beta, protein family^[9].
X-ray repair cross complementing 6 is part of Ku70/Ku80 C-terminal arm, protein family^[10].
X-ray repair cross complementing 6 is part of Ku70/Ku80 beta-barrel domain, protein family^[11].
X-ray repair cross complementing 6 is part of SAP domain, protein family^[12].
X-ray repair cross complementing 6 comprises SAP domain^[13].
X-ray repair cross complementing 6 comprises Ku70/Ku80 C-terminal arm^[14].
X-ray repair cross complementing 6 comprises Ku70/Ku80 beta-barrel domain^[15].
X-ray repair cross complementing 6 comprises Ku70/Ku80, N-terminal alpha/beta^[16].
X-ray repair cross complementing 6's molecular function is recorded as nucleotide binding^[17].
X-ray repair cross complementing 6's molecular function is recorded as double-stranded telomeric DNA binding^[18].
X-ray repair cross complementing 6's molecular function is recorded as telomeric DNA binding^[19].
X-ray repair cross complementing 6's molecular function is recorded as helicase activity^[20].
X-ray repair cross complementing 6's molecular function is recorded as 5'-deoxyribose-5-phosphate lyase activity^[21].
X-ray repair cross complementing 6's molecular function is recorded as DNA helicase activity^[22].
X-ray repair cross complementing 6's molecular function is recorded as protein C-terminus binding^[23].
X-ray repair cross complementing 6's molecular function is recorded as catalytic activity^[24].
X-ray repair cross complementing 6's molecular function is recorded as protein binding^[25].
X-ray repair cross complementing 6's molecular function is recorded as lyase activity^[26].
X-ray repair cross complementing 6's molecular function is recorded as hydrolase activity^[27].

Why It Matters

X-ray repair cross complementing 6 is known by 26 alternative names across languages and contexts.^[2]

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Quick Facts

Instance of protein

Part of von Willebrand factor A-like domain superfamily, SAP domain superfamily, Ku70, Ku70, bridge and pillars domain superfamily, SPOC-like, C-terminal domain superfamily, Ku70/Ku80, N-terminal alpha/beta, protein family, Ku70/Ku80 C-terminal arm, protein family, Ku70/Ku80 beta-barrel domain, protein family, SAP domain, protein family

Properties

Biological process double-strand break repair via classical nonhomologous end joining, protein heterotetramerization, regulation of transcription, DNA-templated, regulation of smooth muscle cell proliferation, transcription, DNA-templated, cellular response to DNA damage stimulus, positive regulation of transcription, DNA-templated, DNA ligation, establishment of integrated proviral latency, metabolism, negative regulation of transcription, DNA-templated, double-strand break repair via nonhomologous end joining, telomere maintenance, positive regulation of type I interferon production, positive regulation of transcription by RNA polymerase II, DNA duplex unwinding, DNA repair, cellular hyperosmotic salinity response, brain development, DNA recombination, neutrophil degranulation, cellular response to gamma radiation, cellular response to X-ray, positive regulation of protein kinase activity, activation of innate immune response, immune system process, innate immune response, telomere maintenance, double-strand break repair via nonhomologous end joining, cellular response to gamma radiation, cellular response to X-ray, double-strand break repair via nonhomologous end joining, telomere maintenance

Cell component cytosol, nuclear telomere cap complex, membrane, transcription regulator complex, chromosome, nucleoplasm, nonhomologous end joining complex, nucleus, Ku70:Ku80 complex, cytoplasm, extracellular region, secretory granule lumen, ficolin-1-rich granule lumen, protein-DNA complex, nucleolus, membrane, protein-containing complex, Ku70:Ku80 complex, Ku70:Ku80 complex, nucleus, nucleoplasm, nucleolus, protein-containing complex

Ec enzyme number 4.2.99.18, 5.6.2.4

Encoded by XRCC6

Found in taxon Homo sapiens

Has part(s) SAP domain, Ku70/Ku80 C-terminal arm, Ku70/Ku80 beta-barrel domain, Ku70/Ku80, N-terminal alpha/beta

Molecular function nucleotide binding, double-stranded telomeric DNA binding, telomeric DNA binding, helicase activity, 5'-deoxyribose-5-phosphate lyase activity, DNA helicase activity, protein C-terminus binding, catalytic activity, protein binding, lyase activity, hydrolase activity, ATP binding, DNA binding, double-stranded DNA binding, damaged DNA binding, RNA binding, cyclin binding, double-stranded DNA binding, RNA binding, telomeric DNA binding, protein-containing complex binding, DNA binding, DNA helicase activity, double-stranded DNA binding

External References (6)

Ensembl protein id ENSP00000352257, ENSP00000353192, ENSP00000384257, ENSP00000384941, ENSP00000384082, ENSP00000403679

Mesh descriptor id C000606509

Pdb structure id 1JEQ, 1JEY, 1JJR, 3RZX

Refseq protein id NP_001275905, NP_001275906, NP_001275907, NP_001460, NP_001275905.1, NP_001460.1

Umls cui C4308049

Uniprot protein id P12956, A0A024R1N4

🏷️ Also known as

en 5'-deoxyribose-5-phosphate lyase Ku70 en 5'-dRP lyase Ku70 en 70 kDa subunit of Ku antigen en ATP-dependent DNA helicase 2 subunit 1 en ATP-dependent DNA helicase II 70 kDa subunit en ATP-dependent DNA helicase II, 70 kDa subunit en CTC75 en CTCBF en CTC box binding factor 75 kDa subunit en CTC box-binding factor 75 kDa subunit en DNA repair protein XRCC6 en Ku70 en Ku autoantigen, 70kDa en Ku autoantigen p70 subunit en lupus Ku autoantigen protein p70 en thyroid autoantigen 70kDa (Ku antigen) en thyroid autoantigen 70kD (Ku antigen) en Thyroid-lupus autoantigen en thyroid-lupus autoantigen p70 en TLAA

References

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). X-ray repair cross complementing 6. Retrieved May 3, 2026, from https://4ort.xyz/entity/x-ray-repair-cross-complementing-6

MLA

“X-ray repair cross complementing 6.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/x-ray-repair-cross-complementing-6.

BibTeX

@misc{4ortxyz_x-ray-repair-cross-complementing-6_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{X-ray repair cross complementing 6}}, year = {2026}, url = {https://4ort.xyz/entity/x-ray-repair-cross-complementing-6}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): X-ray repair cross complementing 6 — https://4ort.xyz/entity/x-ray-repair-cross-complementing-6 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/x-ray-repair-cross-complementing-6 · Last refreshed: May 3, 2026

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

7w ago · Boghog · 2026-07-24 view diff on Wikidata ↗

Imported from → —

Encoded by → XRCC6

Wikidata description → mammalian protein found in Homo sapiens

Molecular function → nucleotide binding, double-stranded telomeric DNA binding, telomeric DNA binding +21

+ 13 other properties edited (see Wikidata diff for full list)

"/* wbcreateclaim-create:1| */ [[Property:P591]]: 4.2.99.18, [[:toollabs:quickstatements/#/batch/261491|batch #261491]]"

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X-ray repair cross complementing 6

X-ray repair cross complementing 6

Summary

Key Facts

Why It Matters

References

Direct Wikidata claims

Class ancestry

Aggregate / graph-position facts

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