Vascular endothelial growth factor A

mammalian protein found in Mus musculus

Protein protein Q21992409

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Summary

Vascular endothelial growth factor An is a protein^[1].

Key Facts

Vascular endothelial growth factor A's instance of is recorded as protein^[2].
Vascular endothelial growth factor A's UniProt protein ID is recorded as Q00731^[3].
Vascular endothelial growth factor A's part of is recorded as Cystine-knot cytokine^[4].
Vascular endothelial growth factor A's part of is recorded as Vascular endothelial growth factor, heparin-binding domain superfamily^[5].
Vascular endothelial growth factor A's part of is recorded as membrane protein^[6].
Vascular endothelial growth factor A's part of is recorded as Vascular endothelial growth factor, heparin-binding domain, protein family^[7].
Vascular endothelial growth factor A's part of is recorded as PDGF/VEGF domain, protein family^[8].
Vascular endothelial growth factor A's part of is recorded as Platelet-derived growth factor, conserved site, protein family^[9].
Vascular endothelial growth factor A's has part is recorded as PDGF/VEGF domain^[10].
Vascular endothelial growth factor A's has part is recorded as Platelet-derived growth factor, conserved site^[11].
Vascular endothelial growth factor A's has part is recorded as Vascular endothelial growth factor, heparin-binding domain^[12].
Vascular endothelial growth factor A's RefSeq protein ID is recorded as NP_001020421^[13].
Vascular endothelial growth factor A's RefSeq protein ID is recorded as NP_001020428^[14].
Vascular endothelial growth factor A's RefSeq protein ID is recorded as NP_001103736^[15].
Vascular endothelial growth factor A's RefSeq protein ID is recorded as NP_001103737^[16].
Vascular endothelial growth factor A's RefSeq protein ID is recorded as NP_001103738^[17].
Vascular endothelial growth factor A's RefSeq protein ID is recorded as NP_001273985^[18].
Vascular endothelial growth factor A's RefSeq protein ID is recorded as NP_001273986^[19].
Vascular endothelial growth factor A's RefSeq protein ID is recorded as NP_001273987^[20].
Vascular endothelial growth factor A's RefSeq protein ID is recorded as NP_001303970^[21].
Vascular endothelial growth factor A's RefSeq protein ID is recorded as NP_033531^[22].
Vascular endothelial growth factor A's molecular function is recorded as heparin binding^[23].
Vascular endothelial growth factor A's molecular function is recorded as extracellular matrix binding^[24].
Vascular endothelial growth factor A's molecular function is recorded as signaling receptor binding^[25].
Vascular endothelial growth factor A's molecular function is recorded as cytokine activity^[26].

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Quick Facts

Instance of protein

Part of Cystine-knot cytokine, Vascular endothelial growth factor, heparin-binding domain superfamily, membrane protein, Vascular endothelial growth factor, heparin-binding domain, protein family, PDGF/VEGF domain, protein family, Platelet-derived growth factor, conserved site, protein family

Properties

Biological process negative regulation of neuron apoptotic process, cardiac vascular smooth muscle cell development, positive regulation of protein phosphorylation, positive regulation of MAP kinase activity, positive regulation of receptor internalization, outflow tract morphogenesis, mammary gland alveolus development, monocyte differentiation, blood vessel endothelial cell proliferation involved in sprouting angiogenesis, cell migration involved in sprouting angiogenesis, positive regulation of retinal ganglion cell axon guidance, vascular endothelial growth factor receptor signaling pathway, blood vessel development, positive regulation of mesenchymal cell proliferation, angiogenesis, positive regulation of blood vessel endothelial cell migration, mesoderm development, cell population proliferation, cellular response to hypoxia, positive regulation of positive chemotaxis, positive regulation of p38MAPK cascade, positive regulation of neuroblast proliferation, dopaminergic neuron differentiation, negative regulation of fat cell differentiation, positive regulation of protein kinase B signaling, positive regulation of branching involved in ureteric bud morphogenesis, blood vessel morphogenesis, kidney development, lymphangiogenesis, lung development, coronary artery morphogenesis, negative regulation of extrinsic apoptotic signaling pathway, neuron development, in utero embryonic development, cell maturation, positive regulation of lymphangiogenesis, commissural neuron axon guidance, positive regulation of peptidyl-serine phosphorylation, positive regulation of CREB transcription factor activity, artery morphogenesis, retinal blood vessel morphogenesis, positive regulation of peptidyl-tyrosine autophosphorylation, positive regulation of peptidyl-tyrosine phosphorylation, branching involved in blood vessel morphogenesis, primitive erythrocyte differentiation, positive regulation of protein kinase D signaling, lactation, cell differentiation, epithelial cell differentiation, positive regulation of epithelial cell proliferation, negative regulation of apoptotic process, sprouting angiogenesis, negative regulation of transcription by RNA polymerase II, macrophage differentiation, positive regulation of angiogenesis, regulation of retinal ganglion cell axon guidance, positive regulation of osteoblast differentiation, lymph vessel morphogenesis, post-embryonic camera-type eye development, regulation of cell shape, ovarian follicle development, homeostasis of number of cells within a tissue, lung vasculature development, branching morphogenesis of an epithelial tube, coronary vein morphogenesis, surfactant homeostasis, positive regulation of vascular endothelial growth factor receptor signaling pathway, negative regulation of cysteine-type endopeptidase activity involved in apoptotic process, positive regulation of endothelial cell proliferation, positive regulation of cell migration involved in sprouting angiogenesis, positive regulation of protein-containing complex assembly, negative regulation of cell-cell adhesion, positive regulation of protein kinase C signaling, positive regulation of cell migration, heart morphogenesis, bone trabecula formation, positive regulation of axon extension involved in axon guidance, positive regulation of endothelial cell migration, multicellular organism development, regulation of endothelial cell differentiation, tube formation, positive regulation of gene expression, vasculature development, positive regulation of histone deacetylase activity, regulation of hematopoietic progenitor cell differentiation, positive regulation of protein autophosphorylation, positive regulation of cell population proliferation, endothelial cell chemotaxis, bone trabecula morphogenesis, positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway, positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway, eye photoreceptor cell development, positive regulation of transcription from RNA polymerase II promoter in response to hypoxia, positive regulation of focal adhesion assembly, cellular response to vascular endothelial growth factor stimulus, cell migration, activation of protein kinase activity, positive regulation of cell division, endothelial cell migration, camera-type eye morphogenesis, positive regulation of transcription by RNA polymerase II, positive regulation of cell adhesion, positive chemotaxis, response to hypoxia, basophil chemotaxis, regulation of transcription by RNA polymerase II, vascular endothelial growth factor signaling pathway, positive regulation of vascular permeability, induction of positive chemotaxis, positive regulation of mast cell chemotaxis, positive regulation of ERK1 and ERK2 cascade, positive regulation of protein localization to early endosome, motor neuron migration, negative regulation of epithelial to mesenchymal transition, growth, regulation of signaling receptor activity, VEGF-activated neuropilin signaling pathway, positive regulation of phosphorylation, negative regulation of gene expression, angiogenesis, positive regulation of protein phosphorylation, positive regulation of endothelial cell proliferation, blood vessel remodeling, sprouting angiogenesis, nervous system development, positive regulation of signal transduction, regulation of nitric oxide mediated signal transduction, lung development, vascular endothelial growth factor signaling pathway, VEGF-activated neuropilin signaling pathway, regulation of growth, T-helper 1 type immune response, negative regulation of programmed cell death, positive regulation of angiogenesis, negative regulation of bone resorption, vascular endothelial growth factor receptor signaling pathway, mRNA stabilization, lung alveolus development, positive regulation of smooth muscle cell proliferation, positive regulation of axon extension involved in axon guidance, positive chemotaxis, cell chemotaxis, lung vasculature development, angiogenesis involved in coronary vascular morphogenesis, positive regulation of ERK1 and ERK2 cascade, commissural neuron axon guidance, regulation of retinal ganglion cell axon guidance, cellular stress response to acid chemical, positive regulation of cold-induced thermogenesis, negative regulation of neuron death, positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis, positive regulation of sprouting angiogenesis, positive regulation of DNA biosynthetic process, retina blood vessel maintenance

Cell component cytoplasm, membrane, extracellular region, nucleus, cell surface, plasma membrane, secretory granule, extracellular space, extracellular region, basement membrane, extracellular space, vesicle

Encoded by Vegfa

Found in taxon house mouse

Has part(s) PDGF/VEGF domain, Platelet-derived growth factor, conserved site, Vascular endothelial growth factor, heparin-binding domain

Imported from wholeness_audit_2026-05-02

Molecular function heparin binding, extracellular matrix binding, signaling receptor binding, cytokine activity, growth factor activity, vascular endothelial growth factor receptor 2 binding, receptor ligand activity, vascular endothelial growth factor receptor 1 binding, platelet-derived growth factor receptor binding, protein binding, vascular endothelial growth factor receptor binding, fibronectin binding, chemoattractant activity, identical protein binding, protein heterodimerization activity, neuropilin binding, vascular endothelial growth factor receptor binding, growth factor activity, heparin binding, growth factor binding, chemoattractant activity, protein homodimerization activity, vascular endothelial growth factor receptor 1 binding, vascular endothelial growth factor receptor 2 binding

External References (3)

Ensembl protein id ENSMUSP00000024747, ENSMUSP00000071575, ENSMUSP00000109147, ENSMUSP00000109148, ENSMUSP00000115883

Refseq protein id NP_001020421, NP_001020428, NP_001103736, NP_001103737, NP_001103738, NP_001273985, NP_001273986, NP_001273987, NP_001303970, NP_033531

Uniprot protein id Q00731

🏷️ Also known as

en Vascular endothelial growth factor A en vascular permeability factor en Vegfa en VPF

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Vascular endothelial growth factor A — instance of (P31): protein. UniProt. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Vascular endothelial growth factor A — UniProt protein ID (P352): Q00731. UniProt. Retrieved 2022-05-25. wikidata.org.
[4] ↑ Vascular endothelial growth factor A — part of (P361): Cystine-knot cytokine. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Vascular endothelial growth factor A — part of (P361): Vascular endothelial growth factor, heparin-binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Vascular endothelial growth factor A — part of (P361): membrane protein. wikidata.org.
[7] ↑ Vascular endothelial growth factor A — part of (P361): Vascular endothelial growth factor, heparin-binding domain, protein family. wikidata.org.
[8] ↑ Vascular endothelial growth factor A — part of (P361): PDGF/VEGF domain, protein family. wikidata.org.
[9] ↑ Vascular endothelial growth factor A — part of (P361): Platelet-derived growth factor, conserved site, protein family. wikidata.org.
[10] ↑ Vascular endothelial growth factor A — has part(s) (P527): PDGF/VEGF domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ Vascular endothelial growth factor A — has part(s) (P527): Platelet-derived growth factor, conserved site. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ Vascular endothelial growth factor A — has part(s) (P527): Vascular endothelial growth factor, heparin-binding domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ Vascular endothelial growth factor A — RefSeq protein ID (P637): NP_001020421. Q20641742. Retrieved 2022-03-20. wikidata.org.
[14] ↑ Vascular endothelial growth factor A — RefSeq protein ID (P637): NP_001020428. Q20641742. Retrieved 2022-03-20. wikidata.org.
[15] ↑ Vascular endothelial growth factor A — RefSeq protein ID (P637): NP_001103736. Q20641742. Retrieved 2022-03-20. wikidata.org.
[16] ↑ Vascular endothelial growth factor A — RefSeq protein ID (P637): NP_001103737. Q20641742. Retrieved 2022-03-20. wikidata.org.
[17] ↑ Vascular endothelial growth factor A — RefSeq protein ID (P637): NP_001103738. Q20641742. Retrieved 2022-03-20. wikidata.org.
[18] ↑ Vascular endothelial growth factor A — RefSeq protein ID (P637): NP_001273985. Q20641742. Retrieved 2022-03-20. wikidata.org.
[19] ↑ Vascular endothelial growth factor A — RefSeq protein ID (P637): NP_001273986. Q20641742. Retrieved 2022-03-20. wikidata.org.
[20] ↑ Vascular endothelial growth factor A — RefSeq protein ID (P637): NP_001273987. Q20641742. Retrieved 2022-03-20. wikidata.org.
[21] ↑ Vascular endothelial growth factor A — RefSeq protein ID (P637): NP_001303970. Q20641742. Retrieved 2022-03-20. wikidata.org.
[22] ↑ Vascular endothelial growth factor A — RefSeq protein ID (P637): NP_033531. Q20641742. Retrieved 2022-03-20. wikidata.org.
[23] ↑ Vascular endothelial growth factor A — molecular function (P680): heparin binding. GOA. Retrieved 2018-01-01. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Vascular endothelial growth factor A — molecular function (P680): extracellular matrix binding. Molecular mapping and functional characterization of the VEGF164 heparin-binding domain. Retrieved 2018-01-01. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Vascular endothelial growth factor A — molecular function (P680): signaling receptor binding. Molecular mapping and functional characterization of the VEGF164 heparin-binding domain. Retrieved 2018-01-01. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Vascular endothelial growth factor A — molecular function (P680): cytokine activity. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Vascular endothelial growth factor A is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

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MLA

“Vascular endothelial growth factor A.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/vascular-endothelial-growth-factor-a-q21992409.

BibTeX

@misc{4ortxyz_vascular-endothelial-growth-factor-a-q21992409_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Vascular endothelial growth factor A}}, year = {2026}, url = {https://4ort.xyz/entity/vascular-endothelial-growth-factor-a-q21992409}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Vascular endothelial growth factor A — https://4ort.xyz/entity/vascular-endothelial-growth-factor-a-q21992409 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/vascular-endothelial-growth-factor-a-q21992409 · Last refreshed: May 3, 2026