Werner syndrome RecQ like helicase

mammalian protein found in Homo sapiens

Protein protein Q6591532

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Werner syndrome RecQ like helicase

Summary

Werner syndrome RecQ like helicase is a protein^[1].

Key Facts

Werner syndrome RecQ like helicase's instance of is recorded as protein^[2].
Werner syndrome RecQ like helicase is part of DNA helicase, ATP-dependent, RecQ type^[3].
Werner syndrome RecQ like helicase is part of winged helix DNA-binding domain superfamily^[4].
Werner syndrome RecQ like helicase is part of Ribonuclease H superfamily^[5].
Werner syndrome RecQ like helicase is part of Ribonuclease H-like superfamily^[6].
Werner syndrome RecQ like helicase is part of P-loop containing nucleoside triphosphate hydrolase^[7].
Werner syndrome RecQ like helicase is part of Winged helix-like DNA-binding domain superfamily^[8].
Werner syndrome RecQ like helicase is part of HRDC-like superfamily^[9].
Werner syndrome RecQ like helicase is part of Helicase superfamily 1/2, ATP-binding domain, protein family^[10].
Werner syndrome RecQ like helicase is part of ATP-dependent DNA helicase RecQ, zinc-binding domain, protein family^[11].
Werner syndrome RecQ like helicase is part of Helicase Helix-turn-helix domain, protein family^[12].
Werner syndrome RecQ like helicase is part of Helicase, C-terminal domain, protein family^[13].
Werner syndrome RecQ like helicase is part of DEAD/DEAH box helicase^[14].
Werner syndrome RecQ like helicase is part of 3'-5' exonuclease domain, protein family^[15].
Werner syndrome RecQ like helicase is part of HRDC domain, protein family^[16].
Werner syndrome RecQ like helicase is part of RQC domain, protein family^[17].
Werner syndrome RecQ like helicase's Commons category is recorded as Werner syndrome ATP-dependent helicase, WRN^[18].
Werner syndrome RecQ like helicase comprises HRDC domain^[19].
Werner syndrome RecQ like helicase comprises DEAD/DEAH box helicase domain^[20].
Werner syndrome RecQ like helicase comprises RQC domain^[21].
Werner syndrome RecQ like helicase comprises ATP-dependent DNA helicase RecQ, zinc-binding domain^[22].
Werner syndrome RecQ like helicase comprises Helicase superfamily 1/2, ATP-binding domain^[23].
Werner syndrome RecQ like helicase comprises Helicase Helix-turn-helix domain^[24].
Werner syndrome RecQ like helicase comprises 3'-5' exonuclease domain^[25].
Werner syndrome RecQ like helicase comprises Helicase, C-terminal^[26].

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Quick Facts

Instance of protein

Part of DNA helicase, ATP-dependent, RecQ type, winged helix DNA-binding domain superfamily, Ribonuclease H superfamily, Ribonuclease H-like superfamily, P-loop containing nucleoside triphosphate hydrolase, Winged helix-like DNA-binding domain superfamily, HRDC-like superfamily, Helicase superfamily 1/2, ATP-binding domain, protein family, ATP-dependent DNA helicase RecQ, zinc-binding domain, protein family, Helicase Helix-turn-helix domain, protein family, Helicase, C-terminal domain, protein family, DEAD/DEAH box helicase, 3'-5' exonuclease domain, protein family, HRDC domain, protein family, RQC domain, protein family

Properties

Biological process regulation of apoptotic process, positive regulation of hydrolase activity, DNA recombination, cellular response to starvation, DNA metabolic process, ageing, response to oxidative stress, cellular response to DNA damage stimulus, regulation of growth rate, brain development, cell metabolism, cellular response to gamma radiation, replication fork processing, multicellular organism aging, metabolism, nucleobase-containing compound metabolic process, response to UV-C, base-excision repair, double-strand break repair, DNA repair, nucleic acid phosphodiester bond hydrolysis, double-strand break repair via homologous recombination, DNA duplex unwinding, DNA replication, telomeric D-loop disassembly, t-circle formation, positive regulation of strand invasion, telomere maintenance, G-quadruplex DNA unwinding, protein localization to nucleolus, DNA synthesis involved in DNA repair, DNA synthesis involved in DNA repair, DNA repair, base-excision repair, DNA recombination, response to oxidative stress, determination of adult lifespan, cellular response to starvation, response to UV-C, multicellular organism aging, replication fork processing, DNA duplex unwinding, regulation of apoptotic process, G-quadruplex DNA unwinding, positive regulation of hydrolase activity, telomeric D-loop disassembly, cellular response to gamma radiation, positive regulation of strand invasion, regulation of signal transduction by p53 class mediator, telomere maintenance, DNA unwinding involved in DNA replication

Cell component centrosome, intracellular anatomical structure, nucleoplasm, nucleolus, neuron projection, MutLalpha complex, nucleus, cytoplasm, nuclear speck, telomere, replication fork, telomere, nucleus, nucleoplasm, replication fork, DNA replication factor A complex, chromosome, centrosome, MutLalpha complex, site of double-strand break

Ec enzyme number 3.1.-.-, 5.6.2.4

Encoded by WRN

Found in taxon Homo sapiens

Has part(s) HRDC domain, DEAD/DEAH box helicase domain, RQC domain, ATP-dependent DNA helicase RecQ, zinc-binding domain, Helicase superfamily 1/2, ATP-binding domain, Helicase Helix-turn-helix domain, 3'-5' exonuclease domain, Helicase, C-terminal

Molecular function DNA binding, nucleotide binding, manganese ion binding, protein homodimerization activity, helicase activity, DNA helicase activity, bubble DNA binding, chromatin binding, helicase activity, metal ion binding, G-quadruplex DNA binding, DNA helicase activity, ATPase activity, protein binding, catalytic activity, 3'-5' exonuclease activity, Y-form DNA binding, nucleic acid binding, nuclease activity, 3'-5' DNA helicase activity, four-way junction helicase activity, ATP binding, magnesium ion binding, hydrolase activity, 3'-5' DNA helicase activity, exonuclease activity, telomeric D-loop binding, 3'-flap-structured DNA binding, four-way junction DNA binding, forked DNA-dependent helicase activity, telomeric G-quadruplex DNA binding, 8-hydroxy-2'-deoxyguanosine DNA binding, protein-containing complex binding, magnesium ion binding, four-way junction DNA binding, Y-form DNA binding, bubble DNA binding, DNA binding, chromatin binding, 3'-5' exonuclease activity, four-way junction helicase activity, manganese ion binding, MutLalpha complex binding, protein homodimerization activity, protein-containing complex binding, forked DNA-dependent helicase activity, telomeric D-loop binding, 3'-flap-structured DNA binding, 8-hydroxy-2'-deoxyguanosine DNA binding

External References (7)

Ensembl protein id ENSP00000298139

Mesh descriptor id D000071657

Mesh tree code D08.811.277.040.025.159.249.500, D08.811.277.352.335.375.875, D08.811.277.352.365.290.500, D08.811.399.340.249.500, D12.776.157.687.750, D12.776.660.720.750

Pdb structure id 2AXL, 2DGZ, 2E1E, 2E1F, 2FBT, 2FBV, 2FBX, 2FBY, 2FC0, 3AAF

Refseq protein id NP_000544, XP_011542941, XP_011542942, XP_024303033

Umls cui C4255267

Uniprot protein id East Kotawaringin

🏷️ Also known as

en 3.1.-.- en DNA helicase, RecQ-like type 3 en exonuclease WRN en RecQ3 en recQ protein-like 2 en Werner syndrome ATP-dependent helicase en Werner syndrome, RecQ helicase-like en Werner syndrome RecQ like helicase en WRN

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Werner syndrome RecQ like helicase — instance of (P31): protein. Q905695. Retrieved 2019-01-16. wikidata.org.
[3] ↑ Werner syndrome RecQ like helicase — part of (P361): DNA helicase, ATP-dependent, RecQ type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[4] ↑ Werner syndrome RecQ like helicase — part of (P361): winged helix DNA-binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Werner syndrome RecQ like helicase — part of (P361): Ribonuclease H superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Werner syndrome RecQ like helicase — part of (P361): Ribonuclease H-like superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Werner syndrome RecQ like helicase — part of (P361): P-loop containing nucleoside triphosphate hydrolase. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ Werner syndrome RecQ like helicase — part of (P361): Winged helix-like DNA-binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ Werner syndrome RecQ like helicase — part of (P361): HRDC-like superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ Werner syndrome RecQ like helicase — part of (P361): Helicase superfamily 1/2, ATP-binding domain, protein family. wikidata.org.
[11] ↑ Werner syndrome RecQ like helicase — part of (P361): ATP-dependent DNA helicase RecQ, zinc-binding domain, protein family. wikidata.org.
[12] ↑ Werner syndrome RecQ like helicase — part of (P361): Helicase Helix-turn-helix domain, protein family. wikidata.org.
[13] ↑ Werner syndrome RecQ like helicase — part of (P361): Helicase, C-terminal domain, protein family. wikidata.org.
[14] ↑ Werner syndrome RecQ like helicase — part of (P361): DEAD/DEAH box helicase. wikidata.org.
[15] ↑ Werner syndrome RecQ like helicase — part of (P361): 3'-5' exonuclease domain, protein family. wikidata.org.
[16] ↑ Werner syndrome RecQ like helicase — part of (P361): HRDC domain, protein family. wikidata.org.
[17] ↑ Werner syndrome RecQ like helicase — part of (P361): RQC domain, protein family. wikidata.org.
[18] ↑ Werner syndrome RecQ like helicase — Commons category (P373): Werner syndrome ATP-dependent helicase, WRN. wikidata.org.
[19] ↑ Werner syndrome RecQ like helicase — has part(s) (P527): HRDC domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Werner syndrome RecQ like helicase — has part(s) (P527): DEAD/DEAH box helicase domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Werner syndrome RecQ like helicase — has part(s) (P527): RQC domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Werner syndrome RecQ like helicase — has part(s) (P527): ATP-dependent DNA helicase RecQ, zinc-binding domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Werner syndrome RecQ like helicase — has part(s) (P527): Helicase superfamily 1/2, ATP-binding domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Werner syndrome RecQ like helicase — has part(s) (P527): Helicase Helix-turn-helix domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Werner syndrome RecQ like helicase — has part(s) (P527): 3'-5' exonuclease domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Werner syndrome RecQ like helicase — has part(s) (P527): Helicase, C-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Werner syndrome RecQ like helicase is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

4ort.xyz Knowledge Graph. (2026). Werner syndrome RecQ like helicase. Retrieved May 3, 2026, from https://4ort.xyz/entity/werner-syndrome-recq-like-helicase

MLA

“Werner syndrome RecQ like helicase.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/werner-syndrome-recq-like-helicase.

BibTeX

@misc{4ortxyz_werner-syndrome-recq-like-helicase_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Werner syndrome RecQ like helicase}}, year = {2026}, url = {https://4ort.xyz/entity/werner-syndrome-recq-like-helicase}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Werner syndrome RecQ like helicase — https://4ort.xyz/entity/werner-syndrome-recq-like-helicase (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/werner-syndrome-recq-like-helicase · Last refreshed: May 3, 2026

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

5w ago · Boghog · 2026-07-23 view diff on Wikidata ↗

Uniprot protein id → East Kotawaringin

Umls cui → C4255267

Imported from → —

Mesh descriptor id → D000071657

+ 16 other properties edited (see Wikidata diff for full list)

"/* wbcreateclaim-create:1| */ [[Property:P591]]: 5.6.2.4, [[:toollabs:quickstatements/#/batch/261457|batch #261457]]"

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