Tumor necrosis factor, alpha-induced protein 3

mammalian protein found in Mus musculus

Protein protein Q21991285

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Tumor necrosis factor, alpha-induced protein 3

Summary

Tumor necrosis factor, alpha-induced protein 3 is a protein^[1].

Key Facts

Tumor necrosis factor, alpha-induced protein 3's instance of is recorded as protein^[2].
Tumor necrosis factor, alpha-induced protein 3's subclass of is recorded as protein^[3].
Tumor necrosis factor, alpha-induced protein 3's UniProt protein ID is recorded as Hieronymus Bock^[4].
Tumor necrosis factor, alpha-induced protein 3's part of is recorded as A20 peptidase^[5].
Tumor necrosis factor, alpha-induced protein 3's part of is recorded as OTU domain, protein family^[6].
Tumor necrosis factor, alpha-induced protein 3's part of is recorded as Zinc finger, A20-type, protein family^[7].
Tumor necrosis factor, alpha-induced protein 3's has part is recorded as OTU domain^[8].
Tumor necrosis factor, alpha-induced protein 3's has part is recorded as Zinc finger, A20-type^[9].
Tumor necrosis factor, alpha-induced protein 3's RefSeq protein ID is recorded as NP_001159874^[10].
Tumor necrosis factor, alpha-induced protein 3's RefSeq protein ID is recorded as NP_033423^[11].
Tumor necrosis factor, alpha-induced protein 3's RefSeq protein ID is recorded as XP_006512765^[12].
Tumor necrosis factor, alpha-induced protein 3's PDB structure ID is recorded as 5DQ6^[13].
Tumor necrosis factor, alpha-induced protein 3's molecular function is recorded as DNA binding^[14].
Tumor necrosis factor, alpha-induced protein 3's molecular function is recorded as cysteine-type peptidase activity^[15].
Tumor necrosis factor, alpha-induced protein 3's molecular function is recorded as zinc ion binding^[16].
Tumor necrosis factor, alpha-induced protein 3's molecular function is recorded as metal ion binding^[17].
Tumor necrosis factor, alpha-induced protein 3's molecular function is recorded as ubiquitin-protein transferase activity^[18].
Tumor necrosis factor, alpha-induced protein 3's molecular function is recorded as protease binding^[19].
Tumor necrosis factor, alpha-induced protein 3's molecular function is recorded as protein self-association^[20].
Tumor necrosis factor, alpha-induced protein 3's molecular function is recorded as peptidase activity^[21].
Tumor necrosis factor, alpha-induced protein 3's molecular function is recorded as kinase binding^[22].
Tumor necrosis factor, alpha-induced protein 3's molecular function is recorded as K63-linked polyubiquitin modification-dependent protein binding^[23].
Tumor necrosis factor, alpha-induced protein 3's molecular function is recorded as ubiquitin binding^[24].
Tumor necrosis factor, alpha-induced protein 3's molecular function is recorded as catalytic activity^[25].
Tumor necrosis factor, alpha-induced protein 3's molecular function is recorded as protein binding^[26].

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Quick Facts

Instance of protein

Subclass of protein

Part of A20 peptidase, OTU domain, protein family, Zinc finger, A20-type, protein family

Properties

Biological process regulation of germinal center formation, positive regulation of hepatocyte proliferation, negative regulation of endothelial cell apoptotic process, negative regulation of interleukin-1 beta production, negative regulation of smooth muscle cell proliferation, B-1 B cell homeostasis, regulation of innate immune response, protein K48-linked deubiquitination, positive regulation of protein catabolic process, negative regulation of cyclin-dependent protein serine/threonine kinase activity, protein deubiquitination involved in ubiquitin-dependent protein catabolic process, negative regulation of granuloma formation, negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway, negative regulation of interleukin-6 production, negative regulation of B cell activation, negative regulation of toll-like receptor 5 signaling pathway, tolerance induction to lipopolysaccharide, response to muramyl dipeptide, negative regulation of chronic inflammatory response, negative regulation of cell death, marginal zone B cell differentiation, negative regulation of I-kappaB kinase/NF-kappaB signaling, proteolysis, cellular response to lipopolysaccharide, establishment of protein localization to vacuole, negative regulation of protein ubiquitination, protein K48-linked ubiquitination, protein K63-linked deubiquitination, negative regulation of CD40 signaling pathway, response to wounding, negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, protein K11-linked deubiquitination, negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway, negative regulation of innate immune response, negative regulation of tumor necrosis factor production, metabolism, negative regulation of heterotypic cell-cell adhesion, inflammatory response, response to molecule of bacterial origin, regulation of immunoglobulin production, negative regulation of autophagy, negative regulation of NF-kappaB transcription factor activity, negative regulation of interleukin-2 production, negative regulation of toll-like receptor 3 signaling pathway, negative regulation of inflammatory response, cellular response to hydrogen peroxide, apoptotic process, protein deubiquitination, protein ubiquitination, cytoskeleton organization, cell migration, positive regulation of Wnt signaling pathway, protein K29-linked deubiquitination, protein K11-linked deubiquitination, protein K48-linked deubiquitination, protein K33-linked deubiquitination

Cell component cytoplasm, lysosome, nucleus, intracellular membrane-bounded organelle, cytoplasm

Encoded by Tnfaip3

Found in taxon house mouse

Has part(s) OTU domain, Zinc finger, A20-type

Imported from wholeness_audit_2026-05-02

Molecular function DNA binding, cysteine-type peptidase activity, zinc ion binding, metal ion binding, ubiquitin-protein transferase activity, protease binding, protein self-association, peptidase activity, kinase binding, K63-linked polyubiquitin modification-dependent protein binding, ubiquitin binding, catalytic activity, protein binding, thiol-dependent deubiquitinase, hydrolase activity, identical protein binding, Lys63-specific deubiquitinase activity, thiol-dependent deubiquitinase, transferase activity

External References (4)

Ensembl protein id ENSMUSP00000019997, ENSMUSP00000101167, ENSMUSP00000116318, ENSMUSP00000120627

Pdb structure id 5DQ6

Refseq protein id NP_001159874, NP_033423, XP_006512765

Uniprot protein id Hieronymus Bock

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Tumor necrosis factor, alpha-induced protein 3 — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Tumor necrosis factor, alpha-induced protein 3 — subclass of (P279): protein. Q905695. Retrieved 2017-01-19. wikidata.org.
[4] ↑ Tumor necrosis factor, alpha-induced protein 3 — UniProt protein ID (P352): Hieronymus Bock. Q905695. Retrieved 2022-05-25. wikidata.org.
[5] ↑ Tumor necrosis factor, alpha-induced protein 3 — part of (P361): A20 peptidase. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Tumor necrosis factor, alpha-induced protein 3 — part of (P361): OTU domain, protein family. wikidata.org.
[7] ↑ Tumor necrosis factor, alpha-induced protein 3 — part of (P361): Zinc finger, A20-type, protein family. wikidata.org.
[8] ↑ Tumor necrosis factor, alpha-induced protein 3 — has part(s) (P527): OTU domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ Tumor necrosis factor, alpha-induced protein 3 — has part(s) (P527): Zinc finger, A20-type. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ Tumor necrosis factor, alpha-induced protein 3 — RefSeq protein ID (P637): NP_001159874. Q20641742. Retrieved 2022-03-20. wikidata.org.
[11] ↑ Tumor necrosis factor, alpha-induced protein 3 — RefSeq protein ID (P637): NP_033423. Q20641742. Retrieved 2022-03-20. wikidata.org.
[12] ↑ Tumor necrosis factor, alpha-induced protein 3 — RefSeq protein ID (P637): XP_006512765. Q20641742. Retrieved 2022-03-20. wikidata.org.
[13] ↑ Tumor necrosis factor, alpha-induced protein 3 — PDB structure ID (P638): 5DQ6. Q905695. Retrieved 2016-08-10. wikidata.org.
[14] ↑ Tumor necrosis factor, alpha-induced protein 3 — molecular function (P680): DNA binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ Tumor necrosis factor, alpha-induced protein 3 — molecular function (P680): cysteine-type peptidase activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ Tumor necrosis factor, alpha-induced protein 3 — molecular function (P680): zinc ion binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ Tumor necrosis factor, alpha-induced protein 3 — molecular function (P680): metal ion binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ Tumor necrosis factor, alpha-induced protein 3 — molecular function (P680): ubiquitin-protein transferase activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ Tumor necrosis factor, alpha-induced protein 3 — molecular function (P680): protease binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Tumor necrosis factor, alpha-induced protein 3 — molecular function (P680): protein self-association. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Tumor necrosis factor, alpha-induced protein 3 — molecular function (P680): peptidase activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Tumor necrosis factor, alpha-induced protein 3 — molecular function (P680): kinase binding. The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Tumor necrosis factor, alpha-induced protein 3 — molecular function (P680): K63-linked polyubiquitin modification-dependent protein binding. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Tumor necrosis factor, alpha-induced protein 3 — molecular function (P680): ubiquitin binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Tumor necrosis factor, alpha-induced protein 3 — molecular function (P680): catalytic activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Tumor necrosis factor, alpha-induced protein 3 — molecular function (P680): protein binding. Identification of a novel A20-binding inhibitor of nuclear factor-kappa B activation termed ABIN-2. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Tumor necrosis factor, alpha-induced protein 3 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

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MLA

“Tumor necrosis factor, alpha-induced protein 3.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/tumor-necrosis-factor-alpha-induced-protein-3.

BibTeX

@misc{4ortxyz_tumor-necrosis-factor-alpha-induced-protein-3_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Tumor necrosis factor, alpha-induced protein 3}}, year = {2026}, url = {https://4ort.xyz/entity/tumor-necrosis-factor-alpha-induced-protein-3}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Tumor necrosis factor, alpha-induced protein 3 — https://4ort.xyz/entity/tumor-necrosis-factor-alpha-induced-protein-3 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/tumor-necrosis-factor-alpha-induced-protein-3 · Last refreshed: May 3, 2026