Transformation related protein 53

mammalian protein found in Mus musculus

Protein protein Q14818136

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Transformation related protein 53

Summary

Transformation related protein 53 is a protein^[1].

Key Facts

Transformation related protein 53's instance of is recorded as protein^[2].
Transformation related protein 53's subclass of is recorded as protein^[3].
Transformation related protein 53's UniProt protein ID is recorded as P02340^[4].
Transformation related protein 53's part of is recorded as p53-like transcription factor, DNA-binding^[5].
Transformation related protein 53's part of is recorded as p53-like tetramerisation domain superfamily^[6].
Transformation related protein 53's part of is recorded as p53/RUNT-type transcription factor, DNA-binding domain superfamily^[7].
Transformation related protein 53's part of is recorded as p53 tumour suppressor family^[8].
Transformation related protein 53's part of is recorded as p53 transactivation domain, protein family^[9].
Transformation related protein 53's part of is recorded as p53, tetramerisation domain, protein family^[10].
Transformation related protein 53's part of is recorded as p53, DNA-binding domain, protein family^[11].
Transformation related protein 53's has part is recorded as p53, tetramerisation domain^[12].
Transformation related protein 53's has part is recorded as p53 transactivation domain^[13].
Transformation related protein 53's has part is recorded as p53, DNA-binding domain^[14].
Transformation related protein 53's RefSeq protein ID is recorded as NP_001120705^[15].
Transformation related protein 53's RefSeq protein ID is recorded as NP_035770^[16].
Transformation related protein 53's RefSeq protein ID is recorded as XP_006533220^[17].
Transformation related protein 53's RefSeq protein ID is recorded as XP_030101782^[18].
Transformation related protein 53's RefSeq protein ID is recorded as XP_030101783^[19].
Transformation related protein 53's PDB structure ID is recorded as 1HU8^[20].
Transformation related protein 53's PDB structure ID is recorded as 2GEQ^[21].
Transformation related protein 53's PDB structure ID is recorded as 2P52^[22].
Transformation related protein 53's PDB structure ID is recorded as 3EXJ^[23].
Transformation related protein 53's PDB structure ID is recorded as 3EXL^[24].
Transformation related protein 53's molecular function is recorded as protein N-terminus binding^[25].
Transformation related protein 53's molecular function is recorded as DNA-binding transcription factor activity^[26].

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Quick Facts

Instance of protein

Subclass of protein

Part of p53-like transcription factor, DNA-binding, p53-like tetramerisation domain superfamily, p53/RUNT-type transcription factor, DNA-binding domain superfamily, p53 tumour suppressor family, p53 transactivation domain, protein family, p53, tetramerisation domain, protein family, p53, DNA-binding domain, protein family

Properties

Biological process somitogenesis, positive regulation of histone deacetylation, T cell differentiation in thymus, response to salt stress, rhythmic process, replicative senescence, regulation of transcription by RNA polymerase II, regulation of fibroblast apoptotic process, positive regulation of cardiac muscle cell apoptotic process, negative regulation of telomerase activity, negative regulation of glucose catabolic process to lactate via pyruvate, oligodendrocyte apoptotic process, regulation of mitochondrial membrane permeability involved in apoptotic process, T cell proliferation involved in immune response, cellular response to DNA damage stimulus, positive regulation of neuron apoptotic process, B cell lineage commitment, response to ischemia, positive regulation of reactive oxygen species metabolic process, circadian rhythm, regulation of intrinsic apoptotic signaling pathway by p53 class mediator, cell cycle, positive regulation of thymocyte apoptotic process, transforming growth factor beta receptor signaling pathway, negative regulation of cell population proliferation, apoptotic process, positive regulation of mitochondrial membrane permeability, regulation of apoptotic process, negative regulation of proteolysis, nucleotide-excision repair, cellular response to glucose starvation, regulation of transcription, DNA-templated, mitochondrial DNA repair, regulation of thymocyte apoptotic process, embryonic organ development, cardiac septum morphogenesis, regulation of neuron apoptotic process, in utero embryonic development, negative regulation of transforming growth factor beta receptor signaling pathway, response to oxidative stress, negative regulation of gene expression, transcription, DNA-templated, ER overload response, negative regulation of neuroblast proliferation, positive regulation of transcription, DNA-templated, embryo development ending in birth or egg hatching, negative regulation of mitophagy, development of the heart, central nervous system development, negative regulation of cell growth, intrinsic apoptotic signaling pathway by p53 class mediator, positive regulation of peptidyl-tyrosine phosphorylation, cellular response to UV-C, viral process, response to gamma radiation, negative regulation of fibroblast proliferation, positive regulation of intrinsic apoptotic signaling pathway, response to UV, neuron apoptotic process, determination of adult lifespan, multicellular organism growth, positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress, DNA damage response, signal transduction by p53 class mediator, protein stabilization, negative regulation of apoptotic process, protein tetramerization, chromosome organization, cerebellum development, oxidative stress-induced premature senescence, gastrulation, intrinsic apoptotic signaling pathway in response to hypoxia, positive regulation of release of cytochrome c from mitochondria, regulation of cellular senescence, circadian behavior, negative regulation of transcription, DNA-templated, T cell lineage commitment, protein localization, positive regulation of execution phase of apoptosis, programmed cell death, regulation of tissue remodeling, negative regulation of DNA replication, rRNA transcription, regulation of cell cycle, multicellular organism development, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, positive regulation of gene expression, regulation of cell population proliferation, double-strand break repair, mitotic G1 DNA damage checkpoint signaling, positive regulation of protein oligomerization, positive regulation of apoptotic process, positive regulation of transcription from RNA polymerase II promoter in response to hypoxia, negative regulation of reactive oxygen species metabolic process, necroptosis, entrainment of circadian clock by photoperiod, response to X-ray, positive regulation of transcription by RNA polymerase II, release of cytochrome c from mitochondria, negative regulation of mitotic cell cycle, transcription by RNA polymerase II, autophagy, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, cellular response to UV, positive regulation of transcription from RNA polymerase II promoter in response to stress, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, protein homotetramerization, interferon-gamma-mediated signaling pathway, cellular response to ionizing radiation, cellular response to gamma radiation, signal transduction by p53 class mediator, cellular response to actinomycin D, positive regulation of pri-miRNA transcription by RNA polymerase II, mRNA transcription, negative regulation of transcription by RNA polymerase II, positive regulation of RNA polymerase II transcription preinitiation complex assembly, RNA polymerase II preinitiation complex assembly, protein-containing complex assembly, positive regulation of leukocyte migration, cellular response to reactive oxygen species, positive regulation of cell cycle, negative regulation of smooth muscle cell proliferation, regulation of intracellular pH, regulation of hydrogen peroxide-induced cell death, negative regulation of DNA biosynthetic process, regulation of DNA damage response, signal transduction by p53 class mediator, negative regulation of production of miRNAs involved in gene silencing by miRNA, positive regulation of production of miRNAs involved in gene silencing by miRNA, RNA polymerase II preinitiation complex assembly, programmed necrotic cell death, positive regulation of programmed necrotic cell death, protein import into nucleus, positive regulation of intrinsic apoptotic signaling pathway, hematopoietic progenitor cell differentiation, positive regulation of leukocyte migration, nucleotide-excision repair, autophagy, cellular response to DNA damage stimulus, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, response to oxidative stress, ER overload response, Ras protein signal transduction, multicellular organism development, ageing, protein localization, negative regulation of cell population proliferation, mRNA transcription, response to UV, response to inorganic substance, response to metal ion, response to X-ray, response to UV-B, response to organonitrogen compound, response to gamma radiation, positive regulation of gene expression, response to organic cyclic compound, viral process, negative regulation of cell growth, DNA damage response, signal transduction by p53 class mediator, response to caffeine, mitotic G1 DNA damage checkpoint signaling, positive regulation of protein oligomerization, response to retinoic acid, response to vitamin B3, response to cytokine, cellular response to heat, cellular response to reactive oxygen species, cellular response to UV, wound healing, cellular response to glucose starvation, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, regulation of apoptotic process, positive regulation of apoptotic process, negative regulation of apoptotic process, response to amino acid, response to ethanol, positive regulation of cell cycle, negative regulation of transcription, DNA-templated, positive regulation of transcription, DNA-templated, positive regulation of RNA polymerase II transcription preinitiation complex assembly, positive regulation of transcription by RNA polymerase II, response to antibiotic, negative regulation of fibroblast proliferation, bone marrow development, negative regulation of smooth muscle cell proliferation, RNA polymerase II preinitiation complex assembly, protein homotetramerization, regulation of intracellular pH, negative regulation of telomerase activity, response to hyperoxia, hematopoietic stem cell differentiation, protein-containing complex assembly, cellular response to organonitrogen compound, cellular response to hypoxia, cellular response to ionizing radiation, cellular response to gamma radiation, signal transduction by p53 class mediator, intrinsic apoptotic signaling pathway by p53 class mediator, cellular response to actinomycin D, positive regulation of release of cytochrome c from mitochondria, replicative senescence, oxidative stress-induced premature senescence, oligodendrocyte apoptotic process, positive regulation of execution phase of apoptosis, positive regulation of pri-miRNA transcription by RNA polymerase II, regulation of hydrogen peroxide-induced cell death, positive regulation of production of miRNAs involved in gene silencing by miRNA, negative regulation of DNA biosynthetic process, positive regulation of reactive oxygen species metabolic process, positive regulation of intrinsic apoptotic signaling pathway, hematopoietic progenitor cell differentiation, bone marrow development, hematopoietic stem cell differentiation

Cell component cytoplasm, cytosol, mitochondrion, nucleus, site of double-strand break, nuclear body, transcription factor TFIID complex, nuclear matrix, replication fork, nucleolus, endoplasmic reticulum, nucleoplasm, mitochondrial matrix, intracellular anatomical structure, PML body, protein-containing complex, chromatin, transcription regulator complex, chromatin, transcription regulator complex, chromatin, nucleoplasm, transcription regulator complex, transcription factor TFIID complex, nucleolus, cytosol, nuclear matrix, nuclear body, protein-containing complex

Encoded by Trp53

Found in taxon house mouse

Has part(s) p53, tetramerisation domain, p53 transactivation domain, p53, DNA-binding domain

Imported from wholeness_audit_2026-05-02

Molecular function protein N-terminus binding, DNA-binding transcription factor activity, DNA-binding transcription activator activity, RNA polymerase II-specific, histone deacetylase regulator activity, protein self-association, DNA-binding transcription factor activity, RNA polymerase II-specific, protein phosphatase binding, ATP binding, transcription factor binding, metal ion binding, protein phosphatase 2A binding, enzyme binding, chromatin binding, protease binding, damaged DNA binding, protein binding, histone acetyltransferase binding, copper ion binding, protein kinase binding, DNA binding, chaperone binding, DNA-binding transcription activator activity, RNA polymerase II-specific, receptor tyrosine kinase binding, identical protein binding, protein heterodimerization activity, ubiquitin protein ligase binding, core promoter sequence-specific DNA binding, p53 binding, mRNA 3'-UTR binding, histone deacetylase binding, disordered domain specific binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, TFIID-class transcription factor complex binding, transcription coregulator binding, protein C-terminus binding, sequence-specific DNA binding, MDM2/MDM4 family protein binding, promoter-specific chromatin binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, core promoter sequence-specific DNA binding, p53 binding, ubiquitin protein ligase binding, DNA-binding transcription activator activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, core promoter sequence-specific DNA binding, TFIID-class transcription factor complex binding, transcription coregulator binding, DNA-binding transcription activator activity, RNA polymerase II-specific, protease binding, p53 binding, chromatin binding, mRNA 3'-UTR binding, copper ion binding, ATP binding, protein C-terminus binding, transcription factor binding, enzyme binding, protein kinase binding, protein phosphatase binding, receptor tyrosine kinase binding, ubiquitin protein ligase binding, histone acetyltransferase binding, identical protein binding, protein homodimerization activity, histone deacetylase binding, sequence-specific DNA binding, protein self-association, protein heterodimerization activity, protein N-terminus binding, chaperone binding, protein phosphatase 2A binding, MDM2/MDM4 family protein binding, disordered domain specific binding, promoter-specific chromatin binding, protein homodimerization activity

External References (4)

Ensembl protein id ENSMUSP00000005371, ENSMUSP00000104297, ENSMUSP00000104298, ENSMUSP00000127130

Pdb structure id 1HU8, 2GEQ, 2P52, 3EXJ, 3EXL

Refseq protein id NP_001120705, NP_035770, XP_006533220, XP_030101782, XP_030101783

Uniprot protein id P02340

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Transformation related protein 53 — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Transformation related protein 53 — subclass of (P279): protein. Q905695. Retrieved 2017-01-19. wikidata.org.
[4] ↑ Transformation related protein 53 — UniProt protein ID (P352): P02340. Q905695. Retrieved 2022-05-25. wikidata.org.
[5] ↑ Transformation related protein 53 — part of (P361): p53-like transcription factor, DNA-binding. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Transformation related protein 53 — part of (P361): p53-like tetramerisation domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Transformation related protein 53 — part of (P361): p53/RUNT-type transcription factor, DNA-binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ Transformation related protein 53 — part of (P361): p53 tumour suppressor family. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ Transformation related protein 53 — part of (P361): p53 transactivation domain, protein family. wikidata.org.
[10] ↑ Transformation related protein 53 — part of (P361): p53, tetramerisation domain, protein family. wikidata.org.
[11] ↑ Transformation related protein 53 — part of (P361): p53, DNA-binding domain, protein family. wikidata.org.
[12] ↑ Transformation related protein 53 — has part(s) (P527): p53, tetramerisation domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ Transformation related protein 53 — has part(s) (P527): p53 transactivation domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ Transformation related protein 53 — has part(s) (P527): p53, DNA-binding domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ Transformation related protein 53 — RefSeq protein ID (P637): NP_001120705. Q20641742. Retrieved 2022-03-20. wikidata.org.
[16] ↑ Transformation related protein 53 — RefSeq protein ID (P637): NP_035770. Q20641742. Retrieved 2022-03-20. wikidata.org.
[17] ↑ Transformation related protein 53 — RefSeq protein ID (P637): XP_006533220. Q20641742. Retrieved 2022-03-20. wikidata.org.
[18] ↑ Transformation related protein 53 — RefSeq protein ID (P637): XP_030101782. Q20641742. Retrieved 2022-03-20. wikidata.org.
[19] ↑ Transformation related protein 53 — RefSeq protein ID (P637): XP_030101783. Q20641742. Retrieved 2022-03-20. wikidata.org.
[20] ↑ Transformation related protein 53 — PDB structure ID (P638): 1HU8. Q905695. Retrieved 2016-08-09. wikidata.org.
[21] ↑ Transformation related protein 53 — PDB structure ID (P638): 2GEQ. Q905695. Retrieved 2016-08-09. wikidata.org.
[22] ↑ Transformation related protein 53 — PDB structure ID (P638): 2P52. Q905695. Retrieved 2016-08-09. wikidata.org.
[23] ↑ Transformation related protein 53 — PDB structure ID (P638): 3EXJ. Q905695. Retrieved 2016-08-09. wikidata.org.
[24] ↑ Transformation related protein 53 — PDB structure ID (P638): 3EXL. Q905695. Retrieved 2016-08-09. wikidata.org.
[25] ↑ Transformation related protein 53 — molecular function (P680): protein N-terminus binding. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Transformation related protein 53 — molecular function (P680): DNA-binding transcription factor activity. GOA. Retrieved 2019-05-09. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Transformation related protein 53 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

4ort.xyz Knowledge Graph. (2026). Transformation related protein 53. Retrieved May 3, 2026, from https://4ort.xyz/entity/transformation-related-protein-53

MLA

“Transformation related protein 53.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/transformation-related-protein-53.

BibTeX

@misc{4ortxyz_transformation-related-protein-53_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Transformation related protein 53}}, year = {2026}, url = {https://4ort.xyz/entity/transformation-related-protein-53}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): Transformation related protein 53 — https://4ort.xyz/entity/transformation-related-protein-53 (retrieved 2026-05-03)

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