Transcription factor AP-2 alpha

mammalian protein found in Homo sapiens

Protein protein Q21106376

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Transcription factor AP-2 alpha

Summary

Transcription factor AP-2 alpha is a protein^[1].

Key Facts

Transcription factor AP-2 alpha's instance of is recorded as protein^[2].
Transcription factor AP-2 alpha's UniProt protein ID is recorded as P05549^[3].
Transcription factor AP-2 alpha's part of is recorded as transcription factor AP-2^[4].
Transcription factor AP-2 alpha's part of is recorded as Transcription factor AP-2, C-terminal domain, protein family^[5].
Transcription factor AP-2 alpha's part of is recorded as Transcription factor AP-2 alpha, N-terminal domain, protein family^[6].
Transcription factor AP-2 alpha's has part is recorded as Transcription factor AP-2 alpha, N-terminal^[7].
Transcription factor AP-2 alpha's has part is recorded as Transcription factor AP-2, C-terminal^[8].
Transcription factor AP-2 alpha's RefSeq protein ID is recorded as NP_001027451^[9].
Transcription factor AP-2 alpha's RefSeq protein ID is recorded as NP_001035890^[10].
Transcription factor AP-2 alpha's RefSeq protein ID is recorded as NP_003211^[11].
Transcription factor AP-2 alpha's RefSeq protein ID is recorded as XP_006715238^[12].
Transcription factor AP-2 alpha's RefSeq protein ID is recorded as XP_011513135^[13].
Transcription factor AP-2 alpha's RefSeq protein ID is recorded as XP_016866721^[14].
Transcription factor AP-2 alpha's RefSeq protein ID is recorded as NP_001358995^[15].
Transcription factor AP-2 alpha's molecular function is recorded as DNA binding^[16].
Transcription factor AP-2 alpha's molecular function is recorded as protein dimerization activity^[17].
Transcription factor AP-2 alpha's molecular function is recorded as protein homodimerization activity^[18].
Transcription factor AP-2 alpha's molecular function is recorded as DNA-binding transcription factor activity^[19].
Transcription factor AP-2 alpha's molecular function is recorded as transcription coactivator activity^[20].
Transcription factor AP-2 alpha's molecular function is recorded as DNA-binding transcription activator activity, RNA polymerase II-specific^[21].
Transcription factor AP-2 alpha's molecular function is recorded as chromatin binding^[22].
Transcription factor AP-2 alpha's molecular function is recorded as cis-regulatory region sequence-specific DNA binding^[23].
Transcription factor AP-2 alpha's molecular function is recorded as transcription cis-regulatory region binding^[24].
Transcription factor AP-2 alpha's molecular function is recorded as RNA polymerase II cis-regulatory region sequence-specific DNA binding^[25].
Transcription factor AP-2 alpha's molecular function is recorded as transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding^[26].

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Quick Facts

Instance of protein

Part of transcription factor AP-2, Transcription factor AP-2, C-terminal domain, protein family, Transcription factor AP-2 alpha, N-terminal domain, protein family

Properties

Biological process roof of mouth development, cellular response to iron ion, regulation of transcription, DNA-templated, retina layer formation, kidney development, positive regulation of bone mineralization, trigeminal nerve development, negative regulation of transcription by competitive promoter binding, optic vesicle morphogenesis, bone morphogenesis, negative regulation of apoptotic process, hearing, eyelid development in camera-type eye, transcription, DNA-templated, positive regulation of transcription, DNA-templated, positive regulation of neuron apoptotic process, positive regulation of gene expression, inner ear morphogenesis, optic cup structural organization, regulation of cell differentiation, embryonic cranial skeleton morphogenesis, negative regulation of reactive oxygen species metabolic process, negative regulation of transcription, DNA-templated, embryonic forelimb morphogenesis, oculomotor nerve formation, negative regulation of cell population proliferation, positive regulation of tooth mineralization, transcription by RNA polymerase II, negative regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, positive regulation of nucleic acid-templated transcription, regulation of transcription by RNA polymerase II, negative regulation of transcription by competitive promoter binding

Cell component centrosome, Golgi apparatus, intracellular membrane-bounded organelle, nucleus, nucleoplasm, cytosol, nucleus

Encoded by TFAP2A

Found in taxon Homo sapiens

Has part(s) Transcription factor AP-2 alpha, N-terminal, Transcription factor AP-2, C-terminal

Imported from wholeness_audit_2026-05-02

Molecular function DNA binding, protein dimerization activity, protein homodimerization activity, DNA-binding transcription factor activity, transcription coactivator activity, DNA-binding transcription activator activity, RNA polymerase II-specific, chromatin binding, cis-regulatory region sequence-specific DNA binding, transcription cis-regulatory region binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, protein binding, RNA polymerase II core promoter sequence-specific DNA binding, sequence-specific DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific

External References (3)

Ensembl protein id ENSP00000316516, ENSP00000368928, ENSP00000418541, ENSP00000368933, ENSP00000417495, ENSP00000417735, ENSP00000418391, ENSP00000419696, ENSP00000419823, ENSP00000419961, ENSP00000420568, ENSP00000501092

Refseq protein id NP_001027451, NP_001035890, NP_003211, XP_006715238, XP_011513135, XP_016866721, NP_001358995

Uniprot protein id P05549

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Transcription factor AP-2 alpha — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ Transcription factor AP-2 alpha — UniProt protein ID (P352): P05549. Q905695. Retrieved 2019-11-13. wikidata.org.
[4] ↑ Transcription factor AP-2 alpha — part of (P361): transcription factor AP-2. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[5] ↑ Transcription factor AP-2 alpha — part of (P361): Transcription factor AP-2, C-terminal domain, protein family. wikidata.org.
[6] ↑ Transcription factor AP-2 alpha — part of (P361): Transcription factor AP-2 alpha, N-terminal domain, protein family. wikidata.org.
[7] ↑ Transcription factor AP-2 alpha — has part(s) (P527): Transcription factor AP-2 alpha, N-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ Transcription factor AP-2 alpha — has part(s) (P527): Transcription factor AP-2, C-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ Transcription factor AP-2 alpha — RefSeq protein ID (P637): NP_001027451. Q20641742. Retrieved 2020-05-30. wikidata.org.
[10] ↑ Transcription factor AP-2 alpha — RefSeq protein ID (P637): NP_001035890. Q20641742. Retrieved 2020-05-30. wikidata.org.
[11] ↑ Transcription factor AP-2 alpha — RefSeq protein ID (P637): NP_003211. Q20641742. Retrieved 2020-05-30. wikidata.org.
[12] ↑ Transcription factor AP-2 alpha — RefSeq protein ID (P637): XP_006715238. Q20641742. Retrieved 2020-05-30. wikidata.org.
[13] ↑ Transcription factor AP-2 alpha — RefSeq protein ID (P637): XP_011513135. Q20641742. Retrieved 2020-05-30. wikidata.org.
[14] ↑ Transcription factor AP-2 alpha — RefSeq protein ID (P637): XP_016866721. Q20641742. Retrieved 2020-05-30. wikidata.org.
[15] ↑ Transcription factor AP-2 alpha — RefSeq protein ID (P637): NP_001358995. Q20641742. Retrieved 2020-05-30. wikidata.org.
[16] ↑ Transcription factor AP-2 alpha — molecular function (P680): DNA binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ Transcription factor AP-2 alpha — molecular function (P680): protein dimerization activity. Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ Transcription factor AP-2 alpha — molecular function (P680): protein homodimerization activity. Transcription factor AP-2 regulates human insulin-like growth factor binding protein-5 gene expression. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ Transcription factor AP-2 alpha — molecular function (P680): DNA-binding transcription factor activity. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Transcription factor AP-2 alpha — molecular function (P680): transcription coactivator activity. Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Transcription factor AP-2 alpha — molecular function (P680): DNA-binding transcription activator activity, RNA polymerase II-specific. A family of AP-2 proteins down-regulate manganese superoxide dismutase expression. Retrieved 2018-09-10. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Transcription factor AP-2 alpha — molecular function (P680): chromatin binding. GOA. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Transcription factor AP-2 alpha — molecular function (P680): cis-regulatory region sequence-specific DNA binding. Transcription factor AP-2 regulates human insulin-like growth factor binding protein-5 gene expression. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Transcription factor AP-2 alpha — molecular function (P680): transcription cis-regulatory region binding. Epigenetic regulation of HYAL-1 hyaluronidase expression. identification of HYAL-1 promoter. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Transcription factor AP-2 alpha — molecular function (P680): RNA polymerase II cis-regulatory region sequence-specific DNA binding. Derepression of the C/EBPα gene during adipogenesis: Identification of AP-2α as a repressor. Retrieved 2019-04-08. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Transcription factor AP-2 alpha — molecular function (P680): transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding. Dual association by TFAP2A during activation of the p21cip/CDKN1A promoter. Retrieved 2018-09-10. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Transcription factor AP-2 alpha is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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BibTeX

@misc{4ortxyz_transcription-factor-ap-2-alpha-q21106376_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{Transcription factor AP-2 alpha}}, year = {2026}, url = {https://4ort.xyz/entity/transcription-factor-ap-2-alpha-q21106376}, note = {Accessed: 2026-05-03}}

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