Tyrosyl-tRNA synthetase 2

mammalian protein found in Homo sapiens
Protein protein Q21101330
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Summary

Tyrosyl-tRNA synthetase 2 is a protein[1]. It is known by 7 alternative names across languages and contexts.[2]

Key Facts

  • Part of: Rossmann fold[3], RNA-binding S4 domain superfamily[4], Tyrosine-tRNA ligase, bacterial-type[5], Aminoacyl-tRNA synthetase, class I, conserved site, protein family[6]
  • Has part(s): aminoacyl-tRNA synthetase, class I, conserved site[7]
  • Molecular function: aminoacyl-tRNA ligase activity[8], tRNA binding[9], nucleotide binding[10], tyrosine binding[11], ligase activity[12], protein binding[13], ATP binding[14], protein homodimerization activity[15], tyrosine-tRNA ligase activity[16], RNA binding[17]
  • Cell component: cytoplasm[18], cytosol[19], mitochondrial matrix[20], mitochondrion[21], nuclear body[22]
  • Biological process: tyrosyl-tRNA aminoacylation[23], tRNA aminoacylation[24], tRNA aminoacylation for protein translation[25], protein biosynthesis[26], mitochondrial tyrosyl-tRNA aminoacylation[27]
  • Encoded by: YARS2[28]
  • Found in taxon: Homo sapiens[29]

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [3] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  2. [4] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  3. [5] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  4. [6] ↑ . wikidata.org.
  5. [7] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  6. [8] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  7. [9] ↑ . Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  8. [10] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  9. [11] ↑ . Crystal structure of human mitochondrial tyrosyl-tRNA synthetase reveals common and idiosyncratic features. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  10. [12] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  11. [13] ↑ . A proteome-scale map of the human interactome network. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  12. [14] ↑ . Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [15] ↑ . Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [16] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [17] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [18] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [19] ↑ . Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [20] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [21] ↑ . Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [22] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [23] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [24] ↑ . Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [25] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [26] ↑ . Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [27] ↑ . Mutation of the mitochondrial tyrosyl-tRNA synthetase gene, YARS2, causes myopathy, lactic acidosis, and sideroblastic anemia--MLASA syndrome. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  26. [28] ↑ . UniProt. Retrieved . wikidata.org.
  27. [29] ↑ . UniProt. Retrieved . wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

Aggregate / graph-position facts

  1. [2] ↑ . Wikidata aliases. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). Tyrosyl-tRNA synthetase 2. Retrieved May 3, 2026, from https://4ort.xyz/entity/tyrosyl-trna-synthetase-2
MLA “Tyrosyl-tRNA synthetase 2.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/tyrosyl-trna-synthetase-2.
BibTeX @misc{4ortxyz_tyrosyl-trna-synthetase-2_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Tyrosyl-tRNA synthetase 2}}, year = {2026}, url = {https://4ort.xyz/entity/tyrosyl-trna-synthetase-2}, note = {Accessed: 2026-05-03}}
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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 11w ago · Boghog · 2026-07-24 view diff on Wikidata ↗
    Imported from → —
    Encoded by → YARS2
    Wikidata description → mammalian protein found in Homo sapiens
    Molecular function → aminoacyl-tRNA ligase activity, tRNA binding, nucleotide binding +10
    + 11 other properties edited (see Wikidata diff for full list)
    "/* wbcreateclaim-create:1| */ Ec enzyme number: 6.1.1.1, [[:toollabs:quickstatements/#/batch/261488|batch #261488]]"
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