X-box binding protein 1

mammalian protein found in Mus musculus

Protein protein Q21992827

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X-box binding protein 1

Summary

X-box binding protein 1 is a protein^[1].

Key Facts

X-box binding protein 1's instance of is recorded as protein^[2].
X-box binding protein 1's UniProt protein ID is recorded as O35426^[3].
X-box binding protein 1's part of is recorded as membrane protein^[4].
X-box binding protein 1's part of is recorded as Basic-leucine zipper domain, protein family^[5].
X-box binding protein 1's has part is recorded as Basic-leucine zipper domain^[6].
X-box binding protein 1's RefSeq protein ID is recorded as NP_001258659^[7].
X-box binding protein 1's RefSeq protein ID is recorded as NP_038870^[8].
X-box binding protein 1's molecular function is recorded as DNA-binding transcription factor activity^[9].
X-box binding protein 1's molecular function is recorded as phosphatidylinositol 3-kinase regulatory subunit binding^[10].
X-box binding protein 1's molecular function is recorded as histone deacetylase binding^[11].
X-box binding protein 1's molecular function is recorded as DNA-binding transcription factor activity, RNA polymerase II-specific^[12].
X-box binding protein 1's molecular function is recorded as ubiquitin-like protein ligase binding^[13].
X-box binding protein 1's molecular function is recorded as DNA binding^[14].
X-box binding protein 1's molecular function is recorded as cis-regulatory region sequence-specific DNA binding^[15].
X-box binding protein 1's molecular function is recorded as protein heterodimerization activity^[16].
X-box binding protein 1's molecular function is recorded as RNA polymerase II transcription regulatory region sequence-specific DNA binding^[17].
X-box binding protein 1's molecular function is recorded as protease binding^[18].
X-box binding protein 1's molecular function is recorded as protein kinase binding^[19].
X-box binding protein 1's molecular function is recorded as chromatin DNA binding^[20].
X-box binding protein 1's molecular function is recorded as ubiquitin protein ligase binding^[21].
X-box binding protein 1's molecular function is recorded as identical protein binding^[22].
X-box binding protein 1's molecular function is recorded as sequence-specific DNA binding^[23].
X-box binding protein 1's molecular function is recorded as RNA polymerase II cis-regulatory region sequence-specific DNA binding^[24].
X-box binding protein 1's molecular function is recorded as identical protein binding^[25].
X-box binding protein 1's molecular function is recorded as DNA-binding transcription factor activity^[26].

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Quick Facts

Instance of protein

Part of membrane protein, Basic-leucine zipper domain, protein family

Properties

Biological process cellular triglyceride homeostasis, positive regulation of MHC class II biosynthetic process, regulation of transcription by RNA polymerase II, positive regulation of immunoglobulin production, muscle organ development, cellular response to fructose stimulus, response to insulin-like growth factor stimulus, angiogenesis, cholesterol homeostasis, cellular response to glucose stimulus, apoptotic process, cellular response to glucose starvation, regulation of transcription, DNA-templated, ubiquitin-dependent protein catabolic process, glucose homeostasis, sterol homeostasis, neuron development, transcription, DNA-templated, response to unfolded protein, cellular response to insulin stimulus, protein transport, positive regulation of fat cell differentiation, exocrine pancreas development, cell differentiation, negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, positive regulation of lactation, positive regulation of B cell differentiation, negative regulation of apoptotic process, cellular response to nutrient, regulation of autophagy, fatty acid homeostasis, adipose tissue development, positive regulation of proteasomal protein catabolic process, positive regulation of plasma cell differentiation, positive regulation of T cell differentiation, cellular response to interleukin-4, positive regulation of hepatocyte proliferation, positive regulation of endoplasmic reticulum unfolded protein response, lipid metabolism, epithelial cell maturation involved in salivary gland development, autophagy, multicellular organism development, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, cellular response to peptide hormone stimulus, epithelial cell maturation, negative regulation of myotube differentiation, cellular response to amino acid stimulus, liver development, cellular response to lipopolysaccharide, positive regulation of transcription by RNA polymerase II, negative regulation of transcription by RNA polymerase II, positive regulation of protein phosphorylation, endothelial cell proliferation, positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response, positive regulation of cell population proliferation, positive regulation of autophagy, phosphatidylinositol 3-kinase signaling, positive regulation of cell migration, negative regulation of transforming growth factor beta receptor signaling pathway, positive regulation of histone methylation, regulation of protein stability, protein destabilization, positive regulation of TOR signaling, cellular response to oxidative stress, response to endoplasmic reticulum stress, positive regulation of vascular wound healing, cellular response to vascular endothelial growth factor stimulus, positive regulation of angiogenesis, vascular endothelial growth factor receptor signaling pathway, negative regulation of pathway-restricted SMAD protein phosphorylation, negative regulation of ERK1 and ERK2 cascade, cellular response to fluid shear stress, cellular response to laminar fluid shear stress, negative regulation of endoplasmic reticulum unfolded protein response, positive regulation of protein acetylation, positive regulation of endothelial cell apoptotic process, cellular response to leukemia inhibitory factor, cell growth, transcription by RNA polymerase II, endoplasmic reticulum unfolded protein response, positive regulation of protein import into nucleus, response to electrical stimulus, serotonin secretion, neurotransmission, regulation of cell growth, regulation of cell growth, transcription by RNA polymerase II, positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response, endoplasmic reticulum unfolded protein response, response to endoplasmic reticulum stress, cellular response to lipopolysaccharide, transcription by RNA polymerase II, positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response, positive regulation of endoplasmic reticulum unfolded protein response

Cell component membrane, nucleus, endoplasmic reticulum, integral component of membrane, endoplasmic reticulum membrane, cytoplasm, cytosol, integral component of endoplasmic reticulum membrane, presynapse, nucleus, cytoplasm, nucleus, integral component of endoplasmic reticulum membrane

Encoded by Xbp1

Found in taxon house mouse

Has part(s) Basic-leucine zipper domain

Imported from wholeness_audit_2026-05-02

Molecular function DNA-binding transcription factor activity, phosphatidylinositol 3-kinase regulatory subunit binding, histone deacetylase binding, DNA-binding transcription factor activity, RNA polymerase II-specific, ubiquitin-like protein ligase binding, DNA binding, cis-regulatory region sequence-specific DNA binding, protein heterodimerization activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding, protease binding, protein kinase binding, chromatin DNA binding, ubiquitin protein ligase binding, identical protein binding, sequence-specific DNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, identical protein binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific

External References (3)

Ensembl protein id ENSMUSP00000054852, ENSMUSP00000134088, ENSMUSP00000135768, ENSMUSP00000158915

Refseq protein id NP_001258659, NP_038870

Uniprot protein id O35426

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ X-box binding protein 1 — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ X-box binding protein 1 — UniProt protein ID (P352): O35426. Q905695. Retrieved 2022-05-25. wikidata.org.
[4] ↑ X-box binding protein 1 — part of (P361): membrane protein. wikidata.org.
[5] ↑ X-box binding protein 1 — part of (P361): Basic-leucine zipper domain, protein family. wikidata.org.
[6] ↑ X-box binding protein 1 — has part(s) (P527): Basic-leucine zipper domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ X-box binding protein 1 — RefSeq protein ID (P637): NP_001258659. Q20641742. Retrieved 2022-03-20. wikidata.org.
[8] ↑ X-box binding protein 1 — RefSeq protein ID (P637): NP_038870. Q20641742. Retrieved 2022-03-20. wikidata.org.
[9] ↑ X-box binding protein 1 — molecular function (P680): DNA-binding transcription factor activity. GOA. Retrieved 2018-06-21. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ X-box binding protein 1 — molecular function (P680): phosphatidylinositol 3-kinase regulatory subunit binding. The regulatory subunits of PI3K, p85α and p85β, interact with XBP-1 and increase its nuclear translocation. Retrieved 2018-06-21. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ X-box binding protein 1 — molecular function (P680): histone deacetylase binding. Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation. Retrieved 2018-06-21. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ X-box binding protein 1 — molecular function (P680): DNA-binding transcription factor activity, RNA polymerase II-specific. Transcriptional regulation of the Ufm1 conjugation system in response to disturbance of the endoplasmic reticulum homeostasis and inhibition of vesicle trafficking. Retrieved 2018-07-16. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ X-box binding protein 1 — molecular function (P680): ubiquitin-like protein ligase binding. SUMO modification regulates the transcriptional activity of XBP1. Retrieved 2018-06-21. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ X-box binding protein 1 — molecular function (P680): DNA binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ X-box binding protein 1 — molecular function (P680): cis-regulatory region sequence-specific DNA binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ X-box binding protein 1 — molecular function (P680): protein heterodimerization activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ X-box binding protein 1 — molecular function (P680): RNA polymerase II transcription regulatory region sequence-specific DNA binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ X-box binding protein 1 — molecular function (P680): protease binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ X-box binding protein 1 — molecular function (P680): protein kinase binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ X-box binding protein 1 — molecular function (P680): chromatin DNA binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ X-box binding protein 1 — molecular function (P680): ubiquitin protein ligase binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ X-box binding protein 1 — molecular function (P680): identical protein binding. GOA. Retrieved 2018-07-16. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ X-box binding protein 1 — molecular function (P680): sequence-specific DNA binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ X-box binding protein 1 — molecular function (P680): RNA polymerase II cis-regulatory region sequence-specific DNA binding. XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ X-box binding protein 1 — molecular function (P680): identical protein binding. GOA. Retrieved 2018-06-21. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ X-box binding protein 1 — molecular function (P680): DNA-binding transcription factor activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ X-box binding protein 1 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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BibTeX

@misc{4ortxyz_x-box-binding-protein-1-q21992827_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{X-box binding protein 1}}, year = {2026}, url = {https://4ort.xyz/entity/x-box-binding-protein-1-q21992827}, note = {Accessed: 2026-05-03}}

LLM prompt

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