Twinfilin actin binding protein 1

mammalian protein found in Mus musculus

Protein protein Q21992397

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Summary

Twinfilin actin binding protein 1 is a protein^[1].

Key Facts

Twinfilin actin binding protein 1's instance of is recorded as protein^[2].
Twinfilin actin binding protein 1's subclass of is recorded as protein^[3].
Twinfilin actin binding protein 1's UniProt protein ID is recorded as Q91YR1^[4].
Twinfilin actin binding protein 1's part of is recorded as ADF-H/Gelsolin-like domain superfamily^[5].
Twinfilin actin binding protein 1's part of is recorded as Twinfilin^[6].
Twinfilin actin binding protein 1's part of is recorded as Actin-depolymerising factor homology domain, protein family^[7].
Twinfilin actin binding protein 1's has part is recorded as Actin-depolymerising factor homology domain^[8].
Twinfilin actin binding protein 1's RefSeq protein ID is recorded as NP_032997^[9].
Twinfilin actin binding protein 1's RefSeq protein ID is recorded as XP_006520701^[10].
Twinfilin actin binding protein 1's RefSeq protein ID is recorded as XP_036015163^[11].
Twinfilin actin binding protein 1's RefSeq protein ID is recorded as NP_001389738^[12].
Twinfilin actin binding protein 1's RefSeq protein ID is recorded as NP_001389739^[13].
Twinfilin actin binding protein 1's PDB structure ID is recorded as 1M4J^[14].
Twinfilin actin binding protein 1's PDB structure ID is recorded as 2D8B^[15].
Twinfilin actin binding protein 1's PDB structure ID is recorded as 2HD7^[16].
Twinfilin actin binding protein 1's PDB structure ID is recorded as 3DAW^[17].
Twinfilin actin binding protein 1's molecular function is recorded as protein tyrosine kinase activity^[18].
Twinfilin actin binding protein 1's molecular function is recorded as phosphatidylinositol-4,5-bisphosphate binding^[19].
Twinfilin actin binding protein 1's molecular function is recorded as actin monomer binding^[20].
Twinfilin actin binding protein 1's molecular function is recorded as ATP binding^[21].
Twinfilin actin binding protein 1's molecular function is recorded as cadherin binding^[22].
Twinfilin actin binding protein 1's molecular function is recorded as protein binding^[23].
Twinfilin actin binding protein 1's molecular function is recorded as actin binding^[24].
Twinfilin actin binding protein 1's molecular function is recorded as protein-containing complex binding^[25].
Twinfilin actin binding protein 1's molecular function is recorded as actin monomer binding^[26].

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Quick Facts

Instance of protein

Subclass of protein

Part of ADF-H/Gelsolin-like domain superfamily, Twinfilin, Actin-depolymerising factor homology domain, protein family

Properties

Biological process regulation of actin phosphorylation, sequestering of actin monomers, barbed-end actin filament capping, negative regulation of actin filament polymerization, peptidyl-tyrosine phosphorylation, positive regulation of cardiac muscle hypertrophy, regulation of lamellipodium assembly, positive regulation of neuron projection development, actin filament depolymerization, sequestering of actin monomers, barbed-end actin filament capping

Cell component filopodium, ruffle membrane, perinuclear region of cytoplasm, myofibril, intracellular anatomical structure, cytoskeleton, cell-cell junction, actin cytoskeleton, cytoplasm, cytosol, cytoplasm, actin filament, myofibril

Encoded by Twf1

Found in taxon house mouse

Has part(s) Actin-depolymerising factor homology domain

Imported from wholeness_audit_2026-05-02

Molecular function protein tyrosine kinase activity, phosphatidylinositol-4,5-bisphosphate binding, actin monomer binding, ATP binding, cadherin binding, protein binding, actin binding, protein-containing complex binding, actin monomer binding, actin filament binding

External References (4)

Ensembl protein id ENSMUSP00000023087, ENSMUSP00000119302

Pdb structure id 1M4J, 2D8B, 2HD7, 3DAW

Refseq protein id NP_032997, XP_006520701, XP_036015163, NP_001389738, NP_001389739

Uniprot protein id Q91YR1

🏷️ Also known as

en actin monomer-binding protein en protein A6 en protein tyrosine kinase 9 en PTK9 protein tyrosine kinase 9 en Twf1 en twinfilin-1 en Twinfilin actin binding protein 1 en twinfilin, actin-binding protein, homolog 1

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Twinfilin actin binding protein 1 — instance of (P31): protein. UniProt. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Twinfilin actin binding protein 1 — subclass of (P279): protein. UniProt. Retrieved 2017-01-19. wikidata.org.
[4] ↑ Twinfilin actin binding protein 1 — UniProt protein ID (P352): Q91YR1. UniProt. Retrieved 2022-05-25. wikidata.org.
[5] ↑ Twinfilin actin binding protein 1 — part of (P361): ADF-H/Gelsolin-like domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Twinfilin actin binding protein 1 — part of (P361): Twinfilin. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Twinfilin actin binding protein 1 — part of (P361): Actin-depolymerising factor homology domain, protein family. wikidata.org.
[8] ↑ Twinfilin actin binding protein 1 — has part(s) (P527): Actin-depolymerising factor homology domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ Twinfilin actin binding protein 1 — RefSeq protein ID (P637): NP_032997. Q20641742. Retrieved 2022-03-20. wikidata.org.
[10] ↑ Twinfilin actin binding protein 1 — RefSeq protein ID (P637): XP_006520701. Q20641742. Retrieved 2022-03-20. wikidata.org.
[11] ↑ Twinfilin actin binding protein 1 — RefSeq protein ID (P637): XP_036015163. Q20641742. Retrieved 2022-03-20. wikidata.org.
[12] ↑ Twinfilin actin binding protein 1 — RefSeq protein ID (P637): NP_001389738. Q20641742. Retrieved 2022-04-10. wikidata.org.
[13] ↑ Twinfilin actin binding protein 1 — RefSeq protein ID (P637): NP_001389739. Q20641742. Retrieved 2022-04-10. wikidata.org.
[14] ↑ Twinfilin actin binding protein 1 — PDB structure ID (P638): 1M4J. UniProt. Retrieved 2016-08-09. wikidata.org.
[15] ↑ Twinfilin actin binding protein 1 — PDB structure ID (P638): 2D8B. UniProt. Retrieved 2016-08-09. wikidata.org.
[16] ↑ Twinfilin actin binding protein 1 — PDB structure ID (P638): 2HD7. UniProt. Retrieved 2016-08-09. wikidata.org.
[17] ↑ Twinfilin actin binding protein 1 — PDB structure ID (P638): 3DAW. UniProt. Retrieved 2016-08-09. wikidata.org.
[18] ↑ Twinfilin actin binding protein 1 — molecular function (P680): protein tyrosine kinase activity. Cloning and characterization of the mouse homolog of the human A6 gene. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ Twinfilin actin binding protein 1 — molecular function (P680): phosphatidylinositol-4,5-bisphosphate binding. Mammals have two twinfilin isoforms whose subcellular localizations and tissue distributions are differentially regulated. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Twinfilin actin binding protein 1 — molecular function (P680): actin monomer binding. Mammals have two twinfilin isoforms whose subcellular localizations and tissue distributions are differentially regulated. Retrieved 2018-03-27. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Twinfilin actin binding protein 1 — molecular function (P680): ATP binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Twinfilin actin binding protein 1 — molecular function (P680): cadherin binding. GOA. Retrieved 2018-03-27. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Twinfilin actin binding protein 1 — molecular function (P680): protein binding. Structural basis and evolutionary origin of actin filament capping by twinfilin. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Twinfilin actin binding protein 1 — molecular function (P680): actin binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Twinfilin actin binding protein 1 — molecular function (P680): protein-containing complex binding. Interactions with PIP2, ADP-actin monomers, and capping protein regulate the activity and localization of yeast twinfilin. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Twinfilin actin binding protein 1 — molecular function (P680): actin monomer binding. Mammals have two twinfilin isoforms whose subcellular localizations and tissue distributions are differentially regulated. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Twinfilin actin binding protein 1 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA

4ort.xyz Knowledge Graph. (2026). Twinfilin actin binding protein 1. Retrieved May 3, 2026, from https://4ort.xyz/entity/twinfilin-actin-binding-protein-1

MLA

“Twinfilin actin binding protein 1.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/twinfilin-actin-binding-protein-1.

BibTeX

@misc{4ortxyz_twinfilin-actin-binding-protein-1_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Twinfilin actin binding protein 1}}, year = {2026}, url = {https://4ort.xyz/entity/twinfilin-actin-binding-protein-1}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Twinfilin actin binding protein 1 — https://4ort.xyz/entity/twinfilin-actin-binding-protein-1 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/twinfilin-actin-binding-protein-1 · Last refreshed: May 3, 2026