tumor necrosis factor

Human protein
Protein protein Q21173843
tumor necrosis factor
Ramin Herati · Public Domain · Wikimedia
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tumor necrosis factor

Summary

tumor necrosis factor is a protein[1]. It ranks in the top 1% of protein entities by monthly Wikipedia readership (806 views/month).[2]

Key Facts

  • tumor necrosis factor's instance of is recorded as protein[3].
  • tumor necrosis factor is part of Tumour necrosis factor-like domain superfamily[4].
  • tumor necrosis factor is part of Tumour necrosis factor alpha[5].
  • tumor necrosis factor is part of membrane protein[6].
  • tumor necrosis factor is part of Tumour necrosis factor domain, protein family[7].
  • tumor necrosis factor is part of Tumour necrosis factor, conserved site, protein family[8].
  • tumor necrosis factor's Commons category is recorded as Tumor necrosis factor-alpha[9].
  • tumor necrosis factor comprises Tumour necrosis factor, conserved site[10].
  • tumor necrosis factor comprises Tumour necrosis factor domain[11].
  • tumor necrosis factor's molecular function is recorded as protein binding[12].
  • tumor necrosis factor's molecular function is recorded as protease binding[13].
  • tumor necrosis factor's molecular function is recorded as tumor necrosis factor receptor binding[14].
  • tumor necrosis factor's molecular function is recorded as cytokine activity[15].
  • tumor necrosis factor's molecular function is recorded as identical protein binding[16].
  • tumor necrosis factor's cell component is recorded as membrane[17].
  • tumor necrosis factor's cell component is recorded as cell surface[18].
  • tumor necrosis factor's cell component is recorded as integral component of membrane[19].
  • tumor necrosis factor's cell component is recorded as recycling endosome[20].
  • tumor necrosis factor's cell component is recorded as intracellular anatomical structure[21].
  • tumor necrosis factor's cell component is recorded as integral component of plasma membrane[22].
  • tumor necrosis factor's cell component is recorded as phagocytic cup[23].
  • tumor necrosis factor's cell component is recorded as external side of plasma membrane[24].
  • tumor necrosis factor's cell component is recorded as extracellular region[25].
  • tumor necrosis factor's cell component is recorded as plasma membrane[26].
  • tumor necrosis factor's cell component is recorded as membrane raft[27].

Why It Matters

tumor necrosis factor ranks in the top 1% of protein entities by monthly Wikipedia readership (806 views/month).[2] It has Wikipedia articles in 22 language editions, a strong signal of global cultural recognition.[28] It is known by 11 alternative names across languages and contexts.[29]

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [3] . Q905695. Retrieved . wikidata.org.
  2. [4] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  3. [5] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  4. [6] . wikidata.org.
  5. [7] . wikidata.org.
  6. [8] . wikidata.org.
  7. [9] . wikidata.org.
  8. [10] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  9. [11] . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  10. [12] . Zinc finger protein tristetraprolin interacts with CCL3 mRNA and regulates tissue inflammation. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  11. [13] . Catalytic activity of ADAM8, ADAM15, and MDC-L (ADAM28) on synthetic peptide substrates and in ectodomain cleavage of CD23. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  12. [14] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  13. [15] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  14. [16] . Lymphotoxin α induces apoptosis, necroptosis and inflammatory signals with the same potency as tumour necrosis factor.. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  15. [17] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  16. [18] . Ectodomain shedding of TNF-alpha is enhanced by nardilysin via activation of ADAM proteases. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  17. [19] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  18. [20] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  19. [21] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  20. [22] . Ectodomain shedding of TNF-alpha is enhanced by nardilysin via activation of ADAM proteases. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  21. [23] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [24] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [25] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [26] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [27] . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

  1. [1] . Wikidata. wikidata.org.

Aggregate / graph-position facts

  1. [2] . Wikimedia Foundation. dumps.wikimedia.org.
  2. [28] . Wikidata sitelinks. wikidata.org.
  3. [29] . Wikidata aliases. wikidata.org.

📑 Cite this page

Use these citations when quoting this entity in research, articles, AI prompts, or wherever provenance matters. We aggregate Wikidata + Wikipedia + authoritative open-data sources; the stitched, scored, cross-referenced view is what 4ort.xyz contributes.

APA 4ort.xyz Knowledge Graph. (2026). tumor necrosis factor. Retrieved May 3, 2026, from https://4ort.xyz/entity/tumor-necrosis-factor
MLA “tumor necrosis factor.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/tumor-necrosis-factor.
BibTeX @misc{4ortxyz_tumor-necrosis-factor_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{tumor necrosis factor}}, year = {2026}, url = {https://4ort.xyz/entity/tumor-necrosis-factor}, note = {Accessed: 2026-05-03}}
LLM prompt According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): tumor necrosis factor — https://4ort.xyz/entity/tumor-necrosis-factor (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/tumor-necrosis-factor · Last refreshed:

Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 29d ago · MsynBot bot · 2026-06-20 view diff on Wikidata ↗
    Local thumb
    Biological process regulation of protein phosphorylation, positive regulation of protein phosphorylation, positive regulation of MAP kinase activity +124
    Has parts
    Instance of protein
    + 9 other properties edited (see Wikidata diff for full list)
    "/* wbeditentity-update:0| */ remove badge [[Q70893996]] from ptwiki sitelink; sitelink points to a non-redirect page #msynbotTask10"
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