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Tripartite motif containing 27

mammalian protein found in Homo sapiens
Protein protein Q21113658
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Summary

Tripartite motif containing 27 is a protein[1]. It is known by 10 alternative names across languages and contexts.[2]

Key Facts

  • Part of: Concanavalin A-like lectin/glucanase domain superfamily[3], Zinc finger, RING/FYVE/PHD-type[4], Butyrophylin-like, SPRY domain, protein family[5], B30.2/SPRY domain, protein family[6], TRIM27, PRY/SPRY domain, protein family[7], Zinc finger, B-box, chordata, protein family[8], B-box-type zinc finger, protein family[9], Zinc finger, RING-type, protein family[10], SPRY domain, protein family[11], SPRY-associated domain, protein family[12], Zinc finger, RING-type, conserved site, protein family[13]
  • Has part(s): Zinc finger, RING-type, conserved site[14], SPRY-associated[15], Butyrophylin-like, SPRY domain[16], SPRY domain[17], B30.2/SPRY domain[18], Zinc finger, B-box, chordata[19], Zinc finger, RING-type[20], B-box-type zinc finger[21], TRIM27, PRY/SPRY domain[22]
  • Molecular function: DNA binding[23], zinc ion binding[24], metal ion binding[25], ubiquitin-protein transferase activity[26], protein binding[27], nucleic acid binding[28], transmembrane receptor protein tyrosine kinase activity[29], identical protein binding[30], transferase activity[31], ubiquitin protein ligase activity[32], SUMO transferase activity[33]
  • Cell component: cytoplasm[34], endosome[35], PML body[36], nuclear membrane[37], membrane[38], integral component of plasma membrane[39], intracellular anatomical structure[40], nucleoplasm[41], retromer complex[42], early endosome[43], nucleus[44], fibrillar center[45], nucleolus[46], cytosol[47]
  • Biological process: regulation of transcription, DNA-templated[48], negative regulation of adaptive immune response[49], negative regulation of protein kinase activity[50], protein K63-linked ubiquitination[51], protein trimerization[52], positive regulation of DNA-binding transcription factor activity[53], transcription, DNA-templated[54], negative regulation of calcium ion import[55], negative regulation of gene expression, epigenetic[56], retrograde transport, endosome to Golgi[57], spermatogenesis[58], Arp2/3 complex-mediated actin nucleation[59], negative regulation of tumor necrosis factor production[60], cell population proliferation[61]
  • Encoded by: TRIM27[62]
  • Found in taxon: Homo sapiens[63]

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

  1. [3] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  2. [4] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  3. [5] ↑ . wikidata.org.
  4. [6] ↑ . wikidata.org.
  5. [7] ↑ . wikidata.org.
  6. [8] ↑ . wikidata.org.
  7. [9] ↑ . wikidata.org.
  8. [10] ↑ . wikidata.org.
  9. [11] ↑ . wikidata.org.
  10. [12] ↑ . wikidata.org.
  11. [13] ↑ . wikidata.org.
  12. [14] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  13. [15] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  14. [16] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  15. [17] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  16. [18] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  17. [19] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  18. [20] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  19. [21] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  20. [22] ↑ . InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
  21. [23] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  22. [24] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  23. [25] ↑ . Developmentally regulated expression of a human "finger"-containing gene encoded by the 5' half of the ret transforming gene. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  24. [26] ↑ . Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  25. [27] ↑ . Interaction between the Ret finger protein and the Int-6 gene product and co-localisation into nuclear bodies. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  26. [28] ↑ . Developmentally regulated expression of a human "finger"-containing gene encoded by the 5' half of the ret transforming gene. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  27. [29] ↑ . Cloning and expression of the ret proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  28. [30] ↑ . A proteome-scale map of the human interactome network. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  29. [31] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  30. [32] ↑ . RFP-mediated ubiquitination of PTEN modulates its effect on AKT activation. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  31. [33] ↑ . SUMO E3 ligase activity of TRIM proteins. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  32. [34] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  33. [35] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  34. [36] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  35. [37] ↑ . RET finger protein is a transcriptional repressor and interacts with enhancer of polycomb that has dual transcriptional functions. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  36. [38] ↑ . Cloning and expression of the ret proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  37. [39] ↑ . Cloning and expression of the ret proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  38. [40] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  39. [41] ↑ . RET finger protein is a transcriptional repressor and interacts with enhancer of polycomb that has dual transcriptional functions. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  40. [42] ↑ . Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  41. [43] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  42. [44] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  43. [45] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  44. [46] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  45. [47] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  46. [48] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  47. [49] ↑ . Tripartite motif containing protein 27 negatively regulates CD4 T cells by ubiquitinating and inhibiting the class II PI3K-C2β. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  48. [50] ↑ . Tripartite motif containing protein 27 negatively regulates CD4 T cells by ubiquitinating and inhibiting the class II PI3K-C2β. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  49. [51] ↑ . Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  50. [52] ↑ . Unique features of TRIM5alpha among closely related human TRIM family members. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  51. [53] ↑ . TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  52. [54] ↑ . GOA. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  53. [55] ↑ . Tripartite motif containing protein 27 negatively regulates CD4 T cells by ubiquitinating and inhibiting the class II PI3K-C2β. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  54. [56] ↑ . RET finger protein is a transcriptional repressor and interacts with enhancer of polycomb that has dual transcriptional functions. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  55. [57] ↑ . Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  56. [58] ↑ . Developmentally regulated expression of a human "finger"-containing gene encoded by the 5' half of the ret transforming gene. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  57. [59] ↑ . Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  58. [60] ↑ . Tripartite motif containing protein 27 negatively regulates CD4 T cells by ubiquitinating and inhibiting the class II PI3K-C2β. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  59. [61] ↑ . Activation of the ret-II oncogene without a sequence encoding a transmembrane domain and transforming activity of two ret-II oncogene products differing in carboxy-termini due to alternative splicing. Retrieved . ebi.ac.uk. Provenance: wikidata.org.
  60. [62] ↑ . UniProt. Retrieved . wikidata.org.
  61. [63] ↑ . UniProt. Retrieved . wikidata.org.

Class ancestry

  1. [1] ↑ . Wikidata. wikidata.org.

Aggregate / graph-position facts

  1. [2] ↑ . Wikidata aliases. wikidata.org.

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APA 4ort.xyz Knowledge Graph. (2026). Tripartite motif containing 27. Retrieved May 3, 2026, from https://4ort.xyz/entity/tripartite-motif-containing-27-q21113658
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BibTeX @misc{4ortxyz_tripartite-motif-containing-27-q21113658_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Tripartite motif containing 27}}, year = {2026}, url = {https://4ort.xyz/entity/tripartite-motif-containing-27-q21113658}, note = {Accessed: 2026-05-03}}
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Edit History

Rolling log of changes to this entity's Wikidata record. Values shown reflect the current state of each edited property — follow the history link to see the precise diff for any edit.

  1. 13w ago · Boghog · 2026-07-24 view diff on Wikidata ↗
    Imported from → —
    Encoded by → TRIM27
    Wikidata description → mammalian protein found in Homo sapiens
    Molecular function → DNA binding, zinc ion binding, metal ion binding +8
    + 10 other properties edited (see Wikidata diff for full list)
    "/* wbcreateclaim-create:1| */ Ec enzyme number: 2.3.2.27, [[:toollabs:quickstatements/#/batch/261491|batch #261491]]"
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