Transcription factor AP-4

mammalian protein found in Homo sapiens

Protein protein Q21133097

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Transcription factor AP-4

Summary

Transcription factor AP-4 is a protein^[1].

Key Facts

Transcription factor AP-4's instance of is recorded as protein^[2].
Transcription factor AP-4's UniProt protein ID is recorded as Q01664^[3].
Transcription factor AP-4's part of is recorded as Helix-loop-helix DNA-binding domain superfamily^[4].
Transcription factor AP-4's part of is recorded as Myc-type, basic helix-loop-helix (bHLH) domain, protein family^[5].
Transcription factor AP-4's has part is recorded as Myc-type, basic helix-loop-helix (bHLH) domain^[6].
Transcription factor AP-4's RefSeq protein ID is recorded as NP_003214^[7].
Transcription factor AP-4's RefSeq protein ID is recorded as XP_011520935^[8].
Transcription factor AP-4's RefSeq protein ID is recorded as XP_011520937^[9].
Transcription factor AP-4's molecular function is recorded as sequence-specific DNA binding^[10].
Transcription factor AP-4's molecular function is recorded as RNA polymerase II cis-regulatory region sequence-specific DNA binding^[11].
Transcription factor AP-4's molecular function is recorded as protein homodimerization activity^[12].
Transcription factor AP-4's molecular function is recorded as protein dimerization activity^[13].
Transcription factor AP-4's molecular function is recorded as transcription coactivator activity^[14].
Transcription factor AP-4's molecular function is recorded as histone deacetylase binding^[15].
Transcription factor AP-4's molecular function is recorded as protein heterodimerization activity^[16].
Transcription factor AP-4's molecular function is recorded as transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding^[17].
Transcription factor AP-4's molecular function is recorded as DNA-binding transcription activator activity, RNA polymerase II-specific^[18].
Transcription factor AP-4's molecular function is recorded as protein binding^[19].
Transcription factor AP-4's molecular function is recorded as DNA binding^[20].
Transcription factor AP-4's molecular function is recorded as E-box binding^[21].
Transcription factor AP-4's molecular function is recorded as DNA-binding transcription factor activity, RNA polymerase II-specific^[22].
Transcription factor AP-4's molecular function is recorded as DNA-binding transcription factor activity^[23].
Transcription factor AP-4's molecular function is recorded as DNA-binding transcription factor activity, RNA polymerase II-specific^[24].
Transcription factor AP-4's cell component is recorded as transcription repressor complex^[25].
Transcription factor AP-4's cell component is recorded as nucleus^[26].

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Quick Facts

Instance of protein

Part of Helix-loop-helix DNA-binding domain superfamily, Myc-type, basic helix-loop-helix (bHLH) domain, protein family

Properties

Biological process negative regulation of cell population proliferation, negative regulation of cyclin-dependent protein serine/threonine kinase activity, transcription, DNA-templated, negative regulation of gene expression, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, cellular response to dexamethasone stimulus, negative regulation of DNA binding, positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway, positive regulation of apoptotic process, positive regulation of transcription, DNA-templated, regulation of transcription, DNA-templated, positive regulation of transcription by RNA polymerase II, transcription by RNA polymerase II, negative regulation of transcription, DNA-templated, regulation of mitotic cell cycle phase transition, protein-containing complex assembly, regulation of transcription by RNA polymerase II

Cell component transcription repressor complex, nucleus, mitochondrion, nucleus

Encoded by TFAP4

Found in taxon Homo sapiens

Has part(s) Myc-type, basic helix-loop-helix (bHLH) domain

Imported from wholeness_audit_2026-05-02

Molecular function sequence-specific DNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein homodimerization activity, protein dimerization activity, transcription coactivator activity, histone deacetylase binding, protein heterodimerization activity, transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding, DNA-binding transcription activator activity, RNA polymerase II-specific, protein binding, DNA binding, E-box binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific

External References (3)

Ensembl protein id ENSP00000204517, ENSP00000459390, ENSP00000460067, ENSP00000461352

Refseq protein id NP_003214, XP_011520935, XP_011520937

Uniprot protein id Q01664

🏷️ Also known as

en activating enhancer-binding protein 4 en bHLHc41 en class C basic helix-loop-helix protein 41 en TFAP4 en Transcription factor AP-4 en transcription factor AP-4 (activating enhancer binding protein 4)

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Transcription factor AP-4 — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ Transcription factor AP-4 — UniProt protein ID (P352): Q01664. Q905695. Retrieved 2019-11-13. wikidata.org.
[4] ↑ Transcription factor AP-4 — part of (P361): Helix-loop-helix DNA-binding domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Transcription factor AP-4 — part of (P361): Myc-type, basic helix-loop-helix (bHLH) domain, protein family. wikidata.org.
[6] ↑ Transcription factor AP-4 — has part(s) (P527): Myc-type, basic helix-loop-helix (bHLH) domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ Transcription factor AP-4 — RefSeq protein ID (P637): NP_003214. Q20641742. Retrieved 2020-05-30. wikidata.org.
[8] ↑ Transcription factor AP-4 — RefSeq protein ID (P637): XP_011520935. Q20641742. Retrieved 2020-05-30. wikidata.org.
[9] ↑ Transcription factor AP-4 — RefSeq protein ID (P637): XP_011520937. Q20641742. Retrieved 2020-05-30. wikidata.org.
[10] ↑ Transcription factor AP-4 — molecular function (P680): sequence-specific DNA binding. Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[11] ↑ Transcription factor AP-4 — molecular function (P680): RNA polymerase II cis-regulatory region sequence-specific DNA binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[12] ↑ Transcription factor AP-4 — molecular function (P680): protein homodimerization activity. Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[13] ↑ Transcription factor AP-4 — molecular function (P680): protein dimerization activity. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[14] ↑ Transcription factor AP-4 — molecular function (P680): transcription coactivator activity. Transcription factor AP-4 is a ligand for immunoglobulin-kappa promoter E-box elements. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ Transcription factor AP-4 — molecular function (P680): histone deacetylase binding. Transcriptional repression of human immunodeficiency virus type 1 by AP-4. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ Transcription factor AP-4 — molecular function (P680): protein heterodimerization activity. Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ Transcription factor AP-4 — molecular function (P680): transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding. Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro. Retrieved 2018-09-10. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ Transcription factor AP-4 — molecular function (P680): DNA-binding transcription activator activity, RNA polymerase II-specific. GOA. Retrieved 2018-09-10. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ Transcription factor AP-4 — molecular function (P680): protein binding. Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Transcription factor AP-4 — molecular function (P680): DNA binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Transcription factor AP-4 — molecular function (P680): E-box binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Transcription factor AP-4 — molecular function (P680): DNA-binding transcription factor activity, RNA polymerase II-specific. A census of human transcription factors: function, expression and evolution. Retrieved 2018-09-10. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Transcription factor AP-4 — molecular function (P680): DNA-binding transcription factor activity. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Transcription factor AP-4 — molecular function (P680): DNA-binding transcription factor activity, RNA polymerase II-specific. A census of human transcription factors: function, expression and evolution. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Transcription factor AP-4 — cell component (P681): transcription repressor complex. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Transcription factor AP-4 — cell component (P681): nucleus. GOA. Retrieved 2018-03-27. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Transcription factor AP-4 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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BibTeX

@misc{4ortxyz_transcription-factor-ap-4_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Transcription factor AP-4}}, year = {2026}, url = {https://4ort.xyz/entity/transcription-factor-ap-4}, note = {Accessed: 2026-05-03}}

LLM prompt

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