Transcription factor AP-2, alpha

mammalian protein found in Mus musculus

Protein protein Q21982739

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Transcription factor AP-2, alpha

Summary

Transcription factor AP-2, alpha is a protein^[1].

Key Facts

Transcription factor AP-2, alpha's instance of is recorded as protein^[2].
Transcription factor AP-2, alpha's subclass of is recorded as protein^[3].
Transcription factor AP-2, alpha's UniProt protein ID is recorded as P34056^[4].
Transcription factor AP-2, alpha's part of is recorded as transcription factor AP-2^[5].
Transcription factor AP-2, alpha's part of is recorded as Transcription factor AP-2, C-terminal domain, protein family^[6].
Transcription factor AP-2, alpha's part of is recorded as Transcription factor AP-2 alpha, N-terminal domain, protein family^[7].
Transcription factor AP-2, alpha's has part is recorded as Transcription factor AP-2, C-terminal^[8].
Transcription factor AP-2, alpha's has part is recorded as Transcription factor AP-2 alpha, N-terminal^[9].
Transcription factor AP-2, alpha's RefSeq protein ID is recorded as NP_001116420^[10].
Transcription factor AP-2, alpha's RefSeq protein ID is recorded as NP_001288603^[11].
Transcription factor AP-2, alpha's RefSeq protein ID is recorded as NP_035677^[12].
Transcription factor AP-2, alpha's RefSeq protein ID is recorded as XP_006516965^[13].
Transcription factor AP-2, alpha's RefSeq protein ID is recorded as XP_006516966^[14].
Transcription factor AP-2, alpha's RefSeq protein ID is recorded as XP_017170968^[15].
Transcription factor AP-2, alpha's RefSeq protein ID is recorded as XP_030103084^[16].
Transcription factor AP-2, alpha's molecular function is recorded as protein dimerization activity^[17].
Transcription factor AP-2, alpha's molecular function is recorded as DNA-binding transcription factor activity^[18].
Transcription factor AP-2, alpha's molecular function is recorded as DNA-binding transcription activator activity, RNA polymerase II-specific^[19].
Transcription factor AP-2, alpha's molecular function is recorded as DNA-binding transcription repressor activity, RNA polymerase II-specific^[20].
Transcription factor AP-2, alpha's molecular function is recorded as DNA-binding transcription factor activity, RNA polymerase II-specific^[21].
Transcription factor AP-2, alpha's molecular function is recorded as transcription coactivator activity^[22].
Transcription factor AP-2, alpha's molecular function is recorded as RNA polymerase II transcription regulatory region sequence-specific DNA binding^[23].
Transcription factor AP-2, alpha's molecular function is recorded as transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding^[24].
Transcription factor AP-2, alpha's molecular function is recorded as RNA polymerase II cis-regulatory region sequence-specific DNA binding^[25].
Transcription factor AP-2, alpha's molecular function is recorded as transcription corepressor activity^[26].

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Quick Facts

Instance of protein

Subclass of protein

Part of transcription factor AP-2, Transcription factor AP-2, C-terminal domain, protein family, Transcription factor AP-2 alpha, N-terminal domain, protein family

Properties

Biological process negative regulation of neuron apoptotic process, anterior neuropore closure, negative regulation of epidermal growth factor receptor signaling pathway, embryonic pattern specification, embryonic body morphogenesis, regulation of transcription by RNA polymerase II, trigeminal nerve development, outflow tract morphogenesis, forebrain neuron development, positive regulation of neuron apoptotic process, face morphogenesis, negative regulation of cell population proliferation, forelimb morphogenesis, regulation of neuron differentiation, regulation of transcription, DNA-templated, kidney development, negative regulation of transcription by competitive promoter binding, optic vesicle morphogenesis, transcription, DNA-templated, positive regulation of transcription, DNA-templated, lens morphogenesis in camera-type eye, embryonic camera-type eye morphogenesis, lens induction in camera-type eye, basement membrane organization, optic cup structural organization, positive regulation of tooth mineralization, roof of mouth development, positive regulation of bone mineralization, cornea development in camera-type eye, epidermis morphogenesis, skeletal system morphogenesis, negative regulation of apoptotic process, negative regulation of transcription by RNA polymerase II, eyelid development in camera-type eye, metanephric nephron development, nervous system development, keratinocyte development, sensory organ development, embryonic cranial skeleton morphogenesis, negative regulation of transcription, DNA-templated, embryonic forelimb morphogenesis, skin development, cellular response to iron ion, sympathetic nervous system development, neural crest cell development, positive regulation of cell migration, bone morphogenesis, hearing, neural tube closure, positive regulation of gene expression, inner ear morphogenesis, regulation of cell differentiation, negative regulation of reactive oxygen species metabolic process, oculomotor nerve formation, positive regulation of transcription by RNA polymerase II, transcription by RNA polymerase II, response to lipopolysaccharide, regulation of transcription by RNA polymerase II

Cell component nucleus, centrosome, Golgi apparatus, intracellular membrane-bounded organelle, transcription regulator complex, nucleoplasm, cytosol, nucleus

Encoded by Tfap2a

Found in taxon house mouse

Has part(s) Transcription factor AP-2, C-terminal, Transcription factor AP-2 alpha, N-terminal

Imported from wholeness_audit_2026-05-02

Molecular function protein dimerization activity, DNA-binding transcription factor activity, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, transcription coactivator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding, transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, transcription corepressor activity, chromatin binding, cis-regulatory region sequence-specific DNA binding, protein binding, DNA binding, sequence-specific DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, transcription coactivator activity, transcription cis-regulatory region binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, transcription factor binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific

External References (3)

Ensembl protein id ENSMUSP00000021787, ENSMUSP00000105822, ENSMUSP00000153149, ENSMUSP00000153271, ENSMUSP00000153667, ENSMUSP00000153522

Refseq protein id NP_001116420, NP_001288603, NP_035677, XP_006516965, XP_006516966, XP_017170968, XP_030103084

Uniprot protein id P34056

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ Transcription factor AP-2, alpha — instance of (P31): protein. Q905695. Retrieved 2022-05-25. wikidata.org.
[3] ↑ Transcription factor AP-2, alpha — subclass of (P279): protein. Q905695. Retrieved 2017-01-19. wikidata.org.
[4] ↑ Transcription factor AP-2, alpha — UniProt protein ID (P352): P34056. Q905695. Retrieved 2022-05-25. wikidata.org.
[5] ↑ Transcription factor AP-2, alpha — part of (P361): transcription factor AP-2. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[6] ↑ Transcription factor AP-2, alpha — part of (P361): Transcription factor AP-2, C-terminal domain, protein family. wikidata.org.
[7] ↑ Transcription factor AP-2, alpha — part of (P361): Transcription factor AP-2 alpha, N-terminal domain, protein family. wikidata.org.
[8] ↑ Transcription factor AP-2, alpha — has part(s) (P527): Transcription factor AP-2, C-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[9] ↑ Transcription factor AP-2, alpha — has part(s) (P527): Transcription factor AP-2 alpha, N-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[10] ↑ Transcription factor AP-2, alpha — RefSeq protein ID (P637): NP_001116420. Q20641742. Retrieved 2022-03-20. wikidata.org.
[11] ↑ Transcription factor AP-2, alpha — RefSeq protein ID (P637): NP_001288603. Q20641742. Retrieved 2022-03-20. wikidata.org.
[12] ↑ Transcription factor AP-2, alpha — RefSeq protein ID (P637): NP_035677. Q20641742. Retrieved 2022-03-20. wikidata.org.
[13] ↑ Transcription factor AP-2, alpha — RefSeq protein ID (P637): XP_006516965. Q20641742. Retrieved 2022-03-20. wikidata.org.
[14] ↑ Transcription factor AP-2, alpha — RefSeq protein ID (P637): XP_006516966. Q20641742. Retrieved 2022-03-20. wikidata.org.
[15] ↑ Transcription factor AP-2, alpha — RefSeq protein ID (P637): XP_017170968. Q20641742. Retrieved 2022-03-20. wikidata.org.
[16] ↑ Transcription factor AP-2, alpha — RefSeq protein ID (P637): XP_030103084. Q20641742. Retrieved 2022-03-20. wikidata.org.
[17] ↑ Transcription factor AP-2, alpha — molecular function (P680): protein dimerization activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ Transcription factor AP-2, alpha — molecular function (P680): DNA-binding transcription factor activity. GOA. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[19] ↑ Transcription factor AP-2, alpha — molecular function (P680): DNA-binding transcription activator activity, RNA polymerase II-specific. GOA. Retrieved 2018-09-10. ebi.ac.uk. Provenance: wikidata.org.
[20] ↑ Transcription factor AP-2, alpha — molecular function (P680): DNA-binding transcription repressor activity, RNA polymerase II-specific. GOA. Retrieved 2018-09-10. ebi.ac.uk. Provenance: wikidata.org.
[21] ↑ Transcription factor AP-2, alpha — molecular function (P680): DNA-binding transcription factor activity, RNA polymerase II-specific. GOA. Retrieved 2018-06-05. ebi.ac.uk. Provenance: wikidata.org.
[22] ↑ Transcription factor AP-2, alpha — molecular function (P680): transcription coactivator activity. A Heart-Hand Syndrome Gene: Tfap2b Plays a Critical Role in the Development and Remodeling of Mouse Ductus Arteriosus and Limb Patterning. Retrieved 2018-04-24. ebi.ac.uk. Provenance: wikidata.org.
[23] ↑ Transcription factor AP-2, alpha — molecular function (P680): RNA polymerase II transcription regulatory region sequence-specific DNA binding. Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and AP-2rep, a novel wt-1/egr-related zinc finger repressor. Retrieved 2018-06-05. ebi.ac.uk. Provenance: wikidata.org.
[24] ↑ Transcription factor AP-2, alpha — molecular function (P680): transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding. GOA. Retrieved 2018-09-10. ebi.ac.uk. Provenance: wikidata.org.
[25] ↑ Transcription factor AP-2, alpha — molecular function (P680): RNA polymerase II cis-regulatory region sequence-specific DNA binding. Regulation of Hoxa2 in cranial neural crest cells involves members of the AP-2 family. Retrieved 2019-02-14. ebi.ac.uk. Provenance: wikidata.org.
[26] ↑ Transcription factor AP-2, alpha — molecular function (P680): transcription corepressor activity. A Heart-Hand Syndrome Gene: Tfap2b Plays a Critical Role in the Development and Remodeling of Mouse Ductus Arteriosus and Limb Patterning. Retrieved 2018-04-24. ebi.ac.uk. Provenance: wikidata.org.

Class ancestry

[1] ↑ Transcription factor AP-2, alpha is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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