tumor necrosis factor
Human protein
Facts
8 properties- Instance of
- protein
- Part of
- Tumour necrosis factor-like domain superfamily, Tumour necrosis factor alpha, membrane protein, Tumour necrosis factor domain, protein family, Tumour necrosis factor, conserved site, protein family[2][3][4][5][6]
- Biological process
- regulation of protein phosphorylation, positive regulation of protein phosphorylation, positive regulation of MAP kinase activity, response to salt stress, positive regulation of calcidiol 1-monooxygenase activity, positive regulation of programmed cell death, positive regulation of JNK cascade, response to organic substance, negative regulation of osteoblast differentiation, positive regulation of cysteine-type endopeptidase activity involved in apoptotic process, negative regulation of viral genome replication, humoral immune response, positive regulation of interleukin-8 production, intrinsic apoptotic signaling pathway in response to DNA damage, positive regulation of protein localization to cell surface, positive regulation of ERK1 and ERK2 cascade, glucose metabolic process, animal organ morphogenesis, apoptotic signaling pathway, negative regulation of alkaline phosphatase activity, regulation of I-kappaB kinase/NF-kappaB signaling, defense response to Gram-positive bacterium, regulation of branching involved in salivary gland morphogenesis, positive regulation of phagocytosis, negative regulation of fat cell differentiation, negative regulation of myoblast differentiation, positive regulation of protein kinase B signaling, regulation of insulin secretion, osteoclast differentiation, regulation of tumor necrosis factor-mediated signaling pathway, response to virus, positive regulation of osteoclast differentiation, negative regulation of cytokine production involved in immune response, positive regulation of peptidyl-serine phosphorylation, negative regulation of branching involved in lung morphogenesis, JNK cascade, death-inducing signaling complex assembly, regulation of osteoclast differentiation, defense response to bacterium, positive regulation of interleukin-6 production, I-kappaB kinase/NF-kappaB signaling, positive regulation of translational initiation by iron, sequestering of triglyceride, positive regulation of chronic inflammatory response to antigenic stimulus, positive regulation of chemokine (C-X-C motif) ligand 2 production, positive regulation of JUN kinase activity, positive regulation of hair follicle development, chronic inflammatory response to antigenic stimulus, cellular response to organic cyclic compound, positive regulation of fever generation, extracellular matrix organization, positive regulation of DNA-binding transcription factor activity, cellular response to nicotine, positive regulation of podosome assembly, regulation of reactive oxygen species metabolic process, positive regulation of protein transport, negative regulation of glucose import, immune response, leukocyte tethering or rolling, positive regulation of chemokine production, cellular extravasation, negative regulation of lipid storage, negative regulation of myosin-light-chain-phosphatase activity, negative regulation of transcription, DNA-templated, cortical actin cytoskeleton organization, embryonic digestive tract development, leukocyte migration, lipopolysaccharide-mediated signaling pathway, positive regulation of smooth muscle cell proliferation, positive regulation of protein kinase activity, positive regulation of superoxide dismutase activity, defense response, positive regulation of ceramide biosynthetic process, positive regulation of protein-containing complex assembly, protein kinase B signaling, positive regulation of cytokine production, epithelial cell proliferation involved in salivary gland morphogenesis, positive regulation of nitric oxide biosynthetic process, negative regulation of interleukin-6 production, positive regulation of membrane protein ectodomain proteolysis, positive regulation of humoral immune response mediated by circulating immunoglobulin, positive regulation of interferon-gamma production, response to glucocorticoid, positive regulation of vitamin D biosynthetic process, positive regulation of mononuclear cell migration, MAPK cascade, negative regulation of protein-containing complex disassembly, multicellular organism development, negative regulation of bicellular tight junction assembly, positive regulation of protein-containing complex disassembly, regulation of cell population proliferation, cellular response to amino acid stimulus, negative regulation of extrinsic apoptotic signaling pathway in absence of ligand, cellular response to lipopolysaccharide, negative regulation of lipid catabolic process, regulation of establishment of endothelial barrier, positive regulation of cell adhesion, regulation of protein secretion, positive regulation of apoptotic process, inflammatory response, activation of cysteine-type endopeptidase activity involved in apoptotic process, tumor necrosis factor-mediated signaling pathway, positive regulation of I-kappaB kinase/NF-kappaB signaling, necroptotic signaling pathway, positive regulation of gene expression, extrinsic apoptotic signaling pathway, extrinsic apoptotic signaling pathway via death domain receptors, negative regulation of transcription by RNA polymerase II, positive regulation of NF-kappaB transcription factor activity, positive regulation of transcription, DNA-templated, positive regulation of transcription by RNA polymerase II, positive regulation of leukocyte adhesion to arterial endothelial cell, positive regulation of leukocyte adhesion to vascular endothelial cell, positive regulation of blood microparticle formation, negative regulation of endothelial cell proliferation, positive regulation of heterotypic cell-cell adhesion, negative regulation of mitotic cell cycle, endothelial cell apoptotic process, positive regulation of vascular associated smooth muscle cell proliferation, negative regulation of gene expression, protein localization to plasma membrane, positive regulation of protein catabolic process, regulation of signaling receptor activity, regulation of inflammatory response, cytokine-mediated signaling pathway, positive regulation of calcineurin-NFAT signaling cascade, positive regulation of NIK/NF-kappaB signaling[26][27][28][29][30][31][32][33][34][35][36][37][38][39]
- Cell component
- membrane, cell surface, integral component of membrane, recycling endosome, intracellular anatomical structure, integral component of plasma membrane, phagocytic cup, external side of plasma membrane, extracellular region, plasma membrane, membrane raft, extracellular space[14][15][16][17][18][19][20][21][22][23][24][25]
- Encoded by
- TNF
- Found in taxon
- Homo sapiens
🏷️ Also known as
en tumor necrosis factor
en tumor necrosis factor ligand superfamily member 2
en tumor necrosis factor ligand 1F
en Tumor Necrosis Factor-alpha
en APC1 protein
en cachectin
en TNF
en TNF-a
en TNF-alpha
en TNF, macrophage-derived
en TNF, monocyte-derived
ar عامل نخر الورم ألفا
cs TNF-α
de Tumornekrosefaktor
el Παράγοντας νέκρωσης όγκων
es Factor de necrosis tumoral
fa فاکتور نکروز توموری آلفا
fi Tuumorinekroositekijä alfa
fr Facteur de nécrose tumorale
he גורם נמק בגידול
🔖 Identifiers · 9
- GND ID
- 4202932-6
- OpenAlex ID
- C17991360, C3020084786
- Ensembl protein ID
- ENSP00000365290, ENSP00000372988, ENSP00000389490, ENSP00000389492, ENSP00000392858, ENSP00000398698, ENSP00000410668, ENSP00000389265
- Freebase ID
- /m/01jyp8
- Microsoft Academic ID (discontinued)
- 2.9B (18.0M–2.9B, n=3)
- PDB structure ID
- 1A8M, 1TNF, 2AZ5, 2E7A, 2TUN, 2ZJC, 2ZPX, 3ALQ, 3IT8, 3L9J, 3WD5, 4G3Y, 4TSV, 4TWT, 5TSW
- RefSeq protein ID
- NP_000585
- UMLS CUI
- C1456820
- UniProt protein ID
- P01375
🔗 Connections
Cell component 4
Biological process 1
Found in taxon 1
Instance of 1
Molecular function 1
Part of 1
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Summary
tumor necrosis factor is a protein[1].