Vacuolar protein sorting 4 homolog B

mammalian protein found in Homo sapiens
Protein protein Q21111450
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Summary

Vacuolar protein sorting 4 homolog B is a protein[1]. It is known by 9 alternative names across languages and contexts.[2]

Key Facts

  • Part of: MIT domain superfamily[3], P-loop containing nucleoside triphosphate hydrolase[4], ATPase, AAA-type, core domain, protein family[5], MIT domain, protein family[6], AAA proteins[7], Vps4 oligomerisation, C-terminal domain, protein family[8], ATPase, AAA-type, conserved site, protein family[9]
  • Has part(s): MIT[10], ATPase, AAA-type, conserved site[11], Vps4 oligomerisation, C-terminal[12], AAA+ ATPase domain[13], ATPase, AAA-type, core[14]
  • Molecular function: nucleotide binding[15], protein homodimerization activity[16], ATPase activity[17], protein C-terminus binding[18], protein binding[19], identical protein binding[20], hydrolase activity[21], ATP binding[22]
  • Cell component: cytoplasm[23], cytosol[24], endosome[25], centrosome[26], spindle pole[27], membrane[28], late endosome membrane[29], Flemming body[30], endosome membrane[31], extracellular exosome[32], nucleus[33]
  • Biological process: late endosomal microautophagy[34], regulation of centrosome duplication[35], protein depolymerization[36], viral budding via host ESCRT complex[37], viral life cycle[38], nucleus organization[39], cholesterol transport[40], negative regulation of exosomal secretion[41], multivesicular body assembly[42], negative regulation of cell death[43], regulation of mitotic spindle assembly[44], endosome organization[45], cell division[46], positive regulation of centriole elongation[47]
  • Encoded by: VPS4B[48]
  • Found in taxon: Homo sapiens[49]

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [3] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  2. [4] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  3. [5] ↑ . wikidata.org.
  4. [6] ↑ . wikidata.org.
  5. [7] ↑ . wikidata.org.
  6. [8] ↑ . wikidata.org.
  7. [9] ↑ . wikidata.org.
  8. [10] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  9. [11] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  10. [12] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  11. [13] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  12. [14] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  13. [15] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [16] ↑ . Structural and mechanistic studies of VPS4 proteins. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [17] ↑ . Mammalian cells express two VPS4 proteins both of which are involved in intracellular protein trafficking. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [18] ↑ . ESCRT-III recognition by VPS4 ATPases. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [19] ↑ . Mammalian cells express two VPS4 proteins both of which are involved in intracellular protein trafficking. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [20] ↑ . Structural and mechanistic studies of VPS4 proteins. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [21] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [22] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [23] ↑ . Cholesterol depletion facilitates ubiquitylation of NPC1 and its association with SKD1/Vps4. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [24] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [25] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [26] ↑ . Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [27] ↑ . Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  26. [28] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  27. [29] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  28. [30] ↑ . Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  29. [31] ↑ . Cholesterol depletion facilitates ubiquitylation of NPC1 and its association with SKD1/Vps4. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  30. [32] ↑ . Large-scale proteomics and phosphoproteomics of urinary exosomes. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  31. [33] ↑ . Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  32. [34] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  33. [35] ↑ . Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  34. [36] ↑ . Helical structures of ESCRT-III are disassembled by VPS4. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  35. [37] ↑ . ESCRT requirements for EIAV budding. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  36. [38] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  37. [39] ↑ . Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  38. [40] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  39. [41] ↑ . Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  40. [42] ↑ . Membrane budding and scission by the ESCRT machinery: it's all in the neck. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  41. [43] ↑ . Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  42. [44] ↑ . Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  43. [45] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  44. [46] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  45. [47] ↑ . Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  46. [48] ↑ . UniProt. Retrieved . wikidata.org.
  47. [49] ↑ . UniProt. Retrieved . wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

Aggregate / graph-position facts

  1. [2] ↑ . Wikidata aliases. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). Vacuolar protein sorting 4 homolog B. Retrieved May 3, 2026, from https://4ort.xyz/entity/vacuolar-protein-sorting-4-homolog-b
MLA “Vacuolar protein sorting 4 homolog B.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/vacuolar-protein-sorting-4-homolog-b.
BibTeX @misc{4ortxyz_vacuolar-protein-sorting-4-homolog-b_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Vacuolar protein sorting 4 homolog B}}, year = {2026}, url = {https://4ort.xyz/entity/vacuolar-protein-sorting-4-homolog-b}, note = {Accessed: 2026-05-03}}
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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 13w ago · Boghog · 2026-07-24 view diff on Wikidata ↗
    Imported from → —
    Encoded by → VPS4B
    Wikidata description → mammalian protein found in Homo sapiens
    Molecular function → nucleotide binding, protein homodimerization activity, ATPase activity +6
    + 11 other properties edited (see Wikidata diff for full list)
    "/* wbcreateclaim-create:1| */ Ec enzyme number: 3.6.4.6, [[:toollabs:quickstatements/#/batch/261491|batch #261491]]"
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