Ubiquitin specific peptidase 18

mammalian protein found in Homo sapiens
Protein protein Q21114727
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Summary

Ubiquitin specific peptidase 18 is a protein[1]. It is known by 9 alternative names across languages and contexts.[2]

Key Facts

  • Part of: Papain-like cysteine peptidase superfamily[3], Peptidase C19, ubiquitin carboxyl-terminal hydrolase family[4], Ubiquitin specific protease domain, protein family[5], Ubiquitin specific protease, conserved site, protein family[6]
  • Has part(s): Ubiquitin specific protease domain[7], Ubiquitin specific protease, conserved site[8], Peptidase C19, ubiquitin carboxyl-terminal hydrolase[9]
  • Molecular function: peptidase activity[10], cysteine-type peptidase activity[11], protein binding[12], hydrolase activity[13], thiol-dependent deubiquitinase[14], ISG15-specific protease activity[15], cysteine-type endopeptidase activity[16]
  • Cell component: cytoplasm[17], nucleus[18], cytosol[19]
  • Biological process: regulation of type I interferon-mediated signaling pathway[20], ubiquitin-dependent protein catabolic process[21], proteolysis[22], protein deubiquitination[23], regulation of inflammatory response[24], regulation of protein stability[25]
  • Encoded by: USP18[26]
  • Found in taxon: Homo sapiens[27]

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [3] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  2. [4] ↑ . wikidata.org.
  3. [5] ↑ . wikidata.org.
  4. [6] ↑ . wikidata.org.
  5. [7] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  6. [8] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  7. [9] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  8. [10] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  9. [11] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  10. [12] ↑ . A proteome-scale map of the human interactome network. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  11. [13] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  12. [14] ↑ . Cloning and characterization of a novel human ubiquitin-specific protease, a homologue of murine UBP43 (Usp18). Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [15] ↑ . UBP43 (USP18) Specifically Removes ISG15 from Conjugated Proteins. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [16] ↑ . Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [17] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [18] ↑ . Cloning and characterization of a novel human ubiquitin-specific protease, a homologue of murine UBP43 (Usp18). Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [19] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [20] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [21] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [22] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [23] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [24] ↑ . Human USP18 deficiency underlies type 1 interferonopathy leading to severe pseudo-TORCH syndrome. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [25] ↑ . Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [26] ↑ . UniProt. Retrieved . wikidata.org.
  25. [27] ↑ . UniProt. Retrieved . wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

Aggregate / graph-position facts

  1. [2] ↑ . Wikidata aliases. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). Ubiquitin specific peptidase 18. Retrieved May 3, 2026, from https://4ort.xyz/entity/ubiquitin-specific-peptidase-18
MLA “Ubiquitin specific peptidase 18.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/ubiquitin-specific-peptidase-18.
BibTeX @misc{4ortxyz_ubiquitin-specific-peptidase-18_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Ubiquitin specific peptidase 18}}, year = {2026}, url = {https://4ort.xyz/entity/ubiquitin-specific-peptidase-18}, note = {Accessed: 2026-05-03}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Ubiquitin specific peptidase 18 — https://4ort.xyz/entity/ubiquitin-specific-peptidase-18 (retrieved 2026-05-03)

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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 11w ago · Boghog · 2026-07-24 view diff on Wikidata ↗
    Imported from → —
    Encoded by → USP18
    Wikidata description → mammalian protein found in Homo sapiens
    Molecular function → peptidase activity, cysteine-type peptidase activity, protein binding +6
    + 12 other properties edited (see Wikidata diff for full list)
    "/* wbcreateclaim-create:1| */ Ec enzyme number: 3.4.19.12, [[:toollabs:quickstatements/#/batch/261491|batch #261491]]"
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