toll like receptor 4

mammalian protein found in Homo sapiens

Protein protein Q2335493

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toll like receptor 4

Summary

toll like receptor 4 is a protein^[1].

Key Facts

toll like receptor 4's instance of is recorded as protein^[2].
toll like receptor 4's physically interacts with is recorded as resatorvid^[3].
toll like receptor 4's subclass of is recorded as toll-like receptor^[4].
toll like receptor 4's UniProt protein ID is recorded as O00206^[5].
toll like receptor 4's part of is recorded as Toll/interleukin-1 receptor homology (TIR) domain superfamily^[6].
toll like receptor 4's part of is recorded as Leucine-rich repeat domain superfamily^[7].
toll like receptor 4's part of is recorded as NEAT-domain containing methaemoglobin heme sequestration family^[8].
toll like receptor 4's part of is recorded as Toll/interleukin-1 receptor homology (TIR) domain, protein family^[9].
toll like receptor 4's part of is recorded as Cysteine-rich flanking region, C-terminal domain, protein family^[10].
toll like receptor 4's part of is recorded as Leucine-rich repeat, typical subtype, protein family^[11].
toll like receptor 4's part of is recorded as Leucine-rich repeat, protein family^[12].
toll like receptor 4's MeSH descriptor ID is recorded as D051197^[13].
toll like receptor 4's has part is recorded as cysteine-rich flanking region, C-terminal^[14].
toll like receptor 4's has part is recorded as leucine-rich repeat, typical subtype^[15].
toll like receptor 4's has part is recorded as Leucine-rich repeat^[16].
toll like receptor 4's has part is recorded as Toll/interleukin-1 receptor homology (TIR) domain^[17].
toll like receptor 4's RefSeq protein ID is recorded as NP_003257^[18].
toll like receptor 4's RefSeq protein ID is recorded as NP_612564^[19].
toll like receptor 4's RefSeq protein ID is recorded as NP_612567^[20].
toll like receptor 4's PDB structure ID is recorded as 4G8A^[21].
toll like receptor 4's PDB structure ID is recorded as 2Z62^[22].
toll like receptor 4's PDB structure ID is recorded as 2Z63^[23].
toll like receptor 4's PDB structure ID is recorded as 2Z65^[24].
toll like receptor 4's PDB structure ID is recorded as 2Z66^[25].
toll like receptor 4's PDB structure ID is recorded as 3FXI^[26].

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Quick Facts

Instance of protein

Subclass of toll-like receptor

Part of Toll/interleukin-1 receptor homology (TIR) domain superfamily, Leucine-rich repeat domain superfamily, NEAT-domain containing methaemoglobin heme sequestration family, Toll/interleukin-1 receptor homology (TIR) domain, protein family, Cysteine-rich flanking region, C-terminal domain, protein family, Leucine-rich repeat, typical subtype, protein family, Leucine-rich repeat, protein family

Properties

Biological process positive regulation of MHC class II biosynthetic process, positive regulation of JNK cascade, TRIF-dependent toll-like receptor signaling pathway, cellular response to mechanical stimulus, positive regulation of interleukin-8 production, positive regulation of ERK1 and ERK2 cascade, T-helper 1 type immune response, positive regulation of platelet activation, positive regulation of interleukin-1 production, positive regulation of stress-activated MAPK cascade, positive regulation of NLRP3 inflammasome complex assembly, positive regulation of interleukin-12 production, positive regulation of interferon-alpha production, I-kappaB phosphorylation, positive regulation of nitric-oxide synthase biosynthetic process, positive regulation of B cell proliferation, defense response to bacterium, positive regulation of interleukin-6 production, activation of innate immune response, positive regulation of tumor necrosis factor production, negative regulation of tumor necrosis factor production, innate immune response, negative regulation of interleukin-17 production, I-kappaB kinase/NF-kappaB signaling, positive regulation of interferon-beta production, positive regulation of inflammatory response, toll-like receptor 4 signaling pathway, positive regulation of macrophage cytokine production, positive regulation of interleukin-10 production, immune system process, astrocyte development, intestinal epithelial structure maintenance, positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway, response to lipopolysaccharide, cellular response to lipoteichoic acid, positive regulation of NF-kappaB transcription factor activity, immune response, negative regulation of interleukin-23 production, regulation of inflammatory response, positive regulation of chemokine production, lipopolysaccharide-mediated signaling pathway, detection of fungus, positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway, negative regulation of interferon-gamma production, response to bacterium, negative regulation of osteoclast differentiation, B cell proliferation involved in immune response, positive regulation of nitric oxide biosynthetic process, negative regulation of interleukin-6 production, positive regulation of interferon-gamma production, nitric oxide production involved in inflammatory response, MyD88-dependent toll-like receptor signaling pathway, regulation of dendritic cell cytokine production, positive regulation of gene expression, negative regulation of ERK1 and ERK2 cascade, positive regulation of I-kappaB kinase/NF-kappaB signaling, macrophage activation, detection of lipopolysaccharide, cellular response to lipopolysaccharide, positive regulation of lymphocyte proliferation, positive regulation of transcription by RNA polymerase II, MyD88-independent toll-like receptor signaling pathway, signal transduction, inflammatory response, defense response to Gram-negative bacterium, toll-like receptor signaling pathway, necroptosis, apoptotic signaling pathway, negative regulation of MyD88-independent toll-like receptor signaling pathway

Cell component cytoplasm, membrane, perinuclear region of cytoplasm, cell surface, integral component of membrane, plasma membrane, endosome membrane, intrinsic component of plasma membrane, integral component of plasma membrane, lipopolysaccharide receptor complex, external side of plasma membrane

Encoded by TLR4

Found in taxon Homo sapiens

Has part(s) cysteine-rich flanking region, C-terminal, leucine-rich repeat, typical subtype, Leucine-rich repeat, Toll/interleukin-1 receptor homology (TIR) domain

Imported from wholeness_audit_2026-05-02

Molecular function lipopolysaccharide immune receptor activity, lipopolysaccharide binding, protein binding, transmembrane signaling receptor activity

Physically interacts with resatorvid

External References (9)

Ensembl protein id ENSP00000377997, ENSP00000363089, ENSP00000496429

Freebase id /m/02r7yg2

Mesh descriptor id D051197

Mesh tree code D12.776.543.750.705.910.500.400

Pdb structure id 4G8A, 2Z62, 2Z63, 2Z65, 2Z66, 3FXI, 3UL7, 3UL8, 3UL9, 3ULA

Refseq protein id NP_003257, NP_612564, NP_612567

Transporter classification database id 8.A.43.1.9

Umls cui C1411976

Uniprot protein id O00206

References

Programmatic citations — every numbered marker resolves to a verifiable graph row below.

Direct Wikidata claims

[2] ↑ toll like receptor 4 — instance of (P31): protein. Q905695. Retrieved 2019-11-13. wikidata.org.
[3] ↑ toll like receptor 4 — physically interacts with (P129): resatorvid. Open Targets Platform. Retrieved 2023-08-14. platform.opentargets.org. Provenance: wikidata.org.
[4] ↑ toll like receptor 4 — subclass of (P279): toll-like receptor. wikidata.org.
[5] ↑ toll like receptor 4 — UniProt protein ID (P352): O00206. Q905695. Retrieved 2019-11-13. wikidata.org.
[6] ↑ toll like receptor 4 — part of (P361): Toll/interleukin-1 receptor homology (TIR) domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[7] ↑ toll like receptor 4 — part of (P361): Leucine-rich repeat domain superfamily. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[8] ↑ toll like receptor 4 — part of (P361): NEAT-domain containing methaemoglobin heme sequestration family. Retrieved 2019-10-02. wikidata.org.
[9] ↑ toll like receptor 4 — part of (P361): Toll/interleukin-1 receptor homology (TIR) domain, protein family. wikidata.org.
[10] ↑ toll like receptor 4 — part of (P361): Cysteine-rich flanking region, C-terminal domain, protein family. wikidata.org.
[11] ↑ toll like receptor 4 — part of (P361): Leucine-rich repeat, typical subtype, protein family. wikidata.org.
[12] ↑ toll like receptor 4 — part of (P361): Leucine-rich repeat, protein family. wikidata.org.
[13] ↑ toll like receptor 4 — MeSH descriptor ID (P486): D051197. wikidata.org.
[14] ↑ toll like receptor 4 — has part(s) (P527): cysteine-rich flanking region, C-terminal. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[15] ↑ toll like receptor 4 — has part(s) (P527): leucine-rich repeat, typical subtype. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[16] ↑ toll like receptor 4 — has part(s) (P527): Leucine-rich repeat. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[17] ↑ toll like receptor 4 — has part(s) (P527): Toll/interleukin-1 receptor homology (TIR) domain. InterPro Release 71.0. ebi.ac.uk. Provenance: wikidata.org.
[18] ↑ toll like receptor 4 — RefSeq protein ID (P637): NP_003257. Q20641742. Retrieved 2020-05-30. wikidata.org.
[19] ↑ toll like receptor 4 — RefSeq protein ID (P637): NP_612564. Q20641742. Retrieved 2020-05-30. wikidata.org.
[20] ↑ toll like receptor 4 — RefSeq protein ID (P637): NP_612567. Q20641742. Retrieved 2020-05-30. wikidata.org.
[21] ↑ toll like receptor 4 — PDB structure ID (P638): 4G8A. Q905695. Retrieved 2016-08-05. wikidata.org.
[22] ↑ toll like receptor 4 — PDB structure ID (P638): 2Z62. Q905695. Retrieved 2016-08-05. wikidata.org.
[23] ↑ toll like receptor 4 — PDB structure ID (P638): 2Z63. Q905695. Retrieved 2016-08-05. wikidata.org.
[24] ↑ toll like receptor 4 — PDB structure ID (P638): 2Z65. Q905695. Retrieved 2016-08-05. wikidata.org.
[25] ↑ toll like receptor 4 — PDB structure ID (P638): 2Z66. Q905695. Retrieved 2016-08-05. wikidata.org.
[26] ↑ toll like receptor 4 — PDB structure ID (P638): 3FXI. Q905695. Retrieved 2016-08-05. wikidata.org.

Class ancestry

[1] ↑ toll like receptor 4 is an instance of protein (Q8054) [P31, primary]. Wikidata. wikidata.org.

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APA

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MLA

“toll like receptor 4.” 4ort.xyz Knowledge Graph, 4ort.xyz, 3 May. 2026, https://4ort.xyz/entity/toll-like-receptor-4-q2335493.

BibTeX

@misc{4ortxyz_toll-like-receptor-4-q2335493_2026, author = {{4ort.xyz Knowledge Graph}}, title = {{toll like receptor 4}}, year = {2026}, url = {https://4ort.xyz/entity/toll-like-receptor-4-q2335493}, note = {Accessed: 2026-05-03}}

LLM prompt

According to 4ort.xyz Knowledge Graph (aggregator of Wikidata, Wikipedia, and authoritative open-data sources): toll like receptor 4 — https://4ort.xyz/entity/toll-like-receptor-4-q2335493 (retrieved 2026-05-03)

Canonical URL: https://4ort.xyz/entity/toll-like-receptor-4-q2335493 · Last refreshed: May 3, 2026