Ubiquitin specific peptidase 22

mammalian protein found in Homo sapiens
Protein protein Q21112578
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Summary

Ubiquitin specific peptidase 22 is a protein[1]. It is known by 9 alternative names across languages and contexts.[2]

Key Facts

  • Part of: Zinc finger, RING/FYVE/PHD-type[3], Papain-like cysteine peptidase superfamily[4], Peptidase C19, ubiquitin carboxyl-terminal hydrolase family[5], Zinc finger, UBP-type, protein family[6], Ubiquitin specific protease domain, protein family[7], Ubiquitin specific protease, conserved site, protein family[8]
  • Has part(s): Ubiquitin specific protease domain[9], Zinc finger, UBP-type[10], Ubiquitin specific protease, conserved site[11], Peptidase C19, ubiquitin carboxyl-terminal hydrolase[12]
  • Molecular function: cysteine-type peptidase activity[13], transcription coactivator activity[14], zinc ion binding[15], H4 histone acetyltransferase activity[16], metal ion binding[17], peptidase activity[18], protein binding[19], nuclear receptor coactivator activity[20], thiol-dependent deubiquitinase[21], enzyme binding[22], hydrolase activity[23]
  • Cell component: SAGA-type complex[24], SAGA complex[25], nucleus[26], nucleoplasm[27], nuclear speck[28]
  • Biological process: regulation of transcription, DNA-templated[29], ubiquitin-dependent protein catabolic process[30], positive regulation of mitotic cell cycle[31], transcription, DNA-templated[32], proteolysis[33], positive regulation of transcription, DNA-templated[34], histone deubiquitination[35], cell cycle[36], histone ubiquitination[37], histone H4 acetylation[38], protein deubiquitination[39], embryo development ending in birth or egg hatching[40], chromatin organization[41]
  • Encoded by: USP22[42]
  • Found in taxon: Homo sapiens[43]
  • Exact match: https://identifiers.org/uniprot:Q9UPT9[44], http://purl.uniprot.org/uniprot/Q9UPT9[45], https://www.ncbi.nlm.nih.gov/protein/Q9UPT9[46]

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [3] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  2. [4] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  3. [5] ↑ . wikidata.org.
  4. [6] ↑ . wikidata.org.
  5. [7] ↑ . wikidata.org.
  6. [8] ↑ . wikidata.org.
  7. [9] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  8. [10] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  9. [11] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  10. [12] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  11. [13] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  12. [14] ↑ . A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [15] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [16] ↑ . The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [17] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [18] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [19] ↑ . Cytoplasmic ATXN7L3B Interferes with Nuclear Functions of the SAGA Deubiquitinase Module. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [20] ↑ . A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [21] ↑ . The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [22] ↑ . A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [23] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [24] ↑ . Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [25] ↑ . Cytoplasmic ATXN7L3B Interferes with Nuclear Functions of the SAGA Deubiquitinase Module. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [26] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [27] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  26. [28] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  27. [29] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  28. [30] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  29. [31] ↑ . The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  30. [32] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  31. [33] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  32. [34] ↑ . The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  33. [35] ↑ . A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  34. [36] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  35. [37] ↑ . USP22, an hSAGA subunit and potential cancer stem cell marker, reverses the polycomb-catalyzed ubiquitylation of histone H2A. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  36. [38] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  37. [39] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  38. [40] ↑ . The expression patterns of deubiquitinating enzymes, USP22 and Usp22. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  39. [41] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  40. [42] ↑ . UniProt. Retrieved . wikidata.org.
  41. [43] ↑ . UniProt. Retrieved . wikidata.org.
  42. [44] ↑ . Identifiers.org. registry.identifiers.org. Provenance: wikidata.org.
  43. [45] ↑ . Identifiers.org. registry.identifiers.org. Provenance: wikidata.org.
  44. [46] ↑ . Identifiers.org. registry.identifiers.org. Provenance: wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

Aggregate / graph-position facts

  1. [2] ↑ . Wikidata aliases. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). Ubiquitin specific peptidase 22. Retrieved May 3, 2026, from https://4ort.xyz/entity/ubiquitin-specific-peptidase-22
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BibTeX @misc{4ortxyz_ubiquitin-specific-peptidase-22_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Ubiquitin specific peptidase 22}}, year = {2026}, url = {https://4ort.xyz/entity/ubiquitin-specific-peptidase-22}, note = {Accessed: 2026-05-03}}
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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 11w ago · Boghog · 2026-07-24 view diff on Wikidata ↗
    Imported from → —
    Encoded by → USP22
    Wikidata description → mammalian protein found in Homo sapiens
    Molecular function → cysteine-type peptidase activity, transcription coactivator activity, zinc ion binding +10
    + 11 other properties edited (see Wikidata diff for full list)
    "/* wbcreateclaim-create:1| */ Ec enzyme number: 3.4.19.12, [[:toollabs:quickstatements/#/batch/261491|batch #261491]]"
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