Tumor suppressor ARF

mouse protein (annotated by UniProtKB/Swiss-Prot Q64364)

Protein protein Q21499012

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Tumor suppressor ARF

Summary

Tumor suppressor ARF is a protein^[1].

Key Facts

Tumor suppressor ARF's instance of is recorded as protein^[2].
Tumor suppressor ARF's UniProt protein ID is recorded as Johann Wilhelm Ludwig Gleim^[3].
Tumor suppressor ARF's part of is recorded as tumor suppressor ARF^[4].
Tumor suppressor ARF's RefSeq protein ID is recorded as NP_034007.1^[5].
Tumor suppressor ARF's PDB structure ID is recorded as 1HN3^[6].
Tumor suppressor ARF's molecular function is recorded as DNA binding^[7].
Tumor suppressor ARF's molecular function is recorded as protein N-terminus binding^[8].
Tumor suppressor ARF's molecular function is recorded as DNA-binding transcription factor activity^[9].
Tumor suppressor ARF's molecular function is recorded as NF-kappaB binding^[10].
Tumor suppressor ARF's molecular function is recorded as ubiquitin-protein transferase inhibitor activity^[11].
Tumor suppressor ARF's molecular function is recorded as protein binding^[12].
Tumor suppressor ARF's molecular function is recorded as cyclin-dependent protein serine/threonine kinase inhibitor activity^[13].
Tumor suppressor ARF's molecular function is recorded as protein kinase binding^[14].
Tumor suppressor ARF's molecular function is recorded as p53 binding^[15].
Tumor suppressor ARF's molecular function is recorded as transcription factor binding^[16].
Tumor suppressor ARF's molecular function is recorded as SUMO transferase activity^[17].
Tumor suppressor ARF's molecular function is recorded as MDM2/MDM4 family protein binding^[18].
Tumor suppressor ARF's molecular function is recorded as disordered domain specific binding^[19].
Tumor suppressor ARF's molecular function is recorded as ubiquitin ligase inhibitor activity^[20].
Tumor suppressor ARF's cell component is recorded as cytoplasm^[21].
Tumor suppressor ARF's cell component is recorded as senescence-associated heterochromatin focus^[22].
Tumor suppressor ARF's cell component is recorded as nucleus^[23].
Tumor suppressor ARF's cell component is recorded as granular component^[24].
Tumor suppressor ARF's cell component is recorded as nucleoplasm^[25].
Tumor suppressor ARF's cell component is recorded as nucleolus^[26].

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Quick Facts

Instance of protein

Part of tumor suppressor ARF

Properties

Biological process apoptotic process, regulation of nucleocytoplasmic transport, regulation of cyclin-dependent protein serine/threonine kinase activity, regulation of transcription, DNA-templated, regulation of protein stability, negative regulation of immature T cell proliferation in thymus, somatic stem cell population maintenance, glucose homeostasis, negative regulation of cyclin-dependent protein serine/threonine kinase activity, replicative senescence, somatic stem cell division, ageing, rRNA transcription, negative regulation of mammary gland epithelial cell proliferation, negative regulation of cell cycle, positive regulation of DNA-binding transcription factor activity, negative regulation of protein binding, positive regulation of apoptotic process involved in mammary gland involution, transcription, DNA-templated, negative regulation of cell-matrix adhesion, cellular senescence, negative regulation of cell growth, negative regulation of ubiquitin-protein transferase activity, positive regulation of cellular senescence, epidermis development, rRNA processing, regulation of gene expression, cell cycle, negative regulation of phosphorylation, negative regulation of transcription, DNA-templated, negative regulation of B cell proliferation, negative regulation of NF-kappaB transcription factor activity, negative regulation of cell population proliferation, cellular response to hydrogen peroxide, protein polyubiquitination, autophagy of mitochondrion, negative regulation of protein kinase activity, activation of cysteine-type endopeptidase activity involved in apoptotic process, apoptotic mitochondrial changes, regulation of G2/M transition of mitotic cell cycle, protein sumoylation, protein destabilization, positive regulation of protein sumoylation, positive regulation of apoptotic process, positive regulation of DNA damage response, signal transduction by p53 class mediator, positive regulation of transcription, DNA-templated, positive regulation of transcription by RNA polymerase II, regulation of protein export from nucleus, protein stabilization, mitochondrial depolarization, protein K63-linked ubiquitination, positive regulation of protein localization to nucleus, positive regulation of signal transduction by p53 class mediator, regulation of apoptotic DNA fragmentation, negative regulation of proteolysis involved in cellular protein catabolic process, regulation of protein targeting to mitochondrion, negative regulation of ubiquitin-dependent protein catabolic process, positive regulation of gene expression, negative regulation of ubiquitin protein ligase activity, amyloid fibril formation, negative regulation of protein neddylation, G1/S transition of mitotic cell cycle, response to organonitrogen compound, response to organic cyclic compound, negative regulation of hepatocyte proliferation, regulation of transcription, DNA-templated

Cell component cytoplasm, senescence-associated heterochromatin focus, nucleus, granular component, nucleoplasm, nucleolus, mitochondrion, nuclear body, protein-containing complex

Encoded by Cdkn2a

Found in taxon house mouse

Imported from wholeness_audit_2026-05-02

Molecular function DNA binding, protein N-terminus binding, DNA-binding transcription factor activity, NF-kappaB binding, ubiquitin-protein transferase inhibitor activity, protein binding, cyclin-dependent protein serine/threonine kinase inhibitor activity, protein kinase binding, p53 binding, transcription factor binding, SUMO transferase activity, MDM2/MDM4 family protein binding, disordered domain specific binding, ubiquitin ligase inhibitor activity

External References (3)

Pdb structure id 1HN3

Refseq protein id NP_034007.1

Uniprot protein id Johann Wilhelm Ludwig Gleim

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Tumor suppressor ARF — instance of (P31): protein. wikidata.org.
[3] ↑ Tumor suppressor ARF — UniProt protein ID (P352): Johann Wilhelm Ludwig Gleim. Q905695. Retrieved 2016-08-10. wikidata.org.
[4] ↑ Tumor suppressor ARF — part of (P361): tumor suppressor ARF. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Tumor suppressor ARF — RefSeq protein ID (P637): NP_034007.1. Q905695. Retrieved 2016-08-10. wikidata.org.
[6] ↑ Tumor suppressor ARF — PDB structure ID (P638): 1HN3. Q905695. Retrieved 2016-08-10. wikidata.org.
[7] ↑ Tumor suppressor ARF — molecular function (P680): DNA binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ Tumor suppressor ARF — molecular function (P680): protein N-terminus binding. Structural polymorphism in the N-terminal oligomerization domain of NPM1. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ Tumor suppressor ARF — molecular function (P680): DNA-binding transcription factor activity. CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ Tumor suppressor ARF — molecular function (P680): NF-kappaB binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ Tumor suppressor ARF — molecular function (P680): ubiquitin-protein transferase inhibitor activity. Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ Tumor suppressor ARF — molecular function (P680): protein binding. Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ Tumor suppressor ARF — molecular function (P680): cyclin-dependent protein serine/threonine kinase inhibitor activity. Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ Tumor suppressor ARF — molecular function (P680): protein kinase binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ Tumor suppressor ARF — molecular function (P680): p53 binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ Tumor suppressor ARF — molecular function (P680): transcription factor binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ Tumor suppressor ARF — molecular function (P680): SUMO transferase activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ Tumor suppressor ARF — molecular function (P680): MDM2/MDM4 family protein binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ Tumor suppressor ARF — molecular function (P680): disordered domain specific binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Tumor suppressor ARF — molecular function (P680): ubiquitin ligase inhibitor activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Tumor suppressor ARF — cell component (P681): cytoplasm. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Tumor suppressor ARF — cell component (P681): senescence-associated heterochromatin focus. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Tumor suppressor ARF — cell component (P681): nucleus. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Tumor suppressor ARF — cell component (P681): granular component. CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Tumor suppressor ARF — cell component (P681): nucleoplasm. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Tumor suppressor ARF — cell component (P681): nucleolus. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Tumor suppressor ARF is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

4ort.xyz Knowledge Graph. (2026). Tumor suppressor ARF. Retrieved May 3, 2026, from https://4ort.xyz/entity/tumor-suppressor-arf-q21499012

MLA

“Tumor suppressor ARF.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/tumor-suppressor-arf-q21499012.

BibTeX

@misc{4ortxyz_tumor-suppressor-arf-q21499012_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Tumor suppressor ARF}}, year = {2026}, url = {https://4ort.xyz/entity/tumor-suppressor-arf-q21499012}, note = {Accessed: 2026-05-03}}

LLM prompt

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